Cited by 194Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeuroendocrine regulation and behavior

Whole blood serotonin and plasma beta-endorphin in autistic probands and their first-degree relatives

Leboyer, Marion, Philippe, Anne, Bouvard, Manuel, Guilloud-Bataille, Michel, Bondoux, Dominique, Tabuteau, François, Feingold, Josué, Mouren-Simeoni, Marie-Christine +1 more·1999·Biological Psychiatry

Abstract

Background Whole blood serotonin (5-HT) and C-terminally directed beta-endorphin protein immunoreactivity (C-ter-beta-EP-ir) are known to be elevated in autistic subjects and might be possible markers of genetic liability to autism. This study thus investigates the familial aggregation of 5-HT and of C-ter-beta-EP-ir levels in first degree relatives of autistic probands.Methods In a sample of 62 autistic subjects and 122 of their first-degree relatives, compared to age and sex-matched controls, we measured 5-HT by radioenzymology and C-ter-beta-EP-ir by radioimmunoassay.Results We confirm the previously reported familiality of hyperserotoninemia in autism as mothers (51%), fathers (45%) and siblings (87%) have elevated levels of 5-HT, and we reveal presence of elevated levels of C-ter-beta-EP-ir in mothers (53%) of autistic subjects.Conclusions Familial aggregation of quantitative variables, such as concentration of neurotransmitters, within unaffected relative could serve as an intermediate phenotype and might thus help the search of genetic susceptibility factors in autism.

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Crossref · 10.1016/s0006-3223(97)00532-5

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Authors
Leboyer, M., Philippe, A., Bouvard, M., Guilloud-Bataille, M., Bondoux, D., Tabuteau, F., Feingold, J., Mouren-Simeoni, M.-C., & Launay, J.-M.
Affiliations
  • Inserm (FR)
  • Hôpital Robert-Debré (FR)
  • Hôpital Lariboisière (FR)
Corresponding author
Leboyer, Marion
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
1999-01
Volume
45
Issue
2
Pages
158-163
ISSN
0006-3223 (ISSN-L)
OpenAlex
W1976571596
Cited by
194
References
34
Citations by year
2026: 1 · 2024: 3 · 2023: 6 · 2022: 3 · 2021: 10 · 2020: 4 · 2019: 5 · 2018: 4 · 2017: 10 · 2016: 4 · 2015: 7 · 2014: 16 · 2013: 9 · 2012: 12
FWCI
5.00
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
autism spectrum disorder, serotonin, beta-endorphin, familial aggregation, first-degree relatives, genetic susceptibility, endophenotypes, neurotransmitter levels, mothers of autistic children
MeSH terms
Adolescent, Adult, Autistic Disorder, beta-Endorphin, Child, Child, Preschool, Female, Humans, Intelligence Tests, Male, Radioimmunoassay, Retrospective Studies, Serotonin, Statistics, Nonparametric

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