Stress-Related Modulation of Hippocampal Long-Term Potentiation in Rats: Involvement of Adrenal Steroid Receptors
Open accessAbstract
Stress is usually correlated with an increased release of glucocorticoids from the adrenal glands. Within the hippocampus, a structure long known to be involved in spatial learning, two corticosterone-binding receptors are identified: the glucocorticoid receptor (GR) and the mineralocorticoid receptor (MR). Activation of these receptors impairs or facilitates hippocampal long-term potentiation (LTP), respectively. Stress elicited by behavioral manipulations may interfere with cognitive modulations of LTP during learning experiments. Here, we explore the influence of two stress-inducing procedures, handling and swimming, on the maintenance of dentate gyrus LTP in the rat induced by a weak tetanization of the perforant path. Manipulations started 15 min after tetanization. Handling alone resulted in a complete reversal of LTP. Handling followed by a 2 min swim in a water tank elicited prolonged protein synthesis but not β-adrenergic-dependent LTP compared with either control or handled animals. Blockade of the GRs but not of the MRs prevented the reversal of LTP by handling. Inactivation of the MRs but not of the GRs hindered LTP prolongation by swimming. Because the activated receptor complexes act as transcription factors, MR- and GR-related proteins may play a role in the maintenance of LTP. The data suggest a complex interplay of corticosterone-binding receptors on modulations of hippocampal LTP and thus, of stress on learning and functional plasticity in general.
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Low cortisol concentrations during SWS-rich sleep benefit declarative memory consolidation by preventing activation of glucocorticoid receptors that inhibit hippocampal LTP and CA1 output.
“Low cortisol concentrations during SWS-rich sleep benefit declarative memory consolidation by preventing activation of glucocorticoid receptors that mediate an inhibitory influence on hippocampal LTP and output from CA1 (648, 649, 666).”
From About Sleep's Role in Memory (2013) · cites this paper as [666]
The Introduction (page not specified) states that glucocorticoid-receptor activation impairs hippocampal LTP, and the Discussion says that under basal conditions GRs are not occupied. The paper studies stress-related LTP in rats; it does not establish that low cortisol during SWS-rich sleep benefits declarative-memory consolidation or prevents inhibition of CA1 output. (LLM, conf=0.88)
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- Authors
- Korz, V., & Frey, J. U.
- Affiliations
- Leibniz Institute for Neurobiology (DE)
- ORCID
- Korz, Volker
- Venue
- The Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2003-08-13
- Volume
- 23
- Issue
- 19
- Pages
- 7281-7287
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6740434
- OpenAlex
- W1914097020
- Cited by
- 155
- References
- 7
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 2 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 5 · 2016: 8 · 2015: 3 · 2014: 9 · 2013: 7 · 2012: 10
- FWCI
- 3.59
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Commission
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- hippocampal long-term potentiation, stress, glucocorticoid receptor, mineralocorticoid receptor, corticosterone, dentate gyrus, handling stress, swim stress, protein synthesis, perforant path, functional plasticity, receptor antagonism
- MeSH terms
- Adrenal Glands, Adrenergic beta-Antagonists, Mineralocorticoid Receptor Antagonists, Animals, Behavior, Animal, Handling, Psychological, Male, Propranolol, Receptors, Glucocorticoid, Stress, Physiological, Swimming, Protein Biosynthesis, Rats, Wistar, Long-Term Potentiation, Receptors, Mineralocorticoid, Dentate Gyrus, Excitatory Postsynaptic Potentials, Rats
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