Cited by 50Tryptophan and brain disordersNeuroinflammation and Neurodegeneration MechanismsNeurotransmitter Receptor Influence on Behavior

Effects of interferon-?, interleukin-1?, and tumor necrosis factor-? on the serotonin metabolism in the nucleus raphe dorsalis of the rat

Clement, H. W., Buschmann, J., Rex, S., Grote, C., Opper, C., Gemsa, D., Wesemann, W.·1997·Journal of Neural Transmission

Abstract

The effects of the cytokines interferon (IFN)-gamma, interleukin (IL)-1, and tumor necrosis factor (TNF)-alpha on the serotoninergic transmission in the nucleus raphe dorsalis (NRD) were studied after peripheral and central application. The studies were performed in the freely moving rat using differential pulse voltammetry with multicarbon fibre electrodes to study the extracellular levels of the serotonin (5-HT) metabolite 5-hydroxyindoleacetic acid (5-HIAA). The extracellular 5-HIAA levels were not changed in the NRD after peripheral application of rat recombinant IFN-gamma, but elevated by the cytokines IL-1 beta and TNF-alpha. After intracerebroventricular (i.c.v.) application the cytokines IFN-gamma, IL-1 beta and TNF-alpha stimulated the serotoninergic transmission in the NRD. Our data suggest that the effect of peripherally elevated cytokine concentrations on the serotonin metabolism in the NRD of the rat is cytokine-dependent. In this respect the T-cell and NK-cell cytokine IFN-gamma acts clearly different when compared to the mainly macrophage-derived cytokines IL-1 beta and TNF-alpha, and plays a different role in the communication between immune and central nervous system.

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Crossref · 10.1007/bf01273312

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49 of 49 references verified0 citation errors · 0 not checkable

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  • Proinflammatory cytokines significantly affect the peripheral and central 5-HT systems.

    “Proinflammatory cytokines significantly affect the peripheral and central 5-HT systems.”
  • Peripheral injections of IL-1β and TNF-α increase the extracellular levels of 5-hydroxyindoleacetic acid in the nucleus raphe dorsalis, and central injection of IL-1β, IFN-γ, and TNF-α stimulates 5-HT transmission in the nucleus raphe dorsalis.

    “Peripheral injections of IL-1β and TNF-α increase the extracellular levels of 5-hydroxyindoleacetic acid (5-HIAA) in the nucleus raphe dorsalis, and central injection (intracerebroventricular application) of IL-1β, IFN-γ, and TNF-α stimulates the 5-HT transmission in the nucleus raphe dorsalis[42].”

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Authors
Clement, H. W., Buschmann, J., Rex, S., Grote, C., Opper, C., Gemsa, D., & Wesemann, W.
Affiliations
Philipps University of Marburg (DE)
Venue
Journal of Neural Transmission
Published
1997-10
Volume
104
Issue
10
Pages
981-991
ISSN
  • 0300-9564 (ISSN-L)
  • 1435-1463
OpenAlex
W2094116004
Cited by
50
References
49
Citations by year
2024: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 2
FWCI
1.82
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neural Transmission (publishedVersion)
  • PubMed (publishedVersion)
  • FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
Funders
Philipps-Universität Marburg
Topics
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Keywords
interferon-gamma, IL-1β, TNF-α, serotonin metabolism, dorsal raphe nucleus, 5-hydroxyindoleacetic acid, cytokines, neuroendocrine-immune interaction, intracerebroventricular administration
MeSH terms
Animals, Hydroxyindoleacetic Acid, Injections, Intraperitoneal, Injections, Intraventricular, Interferon-gamma, Interleukin-1, Male, Microelectrodes, Raphe Nuclei, Rats, Inbred Lew, Serotonin, Tumor Necrosis Factor-alpha, Rats

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