Behavioural sensitization to a dopamine agonist is associated with reversal of stress-induced anhedonia
Abstract
Chronic exposure to very mild unpredictable stress (CMS) has previously been found to reduce the consumption of palatable sweet solutions and to impair place preference conditioning; evidence has been presented that these effects may reflect a dysfunction of the mesolimbic dopamine system. In the present study, rats were subjected to CMS for a total of 9 weeks. CMS reduced the consumption of a 1% sucrose solution. During weeks 6 and 7, animals received quinpirole (0-400 micrograms/kg) twice weekly. Both CMS-treated animals and controls showed sensitization to the locomotor stimulant effects of quinpirole. Subsequently, a sustained recovery of sucrose drinking was observed in quinpirole-treated stressed animals. During week 8, all animals received a single pair of place preference conditioning trials, in which quinpirole (200 micrograms/kg) was administered in a distinctive environment, and vehicle in a different environment. Non-stressed animals showed an increase in preference for the environment associated with quinpirole, as did stressed animals that had been sensitized to quinpirole, this effect was absent in untreated stressed animals. Finally, in week 9, acute administration of raclopride (150 micrograms/kg) was found to reverse the recovery of sucrose drinking in quinpirole-treated stressed animals, suggesting that these effects are mediated by an increase in dopamine function.
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Chronic and sequential exposure of rats or mice to a mild stress regimen causes decreases in responsiveness to rewards, including decreased consumption of and preference for sucrose solutions and decreased rewarding properties of pharmacological and natural rewards in the place preference paradigm.
“In particular, Willner and colleagues originally reported that chronic and sequential exposure of rats or mice to a mild stress regimen caused decreases in responsiveness to rewards [190,191], commonly reported as a decrease in the consumption of and preference for sucrose solutions, and a decrease in the rewarding properties of pharmacological and natural rewards in the place preference behavior”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [194]
Cites
Sokoloff, P., Bruno Giros, A., Martres, M., Bouthenet, M.-L., & Schwartz, J. (1990) · Nature · doi:10.1038/347146a0 · Cited by 2,608 · see citing works
Robinson, T. G., & BECKER, J. (1986) · Brain Research · doi:10.1016/s0006-8993(86)80193-7 · Cited by 2,110 · see citing works
Willner, P., Towell, A., Sampson, D., Sophokleous, S., & Muscat, R. (1987) · Psychopharmacology · doi:10.1007/bf00187257 · Cited by 1,993 · see citing works
Self-citationRobinson, T. E., & Becker, J. B. (1986) · Brain Research Reviews · doi:10.1016/0165-0173(86)90002-0 · Cited by 1,796 · see citing works
Papp, M., Willner, P., & Muscat, R. (1991) · Psychopharmacology · doi:10.1007/bf02244188 · Cited by 542 · see citing works
Self-citationThe Mesolimbic Dopamine System: From Motivation to Action
Phillipson, O. T. (1992) · Trends in Neurosciences · doi:10.1016/0166-2236(92)90348-c · Cited by 518 · see citing works
Assessing Anhedonia in Psychiatric Patients
FAWCETT, J. A. (1983) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790010081010 · Cited by 419 · see citing works
Moreau, J., Jenck, F., Martin, J. R., Mortas, P., & Haefely, W. E. (1992) · European Neuropsychopharmacology · doi:10.1016/0924-977x(92)90035-7 · Cited by 250 · see citing works
The neuropharmacological basis of reward
(1991) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(91)90604-b · Cited by 239 · see citing works
Reversal of stress-induced anhedonia by the atypical antidepressants, fluoxetine and maprotiline
Muscat, R., Papp, M., & Willner, P. (1992) · Psychopharmacology · doi:10.1007/bf02247719 · Cited by 237 · see citing works
Self-citationWeiss, S. R. B., Post, R. M., Pert, A., Woodward, R., & Murman, D. (1989) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(89)80001-2 · Cited by 180 · see citing works
Dopaminergic mechanism of imipramine action in an animal model of depression
Muscat, R., Sampson, D., & Willner, P. (1990) · Biological Psychiatry · doi:10.1016/0006-3223(90)90577-o · Cited by 122 · see citing works
Self-citationAntidepressant-like effects of dopamine agonists in an animal model of depression
Muscat, R., Papp, M., & Willner, P. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90119-k · Cited by 119 · see citing works
Self-citationReversal of antidepressant action by dopamine antagonists in an animal model of depression
Sampson, D., Willner, P., & Muscat, R. (1991) · Psychopharmacology · doi:10.1007/bf02245655 · Cited by 115 · see citing works
Self-citationPapp, M., Lappas, S., Muscat, R., & Willner, P. (1992) · Journal of Psychopharmacology · doi:10.1177/026988119200600302 · Cited by 90 · see citing works
Self-citationKelley, A. E., & Lang, C. G. (1989) · European Journal of Pharmacology · doi:10.1016/0014-2999(89)90447-0 · Cited by 82 · see citing works
Changes in mesolimbic dopamine may explain stress-induced anhedonia
Willner, P., Gołembiowska, K., Klimek, V., & Muscat, R. (1991) · Psychobiology · doi:10.1007/bf03337960 · Cited by 81 · see citing works
Self-citationPapp, M., Muscat, R., & Willner, P. (1993) · Psychopharmacology · doi:10.1007/bf02246965 · Cited by 79 · see citing works
Self-citationConditioning and experiential factors affecting the development of sensitization to apomorphine.
Mattingly, B. A., & Gotsick, J. E. (1989) · Behavioral Neuroscience · doi:10.1037//0735-7044.103.6.1311 · Cited by 73 · see citing works
Changes in dopamine autoreceptor sensitivity in an animal model of depression
Muscat, R., Towell, A., & Willner, P. (1988) · Psychopharmacology · doi:10.1007/bf00212853 · Cited by 72 · see citing works
Self-citationde Paulis, T., Kumar, Y., Johansson, L., Raemsby, S., Hall, H., Sällemark, M., Aengeby-Moeller, K., & Oegren, S. O. (1986) · Journal of Medicinal Chemistry · doi:10.1021/jm00151a010 · Cited by 71 · see citing works
Conditioning and experiential factors affecting the development of sensitization to apomorphine.
Mattingly, B. A., & Gotsick, J. E. (1989) · Behavioral Neuroscience · doi:10.1037/0735-7044.103.6.1311 · Cited by 59 · see citing works
Stamford, J. A., Muscat, R., O'Connor, J. J., Patel, J. C., Trout, S. J., Wieczorek, W. J., Kruk, Z. L., & Willner, P. (1991) · Psychopharmacology · doi:10.1007/bf02244322 · Cited by 58 · see citing works
Self-citationEnvironmental influences on behavioural sensitization to the dopamine agonist quinpirole
Willner, P., Papp, M., Cheeta, S., & Muscat, R. (1992) · Behavioural Pharmacology · doi:10.1097/00008877-199203010-00007 · Cited by 55 · see citing works
Self-citationPsychoactive drugs: Tolerance and sensitization
(1990) · General Pharmacology The Vascular System · doi:10.1016/0306-3623(90)90476-3 · Cited by 50 · see citing works
Martin-Iverson, M. T., Stahl, S. M., & Iversen, S. D. (1988) · Psychopharmacology · doi:10.1007/bf00172969 · Cited by 45 · see citing works
Fuller, R. W., & Hemrick-Luecke, S. K. (1985) · Journal of Neural Transmission · doi:10.1007/bf01251910 · Cited by 30 · see citing works
Sensitization to the Actions of Antidepressant Drugs
Willner, P. (1989) · Humana Press eBooks · doi:10.1007/978-1-59259-464-1_8 · Cited by 21 · see citing works
Self-citationSubsensitivity To Dopamine Agonists Following Chronic Unpredictable Mild Stress
Papp, M., Muscat, R., & Willner, P. (1992) · Journal of Psychopharmacology · doi:10.1177/026988119200600152 · Cited by 2 · see citing works
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Willner, P. (2005) · Neuropsychobiology · doi:10.1159/000087097 · Cited by 1,605 · see citing works
Self-citationChronic mild stress-induced anhedonia: A realistic animal model of depression
Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160 · see citing works
Self-citationGender Differences in the Effects of Prenatal Stress on Brain Development and Behaviour
Weinstock, M. (2007) · Neurochemical Research · doi:10.1007/s11064-007-9339-4 · Cited by 349 · see citing works
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Bekris, S., Antoniou, K., Daskas, S., & Papadopoulou-Daifoti, Z. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2005.01.005 · Cited by 281 · see citing works
Stress, depression and Parkinson's disease
Hemmerle, A. M., Herman, J. P., & Seroogy, K. B. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2011.09.035 · Cited by 225 · see citing works
Sharma, S., Fernandes, M. F., & Fulton, S. (2013) · International Journal of Obesity · doi:10.1038/ijo.2012.197 · Cited by 231 · see citing works
- Authors
- Papp, M., Willner, P., & Muscat, R.
- Venue
- Psychopharmacology
- Published
- 1993-01
- Volume
- 110
- Issue
- 1-2
- Pages
- 159-164
- ISSN
- 0033-3158 (ISSN-L)
- 1432-2072
- OpenAlex
- W2049626380
- Cited by
- 47
- References
- 29
- Citations by year
- 2023: 1 · 2022: 1 · 2019: 1 · 2016: 1 · 2014: 1 · 2013: 3 · 2012: 2
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Psychopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- chronic mild stress, quinpirole, dopamine agonists, behavioral sensitization, sucrose intake, mesolimbic dopamine system, raclopride, locomotor stimulant effects
- MeSH terms
- Animals, Behavior, Animal, Conditioning, Operant, Drinking Behavior, Ergolines, Male, Motor Activity, Reward, Salicylamides, Stress, Psychological, Sucrose, Dopamine Agonists, Dopamine Antagonists, Quinpirole, Raclopride, Rats
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