Genes Controlling Affiliative Behavior as Candidate Genes for Autism
Open accessAbstract
Background Autism spectrum disorders (ASD) are neurodevelopmental disorders of complex etiology, with a recognized substantial contribution of heterogeneous genetic factors; one of the core features of ASD is a lack of affiliative behaviors.Methods On the basis of the existing literature, in this study we examined the hypothesis of allelic associations between genetic variants in six genes involved in control of maternal and affiliative behaviors (OXT, OXTR, PRL, PRLR, DbetaH, and FOSB). One hundred and seventy-seven probands with ASD from 151 families (n = 527) were assessed with a set of related instruments capturing multiple facets of ASD. Multivariate and univariate phenotypes were constructed from these assessments and subjected to genetic linkage and association analyses with PBAT and FBAT software.Results The resulting pattern of findings, in general, confirmed the hypotheses of the significance of the genes involved in the development of affiliative behaviors in the manifestation of ASD (p values ranging from .000005 to .05); statistically speaking, the strongest results were obtained for allelic associations with the PRL, PRLR, and OXTR genes.Conclusions These preliminary data provide additional support for the hypothesis that the allelic variants of genes necessary for the development of species-typical affiliative behaviors are associated with ASD. Independent replication of these findings is needed and studies of other genes associated with affiliative behaviors are indicated.
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Polymorphisms in the human OXTR gene are significantly associated with an ASD diagnosis and/or predict the severity of ASD.
“many of these genetic studies have found that polymorphisms in the human OXT receptor (OXTR) gene are significantly associated with an ASD diagnosis and/or predict the severity of ASD4–12.”
From Effect of age and autism spectrum disorder on oxytocin receptor density in the human basal forebrain and midbrain (2018) · cites this paper as [8]
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- Authors
- Yrigollen, C. M., Han, S. S., Kochetkova, A., Babitz, T., Chang, J. T., Volkmar, F. R., Leckman, J. F., & Grigorenko, E. L.
- Affiliations
- Yale University (US)
- Lomonosov Moscow State University (RU)
- Corresponding author
- Grigorenko, Elena L.
- ORCID
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2008-05
- Volume
- 63
- Issue
- 10
- Pages
- 911-916
- ISSN
- 0006-3223 (ISSN-L)
- PMC
- PMC2386897
- OpenAlex
- W1965901834
- Cited by
- 172
- References
- 61
- Citations by year
- 2024: 2 · 2023: 5 · 2022: 6 · 2021: 3 · 2020: 6 · 2019: 5 · 2018: 10 · 2017: 7 · 2016: 16 · 2015: 13 · 2014: 15 · 2013: 14 · 2012: 18
- FWCI
- 8.99
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (K05MH076273)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (U19HD035482, HD03008, P01HD003008)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- autism spectrum disorder, affiliative behavior, candidate genes, allelic association, oxytocin, oxytocin receptor, prolactin, prolactin receptor, DBH, FosB, genetic linkage, maternal behavior, social behavior
- MeSH terms
- Analysis of Variance, Autistic Disorder, Behavior, Child, Dopamine beta-Hydroxylase, Family Health, Female, Genotype, Humans, Genetic Linkage, Male, Organizational Affiliation, Oxytocin, Prolactin, Receptors, Prolactin, Genetic Variation, Proto-Oncogene Proteins c-fos, Receptors, Oxytocin, Genetic Predisposition to Disease, Asperger Syndrome
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