Involvement of nitric oxide in the 5-HT1A autoreceptor-mediated hyperphagia in rats
Abstract
Effects of nitric oxide synthase(NOS) inhibitors on 8-hydroxy-2-di-n-(propylamino)tetralin (8-OH-DPAT)-induced hyperphagia which is mediated by the 5-HT autoreceptor were investigated. The non-selective NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME) and neuronal NOS (nNOS) inhibitor 7-nitroindazole (7-NI) clearly suppressed increases in food intake by 8-OH-DPAT. Both hypophagic effects of L-NAME and 7-NI were reversed by the nitric oxide precursor, L-arginine. The findings suggest that nitric oxide formed in the brain is involved in 8-OH-DPAT-induced hyperphagia.
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NO produced in the brain antagonizes anorectic signals and stimulates food intake.
“Taken together with numerous other studies demonstrating a role for NO in the regulation of hunger [266-270], it would appear that NO produced in the brain antagonizes anorectic signals and stimulates food intake.”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [268]
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- Authors
- Sugimoto, Y., Yoshikawa, T., & Yamada, J.
- Affiliations
- Kobe Pharmaceutical University (JP)
- Venue
- Advances in experimental medicine and biology
- Publisher
- Springer US
- Published
- 1999
- Volume
- 467
- Pages
- 109-111
- ISSN
- 0065-2598 (ISSN-L)
- OpenAlex
- W41821897
- Cited by
- 9
- References
- 7
- Citations by year
- 2014: 2
- FWCI
- 2.15
- Type
- book chapter
- Language
- en
- Open access
- closed
- Locations
- Advances in experimental medicine and biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- nitric oxide, 5-HT1A autoreceptors, hyperphagia, nitric oxide synthase inhibitors, neuronal nitric oxide synthase, 7-nitroindazole, L-NAME, 8-OH-DPAT, dietary intake, L-arginine, serotonin
- MeSH terms
- Animals, Enzyme Inhibitors, Hyperphagia, Indazoles, Male, Nitric Oxide, Receptors, Serotonin, Rats, Sprague-Dawley, Serotonin Receptor Agonists, 8-Hydroxy-2-(di-n-propylamino)tetralin, Nitric Oxide Synthase, NG-Nitroarginine Methyl Ester, Receptors, Serotonin, 5-HT1, Rats
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