Sensors in Disposable Bioreactors Status and Trends
Abstract
For better control of productivity and product quality, detailed monitoring of various parameters is required. Since disposable bioreactors become more and more important for biotechnological applications, adequate sensors for this type of reactor are necessary. The required properties of sensors used in disposable reactors differ from those of sensors for multiuse reactors. For example, sensors which are in direct contact with the medium must be inexpensive, but do not need a long life-time, since they can be used only once.This chapter gives an overview on the state of the art and future trends in the field of sensors suited for use in disposable bioreactors. The main focus here is on in situ sensors, which can be based on optical, semiconductor and ultrasonic technologies, but current concepts for disposable sampling units are also reviewed.
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Fluorescence spectroscopy has been used to track physiological changes such as the transition between bacterial aerobic and anaerobic metabolisms and the change between oxidative and oxidoreductive metabolism in yeasts.
“For that reason, fluorescence spectroscopy has been used to track physiological changes, such as the transition between bacterial aerobic and anerobic metabolisms (Glindkamp et al., 2009), and the change between oxidative and oxidoreductive metabolism in yeasts (Hantelmann et al., 2006).”
From Perspectives of fluorescence spectroscopy for online monitoring in microalgae industry (2022) · cites this paper as Glindkamp et al., 2009
IR spectroscopy can only be used with a short optical path length or in the NIR range from 780 to 2500 nm because water has high IR absorbance for wavelengths higher than 2500 nm.
“Because most bioprocesses occur in aqueous medium, and water is known to have a high IR absorbance for wavelengths higher than 2500 nm, IR spectroscopy can only be used with a short optical path length or in the range of near‐to short‐wave IR range (NIR), from 780 to 2500 nm (Glindkamp et al., 2009).”
From Perspectives of fluorescence spectroscopy for online monitoring in microalgae industry (2022) · cites this paper as Glindkamp et al., 2009
NIR low absorption coefficients enable a higher penetration depth, allowing the use of NIR in solids or turbid liquids such as culture broths.
“The low absorption coefficients enable a higher penetration depth, allowing the use of this technique in solids or turbid liquids, such as culture broths (Marose et al., 1999; Ulber et al., 2003; Glindkamp et al., 2009; Henriques et al., 2010).”
From Perspectives of fluorescence spectroscopy for online monitoring in microalgae industry (2022) · cites this paper as Glindkamp et al., 2009
Parameters measured online are usually less than the required parameters needed for accurate monitoring and control.
“Also, the parameters measured online are usually less than the required parameters needed for accurate monitoring and control (Ulber et al., 2003; Glindkamp et al., 2009).”
From Perspectives of fluorescence spectroscopy for online monitoring in microalgae industry (2022) · cites this paper as Glindkamp et al., 2009
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Sensor systems for bioprocess monitoring
Biechele, P., Busse, C., Solle, D., Scheper, T., & Reardon, K. (2015) · Engineering in Life Sciences · doi:10.1002/elsc.201500014 · Cited by 224 · see citing works
Self-citationClaßen, J., Aupert, F., Reardon, K. F., Solle, D., & Scheper, T. (2017) · Analytical and Bioanalytical Chemistry · doi:10.1007/s00216-016-0068-x · Cited by 176 · see citing works
Self-citationOn-Line Monitoring of Large Cultivations of Microalgae and Cyanobacteria
Havlik, I., Lindner, P., Scheper, T., & Reardon, K. F. (2013) · Trends in Biotechnology · doi:10.1016/j.tibtech.2013.04.005 · Cited by 131 · see citing works
Self-citationThe Use of UV-Vis Spectroscopy in Bioprocess and Fermentation Monitoring
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Perspectives of fluorescence spectroscopy for online monitoring in microalgae industry
Sá, M., Ferrer‐Ledo, N., Gao, F., Bertinetto, C. G., Jansen, J., Crespo, J. G., Wijffels, R. H., Barbosa, M., & Galinha, C. F. (2022) · Microbial Biotechnology · doi:10.1111/1751-7915.14013 · Cited by 29 · see citing works
“IR has been used in bioprocess monitoring for the measurement of several metabolites, such as ethanol, glucose, and fructose (Glindkamp et al., 2009).”
BackgroundMethodInfluentialThe application of bubble column photobioreactor for algal cultivation
O'Higgins, L., Haider, M. N., Verma, N., & Bose, A. (2025) · Algal Bioreactors · doi:10.1016/b978-0-443-14058-7.00003-8 · Cited by 6 · see citing works
- Authors
- Glindkamp, A., Riechers, D., Rehbock, C., Hitzmann, B., Scheper, T., & Reardon, K. F.
- Affiliations
- Leibniz University Hannover (DE)
- Colorado State University (US)
- Corresponding author
- Scheper, Thomas
- Venue
- Advances in Biochemical Engineering/Biotechnology
- Publisher
- Springer Berlin Heidelberg
- Published
- 2009
- Volume
- 115
- Pages
- 145-169
- ISSN
- 0724-6145 (ISSN-L)
- 1616-8542
- OpenAlex
- W1535249854
- Cited by
- 65
- References
- 4
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 2 · 2022: 3 · 2021: 2 · 2020: 2 · 2019: 6 · 2018: 3 · 2017: 6 · 2016: 7 · 2015: 7 · 2014: 3 · 2013: 9 · 2012: 3
- FWCI
- 13.68
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in biochemical engineering, biotechnology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Fluid Dynamics and Mixing
- Physical Sciences › Chemical Engineering › Bioengineering › Analytical Chemistry and Sensors
- Physical Sciences › Environmental Science › Waste Management and Disposal › Water Quality Monitoring and Analysis
- Keywords
- disposable bioreactors, in situ monitoring, optical sensors, semiconductor sensors, ultrasonic sensors, bioprocess control, product quality monitoring
- MeSH terms
- Animals, Biological Products, Carbon Dioxide, Disposable Equipment, Electrodes, Equipment Design, Humans, Hydrogen-Ion Concentration, Oxygen, Quality Control, Semiconductors, Cell Culture Techniques, Bioreactors, Optical Devices
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