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Cited by 143Memory and Neural MechanismsCannabis and Cannabinoid ResearchMemory Processes and Influences

Opposite action of hippocampal CB1 receptors in memory reconsolidation and extinction

de Oliveira Alvares, L., Pasqualini Genro, B., Diehl, F., Molina, V.A., Quillfeldt, J.A.·2008·Neuroscience
DOI 10.1016/j.neuroscience.2008.05.005
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Abstract

Retrieval of a consolidated memory triggers a number of processes which depend, among other factors, on the duration of the reactivation session: reconsolidation requires a brief reactivation session, and extinction, a prolonged one. The scope of this study is to explore the potential role of the hippocampal endocannabinoid system on reconsolidation and extinction processes. Bilateral infusion of the CB1 cannabinoid receptor antagonist, N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (AM251) into the CA1 region of the dorsal hippocampus of Wistar rats after memory reactivation facilitated the reconsolidation of the contextual fear conditioning memory. The inhibition of protein synthesis with DRB in the same brain region blocked memory reconsolidation. Both effects were persistent, lasting up to 7 days after the first retrieval experience. In contrast, the local infusion of anandamide blocked memory reconsolidation, an effect that was antagonized by the combined administration of anandamide with a subthreshold dose of a CB1 antagonist, supporting a CB1-mediated role of the hippocampal endocannabinoid system in the modulation of the memory reconsolidation. Local infusion of AM251 into CA1 blocked memory extinction whereas the administration of anandamide facilitated it; however, when combined with a subthreshold concentration of the CB1 antagonist, anandamide did not affect the extinction process. The clear-cut, opposite effects observed in each situation suggest a possible role of the hippocampal endocannabinoid system as a switching mechanism deciding which processes will take place, either maintaining the original memory (reconsolidation) or promoting a new learning (extinction).

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Crossref · 10.1016/j.neuroscience.2008.05.005

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  • Activating CB1R via systemic or intra-hippocampal or intra-mPFC administration of WIN55212-2, AM404, or AEA facilitates rodent fear extinction, in most cases without affecting conditioned fear.

    “Activating CB1R via systemic or intra-hippocampal or -mPFC administration of either the CB1R agonist, WIN55212-2, the ECB reuptake blocker, AM404, or AEA itself has been shown to facilitate rodent fear extinction, in most cases without affecting conditioned fear [89,95–98] (but see [90]).”

    From Amygdala FAAH and anandamide: mediating protection and recovery from stress (2013) · cites this paper as [98]

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Authors
de Oliveira Alvares, L., Pasqualini Genro, B., Diehl, F., Molina, V. A., & Quillfeldt, J. A.
Affiliations
  • Universidade Federal do Rio Grande do Sul (BR)
  • Universidad Nacional de Córdoba (AR)
Corresponding author
Quillfeldt, J.A.
ORCID
Quillfeldt, J.A.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2008-07
Volume
154
Issue
4
Pages
1648-1655
ISSN
0306-4522 (ISSN-L)
DOI
10.1016/j.neuroscience.2008.05.005
OpenAlex
W2069390584
Cited by
143
References
70
Citations by year
2026: 4 · 2025: 7 · 2024: 1 · 2023: 6 · 2022: 6 · 2021: 7 · 2020: 4 · 2019: 4 · 2018: 6 · 2017: 11 · 2016: 8 · 2015: 15 · 2014: 8 · 2013: 16 · 2012: 12
FWCI
4.82
Type
journal article
Language
en
Open access
closed
Licence
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Conselho Nacional de Desenvolvimento Científico e Tecnológico
  • Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
  • Financiadora de Estudos e Projetos (01.06.0842-00)
  • Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul
  • International Foundation for Science
  • Pró-Reitoria de Pesquisa, Universidade Federal do Rio Grande do Sul
  • Secretaria de Ciencia y Tecnica, Universidad de Buenos Aires
  • Consejo Nacional de Investigaciones Científicas y Técnicas
  • Fondo para la Investigación Científica y Tecnológica
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Health Sciences › Medicine › Pharmacology › Cannabis and Cannabinoid Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory Processes and Influences
Keywords
CB1 receptor, memory reconsolidation, memory extinction, contextual fear conditioning, anandamide, AM251, CA1, protein synthesis inhibition, memory retrieval
MeSH terms
Animals, Arachidonic Acids, Conditioning, Operant, Extinction, Psychological, Hippocampus, Male, Memory, Piperidines, Pyrazoles, Rats, Wistar, Receptor, Cannabinoid, CB1, Rats, Polyunsaturated Alkamides, Cannabinoid Receptor Modulators, Endocannabinoids

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