Cited by 89Gut microbiota and healthRetinal Diseases and TreatmentsOcular Diseases and Behçet’s Syndrome

The Role of Microbiota in Retinal Disease

Rowan, Sheldon, Taylor, Allen·2018·Advances in Experimental Medicine and Biology

Abstract

The ten years since the first publications on the human microbiome project have brought enormous attention and insight into the role of the human microbiome in health and disease. Connections between populations of microbiota and ocular disease are now being established, and increased accessibility to microbiome research and insights into other diseases is expected to yield enormous information in the coming years. With the characterization of the ocular microbiome, important insights have already been made regarding corneal and conjunctival tissues. Roles for non-ocular microbiomes in complex retinal diseases are now being evaluated. For example, the gut microbiome has been implicated in the pathogenesis of uveitis. This short review will summarize the few studies linking gut or oral microbiota to diabetic retinopathy (DR), glaucoma, and age-related macular degeneration (AMD). We will also conjecture where the most significant findings still remain to be elucidated. Finally, we will propose the gut-retina axis, related but distinct from the gut-brain axis.

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Crossref · 10.1007/978-3-319-75402-4_53

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Authors
Rowan, S., & Taylor, A.
Affiliations
Tufts University (US)
Corresponding author
Rowan, Sheldon
Venue
Advances in Experimental Medicine and Biology
Published
2018
Volume
1074
Pages
429-435
ISSN
  • 0065-2598 (ISSN-L)
  • 2214-8019
OpenAlex
W2800339923
Cited by
89
References
31
Citations by year
2026: 9 · 2025: 3 · 2024: 11 · 2023: 17 · 2022: 21 · 2021: 15 · 2020: 9 · 2019: 3 · 2018: 1
FWCI
9.43
Type
book chapter
Language
en
Open access
closed
Locations
  • Advances in experimental medicine and biology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
  • Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
Keywords
gut microbiota, retinal disease, ocular microbiome, diabetic retinopathy, glaucoma, age-related macular degeneration, uveitis, gut-retina axis, gut-brain axis, oral microbiota, cornea, conjunctiva
MeSH terms
Gastrointestinal Microbiome, Animals, Conjunctiva, Cornea, Diabetic Retinopathy, Disease Models, Animal, Germ-Free Life, Glaucoma, Humans, Macular Degeneration, Metformin, Mouth, Retinal Diseases, Uveitis, Mice, Microbiota

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