Cited by 176Iron Metabolism and DisordersHemoglobinopathies and Related DisordersTrace Elements in Health

Potential Role of Increased Iron Stores in Diabetes

Wilson, James G., Maher, Joseph F., Lindquist, Jennifer Hoff, Grambow, Steven C., Crook, Errol D.·2003·The American Journal of the Medical Sciences

Abstract

Diabetes mellitus (DM) is an important risk factor for the development of cardiovascular disease. Extensive clinical, epidemiologic, and basic studies suggest that excessive tissue iron stores may contribute to the occurrence and complications of DM. Secondary diabetes occurs in inherited pathologic iron overload syndromes of European- and African-derived populations and is an established complication of transfusional iron overload. Epidemiologic studies have repeatedly shown positive correlation between levels of serum ferritin and those of fasting glucose, insulin, and glycosylated hemoglobin. Iron reduction therapy in hereditary hemochromatosis and transfusional iron overload is associated with improved glucose tolerance and reduced incidence of secondary diabetes. Trials of iron reduction therapy in diabetes mellitus, although limited and inconclusive, have shown clinical improvement in some patients. The current article reviews evidence suggesting that tissue iron contributes to DM and its complications and presents preliminary data that emphasize the potential importance of iron overload in DM of African Americans.

Integrity signals

Registry

Crossref · 10.1097/00000441-200306000-00004

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62 of 62 references verified0 citation errors · 0 not checkable

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Authors
Wilson, J. G., Maher, J. F., Lindquist, J. H., Grambow, S. C., & Crook, E. D.
Affiliations
  • University of Mississippi Medical Center (US)
  • Durham VA Medical Center (US)
  • Duke Medical Center (US)
  • Wayne State University (US)
Corresponding author
Wilson, James G.
Venue
The American Journal of the Medical Sciences
Publisher
Elsevier BV
Published
2003-06
Volume
325
Issue
6
Pages
332-339
ISSN
0002-9629 (ISSN-L)
OpenAlex
W2015938505
Cited by
176
References
63
Citations by year
2025: 4 · 2024: 6 · 2023: 5 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 5 · 2018: 7 · 2017: 6 · 2016: 10 · 2015: 12 · 2014: 15 · 2013: 17 · 2012: 9
FWCI
4.31
Type
journal article
Language
en
Open access
closed
Locations
  • The American Journal of the Medical Sciences (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
  • Health Sciences › Medicine › Genetics › Hemoglobinopathies and Related Disorders
  • Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords
diabetes mellitus, iron overload, serum ferritin, hereditary hemochromatosis, transfusional iron overload, secondary diabetes, African Americans, cardiovascular risk, glucose tolerance, HbA1c
MeSH terms
Animals, Black or African American, Clinical Trials as Topic, Diabetes Mellitus, Humans, Iron, Iron Overload, White People

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