Cortisol circadian rhythms and response to stress in children with autism
Abstract
Background Autism is a severe neurodevelopmental disorder characterized by impairment in communication, social interaction, repetitive behaviors and difficulty adapting to novel experiences. The Hypothalamic-Pituitary-Adrenocortical (HPA) system responds consistently to perceived novel or unfamiliar situations and can serve as an important biomarker of the response to a variety of different stimuli. Previous research has suggested that children with autism may exhibit dysfunction of the HPA system, but it is not clear whether altered neuroendrocrine regulation or altered responsiveness underlies the differences between children with and without autism. In order to provide preliminary data concerning HPA regulation and responsiveness, we compared circadian rhythms and response to a non-social, environmental stressor in children with and without autism.Methods Circadian rhythms of cortisol were estimated in children with (N=12) and without (N=10) autism via analysis of salivary samples collected in the morning, afternoon and evening on 2 consecutive days. HPA responsiveness was assessed by examining the time course of changes in salivary cortisol in response to a mock MRI.Results Both groups showed expected circadian variation with higher cortisol concentration in morning than in the evening samples. The children with autism, but not typical children, showed a more variable circadian rhythm as well as statistically significant elevations in cortisol following exposure to a novel, nonsocial stimulus.Conclusions The results suggest that children with autism process and respond idiosyncratically to novel and threatening events resulting in an exaggerated cortisol response.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Psychobiological factors such as stress may underlie the poor response to novelty and changes in routine in autism.
“Psychobiological factors, such as stress, might underlie the poor response to novelty and changes in routine in autism [52].”
From The paradox of cognitive flexibility in autism (2009) · cites this paper as [52]
Cites
Diagnostic and Statistical Manual of Mental Disorders
Williams, J. B. W., & First, M. B. (2013) · Oxford University Press eBooks · doi:10.1093/acrefore/9780199975839.013.104 · Cited by 109,841 · see citing works
An Introduction to the Bootstrap
Efron, B., & Tibshirani, R. J. (1994) · doi:10.1201/9780429246593 · Cited by 40,500 · see citing works
Random-Effects Models for Longitudinal Data
Laird, N. M., & Ware, J. H. (1982) · Biometrics · doi:10.2307/2529876 · Cited by 8,923 · see citing works
(1943) · The Nervous child · Cited by 8,870 · see citing works
Neurocircuitry of stress: central control of the hypothalamo–pituitary–adrenocortical axis
Herman, J. P., & Cullinan, W. E. (1997) · Trends in Neurosciences · doi:10.1016/s0166-2236(96)10069-2 · Cited by 2,270 · see citing works
Salivary cortisol in psychoneuroendocrine research: recent developments and applications
Kirschbaum, C., & Hellhammer, D. H. (1994) · Psychoneuroendocrinology · doi:10.1016/0306-4530(94)90013-2 · Cited by 2,107 · see citing works
Social regulation of the cortisol levels in early human development
Gunnar, M. R., & Donzella, B. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00045-2 · Cited by 1,088 · see citing works
Histoanatomic observations of the brain in early infantile autism
Bauman, M., & Kemper, T. L. (1985) · Neurology · doi:10.1212/wnl.35.6.866 · Cited by 964 · see citing works
Brain structural abnormalities in young children with autism spectrum disorder
Sparks, B. F., Friedman, S. D., Shaw, D. W., Aylward, E. H., Echelard, D., Artru, A. A., Maravilla, K. R., Giedd, J. N., Munson, J., Dawson, G., et al. (2002) · Neurology · doi:10.1212/wnl.59.2.184 · Cited by 961 · see citing works
GUNNAR, M. R., & VAZQUEZ, D. M. (2001) · Development and Psychopathology · doi:10.1017/s0954579401003066 · Cited by 900 · see citing works
Schumann, C. M., Hamstra, J., Goodlin-Jones, B. L., Lotspeich, L. J., Kwon, H., Buonocore, M. H., Lammers, C. R., Reiss, A. L., & Amaral, D. G. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.1297-04.2004 · Cited by 840 · see citing works
Murphy, S. A., & Van Der Vaart, A. W. (2000) · Journal of the American Statistical Association · doi:10.1080/01621459.2000.10474219 · Cited by 712 · see citing works
The neuroanatomy of autism: a voxel-based whole brain analysis of structural scans
Abell, F., Krams, M., Ashburner, J., Passingham, R., Friston, K., Frackowiak, R., Happé, F., Frith, C., & Frith, U. (1999) · NeuroReport · doi:10.1097/00001756-199906030-00005 · Cited by 480 · see citing works
Convergent neuroanatomical and behavioural evidence of an amygdala hypothesis of autism
Howard, M. A., Cowell, P. E., Boucher, J., Broks, P., Mayes, A. R., Farrant, A., & Roberts, N. P. (2000) · Neuroreport · doi:10.1097/00001756-200009110-00020 · Cited by 479 · see citing works
Assessing Salivary Cortisol in Studies of Child Development
Schwartz, E. B., Granger, D. A., Susman, E. J., Gunnar, M. R., & Laird, B. (1998) · Child Development · doi:10.1111/j.1467-8624.1998.tb06173.x · Cited by 334 · see citing works
Assessing and interpreting treatment effects in longitudinal clinical trials with missing data
Mallinckrodt, C. H., Sanger, T. M., Dubé, S., DeBrota, D. J., Molenberghs, G., Carroll, R. J., Potter, W. Z., & Tollefson, G. D. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01867-x · Cited by 246 · see citing works
Microscopic Neuroanatomic Abnormalities in Autism
Bauman, M. L. (1991) · Pediatrics · doi:10.1542/peds.87.5.791 · Cited by 242 · see citing works
STRESS, AROUSAL, AND THE PITUITARY-ADRENAL SYSTEM: A PSYCHOENDOCRINE HYPOTHESIS
Hennessy, J. W., & Levine, S. (1979) · Cited by 238 · see citing works
Self-citationNir, I., Meir, D., Zilber, N., Knobler, H., Hadjez, J., & Lerner, Y. (1995) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02178193 · Cited by 221 · see citing works
The Physiological Control of Mammalian Vocalization
(1988) · Springer eBooks · doi:10.1007/978-1-4613-1051-8 · Cited by 180 · see citing works
Plasma β‐Endorphin, Adrenocorticotropin Hormone, and Cortisol in Autism
Tordjman, S., McBride, P., Hertzig, M. E., Snow, M. E., Anderson, G. M., Hall, L. M., Thompson, S., Ferrari, P., & Cohen, D. J. (1997) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1997.tb01697.x · Cited by 152 · see citing works
Groden, J., Diller, A., Bausman, M., Velicer, W., Norman, G., & Cautela, J. (2001) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1010755300436 · Cited by 124 · see citing works
Jansen, L. M., Gispen-de Wied, C. C., van der Gaag, R.-J., & van Engeland, H. (2003) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300046 · Cited by 118 · see citing works
Cortisol and behavior in fragile X syndrome
Hessl, D., Glaser, B., Dyer-Friedman, J., Blasey, C., Hastie, T., Gunnar, M., & Reiss, A. L. (2002) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(01)00087-7 · Cited by 115 · see citing works
Urinary cortisol circadian rhythm in a group of high-functioning children with autism
Richdale, A. L., & Prior, M. R. (1992) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01048245 · Cited by 105 · see citing works
Lower Cortisol and Higher ACTH Levels in Individuals with Autism
Ćurin, J. M., Terzić, J., Petković, Z. B., Zekan, L., Marinovic‐Terzić, I., & Šušnjara, I. M. (2003) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1025019030121 · Cited by 92 · see citing works
Jansen, L. M. C., Wied, C. C. G., van der Gaag, R. J., ten Hove, F., Willemsen‐Swinkels, S. H. N., Harteveld, E. M., & van Engeland, H. (2000) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(00)00020-2 · Cited by 79 · see citing works
Hoshino, Y., Yokoyama, F., Watanabe, M., Murata, S., Kaneko, M., & Kumashiro, H. (1987) · Psychiatry and Clinical Neurosciences · doi:10.1111/j.1440-1819.1987.tb00406.x · Cited by 60 · see citing works
The Dexamethasone Suppression Test in Infantile Autism
Jensen, J. B., Realmuto, G. M., & Garfinkel, B. D. (1985) · Journal of the American Academy of Child Psychiatry · doi:10.1016/s0002-7138(09)61085-2 · Cited by 44 · see citing works
An application of neuroendocrinological studies in autistic children and Heller's syndrome
Yamazaki, K., Saito, Y., Okada, F., Fujieda, T., & Yamashita, I. (1975) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01540679 · Cited by 41 · see citing works
Diurnal cortisol and temperature variation of normal and autistic children
Hill, S. D., Wagner, E. A., Shedlarski, J. G., & Sears, S. P. (1977) · Developmental Psychobiology · doi:10.1002/dev.420100612 · Cited by 40 · see citing works
PECULIARITIES IN THE ENDOCRINE RESPONSE TO INSULIN STRESS IN EARLY INFANTILE AUTISM
Maher, K. R., Harper, J., MACLEAY, A., & KING, M. C. (1975) · The Journal of Nervous and Mental Disease · doi:10.1097/00005053-197509000-00005 · Cited by 34 · see citing works
Assessing Salivary Cortisol in Studies of Child Development
Schwartz, E. B., Granger, D. A., Susman, E. J., Gunnar, M. R., & Laird, B. (1998) · Child Development · doi:10.2307/1132128 · Cited by 32 · see citing works
Endocrine and Neurochemical Sequelae of Primate Vocalizations
Wiener, S. G., Coe, C. L., & Levine, S. D. (1988) · Springer eBooks · doi:10.1007/978-1-4613-1051-8_20 · Cited by 12 · see citing works
Self-citation[Neuroendocrinologic studies on autism].
Aihara, R., & Hashimoto, T. (1989) · PubMed · Cited by 9 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The long-term behavioural consequences of prenatal stress
Weinstock, M. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.03.002 · Cited by 1,045 · see citing works
Psychosis and autism as diametrical disorders of the social brain
Crespi, B. J., & Badcock, C. R. (2008) · Behavioral and Brain Sciences · doi:10.1017/s0140525x08004214 · Cited by 618 · see citing works
Gunnar, M. R., Talge, N. M., & Herrera, A. M. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.02.010 · Cited by 567 · see citing works
The paradox of cognitive flexibility in autism
Geurts, H. M., Corbett, B., & Solomon, M. (2009) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2008.11.006 · Cited by 538 · see citing works
Self-citationThe Intense World Theory – A Unifying Theory of the Neurobiology of Autism
Markram, H., & Markram, H. (2010) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2010.00224 · Cited by 521 · see citing works
Prenatal stress and risk for autism
KINNEY, D., MUNIR, K., CROWLEY, D., & MILLER, A. (2008) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.06.004 · Cited by 440 · see citing works
Sex differences in oxytocin and vasopressin: Implications for autism spectrum disorders?
CARTER, C. (2007) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.08.025 · Cited by 432 · see citing works
Atypical attentional networks and the emergence of autism
Keehn, B., Müller, R.-A., & Townsend, J. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.11.014 · Cited by 412 · see citing works
The intense world syndrome-an alternative hypothesis for autism
Markram, H. (2007) · Frontiers in Neuroscience · doi:10.3389/neuro.01.1.1.006.2007 · Cited by 394 · see citing works
Sex differences in autism spectrum disorder: a review
Ferri, S. L., Abel, T., & Brodkin, E. S. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0874-2 · Cited by 392 · see citing works
Abnormal Fear Conditioning and Amygdala Processing in an Animal Model of Autism
Markram, H., Barkat, T. R., Mendola, D. L., Sandi, C., & Markram, H. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301453 · Cited by 382 · see citing works
Gender Differences in the Effects of Prenatal Stress on Brain Development and Behaviour
Weinstock, M. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9339-4 · Cited by 349 · see citing works
Schneider, T., Roman, A., Basta‐Kaim, A., Kubera, M., Budziszewska, B., Schneider, K., & Przewłocki, R. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.02.011 · Cited by 335 · see citing works
Traumatic Childhood Events and Autism Spectrum Disorder
Kerns, C. M., Newschaffer, C. J., & Berkowitz, S. J. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-015-2392-y · Cited by 312 · see citing works
Autism Prevalence Following Prenatal Exposure to Hurricanes and Tropical Storms in Louisiana
Kinney, D. K., Miller, A. M., Crowley, D. J., Huang, E., & Gerber, E. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0414-0 · Cited by 295 · see citing works
Measurement and meaning of salivary cortisol: A focus on health and disease in children
Jessop, D. S., & Turner‐Cobb, J. M. (2008) · Stress · doi:10.1080/10253890701365527 · Cited by 284 · see citing works
A functional and structural study of emotion and face processing in children with autism
Corbett, B. A., Carmean, V., Ravizza, S., Wendelken, C., Henry, M. L., Carter, C., & Rivera, S. M. (2009) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2008.08.005 · Cited by 227 · see citing works
Self-citationSalivary Cortisol in Ambulatory Assessment—Some Dos, Some Don’ts, and Some Open Questions
Kudielka, B. M., Gierens, A., Hellhammer, D. H., Wüst, S., & Schlotz, W. (2012) · Psychosomatic Medicine · doi:10.1097/psy.0b013e31825434c7 · Cited by 225 · see citing works
BALB/c mice: Low sociability and other phenotypes that may be relevant to autism
Brodkin, E. S. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.06.025 · Cited by 223 · see citing works
Enhanced Cortisol Response to Stress in Children in Autism
Spratt, E. G., Nicholas, J. S., Brady, K. T., Carpenter, L. A., Hatcher, C. R., Meekins, K. A., Furlanetto, R. W., & Charles, J. M. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-011-1214-0 · Cited by 222 · see citing works
Comparing cortisol, stress, and sensory sensitivity in children with autism
Corbett, B. A., Schupp, C. W., Levine, S., & Mendoza, S. P. (2009) · Autism Research · doi:10.1002/aur.64 · Cited by 202 · see citing works
Self-citationCorbett, B. A., Kantor, A. B., Schulman, H., Walker, W. L., Lit, L., Ashwood, P., Rocke, D. M., & Sharp, F. R. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4001943 · Cited by 197 · see citing works
Self-citationCircadian rhythms and sleep in children with autism
Glickman, G. L. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.11.017 · Cited by 171 · see citing works
A review of rhythm and responsiveness of cortisol in individuals with autism spectrum disorders
Taylor, J. L., & Corbett, B. A. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.07.015 · Cited by 156 · see citing works
Self-citationBrief report: theatre as therapy for children with autism spectrum disorder
Corbett, B. A., Gunther, J. R., Comins, D., Price, J., Ryan, N., Simon, D., Schupp, C. W., & Rios, T. (2011) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-1064-1 · Cited by 160 · see citing works
Self-citationHu, V. W., Nguyen, A., Kim, K. S., Lowe, M. S., Sarachana, T., Scully, M. A., Soldin, S. J., Luu, T. V., & Lee, N. H. (2009) · PLoS ONE · doi:10.1371/journal.pone.0005775 · Cited by 157 · see citing works
Variable cortisol circadian rhythms in children with autism and anticipatory stress
Corbett, B. A., Mendoza, S. P., Wegelin, J. A., Carmean, V., & Levine, S. D. (2008) · Journal of Psychiatry and Neuroscience · doi:10.1139/jpn.0823 · Cited by 149 · see citing works
Self-citationRzepecka, H., McKenzie, K., McClure, I., & Murphy, S. (2011) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2011.05.034 · Cited by 150 · see citing works
Gaigg, S. (2012) · Frontiers in Integrative Neuroscience · doi:10.3389/fnint.2012.00113 · Cited by 152 · see citing works
Low stress reactivity and neuroendocrine factors in the BTBR T+tf/J mouse model of autism
Silverman, J. L., Yang, M., Turner, S. M., Katz, A. M., Bell, D. B., Koenig, J. I., & Crawley, J. N. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.09.059 · Cited by 146 · see citing works
Hypothalamic‐Pituitary‐Adrenocortical Axis: Neuropsychiatric Aspects
Jacobson, L. (2014) · Comprehensive physiology · doi:10.1002/cphy.c130036 · Cited by 152 · see citing works
Altered Peripheral and Central Inflammatory Responses in a Mouse Model of Autism
Lucchina, L., & Depino, A. M. (2013) · Autism Research · doi:10.1002/aur.1338 · Cited by 142 · see citing works
Roberts, A. L., Koenen, K. C., Lyall, K., Robinson, E., & Weisskopf, M. G. (2015) · Child Abuse & Neglect · doi:10.1016/j.chiabu.2015.04.010 · Cited by 135 · see citing works
Elevated cortisol during play is associated with age and social engagement in children with autism
Corbett, B. A., Schupp, C. W., Simon, D. M., Ryan, N., & Mendoza, S. P. (2010) · Molecular Autism · doi:10.1186/2040-2392-1-13 · Cited by 130 · see citing works
Self-citationPersonal Space Regulation in Childhood Autism Spectrum Disorders
Gessaroli, E., Santelli, E., di Pellegrino, G., & Frassinetti, F. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074959 · Cited by 128 · see citing works
Bishop‐Fitzpatrick, L., Mazefsky, C. A., Minshew, N. J., & Eack, S. M. (2015) · Autism Research · doi:10.1002/aur.1433 · Cited by 127 · see citing works
Devlin, S., Healy, O., Leader, G., & Hughes, B. M. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-1149-x · Cited by 127 · see citing works
A systematic review of physiological reactivity to stimuli in autism
Lydon, S., Healy, O., Reed, P., Mulhern, T., Hughes, B. M., & Goodwin, M. S. (2016) · Developmental Neurorehabilitation · doi:10.3109/17518423.2014.971975 · Cited by 120 · see citing works
Physiologic arousal to social stress in children with autism spectrum disorders: a pilot study
Levine, T. P., Sheinkopf, S. J., Pescosolido, M., Rodino, A., Elia, G., & Lester, B. (2012) · Research in Autism Spectrum Disorders · doi:10.1016/j.rasd.2011.04.003 · Cited by 121 · see citing works
Characterizing Sleep in Adolescents and Adults with Autism Spectrum Disorders
Goldman, S. E., Alder, M. L., Burgess, H. J., Corbett, B. A., Hundley, R. J., Wofford, D. D., Fawkes, D. B., Wang, L., Laudenslager, M. L., & Malow, B. A. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-017-3089-1 · Cited by 116 · see citing works
Self-citationReynolds, S., Lane, S. J., & Thacker, L. R. (2011) · OTJR Occupational Therapy Journal of Research · doi:10.3928/15394492-20110513-02 · Cited by 119 · see citing works
Lewczuk, B., Redlarski, G., Żak, A. J., Ziółkowska, N., Przybylska‐Gornowicz, B., & Krawczuk, M. (2014) · BioMed Research International · doi:10.1155/2014/169459 · Cited by 103 · see citing works
Verbal ability, social stress, and anxiety in children with Autistic Disorder
Lanni, K. E., Schupp, C. W., Simon, D. M., & Corbett, B. A. (2011) · Autism · doi:10.1177/1362361311425916 · Cited by 92 · see citing works
Self-citationLopata, C. J., Volker, M. A., Putnam, S. K., Thomeer, M. L., & Nida, R. E. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-008-0575-5 · Cited by 92 · see citing works
Examining cortisol rhythmicity and responsivity to stress in children with Tourette syndrome
Corbett, B. A., Mendoza, S. P., Baym, C. L., Bunge, S. A., & Levine, S. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.03.014 · Cited by 90 · see citing works
Self-citationTordjman, S., Anderson, G. M., Kermarrec, S., Bonnot, O., Geoffray, M., Brailly‐Tabard, S., Chaouch, A., Colliot, I., Trabado, S., Bronsard, G., et al. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.08.010 · Cited by 87 · see citing works
Corbett, B. A., Schupp, C. W., & Lanni, K. E. (2012) · Molecular Autism · doi:10.1186/2040-2392-3-13 · Cited by 86 · see citing works
Self-citationPupil and Salivary Indicators of Autonomic Dysfunction in Autism Spectrum Disorder
Anderson, C. J., Colombo, J., & Unruh, K. E. (2012) · Developmental Psychobiology · doi:10.1002/dev.21051 · Cited by 84 · see citing works
Mindfulness in Individuals with Autism Spectrum Disorder: a Systematic Review and Narrative Analysis
Cachia, R. L., Anderson, A., & Moore, D. W. (2016) · Review Journal of Autism and Developmental Disorders · doi:10.1007/s40489-016-0074-0 · Cited by 85 · see citing works
Solomon, M., Ozonoff, S. J., Carter, C., & Caplan, R. (2008) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-007-0526-6 · Cited by 84 · see citing works
Hormonal reactivity to MRI scanning in adolescents
Eatough, E. M., Shirtcliff, E. A., Hanson, J. L., & Pollak, S. D. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.03.006 · Cited by 83 · see citing works
Schupp, C. W., Simon, D. M., & Corbett, B. A. (2013) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1790-2 · Cited by 77 · see citing works
Self-citationHillier, A. J., Murphy, D. A., & Ferrara, C. M. (2011) · Stress and Health · doi:10.1002/smi.1391 · Cited by 76 · see citing works
Majewska, M. D., Hill, M., Urbanowicz, E., Rok-Bujko, P., Bieńkowski, P., Namysłowska, I., & Mierzejewski, P. (2013) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-013-0472-0 · Cited by 76 · see citing works
Brosnan, M., Turner‐Cobb, J. M., Munro-Naan, Z., & Jessop, D. S. (2009) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2009.02.011 · Cited by 74 · see citing works
Kazlauskas, N., Seiffe, A., Campolongo, M., Zappala, C., & Depino, A. M. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104441 · Cited by 71 · see citing works
Bitsika, V., Sharpley, C. F., Sweeney, J. A., & McFarlane, J. R. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2013.12.011 · Cited by 72 · see citing works
Slower cortisol response during ACTH stimulation test in autistic children
Ćurin, J. M., Marinovic‐Terzić, I., Bujas-Petković, Z., Zekan, L., Škrabić, V., Đogaš, Z., & Terzić, J. (2007) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-007-0632-1 · Cited by 70 · see citing works
Affectionate Communication in Close Relationships
Floyd, K. (2018) · Cambridge University Press eBooks · doi:10.1017/9781108653510 · Cited by 68 · see citing works
Huang, F., Long, Z., Zhao, C. N., Li, J., Hu, Z., Qiu, R., Zhuang, W., Tang, B., Xia, K., & Jiang, H. F. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129052 · Cited by 65 · see citing works
Gabriels, R. L., Agnew, J., Pan, Z., Holt, K. D., Reynolds, A., & Laudenslager, M. L. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2013.02.017 · Cited by 63 · see citing works
Gillberg, C., Fernell, E., Kočovská, E., Minnis, H., Bourgeron, T., Thompson, L., & Allely, C. S. (2017) · Autism Research · doi:10.1002/aur.1777 · Cited by 65 · see citing works
Comparing stress and arousal systems in response to different social contexts in children with ASD
Corbett, B. A., Muscatello, R. A., & Baldinger, C. (2018) · Biological Psychology · doi:10.1016/j.biopsycho.2018.12.010 · Cited by 62 · see citing works
Self-citationNeurobiological Basis of Autism
Silver, W. G., & Rapin, I. (2012) · Pediatric Clinics of North America · doi:10.1016/j.pcl.2011.10.010 · Cited by 64 · see citing works
Lorsung, E., Ramanujam, K., & Cao, R. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.642745 · Cited by 63 · see citing works
Stress System Activation in Children and Adolescents With Autism Spectrum Disorder
Makris, G., Agorastos, A., Chrousos, G. P., & Pervanidou, P. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.756628 · Cited by 61 · see citing works
Self-reported mindfulness and cortisol during a Shamatha meditation retreat.
Jacobs, T. L., Shaver, P. R., Epel, E. S., Zanesco, A. P., Aichele, S., Bridwell, D. A., Rosenberg, E. L., King, B. G., MacLean, K. A., Sahdra, B. K., et al. (2013) · Health Psychology · doi:10.1037/a0031362 · Cited by 61 · see citing works
Examining associations between anxiety and cortisol in high functioning male children with autism
Simon, D. M., & Corbett, B. A. (2013) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-5-32 · Cited by 58 · see citing works
Self-citationAutistic behavior in boys with fragile X syndrome: social approach and HPA-axis dysfunction
Roberts, J. E., Clarke, M. A., Alcorn, K. M., Carter, J. C., Long, A. C. J., & Kaufmann, W. E. (2009) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-009-9028-5 · Cited by 58 · see citing works
Theoretical aspects of autism: biomarkers—a review
Ratajczak, H. V. (2011) · Journal of Immunotoxicology · doi:10.3109/1547691x.2010.538749 · Cited by 58 · see citing works
Prenatal Cocaine Exposure Related to Cortisol Stress Reactivity in 11-Year-Old Children
Lester, B. M., LaGasse, L. L., Shankaran, S., Bada, H. S., Bauer, C. R., Lin, R., Das, A., & Higgins, R. D. (2010) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2010.02.039 · Cited by 56 · see citing works
Neuroendocrine Aspects of Tourette Syndrome
Martino, D., Macerollo, A., & Leckman, J. F. (2013) · International review of neurobiology · doi:10.1016/b978-0-12-411546-0.00009-3 · Cited by 55 · see citing works
The hidden link between circadian entropy and mental health disorders
Alachkar, A., Lee, J., Asthana, K., Monfared, R. V., Chen, J., Alhassen, S., Samad, M., Wood, M., Mayer, E., & Baldi, P. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02028-3 · Cited by 65 · see citing works
Autism and the amygdala: an endocrine hypothesis.
Schulkin, J. (2007) · Brain and Cognition · doi:10.1016/j.bandc.2006.02.009 · Cited by 59 · see citing works
Adolescence, stress and cortisol in autism spectrum disorders
Corbett, B., & Simon, D. (2013) · OA Autism · doi:10.13172/2052-7810-1-1-348 · Cited by 50 · see citing works
Self-citationCorticosteroid and neurosteroid dysregulation in an animal model of autism, BTBR mice
Frye, C. A., & Llaneza, D. C. (2010) · Physiology & Behavior · doi:10.1016/j.physbeh.2010.03.005 · Cited by 52 · see citing works
Lueken, U., Muehlhan, M., Evens, R., Wïttchen, H., & Kirschbaum, C. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.01.003 · Cited by 51 · see citing works
Tomarken, A. J., Han, G. T., & Corbett, B. A. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.08.016 · Cited by 49 · see citing works
Self-citationSharpley, C. F., Bitsika, V., Andronicos, N. M., & Agnew, L. L. (2016) · Physiology & Behavior · doi:10.1016/j.physbeh.2016.09.003 · Cited by 47 · see citing works
Reducing Listening-Related Stress in School-Aged Children with Autism Spectrum Disorder
Rance, G., Chisari, D., Saunders, K., & Rault, J. (2017) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-017-3114-4 · Cited by 48 · see citing works
Pan, Z., Granger, D. A., Guérin, N. A., Shoffner, A., & Gabriels, R. L. (2019) · Frontiers in Veterinary Science · doi:10.3389/fvets.2018.00312 · Cited by 47 · see citing works
Muscatello, R. A., & Corbett, B. A. (2017) · Autism Research · doi:10.1002/aur.1879 · Cited by 45 · see citing works
Self-citationAutism Traits, Sensory Over-Responsivity, Anxiety, and Stress: A Test of Explanatory Models
Amos, G. A., Byrne, G., Chouinard, P. A., & Godber, T. (2018) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-018-3695-6 · Cited by 46 · see citing works
Smeekens, I., Didden, R., & Verhoeven, E. W. M. (2015) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-013-1947-z · Cited by 55 · see citing works
Sniecinska-Cooper, A. M., Iles, R. K., Butler, S. A., Jones, H., Bayford, R. H., & Dimitriou, D. (2014) · Sleep Medicine · doi:10.1016/j.sleep.2014.09.003 · Cited by 44 · see citing works
Hamza, R. T., Hewedi, D. H., & Ismail, M. A. (2010) · The Italian Journal of Pediatrics/Italian journal of pediatrics · doi:10.1186/1824-7288-36-71 · Cited by 43 · see citing works
Kidd, S. A., Corbett, B. A., Granger, D. A., Boyce, W. T., Anders, T. F., & Tager, I. B. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-012-1522-z · Cited by 43 · see citing works
Self-citationReduced Plasma Apelin Levels in Patients with Autistic Spectrum Disorder
Boso, M., Emanuele, E., Politi, P., Pace, A., Arra, M., Nemi, S. U. D., & Barale, F. (2006) · Archives of Medical Research · doi:10.1016/j.arcmed.2006.08.003 · Cited by 42 · see citing works
Bitsika, V., Sharpley, C. F., Andronicos, N. M., & Agnew, L. L. (2014) · Physiology & Behavior · doi:10.1016/j.physbeh.2014.11.010 · Cited by 40 · see citing works
Corbett, B. A., Muscatello, R. A., Kim, A., Patel, K., & Vandekar, S. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2020.105115 · Cited by 36 · see citing works
Self-citationThe cortisol awakening response (CAR) in male children with autism spectrum disorder
Corbett, B. A., & Schupp, C. W. (2014) · Hormones and Behavior · doi:10.1016/j.yhbeh.2014.01.012 · Cited by 37 · see citing works
Self-citationAutism - A Neurodevelopmental Journey from Genes to Behaviour
Eapen, V. (2011) · InTech eBooks · doi:10.5772/974 · Cited by 36 · see citing works
Salivary proteomics and biomarkers in neurology and psychiatry
Wormwood, K. L., Aslebagh, R., Channaveerappa, D., Dupree, E. J., Borland, M. M., Ryan, J. P., Darie, C. C., & Woods, A. G. (2015) · PROTEOMICS - CLINICAL APPLICATIONS · doi:10.1002/prca.201400153 · Cited by 36 · see citing works
Sivaratnam, C. S., Newman, L. K., Tonge, B. J., & Rinehart, N. (2015) · Review Journal of Autism and Developmental Disorders · doi:10.1007/s40489-015-0048-7 · Cited by 35 · see citing works
Anesiadou, S., Makris, G., Michou, M., Bali, P., Papassotiriou, I., Apostolakou, F., Κορκολιάκου, Π., Papageorgiou, C., Chrousos, G. P., & Pervanidou, P. (2020) · Stress and Health · doi:10.1002/smi.2971 · Cited by 34 · see citing works
West, D. V., Del‐Favero, J., Deboutte, D., Broeckhoven, C. V., & Claes, S. J. (2010) · Psychiatry Research · doi:10.1016/j.psychres.2009.04.002 · Cited by 33 · see citing works
Stress and the Student with Autism Spectrum Disorders
Lytle, R. K., & Todd, T. A. (2009) · Teaching Exceptional Children · doi:10.1177/004005990904100404 · Cited by 32 · see citing works
Edmiston, E. K., Blain, S. D., & Corbett, B. A. (2016) · Autism Research · doi:10.1002/aur.1660 · Cited by 33 · see citing works
Self-citationHegarty, J. P., Ferguson, B. J., Zamzow, R., Rohowetz, L. J., Johnson, J. D., Christ, S. E., & Beversdorf, D. Q. (2016) · Brain Imaging and Behavior · doi:10.1007/s11682-016-9604-8 · Cited by 31 · see citing works
Juybari, K. B., Sepehri, G., Meymandi, M. S., Shahrbabaki, S. S. V., Moslemizadeh, A., Saeedi, N., Aminzadeh, A., Nozari, M., Khaksari, M., Haghpanah, T., et al. (2020) · Neurotoxicology and Teratology · doi:10.1016/j.ntt.2020.106905 · Cited by 31 · see citing works
- Authors
- Corbett, B. A., Mendoza, S., Abdullah, M., Wegelin, J. A., & Levine, S.
- Affiliations
- University of California, Davis (US)
- Venue
- Psychoneuroendocrinology
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 31
- Issue
- 1
- Pages
- 59-68
- ISSN
- 0306-4530 (ISSN-L)
- OpenAlex
- W2124859267
- Cited by
- 258
- References
- 35
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 11 · 2023: 5 · 2022: 11 · 2021: 15 · 2020: 18 · 2019: 11 · 2018: 21 · 2017: 10 · 2016: 8 · 2015: 16 · 2014: 20 · 2013: 17 · 2012: 14
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychoneuroendocrinology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (1r21mh065672-01)
- University of California, Davis
- National Institute of Mental Health (MH065672)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Keywords
- autism spectrum disorder, cortisol, circadian rhythm, hypothalamic-pituitary-adrenal axis, stress response, salivary cortisol, children, novel stimuli, neuroendocrine regulation, biomarkers
- MeSH terms
- Autistic Disorder, Child, Circadian Rhythm, Environment, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Male, Surveys and Questionnaires, Saliva, Sensation, Specimen Handling, Stress, Psychological, Feedback, Psychological
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
