A Hippocampal Protein Associated with Paraneoplastic Neurologic Syndrome and Small Cell Lung Carcinoma
Abstract
A hippocampal 38 kd autoantigen recognized by an autoantibody from the serum of a patient with paraneoplastic limbic encephalitis (PLE) and small cell lung carcinoma (SCLC) was isolated by screening a human hippocampal cDNA library. The 1,991-nucleotide ple21 clone was obtained and the deduced 350-residue protein encoded by the ple21 cDNA clone was found to be highly homologous to the neuron-specific RNA recognition motifs (RRMs)-containing proteins. The homologies were confined to the RRMs and the RRM connecting region. The presence of RRM in the antigenic protein may be important in the pathogenesis of SCLC-associated paraneoplastic neurologic syndrome.
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nELAVLs are target antigens in patients with paraneoplastic neurological disorders.
“Like NOVA, nELAVLs are target antigens in patients with paraneo-plastic neurological disorders121,122.”
From The neurogenetics of alternative splicing (2016) · cites this paper as [122]
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- Authors
- Sakai, K., Gofuku, M., Kitagawa, Y., Ogasawara, T., Hirose, G., Yamazaki, M., Koh, C. S., Yanagisawa, N., & Steinman, L.
- Affiliations
- Shinshu University (JP)
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1994-03
- Volume
- 199
- Issue
- 3
- Pages
- 1200-1208
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2063574627
- Cited by
- 85
- References
- 0
- Citations by year
- 2025: 1 · 2022: 1 · 2021: 1 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 3 · 2012: 1
- FWCI
- 6.95
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Neurology › Autoimmune Neurological Disorders and Treatments
- Health Sciences › Medicine › Rheumatology › Systemic Lupus Erythematosus Research
- Health Sciences › Medicine › Oncology › Lung Cancer Research Studies
- Keywords
- paraneoplastic neurological syndromes, paraneoplastic limbic encephalitis, small cell lung cancer, autoantibodies, RNA recognition motif, protein homology, autoimmune disease pathogenesis
- MeSH terms
- ELAV-Like Protein 3, Amino Acid Sequence, Autoantigens, Base Sequence, Cerebellum, Cloning, Molecular, Frontal Lobe, Ganglia, Spinal, Hippocampus, Humans, Lung Neoplasms, Male, Middle Aged, Molecular Sequence Data, Nerve Tissue Proteins, Paraneoplastic Syndromes, Poly A, Recombinant Proteins, RNA, RNA, Messenger, Gene Library, RNA-Binding Proteins, Sequence Homology, Amino Acid, DNA, Complementary, Carcinoma, Small Cell, ELAV Proteins
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