Structure and Evolution of Neurexin Genes: Insight into the Mechanism of Alternative Splicing
Abstract
Neurexins are neuron-specific vertebrate proteins with hundreds of differentially spliced isoforms that may function in synapse organization. We now show that Drosophila melanogaster and Caenorhabditis elegans express a single gene encoding only an alpha-neurexin, whereas humans and mice express three genes, each of which encodes alpha- and beta-neurexins transcribed from separate promoters. The neurexin genes are very large (up to 1.62 Mb), with the neurexin-3 gene occupying almost 2% of human chromosome 14. Although invertebrate and vertebrate neurexins exhibit a high degree of evolutionary conservation, only vertebrate neurexins are subject to extensive alternative splicing that uses mechanisms ranging from strings of mini-exons to multiple alternative splice donor and acceptor sites. Consistent with their proposed role in synapse specification, neurexins thus have evolved from relatively simple genes in invertebrates to diversified genes in vertebrates with multiple promoters and extensive alternative splicing.
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Pre-mRNAs from the three Nrxn genes undergo extensive alternative splicing to produce more than 3,000 protein isoforms.
“Pre-mRNAs from the three Nrxn genes undergo extensive alternative splicing to produce more than 3,000 protein isoforms88,89”
From The neurogenetics of alternative splicing (2016) · cites this paper as [89]
Cites
Gapped BLAST and PSI-BLAST: a new generation of protein database search programs
Altschul, S. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.17.3389 · Cited by 73,302 · see citing works
Initial sequencing and analysis of the human genome
International Human Genome Sequencing Consortium, Whitehead Institute for Biomedical Research, C. F. G. R., Lander, E. S., Linton, L. M., Birren, B., Nusbaum, C., Zody, M. C., Baldwin, J., Devon, K., Dewar, K., et al. (2001) · Nature · doi:10.1038/35057062 · Cited by 24,216 · see citing works
The complete sequence of dystrophin predicts a rod-shaped cytoskeletal protein
Koenig, M., Monaco, A. P., & Kunkel, L. M. (1988) · Cell · doi:10.1016/0092-8674(88)90383-2 · Cited by 1,539 · see citing works
Neuroligin Expressed in Nonneuronal Cells Triggers Presynaptic Development in Contacting Axons
Scheiffele, P., Fan, J., Choih, J., Fetter, R., & Serafini, T. (2000) · Cell · doi:10.1016/s0092-8674(00)80877-6 · Cited by 1,060 · see citing works
Binding of Neuroligins to PSD-95
Irie, M., Hata, Y., Takeuchi, M., Ichtchenko, K., Toyoda, A., Hirao, K., Takai, Y., Rosahl, T. W., & Südhof, T. C. (1997) · Science · doi:10.1126/science.277.5331.1511 · Cited by 749 · see citing works
Self-citationNeuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses
Song, J.-Y., Ichtchenko, K., Südhof, T. C., & Brose, N. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.3.1100 · Cited by 696 · see citing works
Self-citationNeurexins: Synaptic Cell Surface Proteins Related to the α-Latrotoxin Receptor and Laminin
Ushkaryov, Y. A., Petrenko, A. G., Geppert, M., & Südhof, T. C. (1992) · Science · doi:10.1126/science.1621094 · Cited by 682 · see citing works
Self-citationNeuroligin 1: A splice site-specific ligand for β-neurexins
Ichtchenko, K., Hata, Y., Nguyen, T., Ullrich, B., Missler, M., Moomaw, C. R., & Südhof, T. C. (1995) · Cell · doi:10.1016/0092-8674(95)90396-8 · Cited by 663 · see citing works
Self-citationThe structural and functional diversity of dystrophin
Ahn, A. H., & Kunkel, L. M. (1993) · Nature Genetics · doi:10.1038/ng0493-283 · Cited by 652 · see citing works
Epithelial cell polarity and cell junctions in Drosophila.
Tepass, U., Tanentzapf, G., Ward, R. E., & Fehon, R. (2001) · Annual Review of Genetics · doi:10.1146/annurev.genet.35.102401.091415 · Cited by 554 · see citing works
Alternative splicing and genome complexity
Brett, D. J., Pospisil, H., Valcárcel, J., Jg, R., & Peer Bork, B. (2001) · Nature Genetics · doi:10.1038/ng803 · Cited by 537 · see citing works
Poliak, S., Gollan, L., Martinez, R., Custer, A., Einheber, S., Salzer, J., Trimmer, J., Shrager, P., & Peles, E. (1999) · Neuron · doi:10.1016/s0896-6273(00)81049-1 · Cited by 530 · see citing works
Ullrich, B., Ushkaryov, Y. A., & Südhof, T. C. (1995) · Neuron · doi:10.1016/0896-6273(95)90306-2 · Cited by 460 · see citing works
Self-citationStructures, Alternative Splicing, and Neurexin Binding of Multiple Neuroligins
Ichtchenko, K., Nguyen, T., & Südhof, T. C. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.5.2676 · Cited by 459 · see citing works
Self-citationA stoichiometric complex of neurexins and dystroglycan in brain
Sugita, S., Saito, F., Tang, J., Satz, J., Campbell, K., & Südhof, T. (2001) · Journal of Cell Biology · doi:10.1083/jcb.200105003 · Cited by 453 · see citing works
Self-citationBaumgartner, S., Littleton, J. T., Broadie, K. S., Bhat, M. A., Harbecke, R., Lengyel, J. A., Chiquet‐Ehrismann, R., Prokop, A., & Bellen, H. J. (1996) · Cell · doi:10.1016/s0092-8674(00)81800-0 · Cited by 432 · see citing works
Neurexins: three genes and 1001 products.
Missler, M., & Südhof, T. (1998) · Trends in Genetics · doi:10.1016/s0168-9525(97)01324-3 · Cited by 376 · see citing works
Self-citationThe human dystrophin gene requires 16 hours to be transcribed and is cotranscriptionally spliced
Tennyson, C. N., Klamut, H. J., & Worton, R. G. (1995) · Nature Genetics · doi:10.1038/ng0295-184 · Cited by 369 · see citing works
Nguyen, T., & Südhof, T. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.41.26032 · Cited by 234 · see citing works
Self-citationalpha-Latrotoxin and its receptors: neurexins and CIRL/latrophilins.
Südhof, T. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.933 · Cited by 215 · see citing works
Self-citationUshkaryov, Y. A., Hata, Y., Ichtchenko, K., Moomaw, C. R., Afendis, S. J., Slaughter, C. A., & Südhof, T. C. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)32671-6 · Cited by 160 · see citing works
Self-citationNeurexin III alpha: extensive alternative splicing generates membrane-bound and soluble forms.
Ushkaryov, Y. A., & Südhof, T. C. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.14.6410 · Cited by 149 · see citing works
Self-citationRudenko, G., Nguyen, T., Chelliah, Y., Südhof, T. C., & Deisenhofer, J. (1999) · Cell · doi:10.1016/s0092-8674(00)80065-3 · Cited by 126 · see citing works
Self-citationNeurexins Are Functional α-Latrotoxin Receptors
Sugita, S., Khvotchev, M. V., & Südhof, T. C. (1999) · Neuron · doi:10.1016/s0896-6273(00)80704-7 · Cited by 95 · see citing works
Self-citationNeurexin Iα Is a Major α-Latrotoxin Receptor That Cooperates in α-Latrotoxin Action
Geppert, M., Khvotchev, M. V., Krasnoperov, V. G., Goda, Y., Missler, M., Hammer, R. E., Ichtchenko, K., Petrenko, A. G., & Südhof, T. C. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.3.1705 · Cited by 94 · see citing works
Self-citationLG/LNS domains: multiple functions – one business end?
Rudenko, G., Hohenester, E., & Muller, Y. A. (2001) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(01)01832-1 · Cited by 93 · see citing works
Tobaben, S., Südhof, T. C., & Stahl, B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m111231200 · Cited by 54 · see citing works
Self-citationExon–Intron Organization of the Human Dystrophin Gene
Nobile, C., Marchi, J., Nigro, V., Roberts, R. G., & Danieli, G. A. (1997) · Genomics · doi:10.1006/geno.1997.4911 · Cited by 47 · see citing works
Peles, E., Joho, K. E., Plowman, G. D., & Schlessinger, J. (1997) · Cell · doi:10.1016/s0092-8674(00)81920-0 · Cited by 42 · see citing works
Nakabayashi, K., & Scherer, S. W. (2001) · Genomics · doi:10.1006/geno.2001.6517 · Cited by 42 · see citing works
Sun, H. B., Yokota, H., Chi, X. X., & Xu, Z. C. (2000) · Molecular Brain Research · doi:10.1016/s0169-328x(00)00237-0 · Cited by 16 · see citing works
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Südhof, T. C. (2008) · Nature · doi:10.1038/nature07456 · Cited by 1,849 · see citing works
Self-citationNeurexins Induce Differentiation of GABA and Glutamate Postsynaptic Specializations via Neuroligins
Graf, E. R., Zhang, X., Jin, S., Linhoff, M. W., & Craig, A. M. (2004) · Cell · doi:10.1016/j.cell.2004.11.035 · Cited by 989 · see citing works
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Südhof, T. C. (2017) · Cell · doi:10.1016/j.cell.2017.10.024 · Cited by 810 · see citing works
Self-citationZoghbi, H. Y., & Bear, M. F. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a009886 · Cited by 797 · see citing works
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Missler, M., Zhang, W., Rohlmann, A., Kattenstroth, G., Hammer, R. E., Gottmann, K., & Südhof, T. C. (2003) · Nature · doi:10.1038/nature01755 · Cited by 699 · see citing works
Self-citationPostnatal neurodevelopmental disorders: meeting at the synapse?
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Sur, M., & Rubenstein, J. L. R. (2005) · Science · doi:10.1126/science.1112070 · Cited by 677 · see citing works
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Craig, A. M., & Kang, Y. (2007) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2007.01.011 · Cited by 640 · see citing works
Disruption of neurexin 1 associated with autism spectrum disorder
Kim, H.-G., Kishikawa, S., Higgins, A. W., Seong, I.-S., Donovan, D. J., Shen, Y., Lally, E., Weiss, L. A., Najm, J., Kutsche, K., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2007.09.011 · Cited by 578 · see citing works
Xie, H. M., Vučetić, S., Iakoucheva, L. M., Oldfield, C. J., Dunker, A. K., Uversky, V. N., & Zoran Obradovic, A. (2007) · Journal of Proteome Research · doi:10.1021/pr060392u · Cited by 556 · see citing works
Boucard, A. A., Chubykin, A. A., Comoletti, D., Taylor, P., & Südhof, T. C. (2005) · Neuron · doi:10.1016/j.neuron.2005.08.026 · Cited by 470 · see citing works
Self-citationEtherton, M. R., Blaiss, C. A., Powell, C. M., & Südhof, T. C. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910297106 · Cited by 447 · see citing works
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Treutlein, B., Gokce, O., Quake, S. R., & Südhof, T. C. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1403244111 · Cited by 348 · see citing works
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Vuong, C. K., Black, D. L., & Zheng, S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.27 · Cited by 340 · see citing works
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Oakeshott, J. G., Claudianos, C., Campbell, P. M., Newcomb, R. D., & Russell, R. J. M. (2005) · Elsevier eBooks · doi:10.1016/b0-44-451924-6/00073-9 · Cited by 331 · see citing works
Aoto, J. N., Martinelli, D. C., Malenka, R. C., Tabuchi, K., & Südhof, T. C. (2013) · Cell · doi:10.1016/j.cell.2013.05.060 · Cited by 299 · see citing works
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Ching, M. S. L., Shen, Y., Tan, W., Jeste, S., Morrow, E. M., Chen, X., Mukaddes, N. M., Yoo, S.-Y., Hanson, E. M., Hundley, R. J., et al. (2010) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31063 · Cited by 298 · see citing works
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Iijima, T., Wu, K., Witte, H., Hanno-Iijima, Y., Glatter, T., Richard, S., & Scheiffele, P. (2011) · Cell · doi:10.1016/j.cell.2011.11.028 · Cited by 279 · see citing works
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Kim, S.-H., Burette, A., Chung, H. S., Kwon, S., Woo, J., Lee, H. W., Kim, K., Kim, H., Weinberg, R. J., & Kim, E. (2006) · Nature Neuroscience · doi:10.1038/nn1763 · Cited by 272 · see citing works
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Neves, G., Zucker, J. P., Daly, M. J., & Chess, A. J. (2004) · Nature Genetics · doi:10.1038/ng1299 · Cited by 268 · see citing works
Missler, M., Sudhof, T. C., & Biederer, T. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005694 · Cited by 255 · see citing works
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Peixoto, R. T., Kunz, P. A., Kwon, H., Mabb, A. M., Sabatini, B. L., Philpot, B. D., & Ehlers, M. (2012) · Neuron · doi:10.1016/j.neuron.2012.07.006 · Cited by 224 · see citing works
Pak, C., Dankó, T., Zhang, Y., Aoto, J. N., Anderson, G. R., Maxeiner, S., Yi, F., Wernig, M., & Südhof, T. C. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.07.017 · Cited by 217 · see citing works
Self-citationWang, Y., Liu, X., Biederer, T., & Südhof, T. C. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.182532999 · Cited by 256 · see citing works
Self-citationReißner, C., Runkel, F., & Missler, M. (2013) · Genome biology · doi:10.1186/gb-2013-14-9-213 · Cited by 211 · see citing works
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Chen, L. Y., Jiang, M., Zhang, B., Gökçe, Ö., & Südhof, T. C. (2017) · Neuron · doi:10.1016/j.neuron.2017.04.011 · Cited by 207 · see citing works
Self-citationRetractedGatto (2010) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2010.00004 · Cited by 204 · see citing works
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Self-citationMolecular Mechanisms of Synaptic Specificity in Developing Neural Circuits
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Li, J., Ashley, J., Budnik, V., & Bhat, M. A. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.002 · Cited by 171 · see citing works
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Synaptic proteins and receptors defects in autism spectrum disorders
Chen, J., Yu, S., Fu, Y., & Li, X. (2014) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2014.00276 · Cited by 168 · see citing works
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Anderson, G. R., Aoto, J. N., Tabuchi, K., Földy, C., Covy, J. P., Yee, A. X., Wu, D., Lee, S., Chen, L., Malenka, R. C., et al. (2015) · Cell · doi:10.1016/j.cell.2015.06.056 · Cited by 166 · see citing works
Self-citationMenezes, L. F., Cai, Y., Nagasawa, Y., da Silva, A. M. G., Watkins, M. L., da Silva, A. M., Somlo, S., Guay‐Woodford, L. M., Germino, G. G., & Onuchic², L. F. (2004) · Kidney International · doi:10.1111/j.1523-1755.2004.00844.x · Cited by 166 · see citing works
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Fernandez, B. A., & Scherer, S. W. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.4/sscherer · Cited by 160 · see citing works
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Schulte, J., Tepaß, U., & Auld, V. J. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200303192 · Cited by 156 · see citing works
Zhang, W., Rohlmann, A., Sargsyan, V., Aramuni, G., Hammer, R. E., Südhof, T. C., & Missler, M. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.0497-05.2005 · Cited by 156 · see citing works
Self-citationGraf, E. R., Kang, Y., Hauner, A. M., & Craig, A. M. (2006) · Journal of Neuroscience · doi:10.1523/jneurosci.1253-05.2006 · Cited by 154 · see citing works
Bhandari, R., Paliwal, J. K., & Kuhad, A. (2020) · Advances in neurobiology · doi:10.1007/978-3-030-30402-7_4 · Cited by 156 · see citing works
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Dahlhaus, R., Hines, R. M., Eadie, B. D., Kannangara, T. S., Hines, D. J., Brown, C. E., Christie, B. R., & El-Husseini, A. (2009) · Hippocampus · doi:10.1002/hipo.20630 · Cited by 145 · see citing works
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Pettem, K. L., Yokomaku, D., Luo, L., Linhoff, M. W., Prasad, T., Connor, S. A., Siddiqui, T. J., Kawabe, H., Chen, F., Zhang, L., et al. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.016 · Cited by 139 · see citing works
Dai, J., Aoto, J. N., & Südhof, T. C. (2019) · Neuron · doi:10.1016/j.neuron.2019.03.032 · Cited by 136 · see citing works
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Wöhr, M., Silverman, J. L., Scattoni, M. L., Turner, S. M., Harris, M., Saxena, R., & Crawley, J. N. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.07.024 · Cited by 124 · see citing works
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Kasem, E. A., Kurihara, T., & Tabuchi, K. (2017) · Neuroscience Research · doi:10.1016/j.neures.2017.10.012 · Cited by 114 · see citing works
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Hishimoto, A., Liu, Q., Drgon, T., Pletniková, O., Walther, D. M., Zhu, X.-G., Troncoso, J. C., & Uhl, G. R. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm247 · Cited by 115 · see citing works
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Self-citationWang, Y., & Südhof, T. C. (2003) · Genomics · doi:10.1016/s0888-7543(02)00024-1 · Cited by 112 · see citing works
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Chanda, S., Hale, W. D., Zhang, B., Wernig, M., & Südhof, T. C. (2017) · Journal of Neuroscience · doi:10.1523/jneurosci.0125-17.2017 · Cited by 106 · see citing works
Self-citationDahlhaus, R., & El-Husseini, A. (2010) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.11.019 · Cited by 102 · see citing works
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Self-citationLowther, C., Speevak, M. D., Armour, C. M., Goh, E. S., Graham, G. E., Li, C. C., Zeesman, S., Nowaczyk, M. J. M., Schultz, L., Morra, A., et al. (2016) · Genetics in Medicine · doi:10.1038/gim.2016.54 · Cited by 91 · see citing works
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Tromp, A., Mowry, B. J., & Giacomotto, J. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00944-8 · Cited by 95 · see citing works
Choi, Y.-B., Li, H.-L., Kassabov, S. R., Jin, I., Puthanveettil, S. V., Karl, K. A., Lu, Y., Kim, J.-H., Bailey, C. H., & Kandel, E. R. (2011) · Neuron · doi:10.1016/j.neuron.2011.03.020 · Cited by 94 · see citing works
Uchigashima, M., Cheung, A., & Futai, K. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.749164 · Cited by 89 · see citing works
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Rohou, A. L., Nield, J., & Ushkaryov, Y. A. (2006) · Toxicon · doi:10.1016/j.toxicon.2006.11.021 · Cited by 93 · see citing works
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Nussbaum, J. M., Xu, Q., Payne, T. J., Ma, J. Z., Huang, W., Gelernter, J. E., & Li, M. D. (2008) · Human Molecular Genetics · doi:10.1093/hmg/ddn044 · Cited by 88 · see citing works
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Pohl, M., Bortfeldt, R. H., Grützmann, K., & Schuster, S. (2013) · Biosystems · doi:10.1016/j.biosystems.2013.07.003 · Cited by 85 · see citing works
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Li, Y., Shen, M., Stockton, M. E., & Zhao, X. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.10.001 · Cited by 84 · see citing works
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Kamimura, K., & Maeda, N. (2021) · Frontiers in Neural Circuits · doi:10.3389/fncir.2021.595596 · Cited by 77 · see citing works
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Biswas, S., Russell, R. J., Jackson, C. J., Vidovic, M., Ganeshina, O., Oakeshott, J. G., & Claudianos, C. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003542 · Cited by 82 · see citing works
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Knight, D., Xie, W., & Boulianne, G. L. (2011) · Molecular Neurobiology · doi:10.1007/s12035-011-8213-1 · Cited by 81 · see citing works
Born, G., Grayton, H. M., Langhorst, H., Dudanova, I., Rohlmann, A., Woodward, B. W., Collier, D. A., Fernandes, C., & Missler, M. (2015) · Frontiers in Synaptic Neuroscience · doi:10.3389/fnsyn.2015.00003 · Cited by 77 · see citing works
Neurexin Dysfunction in Adult Neurons Results in Autistic-like Behavior in Mice
Rabaneda, L. G., Robles-Lanuza, E., Nieto-González, J. L., & Scholl, F. G. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.06.022 · Cited by 78 · see citing works
Arechavaleta-Velasco, M. E., Escamilla, K. I. A., Robles-Rios, C., Tsuruda, J. M., & Hunt, G. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0047269 · Cited by 78 · see citing works
Neurexin gene family variants as risk factors for autism spectrum disorder
Wang, J., Gong, J., Li, L., Chen, Y., Liu, L., Gu, H., Luo, X., Hou, F., Zhang, J., & Song, R. (2017) · Autism Research · doi:10.1002/aur.1881 · Cited by 76 · see citing works
Monogenic mouse models of autism spectrum disorders: Common mechanisms and missing links
Hulbert, S. W., & Jiang, Y. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.040 · Cited by 72 · see citing works
Dystroglycan Binding to α-Neurexin Competes with Neurexophilin-1 and Neuroligin in the Brain
Reißner, C., Stahn, J., Breuer, D., Klose, M., Pohlentz, G., Mormann, M., & Missler, M. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.595413 · Cited by 75 · see citing works
Sperry and Hebb: oil and vinegar?
Cline, H. T. (2003) · Trends in Neurosciences · doi:10.1016/j.tins.2003.10.005 · Cited by 71 · see citing works
NRXN1 deletion syndrome; phenotypic and penetrance data from 34 families
Shehhi, M. R. A., Forman, E., Fitzgerald, J. E., McInerney, V., Krawczyk, J., Shen, S., Betts, D. R., Ardle, L. M., Gorman, K. M., King, M. D., et al. (2018) · European Journal of Medical Genetics · doi:10.1016/j.ejmg.2018.07.015 · Cited by 74 · see citing works
Cuttler, K., Hassan, M., Carr, J. A., Cloete, R. E. A., & Bardien, S. (2021) · Open Biology · doi:10.1098/rsob.210091 · Cited by 71 · see citing works
Neurexins and neuroligins: synapses look out of the nervous system
Bottos, A., Rissone, A., Bussolino, F., & Arese, M. (2011) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-011-0664-z · Cited by 70 · see citing works
Bottos, A., Destro, E., Rissone, A., Graziano, S., Cordara, G., Assenzio, B., Cera, M. R., Mascia, L., Bussolino, F., & Arese, M. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0809510106 · Cited by 70 · see citing works
- Authors
- Tabuchi, K., & Südhof, T. C.
- Affiliations
- Howard Hughes Medical Institute (US)
- Venue
- Genomics
- Publisher
- Elsevier BV
- Published
- 2002-06
- Volume
- 79
- Issue
- 6
- Pages
- 849-859
- ISSN
- 0888-7543 (ISSN-L)
- OpenAlex
- W2051468191
- Cited by
- 305
- References
- 31
- Citations by year
- 2026: 11 · 2025: 12 · 2024: 9 · 2023: 13 · 2022: 9 · 2021: 14 · 2020: 12 · 2019: 8 · 2018: 8 · 2017: 10 · 2016: 12 · 2015: 15 · 2014: 19 · 2013: 16 · 2012: 17
- FWCI
- 3.48
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Genomics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (R01 MH52804, R01MH052804)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › RNA Research and Splicing
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- neurexin, alternative splicing, gene evolution, NRXN3, multiple promoters, mini-exon, alternative splice sites, Drosophila melanogaster, Caenorhabditis elegans, chromosome 14, gene structure
- MeSH terms
- Animals, Humans, Nerve Tissue Proteins, Alternative Splicing, Sequence Analysis, DNA, Evolution, Molecular, Mice
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