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Making the Most of Text Semantics to Improve Biomedical Vision-Language Processing
Open accessAbstract
Multi-modal data abounds in biomedicine, such as radiology images and reports. Interpreting this data at scale is essential for improving clinical care and accelerating clinical research. Biomedical text with its complex semantics poses additional challenges in vision--language modelling compared to the general domain, and previous work has used insufficiently adapted models that lack domain-specific language understanding. In this paper, we show that principled textual semantic modelling can substantially improve contrastive learning in self-supervised vision--language processing. We release a language model that achieves state-of-the-art results in radiology natural language inference through its improved vocabulary and novel language pretraining objective leveraging semantics and discourse characteristics in radiology reports. Further, we propose a self-supervised joint vision--language approach with a focus on better text modelling. It establishes new state of the art results on a wide range of publicly available benchmarks, in part by leveraging our new domain-specific language model. We release a new dataset with locally-aligned phrase grounding annotations by radiologists to facilitate the study of complex semantic modelling in biomedical vision--language processing. A broad evaluation, including on this new dataset, shows that our contrastive learning approach, aided by textual-semantic modelling, outperforms prior methods in segmentation tasks, despite only using a global-alignment objective.
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“We note that the official MIMIC-CXR test split is highly enriched for abnormal cases, 26 hence prior studies are more common (Table 1).”
From MAIRA-2: Grounded Radiology Report Generation (2024) · cites this paper as [26]
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“By inviting a domain expert to review and adapt individual phrase outputs, our approach to qualitative evaluation of report generation differs from most existing works that primarily ask experts to rate overall report quality via a (Likert-) scale; 59 provide total error counts/ categorisation; 48,60 or engage in comparison rankings across different report candidates.61”
From MAIRA-2: Grounded Radiology Report Generation (2024) · cites this paper as [48]
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Citations
Cites
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Backpropagation Applied to Handwritten Zip Code Recognition
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“network (CNN) [37] image encoder Eimg, our CXR-BERT text encoder Etxt, and projection models Pimg and Ptxt to learn representations in a joint space.”
BackgroundMethodInfluentialMIMIC-III, a freely accessible critical care database
Johnson, A. E. W., Pollard, T. J., Shen, L., Lehman, L.-W. H., Feng, M., Ghassemi, M., Moody, B., Szolovits, P., Anthony Celi, L., & Mark, R. G. (2016) · Scientific Data · doi:10.1038/sdata.2016.35 · Cited by 8,141 · cited 10×
“The phases proceed as follows: (I) First, we construct a custom WordPiece [80] vocabulary of 30k to-kens from PubMed abstracts 4 (15 GB), MIMIC-III [35] clinical notes (3.5 GB), and MIMIC-CXR radiology reports (0.1 GB).”
BackgroundMethodInfluentialBioBERT: a pre-trained biomedical language representation model for biomedical text mining
Lee, J., Yoon, W., Kim, S., Kim, D., Kim, S., So, C. H., & Kang, J. (2020) · Bioinformatics · doi:10.1093/bioinformatics/btz682 · Cited by 7,218 · cited 5×
“Related medical VLP work commonly uses publicly available contextual word embedding models including BioBERT [39], ClinicalBERT [2], BioClini-calBERT [2], or PubMedBERT [26].”
BackgroundMethodInfluentialGoogle's Neural Machine Translation System: Bridging the Gap between Human and Machine Translation
Wu, Y., Schuster, M., Chen, Z., Le, Q. V., Norouzi, M., Macherey, W., Krikun, M., Cao, Y., Gao, Q., Macherey, K., et al. (2016) · arXiv · doi:10.48550/arxiv.1609.08144 · Cited by 5,319 · cited 4×
“The phases proceed as follows: (I) First, we construct a custom WordPiece [80] vocabulary of 30k to-kens from PubMed abstracts 4 (15 GB), MIMIC-III [35] clinical notes (3.5 GB), and MIMIC-CXR radiology reports (0.1 GB).”
BackgroundMethodInfluentialWang, X., Peng, Y., Lu, L., Lu, Z., Bagheri, M., & Summers, R. M. (2017) · 2017 IEEE Conference on Computer Vision and Pattern Recognition (CVPR) · doi:10.1109/cvpr.2017.369 · Cited by 4,616
SimCSE: Simple Contrastive Learning of Sentence Embeddings
Gao, T., Yao, X., & Chen, D. (2021) · Proceedings of the 2021 Conference on Empirical Methods in Natural Language Processing · doi:10.18653/v1/2021.emnlp-main.552 · Cited by 2,851 · cited 3×
“[22] Tianyu Gao, Xingcheng Yao, and Danqi Chen.”
BackgroundResultDomain-specific language model pretraining for biomedical natural language processing
Gu, Y., Tinn, R., Cheng, H., Lucas, M., Usuyama, N., Liu, X., Naumann, T., Gao, J., & Poon, H. (2022) · ACM Transactions on Computing for Healthcare · doi:10.1145/3458754 · Cited by 2,170 · cited 8×
“Related medical VLP work commonly uses publicly available contextual word embedding models including BioBERT [39], ClinicalBERT [2], BioClini-calBERT [2], or PubMedBERT [26].”
BackgroundMethodInfluentialSelf-citationUNITER: UNiversal Image-TExt Representation Learning
Chen, Y.-C., Li, L., Yu, L., El Kholy, A., Ahmed, F., Gan, Z., Cheng, Y., & Liu, J. (2020) · Lecture Notes in Computer Science · doi:10.1007/978-3-030-58577-8_7 · Cited by 2,055 · cited 5×
“A variety of self-supervised VLP approaches have been proposed towards jointly learning visual and textual representations of paired data without supervision, such as frameworks using contrastive objectives [26, 42, 60], approaches based on joint transformer architectures [40, 41, 51, 69], self-supervised VLP with wor…”
BackgroundInfluentialAlsentzer, E., Murphy, J., Boag, W., Weng, W.-H., Jindi, D., Naumann, T., & McDermott, M. (2019) · Proceedings of the 2nd Clinical Natural Language Processing Workshop · doi:10.18653/v1/w19-1909 · Cited by 1,736 · cited 10×
“But specific domains often exhibit differences in linguistic characteristics from general text and even related domains, such as between clinical and non-clinical biomedical text as noted in [2], motivating the use of more specialised language models in most related work with a focus on the medical domain.”
BackgroundMethodInfluentialSelf-citationFlickr30k Entities: Collecting Region-to-Phrase Correspondences for Richer Image-to-Sentence Models
Plummer, B. A., Wang, L., Cervantes, C. M., Caicedo, J. C., Hockenmaier, J., & Lazebnik, S. (2015) · 2015 IEEE International Conference on Computer Vision (ICCV) · doi:10.1109/iccv.2015.303 · Cited by 1,444
From captions to visual concepts and back
Fang, H., Gupta, S., Iandola, F., Srivastava, R. K., Deng, L., Dollár, P., Gao, J., He, X., Mitchell, M., Platt, J. C., et al. (2015) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr.2015.7298754 · Cited by 1,321 · cited 2×
“Thus, settings for visual grounding have been explored in which cross-modal pairs are the only form of supervision that is available [7, 11, 21, 26, 48, 74], i.”
BackgroundGeneration and Comprehension of Unambiguous Object Descriptions
Mao, J., Huang, J., Toshev, A., Camburu, O., Yuille, A., & Murphy, K. P. (2016) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr.2016.9 · Cited by 1,281 · cited 2×
“[52] Junhua Mao, Jonathan Huang, Alexander Toshev, Oana Camburu, Alan L Yuille, and Kevin Murphy.”
BackgroundPreparing a collection of radiology examinations for distribution and retrieval
Demner-Fushman, D., Kohli, M. D., Rosenman, M. B., Shooshan, S. E., Rodriguez, L., Antani, S., Thoma, G. R., & McDonald, C. J. (2016) · Journal of the American Medical Informatics Association · doi:10.1093/jamia/ocv080 · Cited by 1,164 · cited 3×
“Importantly, while many remain private, some paired clinical datasets have been released to the research community including MIMIC-CXR [33], Open-I [14], and PadChest [3].”
BackgroundDeep learning algorithms for detection of critical findings in head CT scans: a retrospective study
Chilamkurthy, S., Ghosh, R., Tanamala, S., Biviji, M., Campeau, N. G., Venugopal, V. K., Mahajan, V., Rao, P., & Warier, P. (2018) · The Lancet · doi:10.1016/s0140-6736(18)31645-3 · Cited by 1,020 · cited 3×
“Such data is collected daily in routine clinical practice, and common examples are X-ray images [18, 32, 75] or computed tomography scans [9, 18, 20, 71] paired with reports written by qualified medical experts.”
BackgroundVL-BERT: Pre-training of Generic Visual-Linguistic Representations
Su, W., Zhu, X., Cao, Y., Li, B., Lu, L., Wei, F., & Dai, J. (2019) · arXiv · doi:10.48550/arxiv.1908.08530 · Cited by 950 · cited 3×
“[69] Weijie Su, Xizhou Zhu, Yue Cao, Bin Li, Lewei Lu, Furu Wei, and Jifeng Dai.”
BackgroundUnicoder-VL: A Universal Encoder for Vision and Language by Cross-Modal Pre-Training
Li, G., Duan, N., Fang, Y., Gong, M., & Jiang, D. (2020) · Proceedings of the AAAI Conference on Artificial Intelligence · doi:10.1609/aaai.v34i07.6795 · Cited by 795 · cited 2×
“[40] Gen Li, Nan Duan, Yuejian Fang, Ming Gong, and Daxin Jiang.”
BackgroundGeneralized Overlap Measures for Evaluation and Validation in Medical Image Analysis
Crum, W. R., Camara, O., & Hill, D. L. G. (2006) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2006.880587 · Cited by 776 · cited 1×
“We report segmentation results via mean intersection over union (mIoU) and contrast-to-noise ratio (CNR), and report the Dice score [10] to compare to [56].”
MethodDenseCLIP: Language-Guided Dense Prediction with Context-Aware Prompting
Rao, Y., Zhao, W., Chen, G., Tang, Y., Zhu, Z., Huang, G., Zhou, J., & Lu, J. (2022) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr52688.2022.01755 · Cited by 718
Generating Radiology Reports via Memory-driven Transformer
Chen, Z., Song, Y., Chang, T.-H., & Wan, X. (2020) · Proceedings of the 2020 Conference on Empirical Methods in Natural Language Processing (EMNLP) · doi:10.18653/v1/2020.emnlp-main.112 · Cited by 693 · cited 1×
“Other closely related tasks in the CXR domain that share similar NLP challenges include report summarisation [11,84], automatic report generation [8,46,54], and natural language inference for radiology reports [54].”
BackgroundPadChest: A large chest x-ray image dataset with multi-label annotated reports
Bustos, A., Pertusa, A., Salinas, J.-M., & de la Iglesia-Vayá, M. (2020) · Medical Image Analysis · doi:10.1016/j.media.2020.101797 · Cited by 691 · cited 3×
“Importantly, while many remain private, some paired clinical datasets have been released to the research community including MIMIC-CXR [33], Open-I [14], and PadChest [3].”
BackgroundHuang, S.-C., Shen, L., Lungren, M. P., & Yeung, S. (2021) · 2021 IEEE/CVF International Conference on Computer Vision (ICCV) · doi:10.1109/iccv48922.2021.00391 · Cited by 489 · cited 10×
“Related self-supervised VLP work [30,31,45,56,85] has achieved impressive downstream classification and zero-shot classification performance.”
BackgroundMethodResultInfluentialAutomated deep-neural-network surveillance of cranial images for acute neurologic events
Titano, J. J., Badgeley, M., Schefflein, J., Pain, M., Su, A., Cai, M., Swinburne, N., Zech, J., Kim, J., Bederson, J., et al. (2018) · Nature Medicine · doi:10.1038/s41591-018-0147-y · Cited by 458 · cited 4×
“[71] Joseph J Titano, Marcus Badgeley, Javin Schefflein, Margaret Pain, Andres Su, Michael Cai, Nathaniel Swinburne, John Zech, Jun Kim, Joshua Bederson, et al.”
BackgroundInfluentialCheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparison
Irvin, J., Rajpurkar, P., Ko, M., Yu, Y., Ciurea-Ilcus, S., Chute, C., Marklund, H., Haghgoo, B., Ball, R., Shpanskaya, K., et al. (2019) · Proceedings of the AAAI Conference on Artificial Intelligence · doi:10.1609/aaai.v33i01.3301590 · Cited by 392 · cited 5×
“Finally, while the name implies close similarity to our CXR-BERT, CheXbert [69] is a BERT based sentence classification model developed for improving the CheXpert [33] labeller, and the model does not have a domain-specific vocabulary like ours or PubMed-BERT.”
BackgroundMethodInfluentialVirTex: Learning Visual Representations from Textual Annotations
Desai, K., & Johnson, J. (2021) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr46437.2021.01101 · Cited by 376 · cited 3×
“Free-text image descriptions provide a semantically dense learning signal compared to image-only contrastive methods and supervised classification [15].”
BackgroundShih, G., Wu, C. C., Halabi, S. S., Kohli, M. D., Prevedello, L. M. S., Cook, T. S., Sharma, A., Amorosa, J. K., Arteaga, V. A., Galperin-Aizenberg, M., et al. (2019) · Radiology Artificial Intelligence · doi:10.1148/ryai.2019180041 · Cited by 341 · cited 6×
“…evaluation, we use RadNLI [54] to assess the proposed CXR-BERT text model in isolation, the new MS-CXR assesses joint image–text understanding via phrase grounding, and the RSNA Pneumonia dataset [66,76] to test zero-shot segmentation, as well as zero-shot and fine-tuned classification performance.”
BackgroundMethodInfluentialLearning Visual Features from Large Weakly Supervised Data
Joulin, A., van der Maaten, L. J. P., Jabri, A., & Vasilache, N. (2016) · Lecture notes in computer science · doi:10.1007/978-3-319-46478-7_5 · Cited by 316 · cited 2×
“[35] Armand Joulin, Laurens Van Der Maaten, Allan Jabri, and Nicolas Vasilache.”
BackgroundSmit, A., Jain, S., Rajpurkar, P., Pareek, A., Ng, A., & Lungren, M. (2020) · Proceedings of the 2020 Conference on Empirical Methods in Natural Language Processing (EMNLP) · doi:10.18653/v1/2020.emnlp-main.117 · Cited by 262 · cited 9×
“To link each proposal region with candidate phrases, we sample sentences from the report of each study by extracting the highest matching sentences to the annotated labels using scores of the CheXbert sentence classifier [68], and also use transcriptions of dictations when available [36].”
BackgroundMethodInfluentialClinically Accurate Chest X-Ray Report GenerationPreprint
Liu, G., Hsu, T.-M. H., McDermott, M. B. A., Boag, W., Weng, W., Peter Szolovits, B., & Ghassemi, M. (2019) · arXiv (Cornell University) · doi:10.48550/arxiv.1904.02633 · Cited by 212 · cited 2×
“[45] Guanxiong Liu, Tzu-Ming Harry Hsu, Matthew McDermott, Willie Boag, Wei-Hung Weng, Peter Szolovits, and Marzyeh Ghassemi.”
BackgroundThe radiology report — Are we getting the message across?
Wallis, A., & McCoubrie, P. (2011) · Clinical Radiology · doi:10.1016/j.crad.2011.05.013 · Cited by 187 · cited 1×
“Note that a raw radiology report xtxt typically consists of several sections, including a ‘Findings’ section that details clinical observations, and an ‘Impression’ section summarising the clinical assessment [74,77].”
BackgroundRanjbari, S., Khatibi, T., Vosough, A., Sajadi, H., Totonchi, M., & Ghaffari, F. (2021) · BMC Medical Informatics and Decision Making · doi:10.1186/s12911-020-01362-0 · Cited by 186
Improving Factual Completeness and Consistency of Image-to-Text Radiology Report Generation
Miura, Y., Zhang, Y., Tsai, E., Langlotz, C., & Jurafsky, D. (2021) · Proceedings of the 2021 Conference of the North American Chapter of the Association for Computational Linguistics: Human Language Technologies · doi:10.18653/v1/2021.naacl-main.416 · Cited by 149 · cited 14×
“[53] Yasuhide Miura, Yuhao Zhang, Emily Tsai, Curtis Langlotz, and Dan Jurafsky.”
BackgroundMethodResultInfluentialLearning to Summarize Radiology Findings
Zhang, Y., Ding, D. Y., Qian, T., Manning, C. D., & Langlotz, C. P. (2018) · Proceedings of the Ninth International Workshop on Health Text Mining and Information Analysis · doi:10.18653/v1/w18-5623 · Cited by 126 · cited 2×
“[83] Yuhao Zhang, Daisy Yi Ding, Tianpei Qian, Christopher D Manning, and Curtis P Langlotz.”
BackgroundContrastive Learning for Weakly Supervised Phrase Grounding
Gupta, T., Vahdat, A., Chechik, G., Yang, X., Kautz, J., & Hoiem, D. (2020) · Lecture notes in computer science · doi:10.1007/978-3-030-58580-8_44 · Cited by 125 · cited 5×
“[26] Tanmay Gupta, Arash Vahdat, Gal Chechik, Xiaodong Yang, Jan Kautz, and Derek Hoiem.”
BackgroundInfluentialCounterfactual Contrastive Learning for Weakly-Supervised Vision-Language Grounding
Zhang, Z., Zhao, Z., Lin, Z., et al. (2020) · neural information processing systems · Cited by 110
Chest ImaGenome Dataset for Clinical ReasoningPreprint
Wu, J. T.-Y., Agu, N. N., Lourentzou, I., Sharma, A., Paguio, J. A., Yao, J. S., Dee, E. C., Mitchell, W. G., Kashyap, S., Giovannini, A. A., et al. (2021) · arXiv (Cornell University) · doi:10.48550/arxiv.2108.00316 · Cited by 102 · cited 10×
“Furthermore, ImaGenome sentence annotations are not curated, see Table C.3 for some examples.”
BackgroundMethodInfluentialLearning Visual N-Grams from Web Data
Li, A., Jabri, A., Joulin, A., & van der Maaten, L. J. P. (2017) · IEEE/CVF International Conference on Computer Vision (ICCV) · doi:10.1109/iccv.2017.449 · Cited by 94 · cited 2×
“A number of different objectives have been explored for representation learning in VLP, including the prediction of words in image captions [35], predicting phrase n-grams [39], predicting of entire captions [15], global contrastive objectives defined on the embeddings of the entire image and text instances [84], and…”
BackgroundAlign2Ground: Weakly Supervised Phrase Grounding Guided by Image-Caption Alignment
Datta, S., Sikka, K., Roy, A., Ahuja, K., Parikh, D., & Divakaran, A. (2019) · IEEE/CVF International Conference on Computer Vision (ICCV) · doi:10.1109/iccv.2019.00269 · Cited by 90 · cited 4×
“Thus, settings for visual grounding have been explored in which cross-modal pairs are the only form of supervision that is available [7, 11, 21, 26, 48, 74], i.”
BackgroundInfluentialLi, Y., Wang, H., & Luo, Y. (2020) · 2020 IEEE International Conference on Bioinformatics and Biomedicine (BIBM) · doi:10.1109/bibm49941.2020.9313289 · Cited by 81 · cited 2×
“[43] Yikuan Li, Hanyin Wang, and Yuan Luo.”
BackgroundMethodMulti-Level Multimodal Common Semantic Space for Image-Phrase Grounding
Akbari, H., Karaman, S., Bhargava, S., Chen, B., Vondrick, C., & Chang, S. (2019) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr.2019.01276 · Cited by 73
Cross-Modal Data Programming Enables Rapid Medical Machine Learning
Dunnmon, J., Ratner, A., Saab, K. K., Khandwala, N., Markert, M. S., Sagreiya, H., Goldman, R. E., Lee‐Messer, C., Lungren, M. P., Rubin, D. L., et al. (2020) · Patterns · doi:10.1016/j.patter.2020.100019 · Cited by 64 · cited 2×
“Such data is collected daily in routine clinical practice, and common examples are X-ray images [18, 32, 75] or computed tomography scans [9, 18, 20, 71] paired with reports written by qualified medical experts.”
BackgroundJoint Modeling of Chest Radiographs and Radiology Reports for Pulmonary Edema Assessment
Chauhan, G., Liao, R., Wells, W. M., Andreas, J., Wang, X., Berkowitz, S. J., Horng, S., Szolovits, P., & Golland, P. (2020) · Lecture notes in computer science · doi:10.1007/978-3-030-59713-9_51 · Cited by 59 · cited 4×
“While most related approaches use no ground truth, [5] study a semi-supervised edema severity classification setting, and [27] assume sets of seen and unseen labels towards CXR zero-shot classification.”
BackgroundMethodInfluentialRelation-aware Instance Refinement for Weakly Supervised Visual Grounding
Liu, Y., Wan, B., Ma, L., & He, X. (2021) · IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings - IEEE Computer Society Conference on Computer Vision and Pattern Recognition/Proceedings · doi:10.1109/cvpr46437.2021.00556 · Cited by 58 · cited 2×
“Thus, settings for visual grounding have been explored in which cross-modal pairs are the only form of supervision that is available [7, 11, 21, 26, 48, 74], i.”
BackgroundMultimodal Representation Learning via Maximization of Local Mutual Information
Liao, R., Moyer, D., Cha, M., Quigley, K., Berkowitz, S. J., Horng, S., Golland, P., & Wells, W. M. (2021) · Lecture notes in computer science · doi:10.1007/978-3-030-87196-3_26 · Cited by 44 · cited 10×
“Related self-supervised VLP work [29, 84, 44, 30, 55] has achieved impressive downstream classification and zero-shot classification performance.”
BackgroundMethodInfluentialEyuboglu, S., Angus, G., Patel, B. N., Pareek, A., Davidzon, G., Long, J., Dunnmon, J., & Lungren, M. P. (2021) · Nature Communications · doi:10.1038/s41467-021-22018-1 · Cited by 43 · cited 3×
“Such data is collected daily in routine clinical practice, and common examples are X-ray images [18, 32, 75] or computed tomography scans [9, 18, 20, 71] paired with reports written by qualified medical experts.”
BackgroundDiscovering body site and severity modifiers in clinical texts
Dligach, D., Bethard, S. J., Becker, L. A., et al. (2013) · Journal of the American Medical Informatics Association · doi:10.1136/amiajnl-2013-001766 · Cited by 38 · cited 2×
“In addition to spatial modifiers, severity modifiers such as “mild”, “moderate” or “severe” are also commonly attached to an identified disorder or abnormality [17].”
BackgroundMAF: Multimodal Alignment Framework for Weakly-Supervised Phrase Grounding
Wang, Q., Tan, H. X., Shen, S., Mahoney, M. W., & Yao, Z. (2020) · Conference on Empirical Methods in Natural Language Processing (EMNLP) · doi:10.18653/v1/2020.emnlp-main.159 · Cited by 37
Disentangled Motif-aware Graph Learning for Phrase Grounding
Mu, Z., Tang, S., Tan, J., Yu, Q., & Zhuang, Y. (2021) · Proceedings of the AAAI Conference on Artificial Intelligence · doi:10.1609/aaai.v35i15.17602 · Cited by 36 · cited 2×
“[54] Zongshen Mu, Siliang Tang, Jie Tan, Qiang Yu, and Yueting Zhuang.”
BackgroundDatta, S., Si, Y., Rodriguez, L. M., Shooshan, S. E., Demner‐Fushman, D., & Roberts, K. E. (2020) · Journal of Biomedical Informatics · doi:10.1016/j.jbi.2020.103473 · Cited by 35 · cited 1×
“[13] Surabhi Datta, Yuqi Si, Laritza Rodriguez, Sonya E Shooshan, Dina Demner-Fushman, and Kirk Roberts.”
BackgroundJoint Learning of Localized Representations from Medical Images and Reports
Müller, P., Kaissis, G. A., Zou, C., & Rückert, D. (2022) · Lecture notes in computer science · doi:10.1007/978-3-031-19809-0_39 · Cited by 30 · cited 10×
“Related self-supervised VLP work [30,31,45,56,85] has achieved impressive downstream classification and zero-shot classification performance.”
BackgroundMethodInfluentialWILCOX, J. (2006) · Applied Radiology · doi:10.37549/ar1440 · Cited by 28 · cited 1×
“Note that a raw radiology report xtxt typically consists of several sections, including a ‘Findings’ section that details clinical observations, and an ‘Impression’ section summarising the clinical assessment [73, 76].”
BackgroundVinDr-CXR: An open dataset of chest X-rays with radiologist annotations
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BDKG at MEDIQA 2021: System Report for the Radiology Report Summarization Task
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“In the CXR application, reports can roughly be divided into normal and abnormal scans, where abnormal ones reveal signs or findings observed during the exam [10].”
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“Multiple large Chest X-ray datasets have been released to the public (see [70] for an overview of CXR image datasets), including multi-modal ones of images and text such as MIMIC-CXR [33], some also accompanied by small sets of expert-verified ground-truth annotations of various nature, making the application a popula…”
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“Another characteristic is the use of highly specialised spatial language in radiology, which is crucial for correct diagnosis, often describing the positioning of radiographic findings or medical devices with respect to anatomical structures, see e.g. [13,14].”
BackgroundCross-Modal Omni Interaction Modeling for Phrase Grounding
Yu, T., Hui, T., Yu, Z., Liao, Y., Yu, S., Zhang, F., & Liu, S. (2020) · ACM International Conference on Multimedia (ACM MM) · doi:10.1145/3394171.3413846 · Cited by 12 · cited 2×
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BackgroundREFLACX: Reports and eye-tracking data for localization of abnormalities in chest x-rays
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Cited by
Sorted by citations
A multimodal generative AI copilot for human pathology
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The shaky foundations of large language models and foundation models for electronic health records
Wornow, M., Xu, Y., Thapa, R., Patel, B., Steinberg, E., Fleming, S., Pfeffer, M. A., Fries, J., & Shah, N. H. (2023) · npj Digital Medicine · doi:10.1038/s41746-023-00879-8 · Cited by 324
A Multimodal Biomedical Foundation Model Trained from Fifteen Million Image–Text Pairs
Zhang, S., Xu, Y., Usuyama, N., Xu, H., Bagga, J., Tinn, R., Preston, S., Rao, R., Wei, M., Valluri, N., et al. (2025) · NEJM AI · doi:10.1056/aioa2400640 · Cited by 283
Self-citationLLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day
Li, C., Wong, C., Zhang, S., Usuyama, N., Liu, H., Yang, J., Naumann, T., Poon, H., & Gao, J. (2023) · arXiv · doi:10.48550/arxiv.2306.00890 · Cited by 590
“Domain-specific pretraining has been shown to be effective for biomedical natural language processing (NLP) applications [18, 15, 11, 31] and biomedical vision-language (VL) tasks [16, 7, 41, 51, 9].”
BackgroundSelf-citationLearning to Exploit Temporal Structure for Biomedical Vision-Language Processing
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“Despite this, the existing VLP work to date considers alignment between only single images and reports [9,32,46,81], going so far as to remove temporal content from reports in training data to prevent ‘hallucinations’ in downstream report generation [54].”
BackgroundMethodInfluentialSelf-citation
Metadata
- Authors
- Boecking, B., Usuyama, N., Bannur, S., Castro, D. C., Schwaighofer, A., Hyland, S., Wetscherek, M., Naumann, T., Nori, A., Alvarez-Valle, J., Poon, H., & Oktay, O.
- Affiliations
- Microsoft (United States) (US)
- Corresponding author
- Oktay, Ozan
- ORCID
- Venue
- Lecture Notes in Computer Science
- Publisher
- Springer Nature Switzerland
- Published
- 2022
- Pages
- 1-21
- ISSN
- 0302-9743 (ISSN-L)
- 1611-3349
- OpenAlex
- W4312533035
- Semantic Scholar
- a1aeb5442e31276b197696f49b3243112a4049ce
- Cited by
- 317
- References
- 68
- Citations by year
- 2026: 88 · 2025: 122 · 2024: 73 · 2023: 34
- FWCI
- 20.76
- Type
- conference paper
- Language
- en
- Open access
- green
- arxiv.org
- Licence
- Locations
- Lecture notes in computer science (publishedVersion)
- arXiv (Cornell University) (submittedVersion)
- arXiv (Cornell University)
- Topics
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Multimodal Machine Learning Applications
- Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiomics and Machine Learning in Medical Imaging
- Keywords
- radiology reports, contrastive learning, domain-specific language models, natural language inference, phrase grounding, multimodal medical data
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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