Mechanisms of synaptic depression triggered by metabotropic glutamate receptors
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Glutamate, by activation of metabotropic receptors (mGluRs), can lead to a reduction of synaptic efficacy at many synapses. These forms of synaptic plasticity are referred to as long-term depression (mGluR-LTD). We will distinguish between mGluR-LTD induced by pre- or postsynaptic receptors and mGluR-LTD induced by the locus of the expression mechanism of the synaptic depression. We will also review recent evidence that mGluR-mediated responses themselves are subject to depression, which may constitute a form of metaplasticity.
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LTD mediated through metabotropic glutamate receptors (mGluRs) has emerged as a major alternative to NMDAR-mediated LTD in widespread areas of the brain.
“Notably, LTD mediated through metabotropic glutamate receptors (mGluRs) has emerged as a major alterative to NMDAR-mediated LTD in widespread areas of the brain124, 125, 126”
From A role for synaptic plasticity in the adolescent development of executive function (2013) · cites this paper as [124]
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Santschi, L. A., Zhang, X.-L., & Stanton, P. K. (2005) · Journal of Neurobiology · doi:10.1002/neu.20213 · Cited by 39 · see citing works
Synaptic signalling in cerebellar plasticity
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Neurotransmission: Emerging Roles of Endocannabinoids
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Homer 1a Suppresses Neocortex Long-Term Depression in a Cortical Layer-Specific Manner
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Flagged first, then by citations
Research works printed but not linked: 1
- Chowdhury, S., Shepherd, J. D., Okuno, H., Lyford, G., Petralia, R. S., Plath, N., Kuhl, D., Huganir, R. L. and Worley, Cell. Mol. Life Sci. Vol. 65, 2008 Review Article 2921
Cited by
Sorted by citations
Lüscher, C., & Huber, K. M. (2010) · Neuron · doi:10.1016/j.neuron.2010.01.016 · Cited by 627 · see citing works
Self-citationA role for synaptic plasticity in the adolescent development of executive function
Selemon, L. D. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.7 · Cited by 439 · see citing works
Metabotropic Glutamate Receptor-Mediated Long-Term Depression: Molecular Mechanisms
Gladding, C. M., Fitzjohn, S. M., & Molnár, E. (2009) · Pharmacological Reviews · doi:10.1124/pr.109.001735 · Cited by 233 · see citing works
Goriounova, N. A., & Mansvelder, H. D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.5502-11.2012 · Cited by 51 · see citing works
Yohn, S. E., Galbraith, J., Calipari, E. S., & Conn, P. J. (2019) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00601 · Cited by 36 · see citing works
- Authors
- Bellone, C., Lüscher, C., & Mameli, M.
- Affiliations
- University of Geneva (CH)
- Corresponding author
- Lüscher, C.
- Venue
- Cellular and Molecular Life Sciences
- Published
- 2008-08-19
- Volume
- 65
- Issue
- 18
- Pages
- 2913-2923
- ISSN
- 1420-682X (ISSN-L)
- 1420-9071
- PMC
- PMC11131865
- OpenAlex
- W2128266752
- Cited by
- 150
- References
- 118
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 3 · 2022: 7 · 2021: 9 · 2020: 7 · 2019: 7 · 2018: 4 · 2017: 4 · 2016: 8 · 2015: 9 · 2014: 11 · 2013: 11 · 2012: 15
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Cellular and Molecular Life Sciences (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Archive ouverte UNIGE (University of Geneva) (publishedVersion, other-oa)
- reroDoc Digital Library (submittedVersion)
- Archive ouverte UNIGE (University of Geneva) (submittedVersion, cc-by)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- metabotropic glutamate receptors, long-term depression, synaptic depression, metaplasticity, synaptic plasticity, glutamate signaling
- MeSH terms
- Animals, Humans, Synaptic Transmission, Neuronal Plasticity, Synapses, Receptors, Metabotropic Glutamate, Excitatory Postsynaptic Potentials, Protein Isoforms, Long-Term Synaptic Depression
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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