The L-Arginine: Nitric Oxide Pathway Is the Major Source of Plasma Nitrite in Fasted Humans
Abstract
15N guanidino-labelled L-arginine was infused into fasted human volunteers giving, at equilibrium, a stable 1:10 ratio of 15N to 14N arginine in the plasma. Separate GC-MS assays were used to compare the degree of enrichment of plasma arginine, nitrite and nitrate and thus define the quantitative relationship between the L-arginine:nitric oxide (NO) pathway and the formation of these oxides of nitrogen. 15N nitrite enrichments rose to 8.3% (SD 0.5), five hours after the start of the infusion. In contrast, 15N nitrate enrichments apparently rose to only 1.6% (SD 0.4) at this time. This discrepancy could be explained by our finding that the commonly used Tesch GC-MS nitrate assay is subject to considerable interference from non-nitrate sources in plasma. Taking this into account, nitrate enrichments were similar to those observed for plasma nitrite. These results therefore indicate that the measurement of these compounds in plasma is a valid indicator of NO generation in fasted humans.
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Nitrate is also produced endogenously.
“It should be remembered that nitrate is also produced endogenously.”
From Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway (2013) · cites this paper as [52]
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Lauer, T., Preik, M., Rassaf, T., Strauer, B. E., Deussen, A., Feelisch, M., & Kelm, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.221381098 · Cited by 585 · see citing works
Blachier, F., Mariotti, F., Huneau, J. F., & Tomé, D. (2007) · Amino Acids · doi:10.1007/s00726-006-0477-9 · Cited by 452 · see citing works
Nitrite as Regulator of Hypoxic Signaling in Mammalian Physiology
van Faassen, E. E., Bahrami, S., Feelisch, M., Hogg, N., Kelm, M., Kim‐Shapiro, D. B., Kozlov, A. V., Li, H., Lundberg, J. O., Mason, R., et al. (2009) · Medicinal Research Reviews · doi:10.1002/med.20151 · Cited by 435 · see citing works
Maia, L. B., & Moura, J. J. G. (2014) · Chemical Reviews · doi:10.1021/cr400518y · Cited by 401 · see citing works
Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans
Kleinbongard, P., Dejam, A., Lauer, T., Jax, T., Kerber, S., Gharini, P., Balzer, J., Zotz, R. B., Scharf, R. E., Willers, R., et al. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.08.025 · Cited by 388 · see citing works
Raedschelders, K., Ansley, D. M., & Chen, D. D. Y. (2011) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2011.11.004 · Cited by 387 · see citing works
Metabolic Effects of Dietary Nitrate in Health and Disease
Lundberg, J. O., Carlström, M., & Weitzberg, E. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.06.007 · Cited by 374 · see citing works
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ERZURUM, S. C., Ghosh, S., Janocha, A. J., Xu, W., Bauer, S. M., Bryan, N. S., Tejero, J., Hemann, C. F., Hille, R., Stuehr, D. J., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707462104 · Cited by 364 · see citing works
Lidder, S., & Webb, A. J. (2013) · British Journal of Clinical Pharmacology · doi:10.1111/j.1365-2125.2012.04420.x · Cited by 360 · see citing works
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Kielstein, J. T., Böger, R. H., BODE-BÖGER, S. M., SCHÄFFER, J., BARBEY, M., Koch, K. M., & Frölich, J. C. (1999) · Journal of the American Society of Nephrology · doi:10.1681/asn.v103594 · Cited by 360 · see citing works
Tsikas, D. (2005) · Free Radical Research · doi:10.1080/10715760500053651 · Cited by 357 · see citing works
Erythrocytes are the major intravascular storage sites of nitrite in human blood
Dejam, A. (2005) · Blood · doi:10.1182/blood-2005-02-0567 · Cited by 350 · see citing works
Nagababu, E., Ramasamy, S., Abernethy, D. R., & Rifkind, J. M. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m307572200 · Cited by 349 · see citing works
NO Generation From Nitrite and Its Role in Vascular Control
Lundberg, J. O., & Weitzberg, E. (2005) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000161048.72004.c2 · Cited by 341 · see citing works
Marzinzig, M., Nussler, A. K., Stadler, J., Marzinzig, E., Barthlen, W., Nüssler, N. C., Beger, H. G., Morris, S. M., & Brückner, U. B. (1997) · Nitric Oxide · doi:10.1006/niox.1997.0116 · Cited by 331 · see citing works
Nonenzymatic Nitric Oxide Production in Humans
Weitzberg, E., & Lundberg, J. O. N. (1998) · Nitric Oxide · doi:10.1006/niox.1997.0162 · Cited by 296 · see citing works
Bondonno, C. P., Yang, X., Croft, K. D., Considine, M. J., Ward, N. C., Rich, L., Puddey, I. B., Swinny, E., Mubarak, A., & Hodgson, J. M. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.09.028 · Cited by 292 · see citing works
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Ellis, G., Adatia, I., Yazdanpanah, M., & Makela, S. K. (1998) · Clinical Biochemistry · doi:10.1016/s0009-9120(98)00015-0 · Cited by 263 · see citing works
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Nitrite in nitric oxide biology: Cause or consequence?
Bryan, N. S. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.05.019 · Cited by 260 · see citing works
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Bode‐Böger, S. M., Böger, R. H., Galland, A., Tsikas, D., & Frölich, J. C. (1998) · British Journal of Clinical Pharmacology · doi:10.1046/j.1365-2125.1998.00803.x · Cited by 258 · see citing works
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Tsikas, D. (2000) · Analytical Chemistry · doi:10.1021/ac9913255 · Cited by 228 · see citing works
Emerging role of nitrite in human biology
Dejam, A., Hunter, C. J., Schechter, A. N., & Gladwin, M. T. (2004) · Blood Cells, Molecules, and Diseases · doi:10.1016/j.bcmd.2004.02.002 · Cited by 221 · see citing works
Yoon, Y., Song, J., Hong, S. H., & Kim, J. Q. (2000) · Clinical Chemistry · doi:10.1093/clinchem/46.10.1626 · Cited by 216 · see citing works
Baylis, C., & Vallance, P. J. (1998) · Current Opinion in Nephrology & Hypertension · doi:10.1097/00041552-199801000-00010 · Cited by 210 · see citing works
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Anthony, A. R., & Rhodes, P. (1997) · Analytical Biochemistry · doi:10.1006/abio.1997.2129 · Cited by 182 · see citing works
Self-citationAnalysis of nitrite and nitrate in biological samples using high-performance liquid chromatography
Jobgen, W. S., Jobgen, S. C., Li, H. Z., Meininger, C. J., & Wu, G. (2006) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.07.018 · Cited by 178 · see citing works
Stokes, K. Y., Dugas, T. R., Tang, Y., Garg, H., Guidry, E., & Bryan, N. S. (2009) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01291.2008 · Cited by 171 · see citing works
Gilchrist, M., Winyard, P. G., & Benjamin, N. (2010) · Nitric Oxide · doi:10.1016/j.niox.2009.10.005 · Cited by 157 · see citing works
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Girgis, R. E., Champion, H. C., Diette, G. B., Johns, R. A., Permutt, S., & SYLVESTER, J. T. (2005) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200412-1684oc · Cited by 144 · see citing works
Dietary nitrite and nitrate: a review of potential mechanisms of cardiovascular benefits
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Kelm, M. (1999) · Cardiovascular Research · doi:10.1016/s0008-6363(98)00259-4 · Cited by 141 · see citing works
L-Arginine as a Potential Ergogenic Aid in Healthy Subjects
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Tsikas, D. (2008) · Analytical Biochemistry · doi:10.1016/j.ab.2008.04.018 · Cited by 131 · see citing works
Nitrite Reduction and Cardiovascular Protection
Omar, S. A., & Webb, A. J. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.01.012 · Cited by 121 · see citing works
Metzger, I. F., Souza-Costa, D. C., Marroni, A. S., Nagassaki, S., Desta, Z., Flockhart, D. A., & Tanus-Santos, J. E. (2005) · Pharmacogenetics and Genomics · doi:10.1097/01.fpc.0000167328.85163.44 · Cited by 107 · see citing works
Hussein, G. M. E., Goto, H., Oda, S., Sankawa, U., Matsumoto, K., & Watanabe, H. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.684 · Cited by 107 · see citing works
A comparison of organic and inorganic nitrates/nitrites
Omar, S. A., Artime, E., & Webb, A. J. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.03.008 · Cited by 106 · see citing works
Increased nitric oxide production in patients with Behçet's disease: Is it a new activity marker?
Evereklioğlu, C., Türköz, Y., Er, H., Inaloz, H. S., Özbek, E., & Çekmen, M. (2002) · Journal of the American Academy of Dermatology · doi:10.1067/mjd.2002.118338 · Cited by 103 · see citing works
Grau, M., Hendgen-Cotta, U. B., Brouzos, P., Drexhage, C., Rassaf, T., Lauer, T., Dejam, A., Kelm, M., & Kleinbongard, P. (2007) · Journal of Chromatography B · doi:10.1016/j.jchromb.2007.02.002 · Cited by 100 · see citing works
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Facchini, F. S., DoNascimento, C. A., Reaven, G. M., Yip, J. W., Ni, X. P., & Humphreys, M. H. (1999) · Hypertension · doi:10.1161/01.hyp.33.4.1008 · Cited by 99 · see citing works
Babu, G. N., Kumar, A., Chandra, R., Puri, S. K., Kalita, J., & Misra, U. K. (2008) · Neurochemical Research · doi:10.1007/s11064-007-9564-x · Cited by 96 · see citing works
Multiple Apical Periodontitis Influences Serum Levels of Cytokines and Nitric Oxide
Cintra, L. T. Â., Samuel, R. O., Azuma, M. M., de Queiróz, A. O. S., Ervolino, E., Sumida, D. H., de Lima, V. M. F., & Gomes‐Filho, J. E. (2016) · Journal of Endodontics · doi:10.1016/j.joen.2016.01.022 · Cited by 93 · see citing works
Nitric oxide as a challenge for the clinical chemistry laboratory
Viinikka, L. U. (1996) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365519609090591 · Cited by 93 · see citing works
Freestone, B., Chong, A., Nuttall, S., & Lip, G. Y. H. (2007) · Thrombosis Research · doi:10.1016/j.thromres.2007.09.008 · Cited by 92 · see citing works
Measurement of the NO metabolites, nitrite and nitrate, in human biological fluids by GC–MS
Helmke, S. M., & Duncan, M. W. (2006) · Journal of Chromatography B · doi:10.1016/j.jchromb.2006.09.047 · Cited by 90 · see citing works
Acute Right Ventricular Restrictive Physiology After Repair of Tetralogy of Fallot
Chaturvedi, R. R., Shore, D. F., Lincoln, C. R., Mumby, S. E., Kemp, M., Brierly, J., Petros, A., Gutteridge, J. M. C., Hooper, J., & Redington, A. N. (1999) · Circulation · doi:10.1161/01.cir.100.14.1540 · Cited by 90 · see citing works
Cerebrospinal fluid studies in children with cerebral malaria: an excitotoxic mechanism?
Dobbie, M. S., Crawley, J., Waruiru, C., Marsh, K., & Surtees, R. A. H. (2000) · American Journal of Tropical Medicine and Hygiene · doi:10.4269/ajtmh.2000.62.284 · Cited by 88 · see citing works
Nitric Oxide Determinations: Much Ado About NO•-Thing?
Moshage, H. J. (1997) · Clinical Chemistry · doi:10.1093/clinchem/43.4.553 · Cited by 88 · see citing works
Mechanisms underlying blood pressure reduction by dietary inorganic nitrate
Carlström, M., Lundberg, J. O., & Weitzberg, E. (2018) · Acta Physiologica · doi:10.1111/apha.13080 · Cited by 86 · see citing works
Ma, X., Gao, F., Nelson, A. H., Lopez, B. L., Christopher, T. A., Yue, T., & Barone, F. C. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)29452-0 · Cited by 86 · see citing works
Tsikas, D., Sandmann, J., Savva, A., Lueßen, P., Böger, R. H., Gutzki, F., Mayer, B., & Frölich, J. C. (2000) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(00)00142-0 · Cited by 85 · see citing works
Nitrite uptake and metabolism and oxidant stress in human erythrocytes
May, J. M., Qu, Z., Li, X., & Cobb, C. E. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.6.c1946 · Cited by 82 · see citing works
Sandrim, V. C., de Syllos, R. W. C., Lisboa, H. R. K., Tres, G. S., & Tanus-Santos, J. E. (2007) · Nitric Oxide · doi:10.1016/j.niox.2006.12.007 · Cited by 80 · see citing works
Nagababu, E., & Rifkind, J. M. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.029 · Cited by 79 · see citing works
Castiglione, N., Rinaldo, S., Giardina, G., Stelitano, V., & Cutruzzolà, F. (2012) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4196 · Cited by 79 · see citing works
Relationship between systemic nitric oxide metabolites and cyclic GMP in healthy male volunteers
Metzger, I. F., Sertorio, J. T. C., & Tanus-Santos, J. E. (2006) · Acta Physiologica · doi:10.1111/j.1748-1716.2006.01612.x · Cited by 77 · see citing works
Reduced arginine availability and nitric oxide production
Hallemeesch, M. M., Lamers, W. H., & Deutz, N. E. P. (2002) · Clinical Nutrition · doi:10.1054/clnu.2002.0571 · Cited by 75 · see citing works
Single-cell analyses of nitrergic neurons in simple nervous systems
Moroz, L. L., Gillette, R., & Sweedler, J. V. (1999) · Journal of Experimental Biology · doi:10.1242/jeb.202.4.333 · Cited by 72 · see citing works
Endothelial nitric oxide synthase gene polymorphisms and genetic susceptibility to prostate cancer
Medeiros, R., Morais, A., Vasconcelos, A., Costa, S., Pinto, D., Oliveira, J., & Lopes, C. (2002) · European Journal of Cancer Prevention · doi:10.1097/00008469-200208000-00005 · Cited by 73 · see citing works
Tsikas, D., Gutzki, F., & Stichtenoth, D. O. (2005) · European Journal of Clinical Pharmacology · doi:10.1007/s00228-005-0020-z · Cited by 72 · see citing works
Álvares, T. S., Conte, C. A., Paschoalin, V. M. F., Silva, J. T., Meirelles, C. D. M., Bhambhani, Y. N., & Gomes, P. S. C. (2012) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h11-144 · Cited by 71 · see citing works
Khan, F., Davidson, N. C., Littleford, R. C., Litchfield, S. J., Struthers, A. D., & Belch, J. J. F. (1997) · Vascular Medicine · doi:10.1177/1358863x9700200202 · Cited by 71 · see citing works
Self-citationAndrukhov, O., Haririan, H., Bertl, K., Rausch, W., Bantleon, H., Moritz, A., & Rausch‐Fan, X. (2013) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12145 · Cited by 70 · see citing works
Nitrite and nitric oxide metabolism in peripheral artery disease
Allen, J. D., Giordano, T., & Kevil, C. G. (2012) · Nitric Oxide · doi:10.1016/j.niox.2012.03.003 · Cited by 69 · see citing works
Endothelial function in patients with atrial fibrillation
Khan, A. A., Thomas, G. N., Lip, G. Y. H., & Shantsila, A. (2020) · Annals of Medicine · doi:10.1080/07853890.2019.1711158 · Cited by 67 · see citing works
The mechanisms for nitration and nitrotyrosine formationin vitroandin vivo: Impact of diet
Oldreive, C., & Rice-Evans, C. A. (2001) · Free Radical Research · doi:10.1080/10715760100300761 · Cited by 66 · see citing works
Preik-Steinhoff, H., & Kelm, M. (1996) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/s0378-4347(96)00264-2 · Cited by 63 · see citing works
Bode‐Böger, S. M., Böger, R. H., Kielstein, J. T., Löffler, M., SchJäffer, J., & Frölich, J. C. (2000) · Journal of Investigative Medicine · doi:10.1177/108155890004800208 · Cited by 62 · see citing works
Decreased Nitric Oxide Production in Patients with Behçet’s Disease
Örem, A., Vanizor, B., Çimşit, G., Kiran, E., Değer, O., & Malkoç, M. (1999) · Dermatology · doi:10.1159/000018061 · Cited by 62 · see citing works
Rajeshwar, K., Kaul, S., Al‐Hazzani, A. A., Babu, M. S., Balakrishna, N., Sharma, V., Jyothy, A., & Munshi, A. (2011) · Inflammation · doi:10.1007/s10753-011-9401-x · Cited by 61 · see citing works
Pharmacology and therapeutic role of inorganic nitrite and nitrate in vasodilatation
Bailey, J., Feelisch, M., Horowitz, J. D., Frenneaux, M. P., & Madhani, M. (2014) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2014.06.009 · Cited by 60 · see citing works
Bondonno, C. P., Downey, L. A., Croft, K. D., Scholey, A. B., Stough, C. K. K., Yang, X., Considine, M. J., Ward, N. C., Puddey, I. B., Swinny, E. E., et al. (2014) · Food & Function · doi:10.1039/c3fo60590f · Cited by 60 · see citing works
eNOS genotype is without effect on circulating nitrite/nitrate level in healthy male population
Nagassaki, S., Metzger, I. F., Souza-Costa, D. C., Marroni, A. S., Uzuelli, J. A., & Tanus-Santos, J. E. (2004) · Thrombosis Research · doi:10.1016/j.thromres.2004.09.003 · Cited by 58 · see citing works
Böger, R. H., Tsikas, D., Bode‐Böger, S. M., Phivthong‐ngam, L., Schwedhelm, E., & Frölich, J. C. (2004) · Nitric Oxide · doi:10.1016/j.niox.2004.07.008 · Cited by 56 · see citing works
Song, J., Yoon, Y., Park, K. U., Park, J., Hong, Y. J., Hong, S. H., & Kim, J. Q. (2003) · Clinical Chemistry · doi:10.1373/49.6.847 · Cited by 56 · see citing works
Blunted nitric oxide regulation in Tibetans under high-altitude hypoxia
He, Y., Qi, X., Ouzhuluobu, Liu, S., Li, J., Zhang, H., Baimakangzhuo, Bai, C., Zheng, W., Guo, Y., et al. (2018) · National Science Review · doi:10.1093/nsr/nwy037 · Cited by 55 · see citing works
Assessment of Nitric Oxide Formation During Exercise
Croix, C. M. S., Wetter, T. J., Pegelow, D. F., Meyer, K. C., & Dempsey, J. A. (1999) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.159.4.9806144 · Cited by 55 · see citing works
Nitric oxide and salt sensitivity
Cubeddu, L. X., Alfieri, A. B., Hoffmann, I., Jimenez, E., Roa, C. M., Cubeddu, R. J., Palermo, C., & Baldonedo, R. M. (2000) · American Journal of Hypertension · doi:10.1016/s0895-7061(00)00283-1 · Cited by 55 · see citing works
Babu, G. N., Kumar, A., Kalita, J., & Misra, U. K. (2008) · Neuroscience Letters · doi:10.1016/j.neulet.2008.02.060 · Cited by 53 · see citing works
Effects of chronic cigarette smoking on endothelial function in young men
Ozaki, K., Hori, T., Ishibashi, T., Nishio, M., & Aizawa, Y. (2010) · Journal of Cardiology · doi:10.1016/j.jjcc.2010.07.003 · Cited by 53 · see citing works
Pedersen, H. D., Schütt, T., Søndergaard, R., Qvortrup, K., Olsen, L. H., & Kristensen, A. T. (2003) · Journal of Veterinary Internal Medicine · doi:10.1111/j.1939-1676.2003.tb02431.x · Cited by 53 · see citing works
Albrecht, E. W. J. A., van Goor, H., Tiebosch, A. T. M. G., Moshage, H. J., TEGZESS, A. M., & Stegeman, C. A. (2000) · Transplantation · doi:10.1097/00007890-200012150-00013 · Cited by 53 · see citing works
Siervo, M., Stephan, B. C. M., Feelisch, M., & Bluck, L. J. C. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.05.032 · Cited by 52 · see citing works
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Madigan, M. C., & Zuckerbraun, B. S. (2013) · Frontiers in Immunology · doi:10.3389/fimmu.2013.00174 · Cited by 51 · see citing works
Moroz, L. L., Dahlgren, R. L., Boudko, D., Sweedler, J. V., & Lovell, P. V. (2005) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2005.01.013 · Cited by 50 · see citing works
Kypreos, K. E., Zafirovic, S. S., Πετροπούλου, Π.-Ι., Bjelogrlic, P., Resanović, I., TRAISH, A. M., & Isenović, E. R. (2014) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248413513499 · Cited by 49 · see citing works
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Nasreen, S., Nabika, T., Shibata, H., Moriyama, H., Yamashita, K., Masuda, J., & Kobayashi, S. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000013286.60021.fe · Cited by 48 · see citing works
Nejatizadeh, A., Kumar, R., Stobdan, T., Goyal, A. K., Sikdar, S., Gupta, M. D., Javed, S., & Pasha, M. A. Q. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.02.004 · Cited by 45 · see citing works
Szaleczky, E., Prónai, L., Nakazawa, H. K., & Tulassay, Z. (2000) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-200001000-00008 · Cited by 44 · see citing works
Renal handling of circulating nitrates in anesthetized dogs
Godfrey, M., & Majid, D. S. A. (1998) · American Journal of Physiology-Renal Physiology · doi:10.1152/ajprenal.1998.275.1.f68 · Cited by 42 · see citing works
Plasma Nitrate Levels and Flow-Mediated Vasodilation in Untreated Major Depression
Garcia, R. G., Zarruk, J. G., Barrera, C., Pinzón, A., Trillos, E., Arenas, W. D., Luengas, C., Tomaz, C. A. B., & López-Jaramillo, P. A. (2011) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31821566cf · Cited by 43 · see citing works
Bode‐Böger, S. M., Böger, R. H., Löffler, M., Tsikas, D., Brabant, G. E., & Frölich, J. C. (1999) · Journal of Investigative Medicine · doi:10.1177/108155899904700107 · Cited by 43 · see citing works
Hedetoft, M., & Olsen, N. V. (2014) · Nitric Oxide · doi:10.1016/j.niox.2014.07.003 · Cited by 42 · see citing works
- Authors
- Rhodes, P. M., Leone, A. M., Francis, P. L., Struthers, A. D., & Moncada, S.
- Affiliations
- Ninewells Hospital (GB)
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1995-04
- Volume
- 209
- Issue
- 2
- Pages
- 590-596
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2049563995
- Cited by
- 254
- References
- 0
- Citations by year
- 2025: 2 · 2024: 3 · 2022: 4 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 8 · 2017: 6 · 2016: 3 · 2015: 9 · 2014: 12 · 2013: 9 · 2012: 9
- FWCI
- 3.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Discovery Research Portal (University of Dundee) (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
- Keywords
- L-arginine, nitric oxide, nitrite, nitrate, arginine infusion, fasting state, plasma nitrite, nitrogen oxides
- MeSH terms
- Adult, Arginine, Fasting, Humans, Male, Gas Chromatography-Mass Spectrometry, Nitric Oxide, Nitrites
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