Cited by 99Regulation of Appetite and ObesityPharmacology and Obesity TreatmentEating Disorders and Behaviors

Anorectic activity of NG-nitro-L-arginine, an inhibitor of brain nitric oxide synthase, in obese Zucker rats

Squadrito, Francesco, Calapai, Gioacchino, Cucinotta, Domenico, Altavilla, Domenica, Zingarelli, Basilia, Ioculano, Mariapatrizia, Urna, Guiseppe, Sardella, Aurora +2 more·1993·European Journal of Pharmacology

Abstract

We investigated the effects of NG-nitro-L-arginine (L-NO Arg) administration (12.5, 25 and 50 mg/kg i.p.) on food consumption and body weight of male obese Zucker rats (fa/fa) and in their lean age-matched controls (FA/?; FA/FA), both groups aged 14 weeks. Acute or repeated administration of L-NO Arg reduced food intake and body weight in both obese and lean rats. However the lean rats showed tolerance to the L-NO Arg effects after 5 days of treatment. L-NO Arg anorexia was suppressed by pretreatment with metergoline. These results suggest that L-NO Arg may represent a new anorectic drug.

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Crossref · 10.1016/0014-2999(93)90422-e

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  • In rodents, L-arginine increases food intake and NOS inhibitors decrease food intake.

    “In rodents, L-arginine was shown to increase, and NOS inhibitors to decrease, food intake [155, 251-254].”

    From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [254]

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Authors
Squadrito, F., Calapai, G., Cucinotta, D., Altavilla, D., Zingarelli, B., Ioculano, M., Urna, G., Sardella, A., Campo, G. M., & Caputi, A. P.
Affiliations
University of Messina (IT)
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
1993-01
Volume
230
Issue
1
Pages
125-128
ISSN
0014-2999 (ISSN-L)
OpenAlex
W2035611383
Cited by
99
References
10
Citations by year
2023: 1 · 2022: 1 · 2021: 1 · 2017: 1 · 2015: 1 · 2014: 3 · 2013: 2 · 2012: 2
FWCI
4.75
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Pharmacology › Pharmacology and Obesity Treatment
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
Keywords
L-NNA, nitric oxide synthase inhibition, anorectic activity, dietary intake, body weight, obesity, Zucker rats, Zucker fatty rats, tolerance (pharmacology and immunology), metergoline
MeSH terms
Amino Acid Oxidoreductases, Animals, Appetite Depressants, Arginine, Body Weight, Brain, Eating, Male, Metergoline, Obesity, Rats, Zucker, Serotonin Antagonists, Ritanserin, Nitric Oxide Synthase, Nitroarginine, Rats

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