Intracerebral distribution of DL-2-amino-phosphonopentanoic acid (AP5) and the dissociation of different types of learning

Butcher, S.P.; Hamberger, A.; Morris, R.G.M.

doi:10.1007/bf00229829

Cited by 40Memory and Neural MechanismsNeuroscience and Neuropharmacology ResearchNeurotransmitter Receptor Influence on Behavior

Intracerebral distribution of DL-2-amino-phosphonopentanoic acid (AP5) and the dissociation of different types of learning

Butcher, S.P., Hamberger, A., Morris, R.G.M.·1991·Experimental Brain Research

DOI 10.1007/bf00229829

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Abstract

Chronic intraventricular infusion of the selective NMDA receptor antagonist AP5 appears to cause an impairment of spatial but not visual discrimination learning. However, Goddard (1986) has questioned whether this dissociation in task-selectivity reflects a difference in the underlying neural mechanisms or differential drug diffusion. Two experiments conducted to address this issue established (a) that chronic intraventricular infusion of AP5, at a dose sufficient to cause a spatial learning impairment, results in a relatively uniform distribution of the drug across the brain, and (b) that chronic bilateral intracortical infusion at sites very close to visual cortex also fails to impair visual discrimination learning. These findings argue against differential diffusion being a major cause of the sensitivity of spatial but not visual discrimination tasks to AP5, and raises the possibility that representational and procedural memory tasks may depend upon distinct cell-biological mechanisms of plasticity.

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The target of AP5 infusion is not restricted to the hippocampus.
“Likewise, in pharmacological studies the target of the AP5 infusion is not restricted to the hippocampus (Butcher et al., 1991).”
From The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. (1996) · cites this paper as Butcher et al., 1991

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N‐methyl‐ d ‐aspartate receptors, learning and memory: chronic intraventricular infusion of the NMDA receptor antagonist d ‐ AP 5 interacts directly with the neural mechanisms of spatial learning
Morris, R., Steele, R. J., Bell, J. E., & Martin, S. J. (2013) · European Journal of Neuroscience · doi:10.1111/ejn.12086 · Cited by 54 · see citing works
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Synaptic plasticity and learning: selective impairment of learning rats and blockade of long-term potentiation in vivo by the N-methyl-D- aspartate receptor antagonist AP5
Morris, R. (1989) · Journal of Neuroscience · doi:10.1523/jneurosci.09-09-03040.1989 · Cited by 765 · see citing works
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Intra-ventricular infusion of the NMDA antagonist AP5 impairs performance on a non-spatial operant DRL task in the rat
Tonkiss, J., Morris, R., & Rawlins, J. N. P. (1988) · Experimental Brain Research · doi:10.1007/bf00279671 · Cited by 226 · see citing works
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Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5
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The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro
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Authors: Butcher, S. P., Hamberger, A., & Morris, R. G. M.
Affiliations: University of Edinburgh (GB)
University of Gothenburg (SE)
ORCID: Butcher, S.P.
Morris, R.G.M.
Venue: Experimental Brain Research
Publisher: Springer Science and Business Media LLC
Published: 1991-02
Volume: 83
Issue: 3
Pages: 521-6
ISSN: 0014-4819 (ISSN-L)
1432-1106
DOI: 10.1007/bf00229829
OpenAlex: W2002447155
Cited by: 40
References: 22
Citations by year: 2024: 1 · 2020: 2 · 2013: 3 · 2012: 1
FWCI: 2.08
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Experimental Brain Research (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords: AP5, NMDA receptor antagonism, intraventricular infusion, spatial discrimination learning, visual discrimination learning, learning disabilities, procedural memory, synaptic plasticity
MeSH terms: Animals, Brain, Cerebral Cortex, Cerebral Ventricles, Corpus Striatum, Discrimination, Psychological, Hippocampus, Infusions, Parenteral, Learning, Male, Neurons, Organ Specificity, Rats, Inbred Strains, Reference Values, Space Perception, Visual Cortex, Visual Perception, 2-Amino-5-phosphonovalerate, Rats

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Intracerebral distribution of DL-2-amino-phosphonopentanoic acid (AP5) and the dissociation of different types of learning

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