Age-related macular degeneration: ultrastructural studies of the relationship of leucocytes to angiogenesis
Abstract
We describe the ultrastructural features of subretinal neovascularisation associated with the pathogenesis of age-related macular degeneration (AMD). The choroidal origin of new vessels was confirmed, and ultrastructural details are presented. Serial sectioning of new vessels revealed a relationship between leucocytes and neovascular structures. The results are discussed in the context of the previously established role of leucocytes in angiogenesis. Our results provide circumstantial evidence, based on morphological observations, for the involvement of leucocytes in the promotion of neovascular proliferation and exudation from new vessels.
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Macrophages have been documented both morphologically and functionally in neovascular age-related macular degeneration.
“Macrophages have been documented both morphologically and functionally in neovascular age-related macular degeneration.137–142”
From Age-related macular degeneration (2008) · cites this paper as [138]
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- Authors
- Penfold, P. L., Provis, J. M., & Billson, F. A.
- Affiliations
- The University of Sydney (AU)
- ORCID
- Provis, J. M.
- Venue
- Graefes Archive for Clinical and Experimental Ophthalmology
- Published
- 1987-02
- Volume
- 225
- Issue
- 1
- Pages
- 70-76
- ISSN
- 0721-832X (ISSN-L)
- 1435-702X
- OpenAlex
- W1988476950
- Cited by
- 108
- References
- 23
- Citations by year
- 2025: 2 · 2024: 3 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 4 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 3 · 2015: 6 · 2014: 6 · 2013: 2 · 2012: 1
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Graefe s Archive for Clinical and Experimental Ophthalmology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Ocular Diseases and Behçet’s Syndrome
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Retinal Imaging and Analysis
- Keywords
- age-related macular degeneration, choroidal neovascularization, angiogenesis, leukocytes, leukocyte ultrastructure, exudation
- MeSH terms
- Aged, Aged, 80 and over, Humans, Leukocytes, Macular Degeneration, Microscopy, Electron, Neovascularization, Pathologic, Retina
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