Correlation between mitochondrial DNA 4977-bp deletion and respiratory chain enzyme activities in aging human skeletal muscles
Abstract
The content of the mitochondrial DNA 4977-bp deletion and the respiratory chain enzyme activities were determined in the same human skeletal muscle specimens. A direct correlation between damage to mtDNA and bioenergetic deficiency was observed. The time-course of the appearance of the mtDNA deletion was followed. The highest percentage of mtDNA-deleted molecules was 0.26% and it was found in the eighties which corresponds to the age of the major reduction in the respiratory chain enzyme activities. Two samples with very low mitochondrial respiratory enzyme activities exhibited much higher levels of deletion compared to the similar age counterparts. Given, however, the low absolute level of the deletion also in these samples, we suggest that damage to the respiratory chain complexes, especially complex IV, might be the cause more than the effect of the increased number of mtDNA molecules bearing deletions in aged human skeletal muscle.
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The superoxide radical is not able to cross the inner mitochondrial membrane so it is confined to the matrix where it reacts rapidly with the enzyme manganese-superoxide dismutase Mn-SOD and nitric oxide to form hydrogen peroxide and peroxynitrite, respectively.
“The superoxide radical is not able to cross the inner mitochondrial membrane so it is confined to the matrix where it reacts rapidly with the enzyme manganese-superoxide dismutase Mn-SOD and nitric oxide to form hydrogen peroxide and peroxynitrite, respectively [28], Figure 10.”
From Superoxide Anion Chemistry—Its Role at the Core of the Innate Immunity (2023) · cites this paper as [28]
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Hood, D. A., Chabi, B., Menzies, K. J., O′Leary, M. F. N., & Walkinshaw, D. R. (2007) · Springer eBooks · doi:10.1007/978-88-470-0376-7_3 · Cited by 6 · see citing works
Mitochondrial mutagenesis in the brain in forensic and pathological research
von Wurmb‐Schwark, N., Schwark, T., Meißner, C., & Oehmichen, M. (2003) · Legal Medicine · doi:10.1016/s1344-6223(03)00003-8 · Cited by 5 · see citing works
- Authors
- Lezza, A. M. S., Boffoli, D., Scacco, S., Cantatore, P., & Gadaleta, M. N.
- Affiliations
- University of Bari Aldo Moro (IT)
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1994-11
- Volume
- 205
- Issue
- 1
- Pages
- 772-779
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2078749255
- Cited by
- 118
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 2 · 2022: 2 · 2020: 3 · 2019: 1 · 2018: 4 · 2017: 3 · 2016: 1 · 2015: 2 · 2014: 2 · 2013: 5 · 2012: 4
- FWCI
- 1.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Keywords
- mitochondrial DNA deletions, 4977 bp deletion, respiratory chain enzyme activity, skeletal muscle aging, cytochrome c oxidase, mitochondrial DNA damage, human aging
- MeSH terms
- Adult, Aging, Base Sequence, DNA, Mitochondrial, Electron Transport, Humans, Middle Aged, Molecular Sequence Data, Sequence Deletion, DNA Primers, Muscle, Skeletal
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