METABOLIC COMPLICATIONS OF OBESITY
Abstract
Given a specific research interest in human fatty acid metabolism, this article focuses primarily on the evidence surrounding the hypothesis that dysregulation of the fuel release function of fat cells (lipolysis) is an important contributing factor to the health hazards of obesity.
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Numerous metabolic pathways in adipose tissue, like induction and discouragement of adipokines, are controlled by circadian rhythm that is partly regulated by melatonin, which may act on WAT through MT1 and MT2 or using the sympathetic nervous system.
“Numerous metabolic pathways in adipose tissue, like the induction and discouragement of adipokines, are controlled by circadian rhythm that is partly regulated by melatonin, which may act on WAT through MT1 and MT2 or using the sympathetic nervous system. 3,11,12”
Cites
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Effect of fatty acids on glucose production and utilization in man.
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Self-citationImpaired Insulin-Mediated Skeletal Muscle Blood Flow in Patients With NIDDM
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Effective exercise modality to reduce insulin resistance in women with type 2 diabetes
Cuff, D. J., Meneilly, G. S., Martin, A., Ignaszewski, A., Tildesley, H. D., & Frohlich, J. J. (2003) · Diabetes Care · doi:10.2337/diacare.26.11.2977 · Cited by 545 · see citing works
Mesri Alamdari, N., Namazi Shabestari, A., Najafipour, F., & Mirmazhari, A. (2024) · Biomedicine Advances · doi:10.34172/bma.05 · Cited by 4 · see citing works
“3,11,12 18-20 The aims of this study are the evaluation of melatonin’s effect on the glycemic variables, adipokines level mediated in the regulation of energy, lipid profiles, and anthropometric indices of obese women Melatonin supplementation improves glycemic hemostasis, lipid profile, and…”
- Authors
- Sheehan, M. T., & Jensen, M. D.
- Affiliations
- Mayo Clinic (US)
- Venue
- Medical Clinics of North America
- Publisher
- Elsevier BV
- Published
- 2000-03
- Volume
- 84
- Issue
- 2
- Pages
- 363-385
- ISSN
- 0025-7125 (ISSN-L)
- OpenAlex
- W135102428
- Cited by
- 68
- References
- 13
- Citations by year
- 2026: 1 · 2024: 2 · 2021: 2 · 2020: 2 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 4 · 2014: 4 · 2012: 7
- FWCI
- 1.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Medical Clinics of North America (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (DK 40484, P30DK050456, DK 45343, DK50456, R01DK045343)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- obesity, metabolic syndrome, insulin resistance, type 2 diabetes, visceral fat, waist circumference, waist-to-hip ratio, dyslipidemia, hypertension, cardiovascular disease, hyperinsulinemia, liver function, adipokines, adiponectin, leptin, adiponectin/leptin ratio, adipose tissue
- MeSH terms
- Adipose Tissue, Diabetes Mellitus, Type 2, Fatty Acids, Humans, Hyperlipidemias, Hypertension, Insulin Resistance, Lipolysis, Obesity, Syndrome
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