Cited by 305RNA Research and SplicingNeuroscience and Neuropharmacology ResearchGenetics and Neurodevelopmental Disorders

Structure and Evolution of Neurexin Genes: Insight into the Mechanism of Alternative Splicing

Tabuchi, Katsuhiko, Südhof, Thomas C.·2002·Genomics

Abstract

Neurexins are neuron-specific vertebrate proteins with hundreds of differentially spliced isoforms that may function in synapse organization. We now show that Drosophila melanogaster and Caenorhabditis elegans express a single gene encoding only an alpha-neurexin, whereas humans and mice express three genes, each of which encodes alpha- and beta-neurexins transcribed from separate promoters. The neurexin genes are very large (up to 1.62 Mb), with the neurexin-3 gene occupying almost 2% of human chromosome 14. Although invertebrate and vertebrate neurexins exhibit a high degree of evolutionary conservation, only vertebrate neurexins are subject to extensive alternative splicing that uses mechanisms ranging from strings of mini-exons to multiple alternative splice donor and acceptor sites. Consistent with their proposed role in synapse specification, neurexins thus have evolved from relatively simple genes in invertebrates to diversified genes in vertebrates with multiple promoters and extensive alternative splicing.

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Crossref · 10.1006/geno.2002.6780

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  • Pre-mRNAs from the three Nrxn genes undergo extensive alternative splicing to produce more than 3,000 protein isoforms.

    “Pre-mRNAs from the three Nrxn genes undergo extensive alternative splicing to produce more than 3,000 protein isoforms88,89”

    From The neurogenetics of alternative splicing (2016) · cites this paper as [89]

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Authors
Tabuchi, K., & Südhof, T. C.
Affiliations
Howard Hughes Medical Institute (US)
Venue
Genomics
Publisher
Elsevier BV
Published
2002-06
Volume
79
Issue
6
Pages
849-859
ISSN
0888-7543 (ISSN-L)
OpenAlex
W2051468191
Cited by
305
References
31
Citations by year
2026: 11 · 2025: 12 · 2024: 9 · 2023: 13 · 2022: 9 · 2021: 14 · 2020: 12 · 2019: 8 · 2018: 8 · 2017: 10 · 2016: 12 · 2015: 15 · 2014: 19 · 2013: 16 · 2012: 17
FWCI
3.48
Type
journal article
Language
en
Open access
closed
Locations
  • Genomics (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R01 MH52804, R01MH052804)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
Keywords
neurexin, alternative splicing, gene evolution, NRXN3, multiple promoters, mini-exon, alternative splice sites, Drosophila melanogaster, Caenorhabditis elegans, chromosome 14, gene structure
MeSH terms
Animals, Humans, Nerve Tissue Proteins, Alternative Splicing, Sequence Analysis, DNA, Evolution, Molecular, Mice

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