Cited by 283Multimodal Machine Learning ApplicationsArtificial Intelligence in Healthcare and EducationImage Retrieval and Classification Techniques

A Multimodal Biomedical Foundation Model Trained from Fifteen Million Image–Text Pairs

Zhang, Sheng, Xu, Yanbo, Usuyama, Naoto, Xu, Hanwen, Bagga, Jaspreet, Tinn, Robert, Preston, Sam, Rao, Rajesh +16 more·2025·NEJM AI

Abstract

BACKGROUND: Biomedical data are inherently multimodal, comprising physical measurements and natural-language narratives. A generalist biomedical artificial intelligence (AI) model needs to simultaneously process different modalities of data, including text and images. Therefore, training an effective generalist biomedical model requires high-quality multimodal data, such as parallel image-text pairs. METHODS: Here, we present PMC-15M, a novel dataset that is two orders of magnitude larger than existing biomedical multimodal datasets, such as MIMIC-CXR, and spans a diverse range of biomedical image types. PMC-15M contains 15 million biomedical image-text pairs collected from 4.4 million scientific articles. Based on PMC-15M, we have pretrained BiomedCLIP, a multimodal foundation model, with domain-specific adaptations tailored to biomedical vision-language processing. RESULTS: We conducted extensive experiments and ablation studies on standard biomedical imaging tasks from retrieval to classification to visual question answering (VQA). BiomedCLIP achieved new state-of-the-art results in a wide range of standard datasets, substantially outperforming prior approaches. Intriguingly, by large-scale pretraining on diverse biomedical image types, BiomedCLIP even outperforms state-of-the-art radiology-specific models, such as BioViL, in radiology-specific tasks such as Radiological Society of North America (RSNA) pneumonia detection. CONCLUSIONS: BiomedCLIP is a fully open-access foundation model that achieves state-of-the-art performance on various biomedical tasks, paving the way for transformative multimodal biomedical discovery and applications. We release our models at aka.ms/biomedclip to facilitate future research in multimodal biomedical AI.

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Crossref · 10.1056/aioa2400640

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  • PanDerm surpassed vision-language models such as CLIP, MONET and BiomedCLIP in benchmark evaluations.

    “Furthermore, PanDerm also surpassed vision-language models such as CLIP36, MONET39 and biomedical-specific CLIP (BiomedCLIP)40 in benchmark evaluations (Supplementary Table 1)”
  • CLIP-large outperformed biomedical-specific and dermatology-specific CLIP models.

    “CLIP-large outperformed biomedical-specific and dermatology-specific CLIP models”

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Authors
Zhang, S., Xu, Y., Usuyama, N., Xu, H., Bagga, J., Tinn, R., Preston, S., Rao, R., Wei, M., Valluri, N., Wong, C., Tupini, A., Wang, Y., Mazzola, M., Shukla, S., Liden, L., Gao, J., Crabtree, A., Piening, B., Bifulco, C., Lungren, M. P., Naumann, T., Wang, S., & Poon, H.
Affiliations
  • Microsoft (United States) (US)
  • University of Washington (US)
  • Microsoft Research, Redmond, WA
  • Providence Portland Medical Center (US)
Venue
NEJM AI
Published
2025-01-01
Volume
2
Issue
1
Pages
AIoa2400640-AIoa2400640
ISSN
2836-9386 (ISSN-L)
OpenAlex
W4405669265
Cited by
283
References
41
Citations by year
2026: 156 · 2025: 121 · 2024: 6
FWCI
39.62
Type
journal article
Language
en
Open access
closed
Locations
  • NEJM AI (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Multimodal Machine Learning Applications
  • Health Sciences › Medicine › Health Informatics › Artificial Intelligence in Healthcare and Education
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Image Retrieval and Classification Techniques
Keywords
multimodal foundation models, large language models, multimodal pre-training

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