The signal peptide

SignalP 4.0: discriminating signal peptides from transmembrane regions

Petersen, T. N., Brunak, S., von Heijne, G., & Nielsen, H. (2011) · Nature Methods · doi:10.1038/nmeth.1701 · Cited by 8,847

A Putative Leucine-Rich Repeat Receptor Kinase Involved in Brassinosteroid Signal Transduction

Li, J., & Chory, J. (1997) · Cell · doi:10.1016/s0092-8674(00)80357-8 · Cited by 1,650

Surface Proteins of Gram-Positive Bacteria and Mechanisms of Their Targeting to the Cell Wall Envelope

Navarre, W. W., & Schneewind, O. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.1.174-229.1999 · Cited by 1,391

A comprehensive review of signal peptides: Structure, roles, and applications

Owji, H., Nezafat, N., Negahdaripour, M., Hajiebrahimi, A., & Ghasemi, Y. (2018) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2018.06.003 · Cited by 523

Protein export through the bacterial Sec pathway

Tsirigotaki, A., De Geyter, J., Šoštaric´, N., Economou, A., & Karamanou, S. (2017) · Nature Reviews Microbiology · doi:10.1038/nrmicro.2016.161 · Cited by 447

Processing in the hepatitis C virus E2-NS2 region: identification of p7 and two distinct E2-specific products with different C termini

Lin, C., Lindenbach, B. D., Prágai, B. M., McCourt, D. W., & Rice, C. M. (1994) · Journal of Virology · doi:10.1128/jvi.68.8.5063-5073.1994 · Cited by 355

Differential Interactions between a Twin-Arginine Signal Peptide and Its Translocase in Escherichia coli

Alami, M., Lüke, I., Deitermann, S., Eisner, G., Koch, H.-G., Brunner, J., & Müller, M. (2003) · Molecular Cell · doi:10.1016/s1097-2765(03)00398-8 · Cited by 317

Protein translocation across the inner membrane of Gram-negative bacteria: the Sec and Tat dependent protein transport pathways.

Kudva, R., Denks, K., Kuhn, P., Vogt, A., Müller, M., & Koch, H.-G. (2013) · Research in Microbiology · doi:10.1016/j.resmic.2013.03.016 · Cited by 177

The rpf gene of Micrococcus luteus encodes an essential secreted growth factor

Mukamolova, G. V., Turapov, O. A., Kazarian, K., Telkov, M., Kaprelyants, A. S., Kell, D. B., & Young, M. (2002) · Molecular Microbiology · doi:10.1046/j.1365-2958.2002.03183.x · Cited by 178

The Sec translocon mediated protein transport in prokaryotes and eukaryotes.

Denks, K., Vogt, A., Sachelaru, I., Petriman, N.-A., Kudva, R., & Koch, H.-G. (2014) · Molecular Membrane Biology · doi:10.3109/09687688.2014.907455 · Cited by 170

Diversity and evolution of protein translocation.

Pohlschröder, M., Hartmann, E., Hand, N. J., Dilks, K., & Haddad, A. (2005) · Annual Review of Microbiology · doi:10.1146/annurev.micro.59.030804.121353 · Cited by 122

Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage

(2021) · doi:10.1016/j.molcel.2021.07.031 · Cited by 120

The way is the goal: how SecA transports proteins across the cytoplasmic membrane in bacteria.

Cranford-Smith, T., & Huber, D. (2018) · FEMS Microbiology Letters · doi:10.1093/femsle/fny093 · Cited by 77

Bacterial amylases enable glycogen degradation by the vaginal microbiome

Jenkins, D. J., Woolston, B. M., Hood-Pishchany, M. I., Pelayo, P., Konopaski, A. N., Quinn Peters, M., France, M. T., Ravel, J., Mitchell, C. M., Rakoff-Nahoum, S., et al. (2023) · Nature Microbiology · doi:10.1038/s41564-023-01447-2 · Cited by 63

SecA Cotranslationally Interacts with Nascent Substrate Proteins In Vivo

Huber, D., Jamshad, M., Hanmer, R., Schibich, D., Döring, K., Marcomini, I., Kramer, G., & Bukau, B. (2017) · Journal of Bacteriology · doi:10.1128/jb.00622-16 · Cited by 61

Signals for protein targeting into and across membranes.

von Heijne, G. (1994) · Subcellular Biochemistry · doi:10.1007/978-1-4615-2401-4_1 · Cited by 40

The Sec Pathways and Exportomes of Mycobacterium tuberculosis

Miller, B. K., Zulauf, K. E., & Braunstein, M. (2017) · Microbiology Spectrum · doi:10.1128/microbiolspec.tbtb2-0013-2016 · Cited by 35

Coupling between codon usage, translation and protein export in Escherichia coli

Zalucki, Y. M., Beacham, I. R., & Jennings, M. P. (2011) · Biotechnology Journal · doi:10.1002/biot.201000334 · Cited by 21

Structure of the Human Signal Peptidase Complex Reveals the Determinants for Signal Peptide Cleavage

Liaci, A. M., Steigenberger, B., Tamara, S., de Souza, P. C. T., Gröllers-Mulderij, M., Ogrissek, P., Marrink, S. J., Scheltema, R. A., & Förster, F. (2020) · doi:10.1101/2020.11.11.378711 · Cited by 10

The S-component fold: a link between bacterial transporters and receptors

Partipilo, M., & Slotboom, D. J. (2024) · Communications Biology · doi:10.1038/s42003-024-06295-2 · Cited by 4