Effects of interferon-?, interleukin-1?, and tumor necrosis factor-? on the serotonin metabolism in the nucleus raphe dorsalis of the rat
Abstract
The effects of the cytokines interferon (IFN)-gamma, interleukin (IL)-1, and tumor necrosis factor (TNF)-alpha on the serotoninergic transmission in the nucleus raphe dorsalis (NRD) were studied after peripheral and central application. The studies were performed in the freely moving rat using differential pulse voltammetry with multicarbon fibre electrodes to study the extracellular levels of the serotonin (5-HT) metabolite 5-hydroxyindoleacetic acid (5-HIAA). The extracellular 5-HIAA levels were not changed in the NRD after peripheral application of rat recombinant IFN-gamma, but elevated by the cytokines IL-1 beta and TNF-alpha. After intracerebroventricular (i.c.v.) application the cytokines IFN-gamma, IL-1 beta and TNF-alpha stimulated the serotoninergic transmission in the NRD. Our data suggest that the effect of peripherally elevated cytokine concentrations on the serotonin metabolism in the NRD of the rat is cytokine-dependent. In this respect the T-cell and NK-cell cytokine IFN-gamma acts clearly different when compared to the mainly macrophage-derived cytokines IL-1 beta and TNF-alpha, and plays a different role in the communication between immune and central nervous system.
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Proinflammatory cytokines significantly affect the peripheral and central 5-HT systems.
“Proinflammatory cytokines significantly affect the peripheral and central 5-HT systems.”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [42]
Peripheral injections of IL-1β and TNF-α increase the extracellular levels of 5-hydroxyindoleacetic acid in the nucleus raphe dorsalis, and central injection of IL-1β, IFN-γ, and TNF-α stimulates 5-HT transmission in the nucleus raphe dorsalis.
“Peripheral injections of IL-1β and TNF-α increase the extracellular levels of 5-hydroxyindoleacetic acid (5-HIAA) in the nucleus raphe dorsalis, and central injection (intracerebroventricular application) of IL-1β, IFN-γ, and TNF-α stimulates the 5-HT transmission in the nucleus raphe dorsalis[42].”
From Neuroinflammation and cytokine abnormality in major depression: cause or consequence in that illness? (2016) · cites this paper as [42]
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- Authors
- Clement, H. W., Buschmann, J., Rex, S., Grote, C., Opper, C., Gemsa, D., & Wesemann, W.
- Affiliations
- Philipps University of Marburg (DE)
- ORCID
- Venue
- Journal of Neural Transmission
- Published
- 1997-10
- Volume
- 104
- Issue
- 10
- Pages
- 981-991
- ISSN
- 0300-9564 (ISSN-L)
- 1435-1463
- OpenAlex
- W2094116004
- Cited by
- 50
- References
- 49
- Citations by year
- 2024: 1 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 1 · 2016: 2 · 2015: 2 · 2014: 3 · 2013: 3 · 2012: 2
- FWCI
- 1.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Neural Transmission (publishedVersion)
- PubMed (publishedVersion)
- FreiDok plus (Universitätsbibliothek Freiburg) (submittedVersion)
- Funders
- Philipps-Universität Marburg
- Topics
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- interferon-gamma, IL-1β, TNF-α, serotonin metabolism, dorsal raphe nucleus, 5-hydroxyindoleacetic acid, cytokines, neuroendocrine-immune interaction, intracerebroventricular administration
- MeSH terms
- Animals, Hydroxyindoleacetic Acid, Injections, Intraperitoneal, Injections, Intraventricular, Interferon-gamma, Interleukin-1, Male, Microelectrodes, Raphe Nuclei, Rats, Inbred Lew, Serotonin, Tumor Necrosis Factor-alpha, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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