Elevated blood serotonin in autistic probands and their first-degree relatives
Abstract
Whole blood serotonin levels and platelet counts were studied in 14 families, representing 57 family members and 15 probands who met DSM III criteria for infantile autism. High serotonin appeared to segregate in families. When two parents had high serotonin, the serotonin level in their offspring was twice the parental level. When one parent had high serotonin, the serotonin level in the offspring approximated the level of serotonin in either the high serotonin parent or the low serotonin parent. For the case where both parents had low serotonin, in one family the children had low serotonin and in a second family, high serotonin levels were present in the autistic proband, and a sibling with severe mental retardation. Mean serotonin levels were higher for both male and female, autistics and family members, in the four black families than in the 10 Caucasian families.
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Whole-blood 5-HT levels demonstrate strong heritability.
“Although studies demonstrate a strong heritability of whole-blood 5-HT levels [41–44]”
From Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders (2018) · cites this paper as [42]
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- Authors
- Abramson, R. K., Wright, H. H., Carpenter, R., Brennan, W., Lumpuy, O., Cole, E., & Young, S. R.
- Affiliations
- William S. Hall Psychiatric Institute (US)
- University of South Carolina (US)
- ORCID
- Cole, Elisabeth
- Venue
- Journal of Autism and Developmental Disorders
- Published
- 1989-09
- Volume
- 19
- Issue
- 3
- Pages
- 397-407
- ISSN
- 0162-3257 (ISSN-L)
- 1573-3432
- OpenAlex
- W1990449369
- Cited by
- 123
- References
- 21
- Citations by year
- 2024: 1 · 2023: 1 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 3 · 2014: 9 · 2013: 7 · 2012: 6
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Autism and Developmental Disorders (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Center for Research Resources (2507-RR-0585-01)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- serotonin, infantile autism, first-degree relatives, familial aggregation, platelet count, sex differences, racial differences, genetic transmission
- MeSH terms
- Adolescent, Adult, Autistic Disorder, Blood Platelets, Child, Child, Preschool, Female, Humans, Male, Pedigree, Serotonin, Black People, White People
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