The DOI matches its Crossref record; 64 of the 64 references it cites were found in a registry or an index.
Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza Infection
Open accessAbstract
The clinical response to influenza infection ranges from mild disease to severe pneumonia and it remains unclear whether the inflammatory response to infection is protective or pathogenic. We have defined a novel role for neutrophils in ameliorating lung injury during influenza infection, thereby limiting development of severe disease. Infection of neutrophil-depleted mice with influenza virus HKx31 (H3N2) led to rapid weight loss, pneumonia, and death. Neutropenia was associated with enhanced virus replication in the respiratory tract; however, viral titers were declining at the time of death, leading us to investigate other factors contributing to mortality. In addition to thymic atrophy, lymphopenia, and viremic spread, depletion of neutrophils led to exacerbated pulmonary inflammation, edema, and respiratory dysfunction. Thus, while it is well established that neutrophils contribute to lung injury in a range of pathological conditions, reduced numbers or impaired neutrophil function can facilitate progression of mild influenza to severe clinical disease.
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Cites
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Cited by
Multipotent mesenchymal stromal cells and the innate immune system
Le Blanc, K., & Mougiakakos, D. (2012) · Nature Reviews Immunology · doi:10.1038/nri3209 · Cited by 1,018
Expanding roles for CD4+ T cells in immunity to viruses
Swain, S. L., McKinstry, K. K., & Strutt, T. M. (2012) · Nature Reviews Immunology · doi:10.1038/nri3152 · Cited by 956
Narasaraju, T., Yang, E., Samy, R. P., Ng, H. H., Poh, W. P., Liew, A.-A., Phoon, M. C., van Rooijen, N., & Chow, V. T. (2011) · The American Journal of Pathology · doi:10.1016/j.ajpath.2011.03.013 · Cited by 890
Pathogenesis of influenza-induced acute respiratory distress syndrome
Short, K. R., Kroeze, E. J. B. V., Fouchier, R. A. M., & Kuiken, T. (2014) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(13)70286-x · Cited by 538
Jenne, C. N., Wong, C. H. Y., Zemp, F. J., McDonald, B., Rahman, M. M., Forsyth, P. A., McFadden, G., & Kubes, P. (2013) · Cell Host & Microbe · doi:10.1016/j.chom.2013.01.005 · Cited by 443
Metadata
- Authors
- Tate, M. D., Deng, Y.-M., Jones, J. E., Anderson, G. P., Brooks, A. G., & Reading, P. C.
- Venue
- The Journal of Immunology
- Publisher
- Oxford University Press (OUP)
- Published
- 2009-12-01
- Volume
- 183
- Issue
- 11
- Pages
- 7441-7450
- ISSN
- 0022-1767 (ISSN-L)
- 1550-6606
- OpenAlex
- W2103293702
- Cited by
- 295
- References
- 64
- FWCI
- 11.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Tate, M. D., Deng, Y.-M., Jones, J. E., Anderson, G. P., Brooks, A. G., & Reading, P. C. (2009). Neutrophils Ameliorate Lung Injury and the Development of Severe Disease during Influenza Infection. The Journal of Immunology. https://doi.org/10.4049/jimmunol.0902497
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
