Evidence for 3′ Untranslated Region-Dependent Autoregulation of the Drosophila Gene Encoding the Neuronal Nuclear RNA-Binding Protein ELAV
Abstract
The Drosophila locus embryonic lethal abnormal visual system (elav) encodes a nuclear RNA-binding protein essential for normal neuronal differentiation and maintenance of neurons. ELAV is thought to play its role by binding to RNAs produced by other genes necessary for neuronal differentiation and consequently to affect their metabolism by an as yet unknown mechanism. ELAV structural homologues have been identified in a wide range of organisms, including humans, indicating an important conserved role for the protein. Analysis of elav germline transformants presented here shows that one copy of elav minigenes lacking a complete 3' untranslated region (3' UTR) rescues null mutations at elav, but that two copies are lethal. Additional in vivo experiments demonstrate that elav expression is regulated through the 3' UTR of the gene and indicate that this level of regulation is dependent upon ELAV itself. Because ELAV is an RNA-binding protein, the simplest model to account for these findings is that ELAV binds to the 3' UTR of its own RNA to autoregulate its expression. I discuss the implications of these results for normal elav function.
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The Drosophila ELAV homolog negatively regulates its own transcript.
“Another possible significance of this interaction may be similar to the one found for the Drosophila ELAV homolog, which was demonstrated to negatively regulate its own transcript (Samson 1998; Borgeson and Samson 2005).”
From Emerging complexity of the HuD/ELAVl4 gene; implications for neuronal development, function, and dysfunction (2013) · cites this paper as Samson 1998
Cites
AU-rich elements: characterization and importance in mRNA degradation
Chen, C.-Y. A., & Shyu, A.-B. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89102-1 · Cited by 1,948 · see citing works
Conserved Structures and Diversity of Functions of RNA-Binding Proteins
Burd, C. G., & Dreyfuss, G. (1994) · Science · doi:10.1126/science.8036511 · Cited by 1,878 · see citing works
Messenger RNA degradation in eukaryotes
Sachs, A. B. (1993) · Cell · doi:10.1016/0092-8674(93)80043-e · Cited by 846 · see citing works
RNA recognition: towards identifying determinants of specificity
Kenan, D. J., Query, C. C., & Keene, J. D. (1991) · Trends in Biochemical Sciences · doi:10.1016/0968-0004(91)90088-d · Cited by 748 · see citing works
Analysis of P transposable element functions in drosophila
Karess, R. E., & Rubin, G. M. (1984) · Cell · doi:10.1016/0092-8674(84)90534-8 · Cited by 731 · see citing works
Cloning and Characterization of HuR, a Ubiquitously Expressed Elav-like Protein
Ma, W.-J., Cheng, S., Campbell, C., Wright, A., & Furneaux, H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.14.8144 · Cited by 667 · see citing works
INTERRELATIONSHIPS OF THE PATHWAYS OF mRNA DECAY AND TRANSLATION IN EUKARYOTIC CELLS
Jacobson, A., & Peltz, S. W. (1996) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.65.070196.003401 · Cited by 658 · see citing works
Szabo, A., Dalmau, J., Manley, G., Rosenfeld, M., Wong, E., Henson, J., Posner, J. B., & Furneaux, H. M. (1991) · Cell · doi:10.1016/0092-8674(91)90184-z · Cited by 553 · see citing works
Vectors for Drosophila P-element-mediated transformation and tissue culture transfection
Thummel, C. S., Boulet, A. M., & Lipshitz, H. D. (1988) · Gene · doi:10.1016/0378-1119(88)90177-1 · Cited by 549 · see citing works
Robinow, S., & White, K. (1991) · Journal of Neurobiology · doi:10.1002/neu.480220503 · Cited by 507 · see citing works
Vectors for P-Mediated Transformation in Drosophila
Pirrotta, V. (1988) · Elsevier eBooks · doi:10.1016/b978-0-409-90042-2.50028-3 · Cited by 402 · see citing works
Translational regulation in development
Curtis, D., Lehmann, R., & Zamore, P. D. (1995) · Cell · doi:10.1016/0092-8674(95)90325-9 · Cited by 395 · see citing works
A Hierarchy of Hu RNA Binding Proteins in Developing and Adult Neurons
Okano, H. J., & Darnell, R. B. (1997) · The Journal of Neuroscience · doi:10.1523/jneurosci.17-09-03024.1997 · Cited by 379 · see citing works
Levine, T., Gao, F., King, P. H., Andrews, L. G., & Keene, J. D. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.6.3494 · Cited by 356 · see citing works
A conserved family of elav-like genes in vertebrates.
Good, P. J. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4557 · Cited by 319 · see citing works
Identification of HuR as a protein implicated in AUUUA‐mediated mRNA decay
Myer, V. E., Fan, X. C., & Steitz, J. A. (1997) · The EMBO Journal · doi:10.1093/emboj/16.8.2130 · Cited by 302 · see citing works
The elav Gene Product of Drosophila , Required in Neurons, Has Three RNP Consensus Motifs
Robinow, S., Campos, A. R., Yao, K., & White, K. (1988) · Science · doi:10.1126/science.3144044 · Cited by 300 · see citing works
Sex lethal controls dosage compensation in Drosophila by a non-splicing mechanism
Kelley, R. L., Wang, J., Bell, L. R., & Kuroda, M. I. (1997) · Nature · doi:10.1038/387195a0 · Cited by 260 · see citing works
RNA recognition: A family matter?
Mattaj, I. W. (1993) · Cell · doi:10.1016/0092-8674(93)90265-r · Cited by 252 · see citing works
Sequential expression and role of Hu RNA-binding proteins during neurogenesis
Wakamatsu, Y., & Weston, J. A. (1997) · Development · doi:10.1242/dev.124.17.3449 · Cited by 240 · see citing works
The Regulation of the Drosophila Gene Reveals a Function for in Translational Control
Bashaw, G. J., & Baker, B. S. (1997) · Cell · doi:10.1016/s0092-8674(00)80262-7 · Cited by 212 · see citing works
Campos, A. R., And, D. G., & White, K. (1985) · Journal of Neurogenetics · doi:10.3109/01677068509100150 · Cited by 210 · see citing works
The Elav-like proteins bind to AU-rich elements and to the poly(A) tail of mRNA
Ma, W., Chung, S., & Furneaux, H. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.18.3564 · Cited by 210 · see citing works
Jain, R. G., Andrews, L. G., McGowan, K. M., Pekala, P. H., & Keene, J. D. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.2.954 · Cited by 199 · see citing works
Koushika, S. P., Lisbin, M. J., & White, K. (1996) · Current Biology · doi:10.1016/s0960-9822(02)70787-2 · Cited by 181 · see citing works
Purification and Properties of HuD, a Neuronal RNA-binding Protein
Chung, S., Jiang, L., Cheng, S., & Furneaux, H. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.19.11518 · Cited by 168 · see citing works
King, P. H., Levine, T., Fremeau, R. T., & Keene, J. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-04-01943.1994 · Cited by 167 · see citing works
Yao, K., Samson, M., Reeves, R. K., & White, K. (1993) · Journal of Neurobiology · doi:10.1002/neu.480240604 · Cited by 165 · see citing works
Self-citationGao, F., Carson, C. C., Levine, T., & Keene, J. D. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.23.11207 · Cited by 156 · see citing works
Chung, S., Eckrich, M., Perrone-Bizzozero, N., Kohn, D. T., & Furneaux, H. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.10.6593 · Cited by 142 · see citing works
Paraneoplastic Encephalomyelitis Antigens Bind to the AU-rich Elements of mRNA
Liu, J., Dalmau, J., Szabo, A., Rosenfeld, M., Huber, J., & Furneaux, H. (1995) · Neurology · doi:10.1212/wnl.45.3.544 · Cited by 122 · see citing works
Gao, F., & Keene, J. D. (1996) · Journal of Cell Science · doi:10.1242/jcs.109.3.579 · Cited by 121 · see citing works
Campos, A. R., Rosen, D. R., Robinow, S., & White, K. (1987) · The EMBO Journal · doi:10.1002/j.1460-2075.1987.tb04772.x · Cited by 112 · see citing works
Jiménez, F., & Campos‐Ortega, J. A. (1987) · Journal of Neurogenetics · doi:10.3109/01677068709102340 · Cited by 110 · see citing works
Kelley, R. L., & Kuroda, M. I. (1995) · Science · doi:10.1126/science.270.5242.1607 · Cited by 108 · see citing works
Identification and Characterization of a Neuron-Specific Nuclear Antigen in Drosophila
Bier, E., Ackerman, L. D., Barbel, S., Jan, L. Y., & Jan, Y. N. (1988) · Science · doi:10.1126/science.3129785 · Cited by 106 · see citing works
Abe, R., Sakashita, E., Yamamoto, K. I., & Sakamoto, H. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.24.4895 · Cited by 99 · see citing works
Kim, Y., & Baker, B. S. (1993) · Journal of Neuroscience · doi:10.1523/jneurosci.13-03-01045.1993 · Cited by 87 · see citing works
Sakai, K., Gofuku, M., Kitagawa, Y., Ogasawara, T., Hirose, G., Yamazaki, M., Koh, C. S., Yanagisawa, N., & Steinman, L. (1994) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1994.1358 · Cited by 85 · see citing works
Dreyfuss, G., Hentze, M. W., & Lamond, A. I. (1996) · Cell · doi:10.1016/s0092-8674(00)81298-2 · Cited by 70 · see citing works
Abe, R. (1996) · Nucleic Acids Research · doi:10.1093/nar/24.11.2011 · Cited by 47 · see citing works
Homyk, T., Isono, K., & Pak, W. L. (1985) · Journal of Neurogenetics · doi:10.3109/01677068509102326 · Cited by 46 · see citing works
Yannoni, Y. M., & White, K. (1997) · Chromosoma · doi:10.1007/bf02529748 · Cited by 42 · see citing works
Differential Activity of ELAV-like RNA-binding Proteins in Human Neuroblastoma
Chagnovich, D., Fayos, B. E., & Cohn, S. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33587 · Cited by 38 · see citing works
Chagnovich, D., & Cohn, S. L. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.52.33580 · Cited by 37 · see citing works
Distinct mechanisms of splicing regulation in vivo by the Drosophila protein Sex-lethal
Granadino, B., Penalva, L. O. F., Green, M. R., Valcárcel, J., & Sánchez, L. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.14.7343 · Cited by 35 · see citing works
Samson, M., Lisbin, M. J., & White, K. (1995) · Genetics · doi:10.1093/genetics/141.3.1101 · Cited by 34 · see citing works
Self-citationKing, P. H. (1994) · Gene · doi:10.1016/0378-1119(94)90668-8 · Cited by 28 · see citing works
Yao, K., & White, K. (1991) · Molecular and Cellular Biology · doi:10.1128/mcb.11.6.2994 · Cited by 27 · see citing works
Steller, U., Kohls, S., Müller, B., Söller, R., Müller, R., Schlender, J., & Blohm, D. H. (1996) · Molecular Brain Research · doi:10.1016/0169-328x(95)00231-g · Cited by 23 · see citing works
Celniker, S., & Lewis, E. B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.4.1566 · Cited by 19 · see citing works
Perron, M., Théodore, L., & Wegnez, M. R. (1995) · Mechanisms of Development · doi:10.1016/0925-4773(95)00368-1 · Cited by 18 · see citing works
Perron, M., BOURLITIO, P., Wegnez, M. R., & Théodore, L. (1997) · DNA and Cell Biology · doi:10.1089/dna.1997.16.579 · Cited by 11 · see citing works
Flagged first, then by citations
1 of the 54 references couldn’t be matched to a known paper.
Cited by
Sorted by citations
Penalva, L. O. F., & Sánchez, L. (2003) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.67.3.343-359.2003 · Cited by 185 · see citing works
Deciphering the role of RNA-binding proteins in the post-transcriptional control of gene expression
Kishore, S., Luber, S., & Zavolan, M. (2010) · Briefings in Functional Genomics · doi:10.1093/bfgp/elq028 · Cited by 178 · see citing works
Dai, W., Zhang, G., & Makeyev, E. V. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr783 · Cited by 148 · see citing works
Neural-specific elongation of 3′ UTRs during Drosophila development
Hilgers, V., Perry, M., Hendrix, D. A., Stark, A., Levine, M., & Haley, B. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1112672108 · Cited by 142 · see citing works
Neuronal ELAV proteins enhance mRNA stability by a PKCα-dependent pathway
Pascale, A., Amadio, M., Scapagnini, G., Lanni, C., Racchi, M., Provenzani, A., Govoni, S., Alkon, D. L., & Quattrone, A. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504702102 · Cited by 129 · see citing works
Bronicki, L. M., & Jasmin, B. J. (2013) · RNA · doi:10.1261/rna.039164.113 · Cited by 126 · see citing works
Advancing the functional utility of PAR-CLIP by quantifying background binding to mRNAs and lncRNAs
Friedersdorf, M. B., & Keene, J. D. (2014) · Genome biology · doi:10.1186/gb-2014-15-1-r2 · Cited by 124 · see citing works
The RNA‐binding protein HuD: a regulator of neuronal differentiation, maintenance and plasticity
Deschênes‐Furry, J., Perrone‐Bizzozero, N. I., & Jasmin, B. J. (2006) · BioEssays · doi:10.1002/bies.20449 · Cited by 116 · see citing works
Bolognani, F., Contente-Cuomo, T., & Perrone-Bizzozero, N. I. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkp863 · Cited by 113 · see citing works
ELAV mediates 3′ UTR extension in the Drosophila nervous systemPreprint
Hilgers, V., Lemke, S. B., & Levine, M. (2012) · Genes & Development · doi:10.1101/gad.199653.112 · Cited by 101 · see citing works
Lisbin, M. J., Qiu, J., & White, K. (2001) · Genes & Development · doi:10.1101/gad.903101 · Cited by 97 · see citing works
Pre-messenger RNA processing and its regulation: a genomic perspective
Soller, M. (2006) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-005-5391-x · Cited by 88 · see citing works
ELAV inhibits 3′-end processing to promote neural splicing of <i>ewg</i> pre-mRNA
Soller, M., & White, K. (2003) · Genes & Development · doi:10.1101/gad.1106703 · Cited by 89 · see citing works
A role for the ELAV RNA-binding proteins in neural stem cells: stabilization of<i>Msi1</i>mRNA
Ratti, A., Fallini, C., Cova, L., Fantozzi, R., Calzarossa, C., Zennaro, E., Pascale, A., Quattrone, A., & Silani, V. (2006) · Journal of Cell Science · doi:10.1242/jcs.02852 · Cited by 86 · see citing works
Alternative polyadenylation in the regulation and dysregulation of gene expression
Turner, R. E., Pattison, A., & Beilharz, T. H. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.08.056 · Cited by 76 · see citing works
Koushika, S. P., Soller, M., & White, K. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1836-1845.2000 · Cited by 73 · see citing works
Zaharieva, E. E., Haussmann, I. U., Bräuer, U., & Soller, M. (2015) · Molecular and Cellular Biology · doi:10.1128/mcb.00473-15 · Cited by 72 · see citing works
ELAV proteins along evolution: Back to the nucleus?
Colombrita, C., Silani, V., & Ratti, A. (2013) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2013.02.003 · Cited by 69 · see citing works
Ratti, A., Fallini, C., Colombrita, C., Pascale, A., Laforenza, U., Quattrone, A., & Silani, V. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m706082200 · Cited by 66 · see citing works
The third RNA recognition motif of Drosophila ELAV protein has a role in multimerization
Toba, G., & White, K. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkm1168 · Cited by 64 · see citing works
Landscape and evolution of tissue-specific alternative polyadenylation across Drosophila species
Sanfilippo, P., Wen, J., & Lai, E. C. (2017) · Genome biology · doi:10.1186/s13059-017-1358-0 · Cited by 63 · see citing works
Bolognani, F., Tanner, D. C., Merhege, M., Deschênes‐Furry, J., Jasmin, B. J., & Perrone‐Bizzozero, N. I. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2005.03607.x · Cited by 59 · see citing works
Samson, M., & Chalvet, F. (2003) · Mechanisms of Development · doi:10.1016/s0925-4773(02)00444-6 · Cited by 51 · see citing works
Self-citationALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity
Garone, M. G., Birsa, N., Rosito, M., Salaris, F., Mochi, M., de Turris, V., Nair, R., Cunningham, T. J., Fisher, E., Morlando, M., et al. (2021) · Communications Biology · doi:10.1038/s42003-021-02538-8 · Cited by 40 · see citing works
Lisbin, M. J., Gordon, M., Yannoni, Y. M., & White, K. (2000) · Genetics · doi:10.1093/genetics/155.4.1789 · Cited by 39 · see citing works
Shared RNA-binding sites for interacting members of the Drosophila ELAV family of neuronal proteins
Borgeson, C. D. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki942 · Cited by 36 · see citing works
Haussmann, I. U., Li, M., & Soller, M. (2011) · Genetics · doi:10.1534/genetics.111.131383 · Cited by 35 · see citing works
Nie, Z., Wu, J., Zhai, J., Lin, H., Ge, W., Schlaepfer, W. W., & Cañete-Soler, R. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-17-07662.2002 · Cited by 34 · see citing works
Samson, M. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m001346200 · Cited by 32 · see citing works
Self-citationMoschall, R., Gaik, M., & Medenbach, J. (2017) · FEBS Letters · doi:10.1002/1873-3468.12652 · Cited by 28 · see citing works
Deletion of the Drosophila neuronal gene found in neurons disrupts brain anatomy and male courtship
Zanini, D., Jallon, J. M., Rabinow, L., & Samson, M. L. (2012) · Genes Brain & Behavior · doi:10.1111/j.1601-183x.2012.00817.x · Cited by 28 · see citing works
Self-citationDomain necessary for Drosophila ELAV nuclear localization: function requires nuclear ELAV
Yannoni, Y. M., & White, K. (1999) · Journal of Cell Science · doi:10.1242/jcs.112.24.4501 · Cited by 27 · see citing works
Regulation of neuronal RNA signatures by ELAV /Hu proteins
Hilgers, V. (2022) · Wiley Interdisciplinary Reviews - RNA · doi:10.1002/wrna.1733 · Cited by 24 · see citing works
Alternative splicing in Drosophila neuronal development
Mohr, C., & Hartmann, B. (2014) · Journal of Neurogenetics · doi:10.3109/01677063.2014.936437 · Cited by 23 · see citing works
Takada, H., Kawana, T., Ito, Y., Kikuno, R. F., Mamada, H., Araki, T., Koga, H., Asashima, M., & Taira, M. (2009) · Development · doi:10.1242/dev.029165 · Cited by 23 · see citing works
Toba, G., Qui, J., Koushika, S. P., & White, K. (2002) · Journal of Cell Science · doi:10.1242/jcs.115.11.2413 · Cited by 20 · see citing works
Sun, X., Yang, H., Sturgill, D. M., Oliver, B., Rabinow, L., & Samson, M. (2015) · G3 Genes Genomes Genetics · doi:10.1534/g3.115.023721 · Cited by 20 · see citing works
Self-citationAssociations between variants of bone morphogenetic protein 7 gene and growth traits in chickens
Wang, Y., Guo, F., Qu, H., Luo, C., Wang, J., & Shu, D. (2018) · British Poultry Science · doi:10.1080/00071668.2018.1454586 · Cited by 17 · see citing works
Cup is essential for oskar mRNA translational repression during early Drosophila oogenesis
Bayer, L. V., Milano, S. N., Formel, S. K., Kaur, H., Ravichandran, R., Cambeiro, J. A., Slinko, L., Catrina, I. E., & Bratu, D. P. (2023) · RNA Biology · doi:10.1080/15476286.2023.2242650 · Cited by 14 · see citing works
Bronicki, L., Bélanger, G., & Jasmin, B. J. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.2247-12.2012 · Cited by 13 · see citing works
Badaoui, M., Sobolewski, C., Lüscher, A., Bacchetta, M., Köhler, T., van Delden, C., Foti, M., & Chanson, M. (2023) · JCI Insight · doi:10.1172/jci.insight.161961 · Cited by 12 · see citing works
Determinants of ELAV gene-specific regulation
Soller, M., Li, M., & Haussmann, I. U. (2010) · Biochemical Society Transactions · doi:10.1042/bst0381122 · Cited by 12 · see citing works
Regulation of the ELAV target ewg: insights from an evolutionary perspective
Soller, M., Li, M., & Haussmann, I. U. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360502 · Cited by 11 · see citing works
Characterization of Two Promoters of the Xenopus laevis elrD Gene
Nassar, F., & Wegnez, M. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.4812 · Cited by 6 · see citing works
Characterization of fly strains permitting GAL4‐directed expression of found in neurons
Chalvet, F., & Samson, M. (2002) · genesis · doi:10.1002/gene.10108 · Cited by 4 · see citing works
Self-citationRegulation and expression of elrD1 and elrD2 transcripts during early Xenopus laevis development
Nassar, F. (2011) · The International Journal of Developmental Biology · doi:10.1387/ijdb.093050fn · Cited by 1 · see citing works
Garg, K., Sharma, G., Samaddar, S., & Banerjee, S. (2025) · Open Biology · doi:10.1098/rsob.250164
Garone, M. G., Birsa, N., Rosito, M., Salaris, F., Mochi, M., de Turris, V., Nair, R., Cunningham, T. J., Fisher, E., Morlando, M., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.26.268631 · Cited by 1 · see citing works
Post-Transcriptional Control of the GAP-43 mRNA by the ELAV-Like Protein HuD
Perrone‐Bizzozero, N. I., & Keller, R. W. (2002) · Endocrine updates · doi:10.1007/978-1-4757-6446-8_9
Unravelling molecular mechanisms of polo alternative polyadenylation
Pinho, M. S. B. (2014) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT) · doi:10.34626/y9e1-gw60
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Garg, K., Sharma, G., Samaddar, S., & Banerjee, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.28.601280
- Authors
- Samson, M.-L.
- Affiliations
- University of Nebraska Medical Center (US)
- Corresponding author
- Samson, Marie-Laure
- Venue
- Genetics
- Publisher
- Oxford University Press (OUP)
- Published
- 1998-10-01
- Volume
- 150
- Issue
- 2
- Pages
- 723-733
- ISSN
- 0016-6731 (ISSN-L)
- 1943-2631
- OpenAlex
- W1895804627
- Cited by
- 51
- References
- 54
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 1 · 2018: 1 · 2017: 3 · 2015: 2 · 2014: 3 · 2013: 2 · 2012: 3
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model (vor)
- Locations
- Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA and protein synthesis mechanisms
- Keywords
- ELAV, 3' untranslated region, autoregulation, RNA-binding proteins, gene expression regulation, neuronal differentiation, Drosophila
- MeSH terms
- Animals, Drosophila, Female, Gene Expression Regulation, Genes, Lethal, Homeostasis, Infertility, Male, Mutation, Ribonucleoproteins, Sex Factors, Restriction Mapping, Sequence Deletion, Gene Dosage, Transgenes, 3' Untranslated Regions, Animals, Genetically Modified, ELAV Proteins
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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