Cited by 41Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Retinoic acid isomers protect hippocampal neurons from amyloid-β induced neurodegeneration

Sahin, Mehmet, Karaüzüm, Sibel Berker, Perry, George, Smith, Mark A., Alicigüzel, Yakup·2005·Neurotoxicity Research

Abstract

Attenuating amyloid-beta mediated neurodegeneration is of major therapeutic consideration in the potential treatment of Alzheimer disease. Previously, we found that a high dietary consumption of retinoic acid was associated with a reduced incidence of Alzheimer disease. Therefore, in this study, we investigated whether amyloid-beta mediated cell death in primary hippocampal neurons could be prevented by retinoic acid isomers. Our results suggest that retinoic acid isomers, including all-trans retinoic acid, 9-cis retinoic acid, and 13-cis retinoic acid, may play an important role in protecting neurons from amyloid-beta -induced cell death. Retinoic acid may therefore afford a novel therapeutic mechanism for the treatment and prevention of Alzheimer disease.

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Crossref · 10.1007/bf03036453

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Authors
Sahin, M., Karaüzüm, S. B., Perry, G., Smith, M. A., & Alicigüzel, Y.
Affiliations
  • Akdeniz University (TR)
  • Case Western Reserve University (US)
Corresponding author
Smith, Mark A.
Venue
Neurotoxicity Research
Published
2005-01
Volume
7
Issue
3
Pages
243-250
ISSN
  • 1029-8428 (ISSN-L)
  • 1476-3524
OpenAlex
W2091587778
Cited by
41
References
59
Citations by year
2026: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2019: 3 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
1.79
Type
journal article
Language
en
Open access
closed
Locations
  • Neurotoxicity Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Akdeniz Üniversitesi
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
retinoic acid isomers, amyloid-beta, neurodegeneration, hippocampal neurons, Alzheimer's disease, all-trans retinoic acid, 9-cis-retinoic acid, isotretinoin, neuronal cell death, neuroprotection
MeSH terms
Alitretinoin, Animals, Animals, Newborn, Cell Count, Dose-Response Relationship, Drug, Drug Interactions, Hippocampus, Nerve Degeneration, Neurons, Peptide Fragments, Tretinoin, Isotretinoin, Amyloid beta-Peptides, Cell Death, Protein Isoforms, Rats

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