Influence of fish oil supplementation on the minimal erythema dose in humans
Abstract
A previous study using the hairless mouse model demonstrated that diets containing a fish-oil lipid source, which contained high levels of omega-3 fatty acids, markedly increased the minimum erythema dose (MED) when compared with diets containing other polyunsaturated fatty acids. To determine whether fish oil supplementation could produce a similar effect in humans, 20 subjects were randomized into two groups, a placebo group and a group receiving fish-oil supplements over a 4-week period. Results showed a small, but statistically significant, increase in MED in patients whose diet was supplemented with fish oil. Cholesterol and prostaglandin E2 levels were unchanged, while triglyceride levels were significantly decreased in the fish oil group. No significant changes in any of these parameters occurred in the placebo group.
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Fish oil supplementation containing eicosapentaenoic acid and docosahexaenoic acid increases minimal erythema dose significantly and decreases erythema and p53 induction in human skin.
“Research suggests that fish oil supplementation (containing eicosapentaenoic acid and docosahexaenoic acid) increases minimal erythema dose significantly and decreases erythema and p53 induction in human skin [132].”
From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [132]
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- Authors
- Orengo, I. F., Black, H. S., & Wolf, J. E.
- Affiliations
- Baylor College of Medicine (US)
- Venue
- Archives of Dermatological Research
- Published
- 1992-08
- Volume
- 284
- Issue
- 4
- Pages
- 219-221
- ISSN
- 0003-9187 (ISSN-L)
- 0340-3696
- 1432-069X
- OpenAlex
- W2042859095
- Cited by
- 66
- References
- 23
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2018: 4 · 2017: 2 · 2016: 2 · 2015: 1 · 2014: 2 · 2013: 5 · 2012: 2
- FWCI
- 0.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Archives of Dermatological Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
- Keywords
- fish oil supplementation, omega-3 fatty acids, minimal erythema dose, sun sensitivity, photoprotection, triglycerides, prostaglandin E2, cholesterol, polyunsaturated fatty acids, dietary supplementation
- MeSH terms
- Adult, Erythema, Female, Fish Oils, Humans, Male, Middle Aged, Ultraviolet Rays, Fatty Acids, Omega-3
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