The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.
Unsupervised Learning for Fast Probabilistic Diffeomorphic Registration
Open accessAbstract
Traditional deformable registration techniques achieve impressive results and offer a rigorous theoretical treatment, but are computationally intensive since they solve an optimization problem for each image pair. Recently, learning-based methods have facilitated fast registration by learning spatial deformation functions. However, these approaches use restricted deformation models, require supervised labels, or do not guarantee a diffeomorphic (topology-preserving) registration. Furthermore, learning-based registration tools have not been derived from a probabilistic framework that can offer uncertainty estimates. In this paper, we present a probabilistic generative model and derive an unsupervised learning-based inference algorithm that makes use of recent developments in convolutional neural networks (CNNs). We demonstrate our method on a 3D brain registration task, and provide an empirical analysis of the algorithm. Our approach results in state of the art accuracy and very fast runtimes, while providing diffeomorphic guarantees and uncertainty estimates. Our implementation is available online at this http URL .
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
U-Net: Convolutional Networks for Biomedical Image Segmentation
Ronneberger, O., Fischer, P., & Brox, T. (2015) · Lecture notes in computer science · doi:10.1007/978-3-319-24574-4_28 · Cited by 99,404
Adam: A Method for Stochastic Optimization
Kingma, D. P., & Ba, J. (2014) · arXiv · doi:10.48550/arxiv.1412.6980 · Cited by 98,946
Auto-Encoding Variational Bayes
Kingma, D. P., & Welling, M. (2013) · arXiv · doi:10.48550/arxiv.1312.6114 · Cited by 20,067
Fischl, B. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.01.021 · Cited by 9,526
TensorFlow: Large-Scale Machine Learning on Heterogeneous Distributed Systems
Abadi, M., Agarwal, A., Barham, P., Brevdo, E., Chen, Z., Citro, C., Corrado, G. S., Davis, A., Dean, J., Devin, M., et al. (2016) · arXiv · doi:10.48550/arxiv.1603.04467 · Cited by 9,408
A fast diffeomorphic image registration algorithm
Ashburner, J. (2007) · NeuroImage · doi:10.1016/j.neuroimage.2007.07.007 · Cited by 8,122
Nonrigid registration using free-form deformations: application to breast mr images
Rueckert, D., Sonoda, L. I., Hayes, C., Hill, D. L. G., Leach, M. O., & Hawkes, D. J. (1999) · IEEE Transactions on Medical Imaging · doi:10.1109/42.796284 · Cited by 5,265
Image matching as a diffusion process: an analogy with maxwell’s demons
Thirion, J.-P. (1998) · Medical Image Analysis · doi:10.1016/s1361-8415(98)80022-4 · Cited by 2,445
Evaluation of 14 nonlinear deformation algorithms applied to human brain MRI registration
Klein, A., Andersson, J., Ardekani, B. A., Ashburner, J., Avants, B., Chiang, M.-C., Christensen, G. E., Collins, D. L., Gee, J., Hellier, P., et al. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2008.12.037 · Cited by 2,227
Quicksilver: Fast predictive image registration – A deep learning approach
Yang, X., Kwitt, R., Styner, M., & Niethammer, M. (2017) · NeuroImage · doi:10.1016/j.neuroimage.2017.07.008 · Cited by 630 · cited 1×
“which can introduce a bias and necessitate significant preprocessing [23,26,28].”
Background
Research works printed but not linked: 19
- Arsigny, V., Commowick, O., Pennec, X., Ayache, N.: A log-euclidean framework for statistics on diffeomorphisms. In: Larsen, R., Nielsen, M., Sporring, J. (eds.) MICCAI 2006. LNCS, vol. 4190, pp. 924–931. Springer, Heidelberg (2006). https://doi.org/10.1007/11866565_113 · DOI · Paper page
- Avants, B.B., et al.: Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain. Med. Image Anal. 12(1), 26–41 (2008) · DOI · Paper page
- Bajcsy, R., Kovacic, S.: Multiresolution elastic matching. Comput. Vis. Graph. Image Process. 46, 1–21 (1989) · DOI · Paper page
- Beg, M.F., et al.: Computing large deformation metric mappings via geodesic flows of diffeomorphisms. Int. J. Comput. Vis. 61, 139–157 (2005) · DOI · Paper page
- Dagley, A., et al.: Harvard aging brain study: dataset and accessibility. NeuroImage 144, 255–258 (2015) · DOI · Paper page
- Dalca, A.V., Bobu, A., Rost, N.S., Golland, P.: Patch-based discrete registration of clinical brain images. In: Wu, G., et al. (eds.) Patch-MI 2016. LNCS, vol. 9993, pp. 60–67. Springer, Cham (2016). https://doi.org/10.1007/978-3-319-47118-1_8 · DOI
- de Vos, B.D., et al.: End-to-end unsupervised deformable image registration with a convolutional neural network. In: DLMIA, pp. 204–212 (2017) · DOI · Paper page
- Di Martino, A., et al.: The autism brain imaging data exchange: towards a large-scale evaluation of the intrinsic brain architecture in autism. Mol. Psychiatry 19(6), 659–667 (2014) · DOI · Paper page
- Glocker, B., et al.: Dense image registration through MRFs and efficient linear programming. Med. Image Anal. 12(6), 731–741 (2008) · DOI · Paper page
- Gollub, R.L., et al.: The mcic collection: a shared repository of multi-modal, multi-site brain image data from a clinical investigation of schizophrenia. Neuroinformatics 11(3), 367–388 (2013) · DOI · Paper page
- Holmes, A.J., et al.: Brain genomics superstruct project initial data release with structural, functional, and behavioral measures. Sci. Data 2 (2015) · DOI · Paper page
- Jaderberg, M., et al.: Spatial transformer networks. In: NIPS, pp. 2017–2025 (2015)
- Li, H., Fan, H.: Non-rigid image registration using fully convolutional networks with deep self-supervision. arXiv preprint arXiv:1709.00799 (2017) · DOI · Paper page
- Marcus, D.S., et al.: Open access series of imaging studies (oasis): cross-sectional mri data in young, middle aged, nondemented, and demented older adults. J. Cogn. Neurosci. 19(9), 1498–1507 (2007) · DOI · Paper page
- Marek, K., et al.: The parkinson progression marker initiative (PPMI). Prog. Neurobiol. 95(4), 629–635 (2011) · DOI · Paper page
- Milham, M.P., et al.: The adhd-200 consortium: a model to advance the translational potential of neuroimaging in clinical neuroscience. Front. Sys. Neurosci. 6, 62 (2012)
- Mueller, S.G., et al.: Ways toward an early diagnosis in Alzheimer’s disease: the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Alzheimer’s Dement. 1(1), 55–66 (2005) · DOI · Paper page
- Sokooti, H., et al.: Nonrigid image registration using multi-scale 3D convolutional neural networks. In: Descoteaux, M., et al. (eds.) MICCAI 2017. LNCS, vol. 10433, pp. 232–239. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-66182-7_27 · DOI · Paper page
- Zhang, M., et al.: Frequency diffeomorphisms for efficient image registration. In: Niethammer, M., et al. (eds.) IPMI 2017. LNCS, vol. 10265, pp. 559–570. Springer, Cham (2017). https://doi.org/10.1007/978-3-319-59050-9_44 · DOI
Cited by
Deep learning in medical image registration: a review
Fu, Y., Lei, Y., Wang, T., Curran, W. J., Liu, T., & Yang, X. (2020) · Physics in Medicine & Biology · doi:10.1088/1361-6560/ab843e · Cited by 661
Unsupervised Learning of Probabilistic Diffeomorphic Registration for Images and Surfaces
Dalca, A. V., Balakrishnan, G., Guttag, J., & Sabuncu, M. R. (2019) · Medical Image Analysis · doi:10.1016/j.media.2019.07.006 · Cited by 467
Self-citationCycleMorph: Cycle consistent unsupervised deformable image registration
Kim, B., Kim, D. H., Park, S. H., Kim, J., Lee, J.-G., & Ye, J. C. (2021) · Medical Image Analysis · doi:10.1016/j.media.2021.102036 · Cited by 336
He, T., Kong, R., Holmes, A. J., Nguyen, M., Sabuncu, M. R., Eickhoff, S. B., Bzdok, D., Feng, J., & Yeo, B. T. T. (2020) · NeuroImage · doi:10.1016/j.neuroimage.2019.116276 · Cited by 271
Self-citationMedical image registration using deep neural networks: A comprehensive review
Boveiri, H. R., Khayami, R., Javidan, R., & Mehdizadeh, A. (2020) · Computers & Electrical Engineering · doi:10.1016/j.compeleceng.2020.106767 · Cited by 179
Metadata
- Authors
- Dalca, A. V., Balakrishnan, G., Guttag, J., & Sabuncu, M. R.
- Venue
- Lecture Notes in Computer Science
- Publisher
- Springer International Publishing
- Published
- 2018
- Pages
- 729-738
- ISSN
- 0302-9743 (ISSN-L)
- 1611-3349
- OpenAlex
- W2799913653
- Cited by
- 354
- References
- 12
- FWCI
- 13.62
- Type
- conference paper
- Language
- en
- Open access
- green
- Licence
- www.springernature.com/gp/researchers/text-and-data-mining (tdm)
- www.springernature.com/gp/researchers/text-and-data-mining (vor)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Unsupervised Learning for Fast Probabilistic Diffeomorphic Registration. https://app.cochat.ai/papers/10.1007/978-3-030-00928-1_82
- The paper
- Dalca, A. V., Balakrishnan, G., Guttag, J., & Sabuncu, M. R. (2018). Unsupervised Learning for Fast Probabilistic Diffeomorphic Registration. Lecture Notes in Computer Science. https://doi.org/10.1007/978-3-030-00928-1_82
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.