Distinct components of spatial learning revealed by prior training and NMDA receptor blockade
Abstract
Synaptic plasticity dependent on N-methyl-D-aspartate (NMDA) receptors is thought to underlie certain types of learning and memory. In support of this, both hippocampal long-term potentiation and spatial learning in a watermaze are impaired by blocking NMDA receptors with a selective antagonist D(-)-2-amino-5-phosphonovaleric acid (AP5) or by a mutation in one of the receptor subunits. Here we report, however, that the AP5-induced learning deficit can be almost completely prevented if rats are pretrained in a different watermaze before administration of the drug. This is not because of stimulus generalization, and occurs despite learning of the second task remaining hippocampus dependent. An AP5-induced learning deficit is, however, still seen if the animals are pretrained using a non-spatial task. Thus, despite its procedural simplicity, the watermaze may involve multiple cognitive processes with distinct pharmacological properties; although required for some component of spatial learning, NMDA receptors may not be required for encoding the spatial representation of a specific environment.
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- Authors
- Bannerman, D. M., Good, M. A., Butcher, S. P., Ramsay, M., & Morris, R. G. M.
- Affiliations
- University of Edinburgh (GB)
- Cardiff University (GB)
- Venue
- Nature
- Published
- 1995-11
- Volume
- 378
- Issue
- 6553
- Pages
- 182-186
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W2068187395
- Cited by
- 551
- References
- 4
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 5 · 2023: 5 · 2022: 11 · 2021: 10 · 2020: 10 · 2019: 15 · 2018: 17 · 2017: 8 · 2016: 14 · 2015: 16 · 2014: 20 · 2013: 27 · 2012: 18
- FWCI
- 18.28
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- spatial learning, NMDA receptor, AP5, synaptic plasticity, hippocampus, long-term potentiation, water maze, prior training, learning deficits, hippocampus-dependent learning, spatial representation, stimulus generalization
- MeSH terms
- Animals, Cerebrospinal Fluid, Hippocampus, Male, Memory, Space Perception, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, Long-Term Potentiation, Excitatory Amino Acid Antagonists, Maze Learning, Rats
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