Cited by 231Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchMemory Processes and Influences

Correlation between the Pharmacology of Long-Term Potentiation and the Pharmacology of Memory

Izquierdo, I., Medina, J.H.·1995·Neurobiology of Learning and Memory

Abstract

The pharmacology of memory has been recently studied by the infusion of drugs into the hippocampus (HIP), amygdala (AMY), medial septum (MS), and entorhinal cortex (EC) at various times after training or at the time of retention testing. It was found to be remarkably similar to that of long-term potentiation (LTP). Memory and LTP are blocked early on by antagonists of glutamate N-methyl-D-aspartate (NMDA) or metabotropic receptors (mGLUs), by the antagonist of the presynaptic membrane receptor to PAF, BN 52021, by the inhibitor of heme oxygenase, ZnPP, by the inhibitor of NO synthase, N-nitro-arginine, by GABA type A receptor agonists, or by muscarinic blockers. Both memory and LTP are enhanced, at this early stage, by glutamate, mGLU agonists, GABA-A antagonists, muscarinic agonists, and norepinephrine. In the next 1-3 h, memory and LTP are accompanied by enhanced activity of protein kinases and are blocked by specific inhibitors of calcium/calmodulin dependent protein kinase II and protein kinase C. At the time of expression, memory and LTP are blocked by antagonists of glutamate AMPA receptors and are accompanied by an enhanced sensitivity of these receptors. Memories that depend on HIP are affected by drugs given into the HIP but not the MS or AMY, memories that depend on the AMY are affected by drugs given into the AMY, and memories that depend on the HIP, AMY, and MS are affected by drugs given into the three structures.(ABSTRACT TRUNCATED AT 250 WORDS)

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Crossref · 10.1006/nlme.1995.1002

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Authors
Izquierdo, I., & Medina, J. H.
Affiliations
Universidade Federal do Rio Grande do Sul (BR)
Venue
Neurobiology of Learning and Memory
Publisher
Elsevier BV
Published
1995-01
Volume
63
Issue
1
Pages
19-32
ISSN
1074-7427 (ISSN-L)
OpenAlex
W2046474139
Cited by
230
References
0
Citations by year
2026: 3 · 2025: 3 · 2024: 2 · 2023: 2 · 2022: 4 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 5 · 2014: 5 · 2013: 6 · 2012: 7
FWCI
7.86
Type
journal article
Language
en
Open access
closed
Locations
  • Neurobiology of Learning and Memory (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
long-term potentiation, hippocampus, amygdala, medial septum, entorhinal cortex, NMDA receptor antagonists, metabotropic glutamate receptors, PAF receptor antagonists, heme oxygenase inhibition, nitric oxide synthase inhibition, GABAA receptor, muscarinic receptors, norepinephrine, protein kinases, calcium/calmodulin-dependent protein kinase II, protein kinase C, AMPA receptors, memory expression, memory consolidation
MeSH terms
Amygdala, Animals, Brain, Brain Mapping, Hippocampus, Memory, Septum Pellucidum, Neurotransmitter Uptake Inhibitors, Long-Term Potentiation, Receptors, Neurotransmitter, Neurotransmitter Agents, Entorhinal Cortex

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