Decline with age of the respiratory chain activity in human skeletal muscle

Boffoli, D.; Scacco, S.C.; Vergari, R.; Solarino, G.; Santacroce, G.; Papa, S.

doi:10.1016/0925-4439(94)90061-2

Cited by 341Mitochondrial Function and PathologyMuscle Physiology and DisordersAdipose Tissue and Metabolism

Decline with age of the respiratory chain activity in human skeletal muscle

Boffoli, D., Scacco, S.C., Vergari, R., Solarino, G., Santacroce, G., Papa, S.·1994·Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

DOI 10.1016/0925-4439(94)90061-2

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Abstract

Mitochondrial respiratory systems have been screened in 63 orthopaedic patients of age ranging between 17 and 91 years. The results show a statistically significant definite decrease with ageing of mitochondrial respiratory activity with pyruvate plus malate, succinate and ascorbate plus TMPD. This pattern is associated with an equally significant decrease with age of the enzymatic activity of complex I, II and IV. No significant decrease with age is, on the contrary, observed in the mitochondrial content of cytochromes a+a3, and c+c1. Preliminary Western blot analysis indicates an altered polypeptide pattern in cytochrome c oxidase. This study provides evidence for a decline with age of mitochondrial respiratory activity in human skeletal muscle, affecting complex I, II and IV.

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The majority of prior studies describing lower mitochondrial oxidative capacity with aging have not considered important covariates such as cardiorespiratory fitness and BMI.
“There have been many reports describing lower mitochondrial oxidative capacity with aging (6-11), however, the majority have not considered important covariates such as cardiorespiratory fitness (8,9) and BMI (7,8,11).”
From Chronological Age Does not InfluenceEx-vivoMitochondrial Respiration and Quality Control in Skeletal Muscle (2016) · cites this paper as [9]
Most studies of mitochondrial respiration have not considered important covariates such as participant physical activity levels, adiposity, and fiber type percentage, which could confound the relationship between mitochondrial capacity and age.
“Moreover, most studies of mitochondrial respiration have not considered important covariates such as participant physical activity levels (9), adiposity (11), and fiber type percentage, which could confound the relationship between mitochondrial capacity and age (10,12,18,19).”
From Chronological Age Does not InfluenceEx-vivoMitochondrial Respiration and Quality Control in Skeletal Muscle (2016) · cites this paper as [9]
Many prior studies of mitochondrial respiration have used isolated mitochondria.
“Many have also used isolated mitochondria (6,9,11).”
From Chronological Age Does not InfluenceEx-vivoMitochondrial Respiration and Quality Control in Skeletal Muscle (2016) · cites this paper as [9]
Several prior investigations were performed in isolated mitochondria, which has been shown to exaggerate the observed deficit in mitochondrial function compared to measurements conducted on permeabilized myofibers.
“Furthermore, several of these investigations were performed in isolated mitochondria (6,9,11), which has been shown to exaggerate the observed deficit in mitochondrial function, when compared to measurements conducted on permeabilized myofibers (17).”
From Chronological Age Does not InfluenceEx-vivoMitochondrial Respiration and Quality Control in Skeletal Muscle (2016) · cites this paper as [9]

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Authors: Boffoli, D., Scacco, S. C., Vergari, R., Solarino, G., Santacroce, G., & Papa, S.
Affiliations: University of Bari Aldo Moro (IT)
Corresponding author: Papa, S.
ORCID: Scacco, S.C.
Solarino, G.
Papa, S.
Venue: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Publisher: Elsevier BV
Published: 1994-04
Volume: 1226
Issue: 1
Pages: 73-82
ISSN: 0925-4439 (ISSN-L)
DOI: 10.1016/0925-4439(94)90061-2
OpenAlex: W2135792486
Cited by: 341
References: 38
Citations by year: 2026: 1 · 2025: 14 · 2024: 10 · 2023: 9 · 2022: 6 · 2021: 9 · 2020: 10 · 2019: 4 · 2018: 10 · 2017: 5 · 2016: 8 · 2015: 8 · 2014: 13 · 2013: 12 · 2012: 10
FWCI: 4.69
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease (publishedVersion)
PubMed (publishedVersion)
CINECA IRIS Institutional Research Information System (University of Bari Aldo Moro) (submittedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
Keywords: mitochondrial respiratory chain, aging, skeletal muscle, complex I, complex II, cytochrome c oxidase, cytochrome aa3, respiratory chain activity, orthopedic patients
MeSH terms: Adolescent, Adult, Aged, Aged, 80 and over, Aging, Ascorbic Acid, Electron Transport Complex IV, Cytochromes, Humans, Malates, Middle Aged, Mitochondria, Muscle, Multienzyme Complexes, Oxidation-Reduction, Oxidoreductases, Pyruvates, Succinate Dehydrogenase, Succinates, NAD(P)H Dehydrogenase (Quinone), Pyruvic Acid, Succinic Acid, Electron Transport Complex II

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Decline with age of the respiratory chain activity in human skeletal muscle

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