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Unsupervised Learning for Fast Probabilistic Diffeomorphic Registration

Open access
Dalca, Adrian V., Balakrishnan, Guha, Guttag, John, Sabuncu, Mert R.·2018·Lecture Notes in Computer Science

Abstract

Traditional deformable registration techniques achieve impressive results and offer a rigorous theoretical treatment, but are computationally intensive since they solve an optimization problem for each image pair. Recently, learning-based methods have facilitated fast registration by learning spatial deformation functions. However, these approaches use restricted deformation models, require supervised labels, or do not guarantee a diffeomorphic (topology-preserving) registration. Furthermore, learning-based registration tools have not been derived from a probabilistic framework that can offer uncertainty estimates. In this paper, we present a probabilistic generative model and derive an unsupervised learning-based inference algorithm that makes use of recent developments in convolutional neural networks (CNNs). We demonstrate our method on a 3D brain registration task, and provide an empirical analysis of the algorithm. Our approach results in state of the art accuracy and very fast runtimes, while providing diffeomorphic guarantees and uncertainty estimates. Our implementation is available online at this http URL .

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Research works printed but not linked: 19

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Metadata

Authors
Dalca, A. V., Balakrishnan, G., Guttag, J., & Sabuncu, M. R.
Venue
Lecture Notes in Computer Science
Published
2018
Pages
729-738
ISSN
  • 0302-9743 (ISSN-L)
  • 1611-3349
OpenAlex
W2799913653
Cited by
354
References
12
FWCI
13.62
Type
conference paper
Language
en
Open access
green
Licence

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Dalca, A. V., Balakrishnan, G., Guttag, J., & Sabuncu, M. R. (2018). Unsupervised Learning for Fast Probabilistic Diffeomorphic Registration. Lecture Notes in Computer Science. https://doi.org/10.1007/978-3-030-00928-1_82

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