Cited by 16Regulation of Appetite and ObesityNeurotransmitter Receptor Influence on BehaviorNeuroscience and Neuropharmacology Research

Effects of a nitric oxide synthase inhibitor on 5-HT1A receptor agonist 8-OH-DPAT-induced hyperphagia in rats

Yamada, Jun, Sugimoto, Yumi, Yoshikawa, Tomoko, Horisaka, Kazuyoshi·1996·European Journal of Pharmacology

Abstract

We investigated nitric oxide (NO) involvement in the hyperphagia induced by the 5-HT1A receptor agonist 8-hydroxy-2-di-n-(propylamino)tetralin (8-OH-DPAT). A NO synthase inhibitor, NG-nitro-L-arginine methyl ester (L-NAME), dose dependently inhibited 8-OH-DPAT-induced eating in freely feeding rats. However, the inactive isomer D-NAME was without effect. The inhibitory effects of L-NAME on 8-OH-DPAT-induced hyperphagia were reversed by simultaneous administration of L-arginine. These results suggest that NO participates in the 8-OH-DPAT-induced hyperphagia which is elicited by activation of the 5-HT1A receptor.

Integrity signals

Registry

Crossref · 10.1016/s0014-2999(96)00657-7

Cites

16 of 16 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

  • NO produced in the brain antagonizes anorectic signals and stimulates food intake.

    “Taken together with numerous other studies demonstrating a role for NO in the regulation of hunger [266-270], it would appear that NO produced in the brain antagonizes anorectic signals and stimulates food intake.”

    From Regulation of obesity and insulin resistance by nitric oxide (2014) · cites this paper as [266]

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Yamada, J., Sugimoto, Y., Yoshikawa, T., & Horisaka, K.
Affiliations
Kobe Pharmaceutical University (JP)
Corresponding author
Yamada, Jun
Venue
European Journal of Pharmacology
Publisher
Elsevier BV
Published
1996-11
Volume
316
Issue
1
Pages
23-26
ISSN
0014-2999 (ISSN-L)
OpenAlex
W2055985791
Cited by
16
References
16
Citations by year
2014: 2
FWCI
0.46
Type
journal article
Language
en
Open access
closed
Locations
  • European Journal of Pharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
nitric oxide, nitric oxide synthase inhibition, L-NAME, 8-OH-DPAT, 5-HT1A receptor, serotonin receptor agonists, hyperphagia, dietary intake, L-arginine, D-NAME, rats
MeSH terms
Animals, Eating, Enzyme Inhibitors, Hyperphagia, Male, Nitric Oxide, Receptors, Serotonin, Rats, Sprague-Dawley, Serotonin Receptor Agonists, 8-Hydroxy-2-(di-n-propylamino)tetralin, Nitric Oxide Synthase, NG-Nitroarginine Methyl Ester, Receptors, Serotonin, 5-HT1, Rats

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review