Physical performance and longevity in aged rats
Abstract
In humans, physical performance declines with increasing age, and in nondisabled older persons, scores on standardized performance measures, such as walking speed, repeated chair stands, and a balance test, predict the incidence of disability and reduced longevity. Here we show in aged rats (24-month-old Brown Norway x Fischer 344 male rats; n = 48) that conceptually similar performance measures, such as swimming speed and an inclined plane procedure, can be assessed longitudinally, and that over 6 months of follow-up from the age of 24 to 30 months, performance declines progressively with increasing age. High baseline performance scores predict long-term longevity, a relationship that is also found in humans. The application of standardized physical performance measures to a variety of animal models of aging may help to define similarities between species in the underlying mechanisms of the age-related decline in performance, disability, and longevity.
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The rat is particularly amenable to measurements of cognitive-behavioral, endocrine, muscle, and cardiovascular endpoints, and extensive historical data exist on physiological changes with aging.
“The rat is particularly amendable to measurements of cognitive-behavioral, endocrine (e.g., glucose tolerance), muscle, and cardiovascular endpoints, and there is extensive historical data on physiological changes with aging [42–46].”
From Reducing Senescent Cell Burden in Aging and Disease (2020) · cites this paper as [43]
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- Carter CS, Sonntag WE, Pahor M. Physical performance changes in healthy aged rats. Ann Meet Am Geriatr Soc. 2001;27:271-282.
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- Authors
- Carter, C. S., Sonntag, W. E., Onder, G., & Pahor, M.
- Affiliations
- Wake Forest University Health Sciences (US)
- Corresponding author
- Carter, C. S.
- Venue
- The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-05-01
- Volume
- 57
- Issue
- 5
- Pages
- B193-B197
- ISSN
- 1079-5006 (ISSN-L)
- 1758-535X
- OpenAlex
- W2164031447
- Cited by
- 68
- References
- 28
- Citations by year
- 2026: 1 · 2024: 5 · 2023: 4 · 2022: 2 · 2021: 4 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 4 · 2012: 3
- FWCI
- 0.56
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journals of Gerontology Series A (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Wake Forest University
- National Institutes of Health
- National Institute on Aging (P60AG010484, P60 AG-10484, P01AG011370)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Keywords
- physical performance, aging, longevity, aged rats, swimming speed, inclined plane test, age-related decline, disability, animal models of aging, walking speed, chair stand, balance
- MeSH terms
- Aging, Animals, Longevity, Male, Motor Activity, Rats, Inbred BN, Rats, Inbred F344, Survival Analysis, Rats
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