Cited by 316Wnt/β-catenin signaling in development and cancerDevelopmental Biology and Gene RegulationHedgehog Signaling Pathway Studies

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Runnin' with the Dvl: Proteins That Associate with Dsh/Dvl and Their Significance to Wnt Signal Transduction

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Wharton, Keith A·2003·Developmental Biology

DOI 10.1006/dbio.2002.0869

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Abstract

Wnt proteins transmit myriad intercellular signals crucial for the development and homeostasis of metazoan animals from Hydra to human. Abnormal Wnt signaling causes a growing number of diseases, including cancer and osteoporosis. Depending on the context, a given Wnt signal may denote: cell proliferation or apoptosis; cell fate determination, differentiation, or stem cell maintenance; a variety of changes in cell behavior; and/or coordinated interactions with its neighbors. Which event(s) occur in Wnt-responsive cells depends critically on the ability of Dishevelled (Dsh)/Dvl proteins to interpret distinct types of intracellular, receptor-generated stimuli and transmit them to at least two distinct sets of effector molecules, all while apparently ignoring a third type of Wnt-generated Ca(2+) signal. The three conserved domains present in Dsh/Dvl proteins uniquely function in each Wnt pathway, in part by association with 18 (and counting) Dsh/Dvl-associated proteins. The latest data suggest that Dsh/Dvl proteins organize dynamic, pathway-specific subcellular signaling complexes that ensure correct information routing, signal amplification, and dynamic control through feedback regulation. The biochemical and cell biological mechanisms by which Dsh/Dvl proteins accomplish these remarkable tasks remain obscure.

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(1999) · doi:10.1002/(sici)1521-1878(199912)22:1

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Authors: Wharton, K. A.
Affiliations: The University of Texas Southwestern Medical Center (US)
Corresponding author: Wharton, Keith A
ORCID: Wharton, Keith A
Venue: Developmental Biology
Publisher: Elsevier BV
Published: 2003-01
Volume: 253
Issue: 1
Pages: 1-17
ISSN: 0012-1606 (ISSN-L)
DOI: 10.1006/dbio.2002.0869
OpenAlex: W2008770488
Cited by: 315
References: 190
Citations by year: 2026: 2 · 2025: 1 · 2024: 5 · 2023: 9 · 2022: 6 · 2021: 2 · 2020: 4 · 2019: 4 · 2018: 5 · 2017: 4 · 2016: 4 · 2015: 9 · 2014: 6 · 2013: 13 · 2012: 19
FWCI: 2.69
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 3850 d)
Locations: Developmental Biology (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Institutes of Health
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Hedgehog Signaling Pathway Studies
Keywords: Wnt signaling, Dishevelled, signal transduction, signaling complexes, feedback regulation, signal amplification, cell fate determination, stem cell maintenance, cancer, osteoporosis, calcium signaling
MeSH terms: Dishevelled Proteins, Animals, Humans, Phosphoproteins, Proto-Oncogene Proteins, Structure-Activity Relationship, Signal Transduction, Zebrafish Proteins, Adaptor Proteins, Signal Transducing, Wnt Proteins

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Runnin' with the Dvl: Proteins That Associate with Dsh/Dvl and Their Significance to Wnt Signal Transduction

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