Anorectic activity of NG-nitro-L-arginine, an inhibitor of brain nitric oxide synthase, in obese Zucker rats
Abstract
We investigated the effects of NG-nitro-L-arginine (L-NO Arg) administration (12.5, 25 and 50 mg/kg i.p.) on food consumption and body weight of male obese Zucker rats (fa/fa) and in their lean age-matched controls (FA/?; FA/FA), both groups aged 14 weeks. Acute or repeated administration of L-NO Arg reduced food intake and body weight in both obese and lean rats. However the lean rats showed tolerance to the L-NO Arg effects after 5 days of treatment. L-NO Arg anorexia was suppressed by pretreatment with metergoline. These results suggest that L-NO Arg may represent a new anorectic drug.
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In rodents, L-arginine increases food intake and NOS inhibitors decrease food intake.
“In rodents, L-arginine was shown to increase, and NOS inhibitors to decrease, food intake [155, 251-254].”
From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [254]
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- Authors
- Squadrito, F., Calapai, G., Cucinotta, D., Altavilla, D., Zingarelli, B., Ioculano, M., Urna, G., Sardella, A., Campo, G. M., & Caputi, A. P.
- Affiliations
- University of Messina (IT)
- ORCID
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 1993-01
- Volume
- 230
- Issue
- 1
- Pages
- 125-128
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2035611383
- Cited by
- 99
- References
- 10
- Citations by year
- 2023: 1 · 2022: 1 · 2021: 1 · 2017: 1 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 2
- FWCI
- 4.75
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Keywords
- L-NNA, nitric oxide synthase inhibition, anorectic activity, dietary intake, body weight, obesity, Zucker rats, Zucker fatty rats, tolerance (pharmacology and immunology), metergoline
- MeSH terms
- Amino Acid Oxidoreductases, Animals, Appetite Depressants, Arginine, Body Weight, Brain, Eating, Male, Metergoline, Obesity, Rats, Zucker, Serotonin Antagonists, Ritanserin, Nitric Oxide Synthase, Nitroarginine, Rats
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