Cited by 261Neuroinflammation and Neurodegeneration MechanismsAlzheimer's disease research and treatmentsPhagocytosis and Immune Regulation

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Astrocytes Regulate Microglial Phagocytosis of Senile Plaque Cores of Alzheimer's Disease

DeWitt, David A., Perry, George, Cohen, Mark, Doller, Catherine, Silver, Jerry·1998·Experimental Neurology

DOI 10.1006/exnr.1997.6738

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Abstract

We have developed an in vitro model in which isolated senile plaque (SP) cores are presented to rat microglial cells in culture. Microglia rapidly phagocytosed, broke apart, and cleared SP cores. However, when cocultured with astrocytes, microglial phagocytosis was markedly suppressed, allowing the SPs to persist. Suppression of phagocytosis by astrocytes appears to be a general phenomena since microglia in the presence of astrocytes showed reduced capacity to phagocytose latex beads as well. The astrocyte effect on microglia is related in part to a diffusible factor(s) since astrocyte- but not fibroblast-conditioned media also reduced phagocytosis. These results suggest that while microglia have the capacity to phagocytose and remove SPs, astrocytes which lie in close association to microglia may help prevent the efficient clearance of SP material allowing them to persist in Alzheimer's disease.

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Authors: DeWitt, D. A., Perry, G., Cohen, M., Doller, C., & Silver, J.
Affiliations: Case Western Reserve University (US)
ORCID: Perry, George
Cohen, Mark
Silver, Jerry
Venue: Experimental Neurology
Publisher: Elsevier BV
Published: 1998-02
Volume: 149
Issue: 2
Pages: 329-340
ISSN: 0014-4886 (ISSN-L)
DOI: 10.1006/exnr.1997.6738
OpenAlex: W2164956116
Cited by: 261
References: 69
Citations by year: 2026: 2 · 2025: 3 · 2024: 6 · 2023: 11 · 2022: 6 · 2021: 12 · 2020: 3 · 2019: 7 · 2018: 8 · 2017: 6 · 2016: 12 · 2015: 13 · 2014: 11 · 2013: 8 · 2012: 13
FWCI: 6.82
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Experimental Neurology (publishedVersion)
PubMed (publishedVersion)
Scholars Crossing (Liberty University) (submittedVersion)
Funders: National Institutes of Health (5r01ag009287-08)
National Institute on Aging (AG-00105-11A1, T32AG000105, AG 09287)
National Institute of Neurological Disorders and Stroke (NS 25713)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
Keywords: astrocytes, microglia, phagocytosis, amyloid plaques, Alzheimer's disease, plaque clearance, astrocyte-microglia interaction, conditioned medium, diffusible factors, latex bead phagocytosis, fibroblasts
MeSH terms: Alzheimer Disease, Animals, Animals, Newborn, Astrocytes, Brain, Cells, Cultured, Cerebral Cortex, Frontal Lobe, Humans, Phagocytosis, Temporal Lobe, Rats, Sprague-Dawley, Microglia, Coculture Techniques, Rats, Plaque, Amyloid

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Astrocytes Regulate Microglial Phagocytosis of Senile Plaque Cores of Alzheimer's Disease

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