Cited by 132Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeuroendocrine regulation and behavior

The developmental disruptions of serotonin signaling may involved in autism during early brain development

Yang, C.-J., Tan, H.-P., Du, Y.-J.·2014·Neuroscience

Abstract

Autism is a developmental disorder defined by the presence of a triad of communication, social and stereo typical behavioral characteristics with onset before 3years of age. In spite of the fact that there are potential environmental factors for autistic behavior, the dysfunction of serotonin during early development of the brain could be playing a role in this prevalence rise. Serotonin can modulate a number of developmental events, including cell division, neuronal migration, cell differentiation and synaptogenesis. Hyperserotonemia during fetal development results in the loss of serotonin terminals through negative feedback. The increased serotonin causes a decrease of oxytocin in the paraventricular nucleus of the hypothalamus and an increase in calcitonin gene-related peptide (CGRP) in the central nucleus of the amygdale, which are associated with social interactions and vital in autism. However, hyposerotonemia may be also relevant to the development of sensory as well as motor and cognitive faculties. And the paucity of placenta-derived serotonin should have potential importance when the pathogenesis of autism is considered. This review briefly summarized the developmental disruptions of serotonin signaling involved in the pathogenesis of autism during early development of the brain.

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Crossref · 10.1016/j.neuroscience.2014.02.021

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121 of 121 references verified0 citation errors · 0 not checkable

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  • There are indications that serotonergic signaling is affected during PFC development in ASD.

    “There are also indications that serotonergic signaling is affected during PFC development [372].”

    From Development of prefrontal cortex (2022) · cites this paper as [372]

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Authors
Yang, C.-J., Tan, H.-P., & Du, Y.-J.
Affiliations
  • East China Normal University (CN)
  • Fudan University (CN)
Corresponding author
  • Yang, C.-J.
  • Du, Y.-J.
Venue
Neuroscience
Publisher
Elsevier BV
Published
2014-05
Volume
267
Pages
1-10
ISSN
0306-4522 (ISSN-L)
OpenAlex
W1970406018
Cited by
132
References
121
Citations by year
2026: 6 · 2025: 10 · 2024: 12 · 2023: 17 · 2022: 18 · 2021: 13 · 2020: 13 · 2019: 7 · 2018: 5 · 2017: 9 · 2016: 7 · 2015: 12 · 2014: 3
FWCI
1.00
Type
journal article
Language
en
Open access
closed
Locations
  • Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
East China Normal University (7119297K)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
autism spectrum disorder, serotonin signaling, early brain development, fetal development, hyperserotonemia, serotonin terminals, oxytocin, paraventricular nucleus, calcitonin gene-related peptide, amygdala, neuronal migration, synaptogenesis, autism pathogenesis
MeSH terms
Autistic Disorder, Brain, Developmental Disabilities, Humans, Serotonin, Signal Transduction

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