Cited by 150Neuroscience and Neuropharmacology ResearchTreatment of Major DepressionReceptor Mechanisms and Signaling

Mechanisms of synaptic depression triggered by metabotropic glutamate receptors

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Bellone, C., Lüscher, C., Mameli, M.·2008·Cellular and Molecular Life Sciences

Abstract

Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.

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Crossref · 10.1007/s00018-008-8263-3

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  • LTD mediated through metabotropic glutamate receptors (mGluRs) has emerged as a major alternative to NMDAR-mediated LTD in widespread areas of the brain.

    “Notably, LTD mediated through metabotropic glutamate receptors (mGluRs) has emerged as a major alterative to NMDAR-mediated LTD in widespread areas of the brain124, 125, 126”

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Research works printed but not linked: 1

  1. Chowdhury, S., Shepherd, J. D., Okuno, H., Lyford, G., Petralia, R. S., Plath, N., Kuhl, D., Huganir, R. L. and Worley, Cell. Mol. Life Sci. Vol. 65, 2008 Review Article 2921

Authors
Bellone, C., Lüscher, C., & Mameli, M.
Affiliations
University of Geneva (CH)
Corresponding author
Lüscher, C.
Venue
Cellular and Molecular Life Sciences
Published
2008-08-19
Volume
65
Issue
18
Pages
2913-2923
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
OpenAlex
W2128266752
Cited by
150
References
118
Citations by year
2026: 4 · 2025: 8 · 2024: 3 · 2022: 7 · 2021: 9 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 9 · 2014: 11 · 2013: 11 · 2012: 15
FWCI
1.17
Type
journal article
Language
en
Open access
Locations
  • Cellular and Molecular Life Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
  • reroDoc Digital Library (submittedVersion)
  • Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
Keywords
metabotropic glutamate receptors, long-term depression, synaptic depression, metaplasticity, synaptic plasticity, glutamate signaling
MeSH terms
Animals, Humans, Synaptic Transmission, Neuronal Plasticity, Synapses, Receptors, Metabotropic Glutamate, Excitatory Postsynaptic Potentials, Protein Isoforms, Long-Term Synaptic Depression

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