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Cited by 230Autism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersTryptophan and brain disorders

Hyperserotonemia and amine metabolites in autistic and retarded children

Hanley, Henry G.·1977·Archives of General Psychiatry
DOI 10.1001/archpsyc.1977.01770170031002
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Abstract

Mean whole blood serotonin (5-HT) levels were elevated in groups of autistic and severely retarded children. Eight of 27 (30%) individual autistic children, 13 of 25 (52%) severely retarded children, two of 23 (9%) mildly retarded children, and none of the control children had statistically significant blood 5-HT levels elevations (hyperserotonemia). Hyperserotonemic autistic children excreted more urinary 5-HT, 5-hydroxyindoleacetic acid (5-HIAA), tryptamine, and vanillylmandelic acid than did mildly retarded children with normal blood 5-HT levels. Rates of depletion and repletion of blood 5-HT levels in these two groups following reserpine therapy were identical. Oral tryptophan administration doubled urinary 5-HIAA excretion in both groups and raised urinary 5-HT levels in hyperserotonemic autistic children, but lowered urinary 5-HT in mildly retarded, normal blood 5-HT children. No clear mechanism for hyperserotonemia was found; the rationale for further investigations is discussed.

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  • In patients with ASD, altered function and metabolism of neurotransmitters such as 5-HT and catecholamines, and dysfunction of the serotonergic system, have been reported to contribute to symptomatology.

    “In patients with ASD, altered function and metabolism of neurotransmitters, such as 5′-HT and catecholamines, and dysfunction of the serotonergic system have been reported to contribute to symptomatology [188,192,193,194,195,196].”

    From Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions (2019) · cites this paper as [196]

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Authors
Hanley, H. G.
Corresponding author
Hanley, Henry G.
Venue
Archives of General Psychiatry
Publisher
American Medical Association (AMA)
Published
1977-05-01
Volume
34
Issue
5
Pages
521
ISSN
0003-990X (ISSN-L)
DOI
10.1001/archpsyc.1977.01770170031002
OpenAlex
W2054586661
Cited by
230
References
73
Citations by year
2026: 5 · 2025: 3 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 3 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 6 · 2016: 7 · 2015: 6 · 2014: 10 · 2013: 3 · 2012: 5
FWCI
2.00
Type
journal article
Language
en
Open access
closed
Locations
  • Archives of General Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
hyperserotonemia, serotonin, autism spectrum disorder, intellectual disability, 5-hydroxyindoleacetic acid, urinary excretion, tryptamine, vanillylmandelic acid, reserpine, tryptophan, amine metabolites, blood serotonin levels
MeSH terms
Adolescent, Adult, Age Factors, Autistic Disorder, Child, Child, Institutionalized, Child, Preschool, Humans, Hydroxyindoleacetic Acid, Intelligence, Intellectual Disability, Motor Activity, Reserpine, Serotonin, Tryptamines, Tryptophan, Vanilmandelic Acid

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