Nerve fibres and their terminals of the dura mater encephali of the rat
Abstract
The dura mater encephali of the rat is richly supplied by myelinated (A-axons) and unmyelinated (C-axons) nerve fibres. For the supratentorial part the main nerve supply stems from all three branches of the trigeminal nerve. Finally, 250 myelinated and 800 unmyelinated nerve fibres innervate one side of the supratentorial part. The vascular bed of the dura mater exhibits long postcapillary venules up to 200 micron in length with segments of endothelial fenestration. Lymphatic vessels occur within the dura mater. They leave the cranial cavity through the openings of the cribriform plate, rostral to the bulla tympani together with the transverse sinus, and the middle meningeal artery. The perineural sheath builds up a tube-like net containing the A- and C-axons. It is spacious in the parietal dura mater and dense at the sagittal sinus along its extension from rostral to caudal and at the confluence of sinuses. Terminals of both the A- and C-axons are of the unencapsulated type. Unencapsulated Ruffini-like receptors stemming from A-axons are found in the dural connective tissue at sites where superficial cerebral veins enter the sagittal sinus and at the confluence of sinuses. The terminations of single A-axons together with C-fibre bundles mix up in their final course in one Schwann cell to build up multiaxonal units or terminations (up to 15 axonal profiles). A morphological differentiation is made due to the topography of these terminations; firstly, in different segments of the vascular bed: postcapillary venule, venule, the sinus wall, lymphatic vessel wall, and secondly, within the dura mater: inner periosteal layer, collagenous fibre bundles of the meningeal layer and at the mesothelial cell layer of the subdural space.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Lymphatics have been discovered in the dura mater and just outside holes in the skull bone.
“Although the CNS parenchyma does not have a conventional lymphatic drainage system (3), lymphatics have been discovered in the dura mater and just outside holes in the skull bone (4-9).”
From The anatomy and immunology of vasculature in the central nervous system (2019) · cites this paper as [8]
Cites
THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY
Reynolds, E. S. (1963) · The Journal of Cell Biology · doi:10.1083/jcb.17.1.208 · Cited by 24,938 · see citing works
A formaldehyde - glutaraldehyde fixative of high osmolarity for use in electron microscopy
Karnovsky, M. J. (1965) · The Journal of Cell Biology · Cited by 5,882 · see citing works
The neurobiology of vascular head pain
Moskowitz, M. A. (1984) · Annals of Neurology · doi:10.1002/ana.410160202 · Cited by 913 · see citing works
Correlative Anatomy of the Nervous System
Crosby, E. C., Humphrey, T., Lauer, E. W., & Kappers, J. A. (1962) · Biblioteca Digital (Real Academia Nacional de Medicina) · Cited by 844 · see citing works
EXPERIMENTAL STUDIES ON HEADACHE
Ray, B. S. (1940) · Archives of Surgery · doi:10.1001/archsurg.1940.01210040002001 · Cited by 788 · see citing works
Gamse, R., Holzer, P. D., & Lembeck, F. (1980) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1980.tb10409.x · Cited by 594 · see citing works
Correlative Anatomy of the Nervous System
Williams, M. (1963) · Physical Therapy · doi:10.1093/ptj/43.5.405a · Cited by 553 · see citing works
THE STRUCTURE AND FUNCTION OF THE SLOWLY ADAPTING TYPE II MECHANORECEPTOR IN HAIRY SKIN
Mr, C., Andres, K. H., von Duering, M. U., & Iggo, A. (1972) · Quarterly Journal of Experimental Physiology and Cognate Medical Sciences · doi:10.1113/expphysiol.1972.sp002177 · Cited by 461 · see citing works
Self-citationClementi, F., & Palade, G. E. (1969) · The Journal of Cell Biology · doi:10.1083/jcb.41.1.33 · Cited by 365 · see citing works
DURAL HEADACHE AND INNERVATION OF THE DURA MATER
Penfield, W. G. (1940) · Archives of Neurology And Psychiatry · doi:10.1001/archneurpsyc.1940.02280070051003 · Cited by 349 · see citing works
Morphology of Cutaneous Receptors
Iggo, A., & Andres, K. H. (1982) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.05.030182.000245 · Cited by 332 · see citing works
Self-citationMayberg, M. R., Zervas, N. T., & Moskowitz, M. A. (1984) · The Journal of Comparative Neurology · doi:10.1002/cne.902230105 · Cited by 324 · see citing works
Substance P-like immunoreactivity in nerves associated with the vascular system of guinea-pigs
Furness, J. B., Papka, R. E., Della, N. G., Costa, M., & Eskay, R. L. (1982) · Neuroscience · doi:10.1016/0306-4522(82)90279-2 · Cited by 311 · see citing works
PERMEABILITY OF INTESTINAL CAPILLARIES
Simionescu, N., Simionescu, M., & Palade, G. E. (1972) · The Journal of Cell Biology · doi:10.1083/jcb.53.2.365 · Cited by 269 · see citing works
Lundberg, J. M., Brodin, E., Hua, X., & Saria, A. (1984) · Acta Physiologica Scandinavica · doi:10.1111/j.1748-1716.1984.tb00127.x · Cited by 222 · see citing works
The connexions of the spinal sub-arachnoid space with the lymphatic system.
Brierley, J. B., & Field, E. J. (1948) · PubMed · Cited by 190 · see citing works
Jancsó, N. V. (1968) · Elsevier eBooks · doi:10.1016/b978-0-08-003267-2.50008-7 · Cited by 174 · see citing works
Structure and function of cold receptors
Hensel, H., Andres, K. H., & von Düring, M. (1974) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf01061945 · Cited by 164 · see citing works
Self-citationThe fine structure of the Golgi tendon organ
Schoultz, T. W., & Swett, J. E. (1972) · Journal of Neurocytology · doi:10.1007/bf01098642 · Cited by 143 · see citing works
Sensory innervation of the Achilles tendon by group III and IV afferent fibers
Andres, K. H., D�ring, M., & Schmidt, R. F. (1985) · Anatomy and Embryology · doi:10.1007/bf00319597 · Cited by 137 · see citing works
Self-citationWoolf, C. J. (1985) · Pain · doi:10.1016/0304-3959(85)90169-1 · Cited by 135 · see citing works
Simionescu, N., & Simionescu, M. (1983) · doi:10.1007/978-1-349-06859-3_9 · Cited by 134 · see citing works
The ultrastructure of sensory nerve endings in the human knee joint capsule
Halata, Z., Rettig, T., & Schulze, W. (1985) · Anatomy and Embryology · doi:10.1007/bf00318974 · Cited by 97 · see citing works
Referral of pain from dural stimulation in man
Wirth, F. P., & Buren, J. M. V. (1971) · Journal of neurosurgery · doi:10.3171/jns.1971.34.5.0630 · Cited by 76 · see citing works
The fine structure of the pulmonary stretch receptor in the rat
D�ring, M., Andres, K. H., & Iravani, J. (1974) · Anatomy and Embryology · doi:10.1007/bf00525771 · Cited by 71 · see citing works
Self-citationMatsuyama, T., Shiosaka, S., Wanaka, A., Yoneda, S., Kimura, K., Hayakawa, T., Emson, P. C., & Tohyama, M. (1985) · The Journal of Comparative Neurology · doi:10.1002/cne.902350209 · Cited by 62 · see citing works
The sensory representation of the dura mater in the trigeminal ganglion of the cat
Steiger, H. J., Tew, J. M., & Keller, J. T. (1982) · Neuroscience Letters · doi:10.1016/0304-3940(82)90025-8 · Cited by 60 · see citing works
Friedrich, V. L., & Mugnaini, E. (1981) · Springer eBooks · doi:10.1007/978-1-4613-3189-6_10 · Cited by 53 · see citing works
Acetylcholinesterase-containing nerve fibers in the dura mater of guinea pig, mouse, and rat
Amenta, F., Sancesario, G., Ferrante, F., & Cavallotti, C. A. P. (1980) · Journal of Neural Transmission · doi:10.1007/bf01250604 · Cited by 40 · see citing works
Identification of the Ruffini corpuscle in human hairy skin
Halata, Z., & Munger, B. (1981) · Cell and Tissue Research · doi:10.1007/bf00210162 · Cited by 37 · see citing works
Morphological Criteria for the Differentiation of Mechanoreceptors in Vertebrates
Andres, K. H. (1974) · VS Verlag für Sozialwissenschaften eBooks · doi:10.1007/978-3-663-01719-6_11 · Cited by 26 · see citing works
Self-citationGeneral Methods for Characterization of Brain Regions
Andres, K. H., & von Düring, M. (1981) · Springer eBooks · doi:10.1007/978-3-642-68029-8_6 · Cited by 22 · see citing works
Self-citationBemerkungen über die Nerven der Dura mater
Alexander, W. T. (1875) · Archiv für Mikroskopische Anatomie · doi:10.1007/bf02933797 · Cited by 16 · see citing works
Kh, A., & von Düring, M. (1974) · PubMed · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
A dural lymphatic vascular system that drains brain interstitial fluid and macromolecules
Aspelund, A., Antila, S., Proulx, S. T., Karlsen, T. V., Karaman, S., Detmar, M., Wiig, H., & Alitalo, K. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20142290 · Cited by 2,198 · see citing works
CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature.
Louveau, A., Herz, J., Alme, M. N., Salvador, A. F., Dong, M. Q., Viar, K. E., Herod, S. G., Knopp, J., Setliff, J. C., Lupi, A. L., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0227-9 · Cited by 956 · see citing works
Sensitization of meningeal sensory neurons and the origin of headaches
Strassman, A. M., Raymond, S. A., & Burstein, R. (1996) · Nature · doi:10.1038/384560a0 · Cited by 704 · see citing works
Ma, Q., Ineichen, B. V., Detmar, M., & Proulx, S. T. (2017) · Nature Communications · doi:10.1038/s41467-017-01484-6 · Cited by 690 · see citing works
Revisiting the Mechanisms of CNS Immune Privilege
Louveau, A., Harris, T. H., & Kipnis, J. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.08.006 · Cited by 682 · see citing works
Understanding the functions and relationships of the glymphatic system and meningeal lymphatics
Louveau, A., Plog, B. A., Antila, S., Alitalo, K., Nedergaard, M., & Kipnis, J. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90603 · Cited by 640 · see citing works
Burstein, R., Yamamura, H., Malick, A., & Strassman, A. M. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.79.2.964 · Cited by 607 · see citing works
Origin of pain in migraine: evidence for peripheral sensitisation
Olesen, J., Burstein, R., Ashina, M., & Tfelt‐Hansen, P. C. (2009) · The Lancet Neurology · doi:10.1016/s1474-4422(09)70090-0 · Cited by 563 · see citing works
Cai, R., Pan, C., Ghasemigharagoz, A., Todorov, M. I., Förstera, B., Zhao, S., Bhatia, H. S., Parra-Damas, A., Mrowka, L., Theodorou, D., et al. (2019) · Nature Neuroscience · doi:10.1038/s41593-018-0301-3 · Cited by 470 · see citing works
Bartsch, T. (2002) · Brain · doi:10.1093/brain/awf166 · Cited by 475 · see citing works
Bartsch, T. (2003) · Brain · doi:10.1093/brain/awg190 · Cited by 459 · see citing works
Macrophages at CNS interfaces: Ontogeny and function in health and disease
Kierdorf, K., Masuda, T., Jordão, M. J. C., & Prinz, M. (2019) · Nature Reviews Neuroscience · doi:10.1038/s41583-019-0201-x · Cited by 416 · see citing works
Buzzi, M. G., & Moskowitz, M. A. (1990) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1990.tb14679.x · Cited by 415 · see citing works
Proulx, S. T. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03706-5 · Cited by 400 · see citing works
Multifaceted interactions between adaptive immunity and the central nervous system
Kipnis, J. (2016) · Science · doi:10.1126/science.aag2638 · Cited by 376 · see citing works
Vascular, glial, and lymphatic immune gateways of the central nervous system
Engelhardt, B., Carare, R. O., Bechmann, I., Flügel, A., Laman, J. D., & Weller, R. O. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1606-5 · Cited by 362 · see citing works
Bakker, E. N. T. P., Bacskai, B. J., Arbel-Ornath, M., Aldea, R., Bedussi, B., Morris, A. W. J., Weller, R. O., & Carare, R. O. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0273-8 · Cited by 353 · see citing works
The anatomy and immunology of vasculature in the central nervous system
Mastorakos, P., & McGavern, D. (2019) · Science Immunology · doi:10.1126/sciimmunol.aav0492 · Cited by 333 · see citing works
Bernstein, C. A., & Burstein, R. (2012) · Journal of Clinical Neurology · doi:10.3988/jcn.2012.8.2.89 · Cited by 328 · see citing works
Advances in Meningeal Immunity
Rua, R., & McGavern, D. B. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.04.003 · Cited by 326 · see citing works
Neurogenic inflammation and its role in migraine
Ramachandran, R. (2018) · Seminars in Immunopathology · doi:10.1007/s00281-018-0676-y · Cited by 311 · see citing works
Koh, L., Zakharov, A., & Johnston, M. G. (2005) · Cerebrospinal Fluid Research · doi:10.1186/1743-8454-2-6 · Cited by 298 · see citing works
Widner, H., & Brundin, P. (1988) · Brain Research Reviews · doi:10.1016/0165-0173(88)90010-0 · Cited by 287 · see citing works
Eftekhari, S., Warfvinge, K., Blixt, F. W., & Edvinsson, L. I. (2013) · Journal of Pain · doi:10.1016/j.jpain.2013.03.010 · Cited by 263 · see citing works
Lymphatic drainage system of the brain: A novel target for intervention of neurological diseases
Sun, B., Wang, L.-H., Yang, T., Sun, J., Mao, L., Yang, M., Yuan, H., Colvin, R. A., & Yang, X. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.08.007 · Cited by 255 · see citing works
Basic Mechanisms in Vascular Headache
Moskowitz, M. A. (1990) · Neurologic Clinics · doi:10.1016/s0733-8619(18)30318-9 · Cited by 249 · see citing works
Neuroinflammation: Ways in Which the Immune System Affects the Brain
Ransohoff, R. M., Schafer, D. P., Vincent, A. C., Blachère, N. E., & Bar‐Or, A. (2015) · Neurotherapeutics · doi:10.1007/s13311-015-0385-3 · Cited by 245 · see citing works
Non-invasive MR imaging of human brain lymphatic networks with connections to cervical lymph nodes
Albayram, S., Smith, G., Tufan, F., Tuna, İ. S., Bostancıklıoğlu, M., Zile, M. R., & Albayram, Ö. (2022) · Nature Communications · doi:10.1038/s41467-021-27887-0 · Cited by 239 · see citing works
Neurovascular contributions to migraine: Moving beyond vasodilation
Jacobs, B. A., & Dussor, G. O. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.06.012 · Cited by 182 · see citing works
Peptidergic and serotoninergic innervation of the rat dura mater
Keller, J. T., & Marfurt, C. F. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903090408 · Cited by 184 · see citing works
How Do Meningeal Lymphatic Vessels Drain the CNS?
Raper, D. M. S., Louveau, A., & Kipnis, J. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.07.001 · Cited by 181 · see citing works
Tohidpour, A., Morgun, A. V., Boitsova, E. B., Malinovskaya, N. A., Martynova, G. P., Хилажева, Е. Д., Kopylevich, N. V., Gertsog, G. E., & Salmina, A. B. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00276 · Cited by 179 · see citing works
Current understanding of trigeminal ganglion structure and function in headache
Messlinger, K., & Russo, A. F. (2019) · Cephalalgia · doi:10.1177/0333102418786261 · Cited by 178 · see citing works
Louveau, A., Mesquita, S. D., & Kipnis, J. (2016) · Neuron · doi:10.1016/j.neuron.2016.08.027 · Cited by 175 · see citing works
Heterogeneity in the lymphatic vascular system and its origin
Ulvmar, M. H., & Mäkinen, T. (2016) · Cardiovascular Research · doi:10.1093/cvr/cvw175 · Cited by 169 · see citing works
Response Properties of Dural Nociceptors in Relation to Headache
Strassman, A. M., & Levy, D. (2006) · Journal of Neurophysiology · doi:10.1152/jn.01293.2005 · Cited by 163 · see citing works
Schueler, M., Meßlinger, K., Dux, M., Neuhuber, W., & De, R. (2013) · Pain · doi:10.1016/j.pain.2013.04.040 · Cited by 161 · see citing works
Dimitriadou, V., Buzzi, M. G., Theoharides, T. C., & Moskowitz, M. A. (1992) · Neuroscience · doi:10.1016/0306-4522(92)90348-6 · Cited by 161 · see citing works
Waite, P. M. E., & Ashwell, K. W. S. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-374236-0.10031-8 · Cited by 158 · see citing works
Col, R. D., Meßlinger, K., & Carr, R. W. (2007) · The Journal of Physiology · doi:10.1113/jphysiol.2007.145383 · Cited by 155 · see citing works
Ergot alkaloids block neurogenic extravasation in dura mater: Proposed action in vascular headaches
Saito, K., Markowitz, S., & Moskowitz, M. A. (1988) · Annals of Neurology · doi:10.1002/ana.410240607 · Cited by 155 · see citing works
Satô, A., Sato, Y., & Schmidt, R. F. (1997) · Reviews of physiology, biochemistry and pharmacology · doi:10.1007/bfb0046598 · Cited by 155 · see citing works
Self-citationBrain cooling in humans ? anatomical considerations
Zenker, W., & Kubik, S. (1996) · Anatomy and Embryology · doi:10.1007/bf00186829 · Cited by 151 · see citing works
Jacob C. Van der Wal, M. (2009) · International Journal of Therapeutic Massage & Bodywork Research Education & Practice · doi:10.3822/ijtmb.v2i4.62 · Cited by 146 · see citing works
Me�linger, K., Hanesch, U., RTEL, M. B., Trost, B., & Schmidt, R. (1993) · Anatomy and Embryology · doi:10.1007/bf00188214 · Cited by 145 · see citing works
Self-citationSchueler, M., Neuhuber, W., Col, R. D., & Meßlinger, K. (2014) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12371 · Cited by 144 · see citing works
Shields, K. G. (2004) · Brain · doi:10.1093/brain/awh298 · Cited by 144 · see citing works
Kinins and their receptors in hyperalgesia
Dray, A. (1997) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-75-6-704 · Cited by 144 · see citing works
Migraine: where and how does the pain originate?
Meßlinger, K. (2009) · Experimental Brain Research · doi:10.1007/s00221-009-1756-y · Cited by 143 · see citing works
Mollanji, R., Bozanovic-Sosic, R., Zakharov, A., Makarian, L., & Johnston, M. G. (2002) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00695.2001 · Cited by 133 · see citing works
Strassman, A., Mineta, Y., & Vos, B. P. (1994) · Journal of Neuroscience · doi:10.1523/jneurosci.14-06-03725.1994 · Cited by 133 · see citing works
Current understanding of meningeal and cerebral vascular function underlying migraine headache
Levy, D., Labastida‐Ramírez, A., & MaassenVanDenBrink, A. (2018) · Cephalalgia · doi:10.1177/0333102418771350 · Cited by 129 · see citing works
Capsaicin‐sensitive neurogenic sensory vasodilatation in the dura mater of the rat
Dux, M., Sántha, P., & Jancsó, G. (2003) · The Journal of Physiology · doi:10.1113/jphysiol.2003.050633 · Cited by 125 · see citing works
Coles, J. A., Myburgh, E., Brewer, J. M., & McMenamin, P. G. (2017) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2017.05.002 · Cited by 123 · see citing works
Uddman, R., Tajti, J., Hou, M., Sundler, F., & Edvinsson, L. I. (2002) · Cephalalgia · doi:10.1046/j.1468-2982.2002.00324.x · Cited by 119 · see citing works
Brain pharmacology of intrathecal antisense oligonucleotides revealed through multimodal imaging
Mazur, C., Powers, B., Zasadny, K., Sullivan, J. M., Dimant, H., Kamme, F., Hesterman, J., Matson, J., Oestergaard, M., Seaman, M., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.129240 · Cited by 114 · see citing works
Buzzi, M. G., Bonamini, M., & Moskowitz, M. (1995) · Cephalalgia · doi:10.1046/j.1468-2982.1995.1504277.x · Cited by 114 · see citing works
Buzzi, M. G., Moskowitz, M. A., Peroutka, S. J., & Byun, B.-J. (1991) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1991.tb09805.x · Cited by 108 · see citing works
Primary Afferent Neurons Innervating Guinea Pig Dura
Bove, G. M., & Moskowitz, M. A. (1997) · Journal of Neurophysiology · doi:10.1152/jn.1997.77.1.299 · Cited by 103 · see citing works
Spinal and cranial contributions to total cerebrospinal fluid transport
Bozanovic-Sosic, R., Mollanji, R., & Johnston, M. G. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.281.3.r909 · Cited by 103 · see citing works
A (delayed) history of the brain lymphatic system
Sandrone, S., Moreno-Zambrano, D., Kipnis, J., & van Gijn, J. (2019) · Nature Medicine · doi:10.1038/s41591-019-0417-3 · Cited by 102 · see citing works
Axon diameters and intradural trajectories of the dural innervation in the rat
Strassman, A. M., Weissner, W., Williams, M., Saad, A., & Levy, D. (2004) · The Journal of Comparative Neurology · doi:10.1002/cne.20106 · Cited by 100 · see citing works
Response properties of trigeminal brain stem neurons with input from dura mater encephali in the rat
Schepelmann, K., Ebersberger, A., Pawlak, M., Oppmann, M., & Meßlinger, K. (1999) · Neuroscience · doi:10.1016/s0306-4522(98)00423-0 · Cited by 99 · see citing works
Li, G., Cao, Y., Tang, X., Huang, J., Cai, L., & Zhou, L. (2022) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x221098145 · Cited by 99 · see citing works
Immune dynamics in the CNS and its barriers during homeostasis and disease*
Buckley, M. W., & McGavern, D. B. (2022) · Immunological Reviews · doi:10.1111/imr.13066 · Cited by 97 · see citing works
Buzzi, M. G., Dimitriadou, V., Theoharides, T. C., & Moskowitz, M. A. (1992) · Brain Research · doi:10.1016/s0006-8993(10)80017-4 · Cited by 94 · see citing works
Migraine Pain and Nociceptor Activation—Where Do We Stand?
Levy, D. (2010) · Headache The Journal of Head and Face Pain · doi:10.1111/j.1526-4610.2010.01670.x · Cited by 93 · see citing works
Redefining CNS immune privilege
Smyth, L. C. D., & Kipnis, J. (2025) · Nature Reviews Immunology · doi:10.1038/s41577-025-01175-0 · Cited by 80 · see citing works
Mollanji, R., Bozanovic-Sosic, R., Silver, I., Li, B., Kim, C., Midha, R., & Johnston, M. (2001) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.2001.280.5.r1573 · Cited by 90 · see citing works
Sympathetic innervation of the supratentorial dura mater of the rat
Keller, J. T., Marfurt, C. F., Dimlich, R. V. W., & Tierney, B. E. (1989) · The Journal of Comparative Neurology · doi:10.1002/cne.902900210 · Cited by 88 · see citing works
Apolipoprotein E4 and meningeal lymphatics in Alzheimer disease: a conceptual framework
Mentis, A. A., Dardiotis, E., & Chrousos, G. P. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-0731-7 · Cited by 82 · see citing works
Meningeal Mechanisms and the Migraine Connection
Levy, D., & Moskowitz, M. A. (2023) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080422-105509 · Cited by 86 · see citing works
Meningeal lymphatic drainage: novel insights into central nervous system disease
Zhang, Q., Niu, Y., Li, Y., Xia, C., Chen, Z., Chen, Y., & Feng, H. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02177-z · Cited by 98 · see citing works
Advances and controversies in meningeal biology
Betsholtz, C., Engelhardt, B., Koh, G. Y., McDonald, D. M., Proulx, S. T., & Siegenthaler, J. A. (2024) · Nature Neuroscience · doi:10.1038/s41593-024-01701-8 · Cited by 85 · see citing works
Linear arrays of homogenous mast cells in the dura mater of the rat
Dimlich, R. V. W., Keller, J. T., Strauss, T. A., & Fritts, M. J. (1991) · Journal of Neurocytology · doi:10.1007/bf01252276 · Cited by 85 · see citing works
Stimulation of cranial vessels excites nociceptive neurones in several thalamic nuclei of the cat
Zagami, A. S., & Lambert, G. A. (1990) · Experimental Brain Research · doi:10.1007/bf02423504 · Cited by 85 · see citing works
Meningeal Lymphatics in Central Nervous System Diseases
Salvador, A. F., Abduljawad, N., & Kipnis, J. (2024) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-113023-103045 · Cited by 87 · see citing works
Proulx, S. T., & Engelhardt, B. (2022) · Journal of Internal Medicine · doi:10.1111/joim.13469 · Cited by 83 · see citing works
The CNS and the Brain Tumor Microenvironment: Implications for Glioblastoma Immunotherapy
Desland, F. A., & Hormigo, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197358 · Cited by 80 · see citing works
Duan, M., Xu, Y., Li, Y., Feng, H., & Chen, Y. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03101-y · Cited by 82 · see citing works
Strassman, A. M., & Raymond, S. A. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.2.413 · Cited by 79 · see citing works
Targeting NLRP3 inflammasome for neurodegenerative disorders
Yao, J., Wang, Z., Song, W., & Zhang, Y. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02239-0 · Cited by 75 · see citing works
Reassessment of the pathways responsible for cerebrospinal fluid absorption in the neonate
Papaiconomou, C., Zakharov, A., Azizi, N., Djenic, J., & Johnston, M. (2004) · Child s Nervous System · doi:10.1007/s00381-003-0840-z · Cited by 75 · see citing works
Distribution and origin of TRPV1 receptor-containing nerve fibers in the dura mater of rat
Shimizu, T., Toriumi, H., Sato, H., Shibata, M., Nagata, E., Gotoh, K., & Suzuki, N. (2007) · Brain Research · doi:10.1016/j.brainres.2007.07.068 · Cited by 75 · see citing works
An immunohistochemical study of lymphatic elements in the human brain
Mezey, É., Szalayova, I., Hogden, C. T., Brady, A., Dósa, A., Sótonyi, P., & Palkovits, M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2002574118 · Cited by 74 · see citing works
CNS-Draining Meningeal Lymphatic Vasculature: Roles, Conundrums and Future Challenges
das Neves, S. P., Delivanoglou, N., & Mesquita, S. D. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.655052 · Cited by 70 · see citing works
Campbell, G., Lieberman, A. R., Anderson, P. N., & Turmaine, M. (1992) · Journal of Neurocytology · doi:10.1007/bf01237903 · Cited by 72 · see citing works
Kandere‐Grzybowska, K., Gheorghe, D., Priller, J., Esposito, P., Huang, M., Gerard, N. P., & Theoharides, T. C. (2003) · Brain Research · doi:10.1016/s0006-8993(03)02975-5 · Cited by 70 · see citing works
Lambert, G. A., Goadsby, P. J., Zagami, A. S., & Duckworth, J. W. (1988) · Brain Research · doi:10.1016/0006-8993(88)90152-7 · Cited by 69 · see citing works
Zenker, W., Bankoul, S., & Braun, J. (1994) · Anatomy and Embryology · doi:10.1007/bf00239012 · Cited by 68 · see citing works
Innervation of the Cerebral Dura Mater
Lv, X., Wu, Z., & Li, Y. (2014) · The Neuroradiology Journal · doi:10.15274/nrj-2014-10052 · Cited by 66 · see citing works
Efferent and afferent innervation of primate trabecular meshwork and scleral spur.
Selbach, J. M., Gottanka, J., Wittmann, M., & Lütjen-Drecoll, E. (2000) · PubMed · Cited by 63 · see citing works
Nerve endings with structural characteristics of mechanoreceptors in the human scleral spur
Tamm, E. R., Flügel, C., Stefani, F. H., & Lütjen-Drecoll, E. (1994) · PubMed · doi:10.5283/epub.26889 · Cited by 62 · see citing works
Fricke, B., Andres, K. H., & von Düring, M. (2001) · Microscopy Research and Technique · doi:10.1002/jemt.1074 · Cited by 61 · see citing works
Self-citationMeßlinger, K. (1996) · Progress in brain research · doi:10.1016/s0079-6123(08)61094-8 · Cited by 58 · see citing works
Lambert, G. A., Lowy, A. J., Boers, P. M., Angus‐Leppan, H., & Zagami, A. S. (1992) · Brain Research · doi:10.1016/0006-8993(92)91489-2 · Cited by 57 · see citing works
TRP Channels in the Focus of Trigeminal Nociceptor Sensitization Contributing to Primary Headaches
Dux, M., Rosta, J., & Meßlinger, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21010342 · Cited by 56 · see citing works
Davis, K. D., & Dostrovsky, J. O. (1988) · Brain Research · doi:10.1016/0006-8993(88)90806-2 · Cited by 55 · see citing works
Dahlmann-Noor, A. H., & von Düring, M. (1995) · Cell and Tissue Research · doi:10.1007/bf00319118 · Cited by 55 · see citing works
Self-citationNeuropeptide Y- and substance P-like immunoreactive nerve fibers in the rat dura mater encephali
During, M. J., Bauersachs, M., Böhmer, B., Veh, R. W., & Andres, K. H. (1990) · Anatomy and Embryology · doi:10.1007/bf02433496 · Cited by 54 · see citing works
Self-citation
- Authors
- Andres, K. H., D�ring, M., Muszynski, K., & Schmidt, R. F.
- Affiliations
- Ruhr University Bochum (DE)
- University of Würzburg (DE)
- ORCID
- Schmidt, R. F.
- Venue
- Anatomy and Embryology
- Published
- 1987-01
- Volume
- 175
- Issue
- 3
- Pages
- 289-301
- ISSN
- 0340-2061 (ISSN-L)
- 1432-0568
- OpenAlex
- W1989513441
- Cited by
- 289
- References
- 34
- Citations by year
- 2026: 3 · 2025: 11 · 2024: 11 · 2023: 12 · 2022: 20 · 2021: 17 · 2020: 8 · 2019: 11 · 2018: 17 · 2017: 18 · 2016: 15 · 2015: 8 · 2014: 3 · 2013: 4 · 2012: 5
- FWCI
- 7.22
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Anatomy and Embryology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Sensory Systems › Ion Channels and Receptors
- Keywords
- nerve fibers, C-fibers, trigeminal nerve, lymphatic vessels, cribriform plate, perineural sheath, Schwann cells, postcapillary venules
- MeSH terms
- Animals, Axons, Blood Vessels, Brain, Connective Tissue, Dura Mater, Lymphatic System, Nerve Endings, Nerve Fibers, Nerve Fibers, Myelinated, Rats, Inbred Strains, Venules, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
