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Runnin' with the Dvl: Proteins That Associate with Dsh/Dvl and Their Significance to Wnt Signal Transduction
Open accessAbstract
Wnt proteins transmit myriad intercellular signals crucial for the development and homeostasis of metazoan animals from Hydra to human. Abnormal Wnt signaling causes a growing number of diseases, including cancer and osteoporosis. Depending on the context, a given Wnt signal may denote: cell proliferation or apoptosis; cell fate determination, differentiation, or stem cell maintenance; a variety of changes in cell behavior; and/or coordinated interactions with its neighbors. Which event(s) occur in Wnt-responsive cells depends critically on the ability of Dishevelled (Dsh)/Dvl proteins to interpret distinct types of intracellular, receptor-generated stimuli and transmit them to at least two distinct sets of effector molecules, all while apparently ignoring a third type of Wnt-generated Ca(2+) signal. The three conserved domains present in Dsh/Dvl proteins uniquely function in each Wnt pathway, in part by association with 18 (and counting) Dsh/Dvl-associated proteins. The latest data suggest that Dsh/Dvl proteins organize dynamic, pathway-specific subcellular signaling complexes that ensure correct information routing, signal amplification, and dynamic control through feedback regulation. The biochemical and cell biological mechanisms by which Dsh/Dvl proteins accomplish these remarkable tasks remain obscure.
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“the DEP domain functions in non-canonical signaling.8,35”
From Wnt signal transduction pathways (2008) · cites this paper as [35]
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“The PDZ domain of Dsh function in the canonical, non-canonical and Wnt/ Ca2+ pathway”
From Wnt signal transduction pathways (2008) · cites this paper as [35]
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Metadata
- Authors
- Wharton, K. A.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Wharton, Keith A
- ORCID
- Wharton, Keith A
- Venue
- Developmental Biology
- Publisher
- Elsevier BV
- Published
- 2003-01
- Volume
- 253
- Issue
- 1
- Pages
- 1-17
- ISSN
- 0012-1606 (ISSN-L)
- OpenAlex
- W2008770488
- Cited by
- 315
- References
- 190
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 9 · 2014: 6 · 2013: 13 · 2012: 19
- FWCI
- 2.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Developmental Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
- Keywords
- Wnt signaling, Dishevelled, signal transduction, signaling complexes, feedback regulation, signal amplification, cell fate determination, stem cell maintenance, cancer, osteoporosis, calcium signaling
- MeSH terms
- Dishevelled Proteins, Animals, Humans, Phosphoproteins, Proto-Oncogene Proteins, Structure-Activity Relationship, Signal Transduction, Zebrafish Proteins, Adaptor Proteins, Signal Transducing, Wnt Proteins
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