Cited by 317Nanoparticle-Based Drug DeliveryAdvanced Drug Delivery SystemsHydrogels: synthesis, properties, applications

Ph-responsive polymer–drug conjugates: design and progress

Pang, Xin, Jiang, Yue, Xiao, Qicai, Leung, Albert Wingnang, Hua, Heyu, Xu, Chuanshan·2016·Journal of Controlled Release

Abstract

Polymer-drug conjugates are becoming established as a shining platform for drug delivery. Incorporation of pH-responsive linker between drug and polymer is expected to realize triggered release of bioactive agents from conjugates in specific sites, either in mildly acidic extracellular matrices of tumor tissues or, after cellular internalization, in acidic endosomes and lysosomes. As an emerging drug delivery system, such pH-responsive polymer-drug conjugates are able to selectively deliver and activate drug molecules while reducing their systemic side-effects. In this review, we present the recent advances in pH-responsive polymer-drug conjugates with different chemical structures and architectures, and attempt to clarify their mechanism of action, synthesis and characterization technology. Furthermore, several promising approaches for the future will also be suggested.

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Crossref · 10.1016/j.jconrel.2015.12.024

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114 of 114 references verified0 citation errors · 0 not checkable

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  • The ionic interaction can dissolve in response to pH changes, causing the drug to be released from the polymer backbone.

    “The ionic interaction can dissolve in response to pH changes, causing the drug to be released from the polymer backbone (Pang et al., 2016; Deirram et al., 2019).”

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Authors
Pang, X., Jiang, Y., Xiao, Q., Leung, A. W., Hua, H., & Xu, C.
Affiliations
Chinese University of Hong Kong (HK)
Corresponding author
Xu, Chuanshan
Venue
Journal of Controlled Release
Publisher
Elsevier BV
Published
2016-01
Volume
222
Pages
116-129
ISSN
0168-3659 (ISSN-L)
OpenAlex
W2200680635
Cited by
317
References
114
Citations by year
2026: 11 · 2025: 21 · 2024: 32 · 2023: 33 · 2022: 29 · 2021: 34 · 2020: 33 · 2019: 45 · 2018: 34 · 2017: 32 · 2016: 13
FWCI
1.59
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Controlled Release (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Hong Kong research grant committee (476912)
  • Health and Medical Research Fund (1100502)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
Keywords
pH-responsive polymers, polymer-drug conjugates, triggered drug release, targeted drug delivery, conjugate synthesis
MeSH terms
Pharmaceutical Preparations, Hydrogen-Ion Concentration, Polymers, Drug Design, Drug Delivery Systems

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