The serotonin-N-acetylserotonin-melatonin pathway as a biomarker for autism spectrum disorders
Open accessAbstract
Elevated whole-blood serotonin and decreased plasma melatonin (a circadian synchronizer hormone that derives from serotonin) have been reported independently in patients with autism spectrum disorders (ASDs). Here, we explored, in parallel, serotonin, melatonin and the intermediate N-acetylserotonin (NAS) in a large cohort of patients with ASD and their relatives. We then investigated the clinical correlates of these biochemical parameters. Whole-blood serotonin, platelet NAS and plasma melatonin were assessed in 278 patients with ASD, their 506 first-degree relatives (129 unaffected siblings, 199 mothers and 178 fathers) and 416 sex- and age-matched controls. We confirmed the previously reported hyperserotonemia in ASD (40% (35-46%) of patients), as well as the deficit in melatonin (51% (45-57%)), taking as a threshold the 95th or 5th percentile of the control group, respectively. In addition, this study reveals an increase of NAS (47% (41-54%) of patients) in platelets, pointing to a disruption of the serotonin-NAS-melatonin pathway in ASD. Biochemical impairments were also observed in the first-degree relatives of patients. A score combining impairments of serotonin, NAS and melatonin distinguished between patients and controls with a sensitivity of 80% and a specificity of 85%. In patients the melatonin deficit was only significantly associated with insomnia. Impairments of melatonin synthesis in ASD may be linked with decreased 14-3-3 proteins. Although ASDs are highly heterogeneous, disruption of the serotonin-NAS-melatonin pathway is a very frequent trait in patients and may represent a useful biomarker for a large subgroup of individuals with ASD.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Our microbial correlations provide further evidence for the relevance of the tryptophan-serotonin pathway in ASD.
“Our microbial correlations provide further evidence for the relevance of the tryptophan–serotonin pathway in ASD,62 although our sample size did not allow us to focus on an ASD subgroup.”
From Distinct Microbiome-Neuroimmune Signatures Correlate With Functional Abdominal Pain in Children With Autism Spectrum Disorder (2017) · cites this paper as [62]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Pittsburgh Sleep Quality Index: a new instrument for psychiatric practice and research
Buysse, D. J., Reynolds, C. F., Monk, T. H., Berman, S. R., & Kupfer, D. J. (1989) · Psychiatry Research · doi:10.1016/0165-1781(89)90047-4 · Cited by 35,234 · see citing works
A New Method for Measuring Daytime Sleepiness: The Epworth Sleepiness Scale
Johns, M. W. (1991) · Sleep · doi:10.1093/sleep/14.6.540 · Cited by 17,364 · see citing works
Lord, C., Rutter, M., & Le Couteur, A. (1994) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02172145 · Cited by 9,065 · see citing works
Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., Pickles, A., & Rutter, M. (2000) · Journal of Autism and Developmental Disorders · doi:10.1023/a:1005592401947 · Cited by 7,520 · see citing works
Hanley, J. A., & McNeil, B. J. (1983) · Radiology · doi:10.1148/radiology.148.3.6878708 · Cited by 7,016 · see citing works
A self-assessment questionnaire to determine morningness- eveningness in human circadian rhythms
Home, J. K. (1976) · Medical Entomology and Zoology · Cited by 4,783 · see citing works
(1976) · PubMed · Cited by 3,979 · see citing works
Owens, J. A., Spirito, A., & McGuinn, M. (2000) · Sleep · doi:10.1093/sleep/23.8.1d · Cited by 2,535 · see citing works
Lai, M.-C., Lombardo, M. V., & Baron-Cohen, S. (2014) · The Lancet · doi:10.1016/s0140-6736(13)61539-1 · Cited by 2,371 · see citing works
Attention to eyes is present but in decline in 2–6-month-old infants later diagnosed with autism
Jones, W., & Klin, A. (2013) · Nature · doi:10.1038/nature12715 · Cited by 1,293 · see citing works
The basic physiology and pathophysiology of melatonin
Claustrat, B., Brun, J., & Chazot, G. (2004) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2004.08.001 · Cited by 951 · see citing works
Promoting social behavior with oxytocin in high-functioning autism spectrum disorders.
Andari, E., Duhamel, J.-R., Zalla, T., Herbrecht, E., Leboyer, M., & Sirigu, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0910249107 · Cited by 941 · see citing works
Self-citationLam, K. S. L., & Aman, M. G. (2007) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0213-z · Cited by 793 · see citing works
Simonneaux, V., & Ribelayga, C. (2003) · Pharmacological Reviews · doi:10.1124/pr.55.2.2 · Cited by 740 · see citing works
Brain growth across the life span in autism: Age-specific changes in anatomical pathology
Courchesne, E., Campbell, K., & Solso, S. (2011) · Brain Research · doi:10.1016/j.brainres.2010.09.101 · Cited by 711 · see citing works
Richdale, A. L., & Schreck, K. A. (2009) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.02.003 · Cited by 708 · see citing works
A transient placental source of serotonin for the fetal forebrain
Bonnin, A., Goeden, N., Chen, K., Wilson, M. L., King, J., Shih, J. C., Blakely, R. D., Deneris, E. S., & Levitt, P. (2011) · Nature · doi:10.1038/nature09972 · Cited by 608 · see citing works
Oxytocin-Mediated GABA Inhibition During Delivery Attenuates Autism Pathogenesis in Rodent Offspring
Tyzio, R., Nardou, R., Ferrari, D. C., Tsintsadze, T., Shahrokhi, A., Eftekhari, S., Khalilov, I., Tsintsadze, V., Brouchoud, C., Chazal, G., et al. (2014) · Science · doi:10.1126/science.1247190 · Cited by 601 · see citing works
Studies on 5-hydroxyindole metabolism in autistic and other mentally retarded children
Schain, R. J., & Freedman, D. X. (1961) · The Journal of Pediatrics · doi:10.1016/s0022-3476(61)80261-8 · Cited by 579 · see citing works
Rossignol, D. A., & Frye, R. E. (2011) · Molecular Psychiatry · doi:10.1038/mp.2011.165 · Cited by 545 · see citing works
Abnormal melatonin synthesis in autism spectrum disorders
Melke, J., Goubran Botros, H., Chaste, P., Betancur, C., Nygren, G., Anckarsäter, H., Rastam, M., Ståhlberg, O., Gillberg, I. C., Delorme, R., et al. (2008) · Molecular Psychiatry · doi:10.1038/sj.mp.4002016 · Cited by 511 · see citing works
Self-citationMelatonin in autism spectrum disorders: a systematic review and meta-analysis
ROSSIGNOL, D. A., & FRYE, R. E. (2011) · Developmental Medicine & Child Neurology · doi:10.1111/j.1469-8749.2011.03980.x · Cited by 468 · see citing works
The Genetic Landscapes of Autism Spectrum Disorders
Huguet, G., Ey, E., & Bourgeron, T. (2013) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev-genom-091212-153431 · Cited by 447 · see citing works
Self-citationInfant neural sensitivity to dynamic eye gaze is associated with later emerging autism
Elsabbagh, M., Mercure, E., Hudry, K., Chandler, S., Pasco, G., Charman, T., Pickles, A., Baron-Cohen, S., Bolton, P., & Johnson, M. H. (2012) · Current Biology · doi:10.1016/j.cub.2011.12.056 · Cited by 429 · see citing works
Ecker, C., Marquand, A., Mourão-Miranda, J., Johnston, P., Daly, E. M., Brammer, M. J., Maltezos, S., Murphy, C. M., Robertson, D., Williams, S. C., et al. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.5413-09.2010 · Cited by 415 · see citing works
Reciprocal Social Behavior in Children With and Without Pervasive Developmental Disorders
CONSTANTINO, J. N., PRZYBECK, T., FRIESEN, D., & TODD, R. D. (2000) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/00004703-200002000-00002 · Cited by 398 · see citing works
The Endogenous Melatonin Profile as a Marker for Circadian Phase Position
Lewy, A. J., Cutler, N. L., & Sack, R. L. (1999) · Journal of Biological Rhythms · doi:10.1177/074873099129000641 · Cited by 392 · see citing works
Crystal Structure of the 14-3-3ζ:Serotonin N-Acetyltransferase Complex
Obšil, T., Ghirlando, R., Klein, D. C., Ganguly, S., & Dyda, F. (2001) · Cell · doi:10.1016/s0092-8674(01)00316-6 · Cited by 389 · see citing works
Maternal serotonin is crucial for murine embryonic development
Côté, F., Fligny, C., Bayard, E., Launay, J.-M., Gershon, M. D., Mallet, J., & Vodjdani, G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606722104 · Cited by 381 · see citing works
Self-citationSleep in children with autistic spectrum disorder
Cortesi, F., Giannotti, F., Ivanenko, A., & Johnson, K. (2010) · Sleep Medicine · doi:10.1016/j.sleep.2010.01.010 · Cited by 355 · see citing works
Blood serotonin levels in autism spectrum disorder: A systematic review and meta-analysis
Gabriele, S., Sacco, R., & Persico, A. M. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.02.004 · Cited by 346 · see citing works
Neurochemical correlates of autistic disorder: a review of the literature
Lam, K. S. L., Aman, M. G., & Arnold, L. E. (2006) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2005.03.003 · Cited by 318 · see citing works
Nocturnal excretion of 6-sulphatoxymelatonin in children and adolescents with autistic disorder
Tordjman, S., Anderson, G. M., Pichard, N., Charbuy, H., & Touitou, Y. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.003 · Cited by 296 · see citing works
Cortesi, F., Giannotti, F., Sebastiani, T., Panunzi, S., & Valente, D. (2012) · Journal of Sleep Research · doi:10.1111/j.1365-2869.2012.01021.x · Cited by 275 · see citing works
Malow, B., Adkins, K. W., McGrew, S. G., Wang, L., Goldman, S. E., Fawkes, D., & Burnette, C. (2012) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-011-1418-3 · Cited by 274 · see citing works
Melatonin for Insomnia in Children With Autism Spectrum Disorders
Andersen, I. M., Kaczmarska, J., McGrew, S. G., & Malow, B. A. (2008) · Journal of Child Neurology · doi:10.1177/0883073807309783 · Cited by 228 · see citing works
Nir, I., Meir, D., Zilber, N., Knobler, H., Hadjez, J., & Lerner, Y. (1995) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02178193 · Cited by 221 · see citing works
Progress toward treatments for synaptic defects in autism
Delorme, R., Ey, E., Toro, R., Leboyer, M., Gillberg, C., & Bourgeron, T. (2013) · Nature Medicine · doi:10.1038/nm.3193 · Cited by 218 · see citing works
Self-citationN -acetylserotonin activates TrkB receptor in a circadian rhythm
Jang, S., Liu, X., Sompol, P. M., Tosini, G., Chang, Q., Iuvone, P. M., & Ye, K. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912531107 · Cited by 213 · see citing works
Giannotti, F., Cortesi, F., Cerquiglini, A., & Bernabei, P. (2006) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-006-0116-z · Cited by 211 · see citing works
Wright, B., Sims, D., Smart, S., Alwazeer, A., Alderson‐Day, B., Allgar, V. L., Whitton, C., Tomlinson, H., Bennett, S. D., Jardine, J., et al. (2010) · Journal of Autism and Developmental Disorders · doi:10.1007/s10803-010-1036-5 · Cited by 196 · see citing works
Leboyer, M., Philippe, A., Bouvard, M., Guilloud-Bataille, M., Bondoux, D., Tabuteau, F., Feingold, J., Mouren-Simeoni, M.-C., & Launay, J.-M. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(97)00532-5 · Cited by 194 · see citing works
Self-citationBiomarkers in autism spectrum disorder: the old and the new
Ruggeri, B., Sarkans, U., Schumann, G., & Persico, A. M. (2013) · Psychopharmacology · doi:10.1007/s00213-013-3290-7 · Cited by 191 · see citing works
The possible interplay of synaptic and clock genes in autism spectrum disorders
Bourgeron, T. (2007) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2007.72.020 · Cited by 185 · see citing works
Self-citationMitochondrial damage in Alzheimer's disease varies with apolipoprotein E genotype
Gibson, G. E., Haroutunian, V. H., Zhang, H., Park, L. C. H., Shi, Q., LESSER, M. L., Mohs, R. C., Sheu, R., & Blass, J. P. (2000) · Annals of Neurology · doi:10.1002/1531-8249(200009)48:3 · Cited by 184 · see citing works
Switching brain serotonin with oxytocin
Mottolese, R., Redouté, J., Costes, N., Le Bars, D., & Sirigu, A. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1319810111 · Cited by 179 · see citing works
Evidence of pineal endocrine hypofunction in autistic children.
Kullmann, G. A., Lissoni, P., Rovelli, F., Roselli, M. G., Brivio, F., & Sequeri, P. (2000) · PubMed · Cited by 164 · see citing works
Broad and narrow heritabilities of quantitative traits in a founder population
Abney, M., McPeek, M. S., & Ober, C. (2001) · The American Journal of Human Genetics · doi:10.1086/320112 · Cited by 157 · see citing works
MCBRIDE, P. A., ANDERSON, G. M., HERTZIG, M. E., SNOW, M. E., THOMPSON, S. M., KHAIT, V. D., SHAPIRO, T., & COHEN, D. J. (1998) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199807000-00017 · Cited by 141 · see citing works
Effectiveness of Melatonin in the Treatment of Sleep Disturbances in Children with Asperger Disorder
Paavonen, E. J., Wendt, T. N., Vanhala, R., Aronen, E. T., & von Wendt, L. (2003) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/104454603321666225 · Cited by 140 · see citing works
Tordjman, S., Anderson, G. M., Bellissant, E., Botbol, M., Charbuy, H., Camus, F., Graignic, R., Kermarrec, S., Fougerou, C., Cohen, D., et al. (2012) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2012.04.013 · Cited by 129 · see citing works
Capturing the circadian rhythms of free-running blind people with 0.5 mg melatonin
Lewy, A. J., Bauer, V. K., Hasler, B. P., Kendall, A. R., Pires, M. L. N., & Sack, R. L. (2001) · Brain Research · doi:10.1016/s0006-8993(01)02964-x · Cited by 120 · see citing works
Étain, B., Dumaine, A., Bellivier, F., Pagan, C., Francelle, L., Goubran‐Botros, H., Moreno, S., Deshommes, J., Moustafa, K., Dudal, K. L., et al. (2012) · Human Molecular Genetics · doi:10.1093/hmg/dds227 · Cited by 105 · see citing works
Self-citationCook, E. H., LEVENTHAL, B. L., Heller, W., Metz, J. T., Wainwright, M. S., & Freedman, D. X. (1990) · Journal of Neuropsychiatry · doi:10.1176/jnp.2.3.268 · Cited by 104 · see citing works
Relationships of whole blood serotonin and plasma norepinephrine within families
Leventhal, B. L., Cook, E. H., Morford, M., Ravitz, A., & Freedman, D. X. (1990) · Journal of Autism and Developmental Disorders · doi:10.1007/bf02216055 · Cited by 102 · see citing works
Koldewyn, K., Yendiki, A., Weigelt, S., Hyowon Gweon, C., Julian, J. B., Richardson, H., Malloy, C., Saxe, R. R., Fischl, B. R., & Kanwisher, N. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1324037111 · Cited by 98 · see citing works
Kema, I. P., Schellings, A. M., Hoppenbrouwers, C. J. M., Rutgers, H. M., de Vries, E. G. E., & Muskiet, F. A. J. (1993) · Clinica Chimica Acta · doi:10.1016/0009-8981(93)90029-4 · Cited by 90 · see citing works
Daily variations of platelet aggregation in relation to blood and plasma serotonin in diabetes
Małyszko, J., Urano, T., Knöfler, R., Taminato, A., Yoshimi, T., Takada, Y., & Takada, A. (1994) · Thrombosis Research · doi:10.1016/0049-3848(94)90231-3 · Cited by 87 · see citing works
Diurnal and seasonal variations in human platelet serotonin in man
Wirz‐Justice, A., Lichtsteiner, M., & Feer, H. (1977) · Journal of Neural Transmission · doi:10.1007/bf01252961 · Cited by 83 · see citing works
Chaste, P., Klei, L., Sanders, S., Murtha, M. T., Bal, V. H., Lowe, J. K., Willsey, A. J., Moreno‐De‐Luca, D., Yu, T. W., Fombonne, E. J., et al. (2013) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.04.018 · Cited by 81 · see citing works
Examining Autism Spectrum Disorders by Biomarkers: Example From the Oxytocin and Serotonin Systems
Hammock, E. A. D., Veenstra-VanderWeele, J. M., Yan, Z., Kerr, T. M., Morris, M., Anderson, G. M., Carter, C. S., Cook, E. H., & Jacob, S. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.04.010 · Cited by 79 · see citing works
The heritability of melatonin secretion and sensitivity to bright nocturnal light in twins
Hallam, K. T., Olver, J. S., Chambers, V., Begg, D. P., McGrath, C., & Norman, T. R. (2006) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2006.04.004 · Cited by 74 · see citing works
Gałecki, P., Szemraj, J., Bartosz, G., Bieńkiewicz, M., Gałecka, E., Florkowski, A., Lewiñski, A., & Karbownik‐Lewińska, M. (2010) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2010.00754.x · Cited by 64 · see citing works
Control of Pineal N-Acetylserotonin by a Beta Adrenergic Receptor
Brownstein, M., Saavedra, J. M., & Axelrod, J. (1973) · Molecular Pharmacology · doi:10.1016/s0026-895x(25)13981-3 · Cited by 62 · see citing works
Serotonin Relationships of Autistic Probands and Their First-Degree Relatives
Samuel Kuperman, C., Beeghly, J. H. L., Burns, T. L., & Tsai, L. Y. (1985) · Journal of the American Academy of Child Psychiatry · doi:10.1016/s0002-7138(09)60446-5 · Cited by 61 · see citing works
Maturational changes in blood serotonin levels and platelet counts
RITVO, E. R., Yuwiler, A., Geller, E., et al. (1971) · Biochemical Medicine · doi:10.1016/0006-2944(71)90077-9 · Cited by 60 · see citing works
N -acetylserotonin promotes hippocampal neuroprogenitor cell proliferation in sleep-deprived mice
Sompol, P. M., Liu, X., Baba, K., Paul, K. N., Tosini, G., Iuvone, P. M., & Ye, K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1105114108 · Cited by 54 · see citing works
Maronde, E., Saade, A., Ackermann, K., Goubran‐Botros, H., Pagan, C., Bux, R., Bourgeron, T., Dehghani, F., & Stehle, J. H. (2011) · Journal of Pineal Research · doi:10.1111/j.1600-079x.2011.00880.x · Cited by 53 · see citing works
Self-citationClaudio Toma, A., Rossi, M., Sousa, I., Blasi, F., Bacchelli, E., Alén, R., Vanhala, R., Monaco, A. P., Järvelä, I. E., & Maestrini, E. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002069 · Cited by 50 · see citing works
Polymorphisms in melatonin synthesis pathways: possible influences on depression
Kripke, D. F., Nievergelt, C. M., Tranah, G. J., Murray, S. S., McCarthy, M. J., Rex, K. M., Parimi, N., & Kelsoe, J. R. (2011) · Journal of Circadian Rhythms · doi:10.1186/1740-3391-9-8 · Cited by 34 · see citing works
Klemm, P. L., Hecker, M., Stockhausen, H., et al. (1995) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.1995.tb15021.x · Cited by 28 · see citing works
Analgesia induced by N-acetylserotonin in the central nervous system
Psarakis, S., Brown, G. M., & Grota, L. J. (1988) · Life Sciences · doi:10.1016/0024-3205(88)90567-x · Cited by 22 · see citing works
The Autisms: Molecules to Model Systems
Powell, C. R. (2012) · Oxford University Press eBooks · doi:10.1093/med/9780199744312.001.0001 · Cited by 10 · see citing works
Pagan, C., Delorme, R., Launay, J., et al. (2013) · Oxford University Press eBooks · doi:10.1093/med/9780199744312.003.0015 · Cited by 3 · see citing works
Self-citation
Flagged first, then by citations
Research works printed but not linked: 2
- Lai MC Lombardo MV Baron-Cohen S Autism Lancet 2013 383 896 910 24074734
- Kenney K Brechtel C Takahashi H Kurohara K Anderson P Gibbs CJ Jr An enzyme-linked immunosorbent assay to quantify 14-3-3 proteins in the cerebrospinal fluid of suspected Creutzfeldt-Jakob disease patients Ann Neurol 2000 48 395 398 10976650
Cited by
Sorted by citations
From the genetic architecture to synaptic plasticity in autism spectrum disorder
Bourgeron, T. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3992 · Cited by 975 · see citing works
Self-citationThe serotonin system in autism spectrum disorder: From biomarker to animal models
Muller, C. L., Anacker, A. M. J., & Veenstra-VanderWeele, J. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2015.11.010 · Cited by 531 · see citing works
Luna, R. A., Oezguen, N., Balderas, M., Venkatachalam, A., Runge, J. K., Versalovic, J., Veenstra-VanderWeele, J., Anderson, G. M., Savidge, T., & Williams, K. C. (2017) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2016.11.008 · Cited by 295 · see citing works
Gevi, F., Zolla, L., Gabriele, S., & Persico, A. M. (2016) · Molecular Autism · doi:10.1186/s13229-016-0109-5 · Cited by 251 · see citing works
Carmassi, C., Palagini, L., Caruso, D., Masci, I., Nobili, L., Vita, A., & Dell’Osso, L. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2019.00366 · Cited by 220 · see citing works
Cortese, S., Solmi, M., Michelini, G., Bellato, A., Blanner, C., Canozzi, A., Eudave, L., Farhat, L. C., Højlund, M., Köhler‐Forsberg, O., et al. (2023) · World Psychiatry · doi:10.1002/wps.21037 · Cited by 147 · see citing works
Frye, R. E., & Rossignol, D. A. (2016) · Clinical Medicine Insights Pediatrics · doi:10.4137/cmped.s38337 · Cited by 96 · see citing works
Phenolic Melatonin-Related Compounds: Their Role as Chemical Protectors against Oxidative Stress
Galano, A., Castañeda-Arriaga, R., Pérez-González, A., Tan, D.-X., & Reiter, R. (2016) · Molecules · doi:10.3390/molecules21111442 · Cited by 60 · see citing works
Dell’Osso, L., Massoni, L., Battaglini, S., Cremone, I. M., Carmassi, C., & Carpita, B. (2022) · Annals of General Psychiatry · doi:10.1186/s12991-022-00390-6 · Cited by 48 · see citing works
Hannant, P., Cassidy, S., Renshaw, D., & Joyce, A. (2021) · Nutritional Neuroscience · doi:10.1080/1028415x.2019.1588486 · Cited by 16 · see citing works
- Authors
- Pagan, C., Delorme, R., Callebert, J., Goubran-Botros, H., Amsellem, F., Drouot, X., Boudebesse, C., Le Dudal, K., Ngo-Nguyen, N., Laouamri, H., Gillberg, C., Leboyer, M., Bourgeron, T., & Launay, J.-M.
- Affiliations
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Fondation FondaMental (FR)
- University College London (GB)
- Corresponding author
- Launay, J-M
- Venue
- Translational Psychiatry
- Published
- 2014-11-11
- Volume
- 4
- Issue
- 11
- Pages
- e479-e479
- ISSN
- 2158-3188 (ISSN-L)
- PMC
- PMC4259991
- OpenAlex
- W2073804342
- Cited by
- 165
- References
- 74
- Citations by year
- 2026: 8 · 2025: 13 · 2024: 12 · 2023: 14 · 2022: 15 · 2021: 16 · 2020: 18 · 2019: 14 · 2018: 13 · 2017: 16 · 2016: 13 · 2015: 12 · 2014: 1
- FWCI
- 7.81
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Translational Psychiatry (publishedVersion, cc-by-nc-sa)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-sa)
- PubMed Central (publishedVersion, cc-by-nc-sa)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- Funders
- Fondation FondaMental
- Fondation Cognacq-Jay
- Fondation Orange
- Agence Nationale de la Recherche
- Institut National de la Santé et de la Recherche Médicale
- Centre National de la Recherche Scientifique
- Université Paris Diderot
- NIH Clinical Center
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Health Sciences › Medicine › Psychiatry and Mental health › Child Nutrition and Feeding Issues
- Keywords
- autism spectrum disorder, serotonin, N-acetylserotonin, melatonin, hyperserotonemia, biomarkers, plasma melatonin, first-degree relatives, insomnia, 14-3-3 proteins, circadian rhythm
- MeSH terms
- Adolescent, Adult, Child, Child Development Disorders, Pervasive, Female, Humans, Male, Melatonin, Parents, Serotonin, Signal Transduction, Biomarkers, Siblings
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
