Effectiveness of caloric restriction in preventing age-related changes in rat skeletal muscle
Abstract
The dihydropyridine receptor (DHPR) and ryanodine receptor (RYR1) are needed for excitation-contraction coupling in skeletal muscle. Previous studies from this laboratory have shown DHPR-RYR1 uncoupling in 33-month-old Fischer 344 x Brown Norway F1 (F344BNF1) rats fed ad libitum. The purpose of the present study is to determine whether caloric restriction prevents age-related impairments in skeletal muscle function and expression of DHPR and RyR1. Bundles of soleus and extensor digitorum longus (EDL) were studied from rats fed ad libitum and on 60 percent caloric restriction. Significant differences were found in peak twitch or tetanic tension between the ad libitum and calorie-restricted groups in soleus and EDL muscles. A significant increase in the expression of DHPR and RyR1 was observed in caloric restricted rats. These results show that calorie restriction preserves the mechanical properties of aging hind-limb skeletal muscle and maintains the level of DHPR and RyR1 in aged F344BNF1 rats fed ad libitum.
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Exercise training and calorie restriction are the most efficient interventions to attenuate sarcopenia.
“the most efficient interventions to attenuate sarcopenia are exercise training [21,22,23,24] and calorie restriction [25,26,27]”
From Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging (2021) · cites this paper as [26]
Calorie restriction attenuates sarcopenia in rodents.
“calorie restriction, one of the most efficient interventions to attenuate sarcopenia in rodents [25,26,27]”
From Mitochondrial Dynamics and Mitophagy in Skeletal Muscle Health and Aging (2021) · cites this paper as [26]
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- Authors
- Mayhew, M., Renganathan, M., & Delbono, O.
- Affiliations
- Wake Forest University Health Sciences (US)
- Corresponding author
- Delbono, Osvaldo
- Venue
- Biochemical and Biophysical Research Communications
- Publisher
- Elsevier BV
- Published
- 1998-10
- Volume
- 251
- Issue
- 1
- Pages
- 95-99
- ISSN
- 0006-291X (ISSN-L)
- OpenAlex
- W2029030037
- Cited by
- 43
- References
- 23
- Citations by year
- 2025: 1 · 2023: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2018: 2 · 2015: 2 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biochemical and Biophysical Research Communications (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k01ag000692-02)
- National Institute on Aging (P60AG010484, K01AG00692, P60 AG-10484, R29 AG13934, R29AG013934)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Keywords
- caloric restriction, skeletal muscle aging, dihydropyridine receptor, ryanodine receptor, excitation-contraction coupling, twitch tension, soleus muscle, extensor digitorum longus, muscle mechanical properties
- MeSH terms
- Aging, Animals, Energy Intake, Crosses, Genetic, Food Deprivation, Hindlimb, Muscle Proteins, Rats, Inbred BN, Rats, Inbred F344, Calcium Channels, Muscle, Skeletal, Muscle Fibers, Skeletal, Ryanodine Receptor Calcium Release Channel, Calcium Channels, L-Type, Rats
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