The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.
Glucocorticoids in T cell apoptosis and function
Open accessAbstract
Glucocorticoids (GCs) are a class of steroid hormones which regulate a variety of essential biological functions. The profound anti-inflammatory and immunosuppressive activity of synthetic GCs, combined with their power to induce lymphocyte apoptosis place them among the most commonly prescribed drugs worldwide. Endogenous GCs also exert a wide range of immunomodulatory activities, including the control of T cell homeostasis. Most, if not all of these effects are mediated through the glucocorticoid receptor, a member of the nuclear receptor superfamily. However, the signaling pathways and their cell type specificity remain poorly defined. In this review, we summarize our present knowledge on GC action, the mechanisms employed to induce apoptosis and the currently discussed models of how they may participate in thymocyte development. Although our knowledge in this field has substantially increased during recent years, we are still far from a comprehensive picture of the role that GCs play in T lymphocytes.
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Cited by
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Immune regulation by glucocorticoids
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Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza Infection
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Metadata
- Authors
- Herold, M. J., McPherson, K. G., & Reichardt, H. M.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2005-11-28
- Volume
- 63
- Issue
- 1
- Pages
- 60-72
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- OpenAlex
- W2053776694
- Cited by
- 397
- References
- 16
- FWCI
- 7.39
- Type
- journal article
- Language
- en
- Open access
- hybrid
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