Cited by 89Mitochondrial Function and PathologyGenetics, Aging, and Longevity in Model OrganismsMuscle Physiology and Disorders

No decline in skeletal muscle oxidative capacity with aging in long-term calorically restricted rats: Effects are independent of mitochondrial DNA integrity

Open access
Baker, D. J., Betik, A. C., Krause, D. J., Hepple, R. T.·2006·The Journals of Gerontology Series A: Biological Sciences and Medical Sciences

Abstract

We investigated if calorie restriction (CR) preserved skeletal muscle oxidative capacity with aging after accounting for life span extension by CR, and determined if mitochondrial content, mitochondrial DNA integrity, and peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1alpha) were involved. Ad libitum-fed (AL) and CR animals representing young adult, late middle age, and senescence were studied. Whereas citrate synthase and complex IV activities were lower in plantaris and gastrocnemius muscle of young adult CR animals, in contrast to the 15%-40% decline in senescent AL animals, there was no decline with aging in CR animals. There was no decline in citrate synthase protein in gastrocnemius with aging in either group, suggesting that CR preserves oxidative capacity with aging by protecting mitochondrial function rather than content. This protection was independent of mitochondrial DNA damage between groups. However, there was a slower decline in PGC-1alpha gene expression with aging in CR versus AL animals, suggesting a better maintenance of mitochondrial biogenesis with aging in CR animals.

Integrity signals

Registry

Crossref · 10.1093/gerona/61.7.675

Cites

62 of 62 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • Normal ageing is associated with a trend for a decrease in PGC-1α expression.

    “We found that normal ageing is associated with a trend for a decrease in PGC‐1α expression, which is a finding consistent with previous studies (Baker et al. 2006; Chabi et al. 2008; Joseph et al. 2012).”
  • Exercise training and calorie restriction are the most efficient interventions to attenuate sarcopenia.

    “the most efficient interventions to attenuate sarcopenia are exercise training [21,22,23,24] and calorie restriction [25,26,27]”
  • Calorie restriction attenuates sarcopenia in rodents.

    “calorie restriction, one of the most efficient interventions to attenuate sarcopenia in rodents [25,26,27]”
  • PGC-1α protein and its downstream molecular targets are reduced in aging animals and humans.

    “PGC-1α protein and its downstream molecular targets are reduced in aging animals (Baker, Betik, Krause, and Hepple 2006) and humans.(Joseph, Adhihetty, Buford, Wohlgemuth, Lees, Nguyen, Aranda, Sandesara, Pahor, and Manini 2012;Safdar, Hamadeh, Kaczor, Raha, and Tarnopolsky 2010)”

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Baker, D. J., Betik, A. C., Krause, D. J., & Hepple, R. T.
Affiliations
University of Calgary (CA)
Corresponding author
Baker, D. J.
Venue
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
Published
2006-07-01
Volume
61
Issue
7
Pages
675-684
ISSN
  • 1079-5006 (ISSN-L)
  • 1758-535X
OpenAlex
W2151136828
Cited by
89
References
62
Citations by year
2025: 2 · 2024: 2 · 2023: 2 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 7 · 2016: 6 · 2015: 7 · 2014: 4 · 2013: 7 · 2012: 8
FWCI
2.72
Type
journal article
Language
en
Open access
Locations
  • The Journals of Gerontology Series A (publishedVersion)
  • PubMed (publishedVersion)
  • Victoria University Research Repository (Victoria University) (submittedVersion)
  • Own your potential (DEAKIN) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
Funders
Canadian Institutes of Health Research
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Muscle Physiology and Disorders
Keywords
caloric restriction, skeletal muscle, oxidative capacity, aging, mitochondrial DNA integrity, PGC-1α, mitochondrial biogenesis, citrate synthase, cytochrome c oxidase, lifespan extension, gastrocnemius, plantaris, mitochondrial function
MeSH terms
Aging, Analysis of Variance, Animals, DNA, Mitochondrial, Male, Mitochondria, Muscle, Oxygen Consumption, Rats, Inbred F344, Muscle, Skeletal, Caloric Restriction, PPAR alpha, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review