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Cited by 122Fatty Acid Research and HealthSkin Protection and AgingAntioxidant Activity and Oxidative Stress

The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.

Dietary Fish-Oil Supplementation in Humans Reduces UVB-Erythemal Sensitivity but Increases Epidermal Lipid Peroxidation

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Rhodes, Lesley E, Friedmann, Peter S, O'Farrell, Sheryl, Jackson, Malcolm J·1994·Journal of Investigative Dermatology
DOI 10.1111/1523-1747.ep12392604
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Abstract

Ultraviolet radiation (UVR)-induced erythema may be mediated in part by free radical-generated tissue damage, including lipid peroxidation. We have examined the effect of dietary fish oil rich in omega-3 fatty acids upon susceptibility to UVB-induced erythema and epidermal lipid peroxidation. Fifteen volunteers took 10 g fish oil, containing 18% eicosapentaenoic acid and 12% docosahexaenoic acid, daily for 3 or 6 months. Sensitivity to UVB was assessed at intervals on fish oil, and 2.5 months after stopping treatment. Paired skin shave biopsies were taken from six subjects, at baseline and 3 months, from both irradiated and control skin. Fatty acid composition was analyzed and thiobarbituric acid-reactive substances measured as an index of lipid peroxidation. With increasing time on fish oil the minimal erythema dose rose progressively, from 18.9 +/- 13.9 mJ/cm2 (mean +/- SD) at baseline to 41.1 +/- 16.6 mJ/cm2 at 6 months, p < 0.01. Ten weeks after stopping fish oil the minimal erythema dose fell to 23.1 +/- 4.9 mJ/cm2, p < 0.05. Epidermal total omega-3 fatty acids rose from 1.8 +/- 0.4% total fatty acids (mean +/- SEM) to 24.2 +/- 3.9% at 3 months, p < 0.01. This was accompanied by a rise in thiobarbituric acid-reactive substances in irradiated skin from 6 +/- 0.3 (mean +/- SEM) to 18.5 +/- 2.6 A532/g skin, p < 0.01. Hence dietary omega-3 fatty acids produce a pronounced reduction in UVB-erythemal sensitivity, although susceptibility of skin to lipid peroxidation is increased. Thus, omega-3 fatty acids may act as an oxidizable buffer, protecting more vital structures from free radical damage.

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Crossref · 10.1111/1523-1747.ep12392604

Cites

32 of 32 references verified0 citation errors · 0 not checkable

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  • Although fish oil intake reduces UV-induced damage, lipid peroxidation of skin increases due to the unstable nature of n-3 fatty acids.

    “Although fish oil intake reduces UV-induced damage, the lipid peroxidation of skin increases due to the unstable nature of n-3 fatty acids [133].”

    From Boosting the Photoaged Skin: The Potential Role of Dietary Components (2021) · cites this paper as [133]

  • Fish oils have a protective role and can reduce the severity of erythema.

    “There are studies indicating that fish oils have a protective role and can reduce the severity of erythema.”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [186]

  • In a study with a group of 15 people given fish oil containing 1.8 g of EPA and 1.2 g of DHA, a marked reduction in UVB-erythemal sensitivity was observed after six months of supplementation.

    “Rhodes et al., in a study with a group of 15 people given fish oil containing 1.8 g of EPA and 1.2 g of DHA, observed a marked reduction in UVB-erythemal sensitivity after six months of supplementation [186].”

    From Bioactive Compounds for Skin Health: A Review (2021) · cites this paper as [186]

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Research works printed but not linked: 1

  1. Ziboh, 1986, Effects of dietary supplementation of fish oil on neutrophil and epidermal fatty acids, Arch Dermatol, 122, 1277, 10.1001/archderm.1986.01660230069013 · DOI

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Metadata

Authors
Rhodes, L. E., Friedmann, P. S., O'Farrell, S., & Jackson, M. J.
Affiliations
  • Royal Liverpool University Hospital (GB)
  • University of Liverpool (GB)
ORCID
Venue
Journal of Investigative Dermatology
Publisher
Elsevier BV
Published
1994-08
Volume
103
Issue
2
Pages
151-154
ISSN
0022-202X (ISSN-L)
DOI
10.1111/1523-1747.ep12392604
OpenAlex
W2024660458
Cited by
122
References
32
Citations by year
2025: 1 · 2023: 1 · 2022: 2 · 2021: 4 · 2020: 3 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 11 · 2012: 4
FWCI
0.89
Type
journal article
Language
en
Open access
Licence
Locations
  • Journal of Investigative Dermatology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
  • Health Sciences › Medicine › Dermatology › Skin Protection and Aging
  • Health Sciences › Medicine › Biochemistry (medical) › Antioxidant Activity and Oxidative Stress
Keywords
fish oil supplementation, omega-3 fatty acids, minimal erythema dose, eicosapentaenoic acid, docosahexaenoic acid, TBARS, oxidative damage, ultraviolet radiation
MeSH terms
Adolescent, Adult, Aged, Dietary Fats, Unsaturated, Erythema, Female, Fish Oils, Humans, Lipid Peroxides, Middle Aged, Skin, Ultraviolet Rays, Fatty Acids, Omega-3

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