Cited by 221Circadian rhythm and melatoninAutism Spectrum Disorder ResearchStress Responses and Cortisol

Brief report: Circadian melatonin, thyroid-stimulating hormone, prolactin, and cortisol levels in serum of young adults with autism

Nir, Isaac, Meir, Daniel, Zilber, Neli, Knobler, Haim, Hadjez, Jacques, Lerner, Yaacov·1995·Journal of Autism and Developmental Disorders

Abstract

An abnormal circadian pattern of melatonin was found in a group of young adults with an extreme autism syndrome. Although not out of phase, the serum melatonin levels differed from normal in amplitude and mesor. Marginal changes in diurnal rhythms of serum TSH and possibly prolactin were also recorded. Subjects with seizures tended to have an abnormal pattern of melatonin correlated with EEG changes. In others, a parallel was evidenced between thyroid function and impairment in verbal communication. There appears to be a tendency for various types of neuroendocrinological abnormalities in autistics, and melatonin, as well as possibly TSH and perhaps prolactin, could serve as biochemical variables of the biological parameters of the disease.

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Crossref · 10.1007/bf02178193

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37 of 37 references verified0 citation errors · 0 not checkable

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  • The most consistent related finding in prepubertal children, pubertal adolescents and young adults with ASD is reduced melatonin levels in the evening.

    “The most consistent related finding in prepubertal children, pubertal adolescents and young adults with ASD is reduced melatonin levels in the evening99–102.”

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Authors
Nir, I., Meir, D., Zilber, N., Knobler, H., Hadjez, J., & Lerner, Y.
Affiliations
Hebrew University of Jerusalem (IL)
Venue
Journal of Autism and Developmental Disorders
Published
1995-12
Volume
25
Issue
6
Pages
641-654
ISSN
  • 0162-3257 (ISSN-L)
  • 1573-3432
OpenAlex
W1988854674
Cited by
221
References
37
Citations by year
2026: 4 · 2025: 7 · 2024: 9 · 2023: 6 · 2022: 11 · 2021: 12 · 2020: 11 · 2019: 10 · 2018: 12 · 2017: 13 · 2016: 8 · 2015: 11 · 2014: 12 · 2013: 16 · 2012: 6
FWCI
0.46
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Autism and Developmental Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
autism spectrum disorder, melatonin, circadian rhythm, thyroid-stimulating hormone, prolactin, cortisol, diurnal cycle, seizures, EEG, verbal communication impairment, neuroendocrine abnormalities, serum biomarkers, young adults
MeSH terms
Adolescent, Adult, Autistic Disorder, Circadian Rhythm, Humans, Hydrocortisone, Male, Melatonin, Prolactin, Radioimmunoassay, Thyrotropin

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