Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus
Open accessAbstract
The endothelium plays a pivotal role in modulating the reactivity of vascular smooth muscle through the formation of several vasoactive substances. We examined the effects of endothelium-dependent and independent vasodilators on forearm blood flow in 29 patients with Type 2 (non-insulin-dependent) diabetes mellitus and in 21 control subjects, using venous occlusion plethysmography. Via a brachial artery cannula, increasing amounts of acetylcholine and glyceryl trinitrate were infused in doses of 60, 120, 180 and 240 mmol per min and 3, 6 and 9 nmol per min respectively. NG monomethyl-L-arginine, a stereospecific inhibitor of endothelium derived relaxing factor, was infused to inhibit basal and stimulated release of this dilator substance. Reactive hyperaemic forearm blood flow did not differ between groups. Forearm blood flow responses to each dose of acetylcholine were significantly greater in control than diabetic subjects (p less than 0.01 for all doses). NG monomethyl-L-arginine attenuated forearm blood flow from maximal stimulated values when responses were compared with the natural decline to acetylcholine in forearm flow in both control and diabetic subjects (p less than 0.05 for both groups), but had no effect on basal blood flow responses. Forearm blood flow responses to each dose of glyceryl trinitrate were significantly greater in control than diabetic subjects (p less than 0.05 for all). These data provide evidence for endothelial and smooth muscle dysfunction in diabetes which may have important therapeutic implications.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Abnormalities in endothelium-dependent vascular responses have been found among patients with type 2 diabetes mellitus.
“Abnormalities in endothelium-dependent vascular responses, perhaps the earliest demonstrable alteration in vascular health, have been found among patients with type 2 DM (2,3).”
From Improved Endothelial Function With Metformin in Type 2 Diabetes Mellitus (2001) · cites this paper as [2]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Furchgott, R. F., & Zawadzki, J. V. (1980) · Nature · doi:10.1038/288373a0 · Cited by 12,064 · see citing works
Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704 · see citing works
Vascular endothelial cells synthesize nitric oxide from L-arginine
Palmer, R. M. J., Ashton, D., & Moncada, S. (1988) · Nature · doi:10.1038/333664a0 · Cited by 4,745 · see citing works
Abnormal Endothelium-Dependent Vascular Relaxation in Patients with Essential Hypertension
Panza, J. A., Quyyumi, A. A., Brush, J. E., & Epstein, S. E. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007053230105 · Cited by 2,366 · see citing works
Regulatory Functions of the Vascular Endothelium
Epstein, F. H., Vane, J. R., Änggård, E., & Botting, R. M. (1990) · New England Journal of Medicine · doi:10.1056/nejm199007053230106 · Cited by 1,870 · see citing works
Role of endothelium-derived nitric oxide in the regulation of blood pressure.
Rees, D. D., Palmer, R. M. J., & Moncada, S. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.9.3375 · Cited by 1,827 · see citing works
Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man
Vallance, P., Collier, J., & Moncada, S. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91013-1 · Cited by 1,590 · see citing works
The measurement of volume changes in human limbs
Whitney, R. J. (1953) · The Journal of Physiology · doi:10.1113/jphysiol.1953.sp004926 · Cited by 1,496 · see citing works
Bucala, R., Tracey, K. J., & Cerami, A. (1991) · Journal of Clinical Investigation · doi:10.1172/jci115014 · Cited by 1,162 · see citing works
Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans.
Creager, M. A., Cooke, J. P., Mendelsohn, M. E., Gallagher, S. J., Coleman, S. M., Loscalzo, J., & Dzau, V. J. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114688 · Cited by 1,017 · see citing works
Myers, P. R., Minor, R. L., Guerra, R., Bates, J. N., & Harrison, D. G. (1990) · Nature · doi:10.1038/345161a0 · Cited by 973 · see citing works
Ignarro, L. J. (1989) · Circulation Research · doi:10.1161/01.res.65.1.1 · Cited by 964 · see citing works
Yasue, H., Matsuyama, K., Matsuyama, K., Okumura, K., Morikami, Y., & Ogawa, H. (1990) · Circulation · doi:10.1161/01.cir.81.2.482 · Cited by 324 · see citing works
A rate nephelometer for measuring specific proteins by immunoprecipitin reactions.
Sternberg, J. (1977) · Clinical Chemistry · doi:10.1093/clinchem/23.8.1456 · Cited by 303 · see citing works
Diabetes as an atherogenic factor
Ruderman, N. B., & Haudenschild, C. C. (1984) · Progress in Cardiovascular Diseases · doi:10.1016/0033-0620(84)90011-2 · Cited by 282 · see citing works
Bloom, S. R., Till, S. J., Sonksen, P., & Smith, S. (1984) · BMJ · doi:10.1136/bmj.288.6433.1793 · Cited by 278 · see citing works
Cohen, R. A., Zitnay, K. M., Haudenschild, C. C., & Cunningham, L. (1988) · Circulation Research · doi:10.1161/01.res.63.5.903 · Cited by 262 · see citing works
FEATURES OF ENDOTHELIAL DYSFUNCTION IN EARLY DIABETIC NEPHROPATHY
Jensen, T. J., Feldt‐Rasmussen, B., Knudsen, J. B., & Deckert, T. (1989) · The Lancet · doi:10.1016/s0140-6736(89)91365-2 · Cited by 244 · see citing works
Reactive hyperaemia in the human forearm.
Gc, P., & Whelan, R. F. (1955) · PubMed · Cited by 167 · see citing works
Pathogenesis of Atherosclerosis in Diabetes Mellitus
Colwell, J. A., Lopes-Virella, M. F., & Halushka, P. V. (1981) · Diabetes Care · doi:10.2337/diacare.4.1.121 · Cited by 162 · see citing works
Potassium channel openers and vascular smooth muscle relaxation.
Edwards, G., & Weston, A. (1990) · Pharmacology and Therapeutics · doi:10.1016/0163-7258(90)90082-d · Cited by 160 · see citing works
Diabetes and Atherosclerosis: an Overview
Steiner, G. A. (1981) · Diabetes · doi:10.2337/diab.30.2.s1 · Cited by 141 · see citing works
Pathogenesis of Macrovascular Disease in the Human Diabetic
Ganda, O. P. (1980) · Diabetes · doi:10.2337/diab.29.11.931 · Cited by 140 · see citing works
O'Brien, I. A. D., OʼHARE, J. P., Lewin, I. G., & Corrall, R. J. M. (1986) · QJM · doi:10.1093/oxfordjournals.qjmed.a068054 · Cited by 110 · see citing works
Endothelium-derived relaxing factor
Griffith, T. M., LEWIS, M. J., Newby, A. C., & Henderson, A. H. (1988) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(88)90324-5 · Cited by 108 · see citing works
A review of the development of large-vessel disease in diabetes mellitus
Colwell, J. A., & Lopes-Virella, M. F. (1988) · The American Journal of Medicine · doi:10.1016/0002-9343(88)90403-2 · Cited by 69 · see citing works
Studies of Retinopathy: Methodology for Assessment and Classification with Fundus Photographs
Davis, M. D., Hubbard, L. D., Trautmann, J. C., Klein, R., & The Kroc Collaborative Study Group (1985) · Diabetes · doi:10.2337/diab.34.3.s42 · Cited by 47 · see citing works
Johns, R. A., Peach, M. J., Linden, J. M., & Tichotsky, A. (1990) · Circulation Research · doi:10.1161/01.res.67.4.979 · Cited by 46 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases
Pedersen, B. K., & Saltin, B. (2015) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/sms.12581 · Cited by 3,514 · see citing works
Steinberg, H. O., Chaker, H., Leaming, R., Johnson, A., Brechtel, G., & Baron, A. D. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118709 · Cited by 1,687 · see citing works
Creager, M. A., Lüscher, T. F., of, P. W. T. A., Cosentino, F., & Beckman, J. A. (2003) · Circulation · doi:10.1161/01.cir.0000091257.27563.32 · Cited by 1,654 · see citing works
Evidence for prescribing exercise as therapy in chronic disease
Pedersen, B. K., & Saltin, B. (2006) · Scandinavian Journal of Medicine & Science in Sports · doi:10.1111/j.1600-0838.2006.00520.x · Cited by 1,384 · see citing works
Ceriello, A., & Motz, E. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000122852.22604.78 · Cited by 1,378 · see citing works
Protein kinase C activation and the development of diabetic complications.
Koya, D., & King, G. L. (1998) · Diabetes · doi:10.2337/diabetes.47.6.859 · Cited by 1,316 · see citing works
Steinberg, H. O., Brechtel, G., Johnson, A., Fineberg, N. S., & Baron, A. (1994) · Journal of Clinical Investigation · doi:10.1172/jci117433 · Cited by 1,216 · see citing works
Endothelial dysfunction in diabetes
De Vriese, A. S., Verbeuren, T. J., Van de Voorde, J., Lameire, N. H., & Vanhoutte, P. M. (2000) · British Journal of Pharmacology · doi:10.1038/sj.bjp.0703393 · Cited by 1,165 · see citing works
Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus.
Johnstone, M. T., Creager, S. J., Scales, K. M., Cusco, J. A., Lee, B. K., & Creager, M. A. (1993) · Circulation · doi:10.1161/01.cir.88.6.2510 · Cited by 1,117 · see citing works
Effect of exercise training on endothelium‐derived nitric oxide function in humans
Green, D. J., Maiorana, A., O'Driscoll, G., & Taylor, R. (2004) · The Journal of Physiology · doi:10.1113/jphysiol.2004.068197 · Cited by 1,040 · see citing works
Impaired nitric oxide-mediated vasodilation in patients with non-insulin-dependent diabetes mellitus
Williams, S. B., Cusco, J. A., Roddy, M.-A., Johnstone, M. T., & Creager, M. A. (1996) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(95)00522-6 · Cited by 1,014 · see citing works
Activation of Protein Kinase C Isoforms and Its Impact on Diabetic Complications
Geraldes, P., & King, G. L. (2010) · Circulation Research · doi:10.1161/circresaha.110.217117 · Cited by 993 · see citing works
Cardiovascular Actions of Insulin
Muniyappa, R., Montagnani, M., Koh, K. K., & Quon, M. J. (2007) · Endocrine Reviews · doi:10.1210/er.2007-0006 · Cited by 873 · see citing works
Ting, H. H., Timimi, F. K., Boles, K., Creager, S. J., Ganz, P., & Creager, M. A. (1996) · Journal of Clinical Investigation · doi:10.1172/jci118394 · Cited by 869 · see citing works
Endothelial Function and Oxidative Stress in Cardiovascular Diseases
Higashi, Y., Noma, K., Yoshizumi, M., & Kihara, Y. (2009) · Circulation Journal · doi:10.1253/circj.cj-08-1102 · Cited by 796 · see citing works
Acute Hyperglycemia Attenuates Endothelium-Dependent Vasodilation in Humans In Vivo
Williams, S. B., Goldfine, A. B., Timimi, F. K., Ting, H. H., Roddy, M.-A., Simonson, D. C., & Creager, M. A. (1998) · Circulation · doi:10.1161/01.cir.97.17.1695 · Cited by 793 · see citing works
Ceriello, A. (2003) · Diabetes Care · doi:10.2337/diacare.26.5.1589 · Cited by 734 · see citing works
Kolluru, G. K., Bir, S. C., & Kevil, C. G. (2012) · International Journal of Vascular Medicine · doi:10.1155/2012/918267 · Cited by 729 · see citing works
Involvement of neutrophils in the pathogenesis of lethal myocardial reperfusion injury
Vinten-Johansen, J. (2003) · Cardiovascular Research · doi:10.1016/j.cardiores.2003.10.011 · Cited by 676 · see citing works
Diabetes and Endothelial Dysfunction: A Clinical Perspective
Calles-Escandón, J., & Cipolla, M. J. (2001) · Endocrine Reviews · doi:10.1210/edrv.22.1.0417 · Cited by 657 · see citing works
Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implications
Tabit, C. E., Chung, W. B., Hamburg, N. M., & Vita, J. A. (2010) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-010-9134-4 · Cited by 584 · see citing works
The role of nitric oxide in cardiovascular diseases
NASEEM, K. (2005) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2004.09.003 · Cited by 557 · see citing works
Acute vascular effects of estrogen in postmenopausal women.
Gilligan, D. M., Badar, D. M., Panza, J. A., Quyyumi, A. A., & Cannon, R. O. (1994) · Circulation · doi:10.1161/01.cir.90.2.786 · Cited by 554 · see citing works
Exercise Training for Claudication
Stewart, K. J., Hiatt, W. R., Regensteiner, J. G., & Hirsch, A. T. (2002) · New England Journal of Medicine · doi:10.1056/nejmra021135 · Cited by 536 · see citing works
Improved analysis of brachial artery ultrasound using a novel edge-detection software system
Woodman, R. J., Playford, D. A., Watts, G. F., Cheetham, C., Reed, C., Taylor, R. R., Puddey, I. B., Beilin, L. J., Burke, V., Mori, T. A., et al. (2001) · Journal of Applied Physiology · doi:10.1152/jappl.2001.91.2.929 · Cited by 529 · see citing works
Improved Endothelial Function With Metformin in Type 2 Diabetes Mellitus
Mather, K. J., Verma, S., & Anderson, T. J. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01129-9 · Cited by 513 · see citing works
Visceral Obesity: A “Civilization Syndrome”
Björntorp, P. (1993) · Obesity Research · doi:10.1002/j.1550-8528.1993.tb00614.x · Cited by 483 · see citing works
Mechanisms of Disease: endothelial dysfunction in insulin resistance and diabetes
Rask‐Madsen, C., & King, G. L. (2006) · Nature Clinical Practice Endocrinology & Metabolism · doi:10.1038/ncpendmet0366 · Cited by 483 · see citing works
Maiorana, A., O’Driscoll, G., Cheetham, C., Dembo, L. G., Stanton, K. G., Goodman, C., Taylor, R. R., & GREEN, D. J. (2001) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(01)01439-5 · Cited by 481 · see citing works
Allopurinol Normalizes Endothelial Dysfunction in Type 2 Diabetics With Mild Hypertension
Butler, R., Morris, A. D., Belch, J. J. F., Hill, A., & Struthers, A. D. (2000) · Hypertension · doi:10.1161/01.hyp.35.3.746 · Cited by 463 · see citing works
Erectile Dysfunction in Diabetes Mellitus
Malavige, L. S., & Lévy, J. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.01168.x · Cited by 444 · see citing works
Endothelial dysfunction and pathogenesis of diabetic angiopathy
Stehouwer, C. D. A. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00272-6 · Cited by 441 · see citing works
Balletshofer, B. M., Rittig, K., Enderle, M. D., Volk, A., Maerker, E., Jacob, S., Matthaei, S., Kristian, R. E. T. T., & Häring, H. U. (2000) · Circulation · doi:10.1161/01.cir.101.15.1780 · Cited by 437 · see citing works
Alexander, M. Y., Osto, E., Schmidt‐Trucksäss, A., Shechter, M., Trifunović, D., Duncker, D. J., Aboyans, V., Bäck, M., Badimón, L., Cosentino, F., et al. (2020) · Cardiovascular Research · doi:10.1093/cvr/cvaa085 · Cited by 401 · see citing works
Exercise and the Nitric Oxide Vasodilator System
Maiorana, A., Driscoll, G. O., Taylor, R. R., & GREEN, D. J. (2003) · Sports Medicine · doi:10.2165/00007256-200333140-00001 · Cited by 382 · see citing works
Free fatty acid elevation impairs insulin-mediated vasodilation and nitric oxide production.
Steinberg, H. O., Paradisi, G., Brechtel, G., Crowder, K., Cronin, J., & Baron, A. (2000) · Diabetes · doi:10.2337/diabetes.49.7.1231 · Cited by 380 · see citing works
Diabetes mellitus, hypertension, and cardiovascular disease: Which role for oxidative stress?
Giugliano, D., Ceriello, A., & Paolisso, G. (1995) · Metabolism · doi:10.1016/0026-0495(95)90167-1 · Cited by 369 · see citing works
Photoplethysmographic assessment of pulse wave reflection
Chowienczyk, P., Kelly, R. P., MacCallum, H., Millasseau, S., Andersson, T. L. G., Gosling, R. G., Ritter, J. M., & Änggård, E. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00441-6 · Cited by 363 · see citing works
Review of Alterations in Endothelial Nitric Oxide Production in Diabetes
Pieper, G. M. (1998) · Hypertension · doi:10.1161/01.hyp.31.5.1047 · Cited by 353 · see citing works
Molecular Insights and Therapeutic Targets for Diabetic Endothelial Dysfunction
Xu, J., & Zou, M. (2009) · Circulation · doi:10.1161/circulationaha.108.835223 · Cited by 348 · see citing works
Hamdy, O., Ledbury, S., Mullooly, C., Jarema, C., Porter, S., Ovalle, K., Moussa, A., Caselli, A., Caballero, A. E., Economides, P. A., et al. (2003) · Diabetes Care · doi:10.2337/diacare.26.7.2119 · Cited by 335 · see citing works
Blood Letting in High-Ferritin Type 2 Diabetes
Fernández‐Real, J. M., Peñarroja, G., Castro, A., Garcia-Bragado, F., Hernández‐Aguado, I., & Ricart, W. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1000 · Cited by 333 · see citing works
Ascorbate Restores Endothelium-Dependent Vasodilation Impaired by Acute Hyperglycemia in Humans
Beckman, J. A., Goldfine, A. B., Gordon, M. B., & Creager, M. A. (2001) · Circulation · doi:10.1161/01.cir.103.12.1618 · Cited by 314 · see citing works
Endothelial dysfunction: Clinical implications
Drexler, H. (1997) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(97)80030-8 · Cited by 291 · see citing works
The role of nitric oxide and other endothelium-derived vasoactive substances in vascular disease
Cohen, R. A. (1995) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(05)80002-7 · Cited by 284 · see citing works
HOCKING, S. L., Samocha‐Bonet, D., Milner, K., Greenfield, J. R., & Chisholm, D. J. (2013) · Endocrine Reviews · doi:10.1210/er.2012-1041 · Cited by 281 · see citing works
Beckman, J. A., Goldfine, A. B., Gordon, M. B., Garrett, L. A., & Creager, M. A. (2002) · Circulation Research · doi:10.1161/hh0102.102359 · Cited by 276 · see citing works
Ishii, H., Koya, D., & King, G. L. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050187 · Cited by 274 · see citing works
Overweight Women with Polycystic Ovary Syndrome Have Evidence of Subclinical Cardiovascular Disease
Meyer, C., McGrath, B. P., & Teede, H. J. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0011 · Cited by 273 · see citing works
Role of endothelial dysfunction in insulin resistance
Hsueh, W. A., & Quiñones, M. J. (2003) · The American Journal of Cardiology · doi:10.1016/s0002-9149(03)00611-8 · Cited by 271 · see citing works
Morris, S. J., Shore, A. C., & Tooke, J. E. (1995) · Diabetologia · doi:10.1007/bf00401767 · Cited by 269 · see citing works
Endothelial dysfunction and hypertension in aging
Higashi, Y., Kihara, Y., & Noma, K. (2012) · Hypertension Research · doi:10.1038/hr.2012.138 · Cited by 265 · see citing works
Antioxidants, diabetes and endothelial dysfunction
Laight, D. W. (2000) · Cardiovascular Research · doi:10.1016/s0008-6363(00)00054-7 · Cited by 264 · see citing works
Microvascular Function Relates to Insulin Sensitivity and Blood Pressure in Normal Subjects
Serné, E. H., Stehouwer, C. D. A., ter Maaten, J. C., ter Wee, P. M., Rauwerda, H., Donker, A. J. M., & Gans, R. O. B. (1999) · Circulation · doi:10.1161/01.cir.99.7.896 · Cited by 261 · see citing works
Exercise Training and the Cardiovascular Consequences of Type 2 Diabetes and Hypertension
Stewart, K. J. (2002) · JAMA · doi:10.1001/jama.288.13.1622 · Cited by 257 · see citing works
Timimi, F. K., Ting, H. H., Haley, E. A., Roddy, M.-A., Ganz, P., & Creager, M. A. (1998) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(97)00536-6 · Cited by 254 · see citing works
Camici, G. G., Schiavoni, M., Francia, P., Bachschmid, M., Martin-Padura, I., Hersberger, M., Tanner, F. C., Pelicci, P., Volpe, M., Anversa, P., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0609656104 · Cited by 249 · see citing works
l-Citrulline Supplementation: Impact on Cardiometabolic Health
Allerton, T. D., Proctor, D. N., Stephens, J. M., Dugas, T. R., Spielmann, G., & Irving, B. A. (2018) · Nutrients · doi:10.3390/nu10070921 · Cited by 235 · see citing works
Insulin resistance and the endothelium
Hsueh, W. A., Lyon, C. J., & Quiñones, M. J. (2004) · The American Journal of Medicine · doi:10.1016/j.amjmed.2004.02.042 · Cited by 234 · see citing works
Evaluation of the microcirculation in vascular disease
Abularrage, C. J., Sidawy, A. N., Aidinian, G., Singh, N. N., Weiswasser, J. M., & Arora, S. (2005) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2005.05.019 · Cited by 233 · see citing works
Zimmet, P., Boyko, E. J., Collier, G. R., & de Courten, M. (1999) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1999.tb07783.x · Cited by 233 · see citing works
Ocular blood flow and associated functional deviations in diabetic retinopathy
Schmetterer, L. F., & Wolzt, M. (1999) · Diabetologia · doi:10.1007/s001250051171 · Cited by 230 · see citing works
Mather, K. J., Mirzamohammadi, B., Lteif, A. A., Steinberg, H. O., & Baron, A. (2002) · Diabetes · doi:10.2337/diabetes.51.12.3517 · Cited by 229 · see citing works
Pistrosch, F., Passauer, J., Fischer, S., Fuecker, K., Hanefeld, M., & Gross, P. A. (2004) · Diabetes Care · doi:10.2337/diacare.27.2.484 · Cited by 225 · see citing works
Cameron, N. E., & Cotter, M. A. (1994) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610100302 · Cited by 224 · see citing works
Cellular and molecular mechanisms of endothelial dysfunction in diabetes
Roberts, A., & Porter, K. E. (2013) · Diabetes and Vascular Disease Research · doi:10.1177/1479164113500680 · Cited by 223 · see citing works
Pieper, G. M. (1997) · Journal of Cardiovascular Pharmacology · doi:10.1097/00005344-199701000-00002 · Cited by 222 · see citing works
Role of Nitric Oxide in the Control of Ocular Blood Flow
Schmetterer, L. F. (2001) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(01)00014-3 · Cited by 218 · see citing works
Caloric restriction alone and with exercise improves CVD risk in healthy non-obese individuals
Lefevre, M., Redman, L. M., Heilbronn, L. K., Smith, J. V., Martin, C. K., Rood, J. C., Greenway, F. L., Williamson, D. A., Smith, S. R., & Ravussin, E. (2009) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2008.05.036 · Cited by 217 · see citing works
Endothelial Dysfunction and Diabetic Cardiomyopathy
Wang, M., Li, Y., Li, S., & Lv, J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.851941 · Cited by 217 · see citing works
O’Driscoll, G., GREEN, D. J., Rankin, J., Stanton, K., & Taylor, R. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119580 · Cited by 217 · see citing works
Advanced glycosylation end products in diabetic renal and vascular disease
Bucala, R., & Vlassara, H. (1995) · American Journal of Kidney Diseases · doi:10.1016/0272-6386(95)90051-9 · Cited by 212 · see citing works
Effects of exercise training on vascular function in obese children
Watts, K., Beye, P., Siafarikas, A., O’Driscoll, G., Jones, T. W., Davis, E. A., & GREEN, D. J. (2004) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2004.02.027 · Cited by 211 · see citing works
Vascular factors in diabetic neuropathy
Tesfaye, S. H., Malik, R. A., & Ward, J. D. (1994) · Diabetologia · doi:10.1007/bf00400938 · Cited by 210 · see citing works
Advanced Glycation End-products and Atherosclerosis
Vlassara, H. (1996) · Annals of Medicine · doi:10.3109/07853899608999102 · Cited by 209 · see citing works
Tan, K. C. B., Chow, W.-S., Tam, S., Ai, V. H. G., Lam, C. H. L., & Lam, K. S. L. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.2.8249 · Cited by 202 · see citing works
Natali, A., Toschi, E., Baldeweg, S. E., Ciociaro, D., Favilla, S., Saccà, L., & Ferrannini, E. (2006) · Diabetes · doi:10.2337/diabetes.55.04.06.db05-1076 · Cited by 198 · see citing works
Bauer, T. A., Reusch, J. E. B., Levi, M., & Regensteiner, J. G. (2007) · Diabetes Care · doi:10.2337/dc07-0843 · Cited by 198 · see citing works
Woodman, R. J., Mori, T. A., Burke, V., Puddey, I. B., Barden, A. E., Watts, G. F., & Beilin, L. J. (2002) · Atherosclerosis · doi:10.1016/s0021-9150(02)00307-6 · Cited by 198 · see citing works
Insulin Resistance in Adolescents with Type 2 Diabetes Is Associated with Impaired Exercise Capacity
Nadeau, K. J., Zeitler, P. S., Bauer, T. A., Brown, M. S., Dorosz, J. L., Draznin, B., Reusch, J. E. B., & Regensteiner, J. G. (2009) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-2844 · Cited by 196 · see citing works
Impairment of vascular endothelial nitric oxide synthase activity by advanced glycation end products
Biao, X., Chibber, R., Ruggiero, D., Kohner, E., Ritter, J., & Ferro, A. (2003) · The FASEB Journal · doi:10.1096/fj.02-0490fje · Cited by 195 · see citing works
Pathophysiological Association between Diabetes Mellitus and Endothelial Dysfunction
Maruhashi, T., & Higashi, Y. (2021) · Antioxidants · doi:10.3390/antiox10081306 · Cited by 194 · see citing works
Advances in the pharmacological activities and mechanisms of diosgenin
Chen, Y., Tang, Y., Yu, S., Han, Y., Kou, J., Liu, B., & Yu, B. (2015) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(15)30053-4 · Cited by 192 · see citing works
McVeigh, G. E., Brennan, G., Johnston, G. D., McDermott, B. J., McGrath, L. T., Henry, W. R., Andrews, J. W., & Hayes, J. R. (1993) · Diabetologia · doi:10.1007/bf00399090 · Cited by 192 · see citing works
Self-citationBrocq, M. L. L., Leslie, S. J., Milliken, P. H., & Megson, I. L. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.2013 · Cited by 190 · see citing works
Henry, R. M. A., Ferreira, I., Kostense, P. J., Dekker, J. M., Nijpels, G., Heine, R. J., Kamp, O., Bouter, L. M., & Stehouwer, C. D. A. (2004) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.01.002 · Cited by 186 · see citing works
Ždychová, J., & Komers, R. (2005) · Physiological Research · doi:10.33549/physiolres.930582 · Cited by 184 · see citing works
eNOS phosphorylation in health and disease
Kolluru, G. K., Siamwala, J. H., & Chatterjee, S. (2010) · Biochimie · doi:10.1016/j.biochi.2010.03.020 · Cited by 183 · see citing works
Vascular endothelial dysfunction
DEMEYER, G., & HERMAN, A. (1997) · Progress in Cardiovascular Diseases · doi:10.1016/s0033-0620(97)80031-x · Cited by 180 · see citing works
Diabetic-induced endothelial dysfunction in rat aorta: role of hydroxyl radicals
Pieper, G. M., Langenstroer, P., & Siebeneich, W. (1997) · Cardiovascular Research · doi:10.1016/s0008-6363(96)00237-4 · Cited by 179 · see citing works
Metformin administration improves endothelial function in women with polycystic ovary syndrome
Diamanti‐Kandarakis, E., Alexandraki, K., Protogerou, A. D., Piperi, C., Papamichael, C. M., Aessopos, A., Lekakis, J., & Mavrikakis, M. (2005) · European Journal of Endocrinology · doi:10.1530/eje.1.01910 · Cited by 179 · see citing works
GREEN, D. J., Walsh, J. H., Maiorana, A., Best, M. J., Taylor, R. R., & O'Driscoll, J. G. (2003) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00519.2003 · Cited by 178 · see citing works
Tack, C. J. J., Ong, M. K. E., Lutterman, J. A., & Smits, P. (1998) · Diabetologia · doi:10.1007/s001250050948 · Cited by 177 · see citing works
Endothelial dysfunction in metabolic syndrome: Prevalence, pathogenesis and management
Τζιόμαλος, Κ., Athyros, V. G., Karagiannis, A. I., & Mikhailidis, D. P. (2009) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2009.08.006 · Cited by 177 · see citing works
Potential Role of Increased Iron Stores in Diabetes
Wilson, J. G., Maher, J. F., Lindquist, J. H., Grambow, S. C., & Crook, E. D. (2003) · The American Journal of the Medical Sciences · doi:10.1097/00000441-200306000-00004 · Cited by 176 · see citing works
Platelet-Derived Nitric Oxide Signaling and Regulation
Gkaliagkousi, Ε., Ritter, J. M., & Ferro, A. (2007) · Circulation Research · doi:10.1161/circresaha.107.158410 · Cited by 175 · see citing works
Koska, J., Sands, M., Burciu, C., D’Souza, K. M., Raravikar, K., Liu, J., Truran, S., Franco, D. A., Schwartz, E. A., Schwenke, D. C., et al. (2015) · Diabetes · doi:10.2337/db14-0976 · Cited by 174 · see citing works
O’Driscoll, G., GREEN, D. J., Maiorana, A., Stanton, K. G., Colreavy, F. B., & Taylor, R. R. (1999) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(99)00065-0 · Cited by 173 · see citing works
Effects of antioxidants on nerve and vascular dysfunction in experimental diabetes
Cameron, N. E., & Cotter, M. A. (1999) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(99)00043-1 · Cited by 173 · see citing works
- Authors
- McVeigh, G. E., Brennan, G. M., Johnston, G. D., McDermott, B. J., McGrath, L. T., Henry, W. R., Andrews, J. W., & Hayes, J. R.
- Affiliations
- Queen's University Belfast (GB)
- Belfast City Hospital (GB)
- Venue
- Diabetologia
- Published
- 1992-08
- Volume
- 35
- Issue
- 8
- Pages
- 771-776
- ISSN
- 0012-186X (ISSN-L)
- 1432-0428
- OpenAlex
- W1484535674
- Cited by
- 916
- References
- 28
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 13 · 2022: 9 · 2021: 12 · 2020: 21 · 2019: 18 · 2018: 16 · 2017: 20 · 2016: 11 · 2015: 21 · 2014: 19 · 2013: 16 · 2012: 27
- FWCI
- 9.09
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Diabetologia (publishedVersion)
- PubMed (publishedVersion)
- Research Portal (Queen's University Belfast) (submittedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Disease Prevention
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- type 2 diabetes, endothelial dysfunction, vasodilation, acetylcholine, nitroglycerin, L-NMMA, endothelium-derived relaxing factor, forearm blood flow, reactive hyperemia, vascular smooth muscle dysfunction, nitric oxide
- MeSH terms
- Acetylcholine, Analysis of Variance, Arginine, Diabetes Mellitus, Type 2, Endothelium, Vascular, Female, Forearm, Nitroglycerin, Humans, Ischemia, Male, Middle Aged, Muscles, Reference Values, Regional Blood Flow, Vasodilation, omega-N-Methylarginine
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
