Vascular permeability factor (VPF, VEGF) in tumor biology

Inositol trisphosphate and calcium signalling

Berridge, M. J. (1993) · Nature · doi:10.1038/361315a0 · Cited by 6,545

Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis

Shweiki, D., Itin, A., Soffer, D., & Keshet, E. (1992) · Nature · doi:10.1038/359843a0 · Cited by 4,617

Tumors: Wounds That Do Not Heal

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Cell surface, heparin-like molecules are required for binding of basic fibroblast growth factor to its high affinity receptor

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How does the extracellular matrix direct gene expression?

Bissell, M. J., Hall, H. G., & Parry, G. (1982) · Journal of Theoretical Biology · doi:10.1016/0022-5193(82)90388-5 · Cited by 1,522

Dual regulation of vascular endothelial growth factor bioavailability by genetic and proteolytic mechanisms.

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Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing.

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Membrane-anchored and soluble forms of betaglycan, a polymorphic proteoglycan that binds transforming growth factor-beta.

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Angiogenic signaling pathways and anti-angiogenic therapy for cancer

Liu, Z.-L., Chen, H.-H., Zheng, L.-L., Sun, L.-P., & Shi, L. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01460-1 · Cited by 1,300

Increased Vascular Endothelial Growth Factor Levels in the Vitreous of Eyes With Proliferative Diabetic Retinopathy

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Vascular Permeability Factor/Vascular Endothelial Growth Factor and the Significance of Microvascular Hyperpermeability in Angiogenesis

Dvorak, H. F., Nagy, J. A., Feng, D., Brown, L. F., & Dvorak, A. M. (1999) · Current Topics in Microbiology and Immunology · doi:10.1007/978-3-642-59953-8_6 · Cited by 743

Randomized Double-Blind Placebo-Controlled Trial of Bevacizumab Therapy for Radiation Necrosis of the Central Nervous System

Levin, V. A., Bidaut, L., Hou, P., Kumar, A. J., Wefel, J. S., Bekele, B. N., Prabhu, S., Loghin, M., Gilbert, M. R., & Jackson, E. F. (2011) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/j.ijrobp.2009.12.061 · Cited by 729

Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis.

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Post-transcriptional Regulation of Vascular Endothelial Growth Factor by Hypoxia

Levy, A. P., Levy, N. S., & Goldberg, M. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.5.2746 · Cited by 629

Vascular endothelial growth factor (VEGF) induces remodeling and enhances TH2-mediated sensitization and inflammation in the lung

Lee, C. G., Link, H., Baluk, P., Homer, R. J., Chapoval, S., Bhandari, V., Kang, M. J., Cohn, L., Kim, Y. K., McDonald, D. M., et al. (2004) · Nature Medicine · doi:10.1038/nm1105 · Cited by 594

Translation of Vascular Endothelial Growth Factor mRNA by Internal Ribosome Entry: Implications for Translation under Hypoxia

Stein, I., Itin, A., Einat, P., Skaliter, R., Grossman, Z., & Keshet, E. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.6.3112 · Cited by 498

Prognostic Significance of Vascular Endothelial Growth Factor Protein in Node-Negative Breast Carcinoma

Gasparini, G., Bonoldi, E., Gatti, C., Vinante, O., Toi, M., Tominaga, T., Gion, M., Dittadi, R., Verderio, P., Boracchi, P., et al. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.2.139 · Cited by 494

Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis

Weis, S., Cui, J., Barnes, L., & Cheresh, D. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200408130 · Cited by 477

Vascular permeability factor/vascular endothelial growth factor:A multifunctional angiogenic cytokine

Brown, L. F., Detmar, M., Claffey, K., Nagy, J. A., Feng, D., Dvorak, A. M., & Dvorak, H. F. (1997) · Experientia Supplementum · doi:10.1007/978-3-0348-9006-9_10 · Cited by 472

Heterogeneity of the Angiogenic Response Induced in Different Normal Adult Tissues by Vascular Permeability Factor/Vascular Endothelial Growth Factor

Pettersson, A., Nagy, J. A., Brown, L. F., Sundberg, C., Morgan, E., Jungles, S., Carter, R., Krieger, J. E., Manseau, E. J., Harvey, V. S., et al. (2000) · Laboratory Investigation · doi:10.1038/labinvest.3780013 · Cited by 417

Physiological and pathological actions of sphingosine 1-phosphate

Hla, T. (2004) · Seminars in Cell & Developmental Biology · doi:10.1016/j.semcdb.2004.05.002 · Cited by 386

Vascular endothelial growth factor in the sera and effusions of patients with malignant and nonmalignant disease

Kraft, A., Weindel, K., Ochs, A., Marth, C., Zmija, J., Schumacher, P., Unger, C., Marm�, D., & Gastl, G. (1999) · Cancer · doi:10.1002/(sici)1097-0142(19990101)85:1<178::aid-cncr25>3.0.co;2-7 · Cited by 372

Vascular endothelial growth factor expression in early stage ovarian carcinoma

Paley, P. J., Staskus, K. A., Gebhard, K., Mohanraj, D., Twiggs, L. B., Carson, L. F., & Ramakrishnan, S. (1997) · Cancer · doi:10.1002/(sici)1097-0142(19970701)80:1<98::aid-cncr13>3.0.co;2-a · Cited by 364

Expression of vascular endothelial growth factor (VEGF) in epithelial ovarian neoplasms: correlation with clinicopathology and patient survival, and analysis of serum VEGF levels

Yamamoto, S., Konishi, I., Mandai, M., Kuroda, H., Komatsu, T., Nanbu, K., Sakahara, H., & Mori, T. (1997) · British Journal of Cancer · doi:10.1038/bjc.1997.537 · Cited by 356

The α1β1 and α2β1 Integrins Provide Critical Support for Vascular Endothelial Growth Factor Signaling, Endothelial Cell Migration, and Tumor Angiogenesis

Senger, D. R., Perruzzi, C. A., Streit, M., Koteliansky, V. E., de Fougerolles, A. R., & Detmar, M. (2002) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)64363-5 · Cited by 340

The Mouse Gene for Vascular Endothelial Growth Factor

Shima, D. T., Kuroki, M., Deutsch, U., Ng, Y.-S., Adamis, A. P., & D'Amore, P. A. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.7.3877 · Cited by 327

Inflammatory cell infiltration of tumors: Jekyll or Hyde

Talmadge, J. E., Donkor, M., & Scholar, E. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9072-0 · Cited by 313

Angiogenesis: a Dynamic Balance of Stimulators and Inhibitors

Iruela-Arispe, L. M., & Dvorak, H. F. (1997) · Thrombosis and Haemostasis · doi:10.1055/s-0038-1657610 · Cited by 311

Cooperative effect of TNFalpha, bFGF, and VEGF on the formation of tubular structures of human microvascular endothelial cells in a fibrin matrix. Role of urokinase activity.

Koolwijk, P., van Erck, M. G., de Vree, W. J., Vermeer, M. A., Weich, H. A., Hanemaaijer, R., & van Hinsbergh, V. W. (1996) · The Journal of cell biology · doi:10.1083/jcb.132.6.1177 · Cited by 296

Heterodimers of Placenta Growth Factor/Vascular Endothelial Growth Factor

Cao, Y., Chen, H., Zhou, L., Chiang, M.-K., Anand-Apte, B., Weatherbee, J. A., Wang, Y., Fang, F., Flanagan, J. G., & Tsang, M. L.-S. (1996) · Journal of Biological Chemistry · doi:10.1074/jbc.271.6.3154 · Cited by 295

VEGF increases BMEC monolayer permeability by affecting occludin expression and tight junction assembly

Wang, W., Dentler, W. L., & Borchardt, R. T. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.1.h434 · Cited by 288

Multiple Developmental Roles of VEGF Suggested by a LacZ-Tagged Allele

Miquerol, L., Gertsenstein, M., Harpal, K., Rossant, J., & Nagy, A. (1999) · Developmental Biology · doi:10.1006/dbio.1999.9355 · Cited by 281

Expression of vascular endothelial growth factor in digestive neuroendocrine tumours

Terris, Scoazec, Rubbia, Bregeaud, Pepper, Ruszniewski, Belghiti, FLÉjou, & Degott (1998) · Histopathology · doi:10.1046/j.1365-2559.1998.00321.x · Cited by 279

Vascular Endothelial Growth Factor (VEGF) Expression in Human Prostate Cancer: In Situ and in Vitro Expression of VEGF by Human Prostate Cancer Cells

Ferrer, F. A., Miller, L. J., Andrawis, R. I., Kurtzman, S. H., Albertsen, P. C., Laudone, V. P., & Kreutzer, D. L. (1997) · Journal of Urology · doi:10.1016/s0022-5347(01)64775-x · Cited by 278

VEGF and flt: Expression Time Kinetics in Rat Brain Infarct

Kovács, Z., Ikezaki, K., Samoto, K., Inamura, T., & Fukui, M. (1996) · Stroke · doi:10.1161/01.str.27.10.1865 · Cited by 277

RGD-Dependent Vacuolation and Lumen Formation Observed during Endothelial Cell Morphogenesis in Three-Dimensional Fibrin Matrices Involves the αvβ3 and α5β1 Integrins

Bayless, K. J., Salazar, R., & Davis, G. E. (2000) · The American Journal of Pathology · doi:10.1016/s0002-9440(10)65038-9 · Cited by 273

Proinflammatory Mediators Stimulate Neutrophil-Directed Angiogenesis

McCourt, M. (1999) · Archives of Surgery · doi:10.1001/archsurg.134.12.1325 · Cited by 268

Vascular endothelial growth factor is of high prognostic value in node-negative breast carcinoma.

Linderholm, B., Tavelin, B., Grankvist, K., & Henriksson, R. (1998) · Journal of Clinical Oncology · doi:10.1200/jco.1998.16.9.3121 · Cited by 264

Differential expression of thymosin β‐10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: evidence for senescent endothelial cells in vivo at sites of atherosclerosis

VASILE, E., TOMITA, Y., BROWN, L. F., KOCHER, O., & DVORAK, H. F. (2001) · The FASEB Journal · doi:10.1096/fj.00-0051com · Cited by 232

Angiopoietin-2 Interferes with Anti-VEGFR2–Induced Vessel Normalization and Survival Benefit in Mice Bearing Gliomas

Chae, S.-S., Kamoun, W. S., Farrar, C. T., Kirkpatrick, N. D., Niemeyer, E., de Graaf, A. M. A., Sorensen, A. G., Munn, L. L., Jain, R. K., & Fukumura, D. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-3073 · Cited by 135

Differential downregulation of vascular endothelial growth factor by dexamethasone in normoxic and hypoxic rat glioma cells

Machein, Kullmer, Rönicke, Machein, Krieg, Damert, Breier, Risau, & Plate (1999) · Neuropathology and Applied Neurobiology · doi:10.1046/j.1365-2990.1999.00166.x · Cited by 113

Antifibrotic activity of bevacizumab on human Tenon's fibroblasts in vitro

O'Neill, E. C., Qin, Q., Van Bergen, N. J., Connell, P. P., Vasudevan, S., Coote, M. A., Trounce, I. A., Wong, T. T. L., & Crowston, J. G. (2010) · Investigative Opthalmology & Visual Science · doi:10.1167/iovs.10-5669 · Cited by 73

A quantitative analysis of the reduction in oxygen levels required to induce up-regulation of vascular endothelial growth factor (VEGF) mRNA in cervical cancer cell lines

Chiarotto, J. A., & Hill, R. P. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690555 · Cited by 46

Neoplastic transformation and angiogenesis in the thymus of transgenic mice expressing SV40 T and t antigen under an l‐pyruvate kinase promoter (SV12 mice)

Nabarra, B., Pontoux, C., Godard, C., Osborne‐Pellegrin, M., & Ezine, S. (2005) · International Journal of Experimental Pathology · doi:10.1111/j.0959-9673.2005.00451.x · Cited by 3