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Cited by 187Protein Kinase Regulation and GTPase SignalingCancer Mechanisms and TherapyMechanisms of cancer metastasis

CAS proteins in normal and pathological cell growth control

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Tikhmyanova, Nadezhda, Little, Joy L., Golemis, Erica A.·2010·Cellular and Molecular Life Sciences
DOI 10.1007/s00018-009-0213-1PMC PMC2836406
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Abstract

Proteins of the CAS (Crk-associated substrate) family (BCAR1/p130Cas, NEDD9/HEF1/Cas-L, EFS/SIN and CASS4/HEPL) are integral players in normal and pathological cell biology. CAS proteins act as scaffolds to regulate protein complexes controlling migration and chemotaxis, apoptosis, cell cycle, and differentiation, and have more recently been linked to a role in progenitor cell function. Reflecting these complex functions, over-expression of CAS proteins has now been strongly linked to poor prognosis and increased metastasis in cancer, as well as resistance to first-line chemotherapeutics in multiple tumor types including breast and lung cancers, glioblastoma, and melanoma. Further, CAS proteins have also been linked to additional pathological conditions including inflammatory disorders, Alzheimer's and Parkinson's disease, as well as developmental defects. This review will explore the roles of the CAS proteins in normal and pathological states in the context of the many mechanistic insights into CAS protein function that have emerged in the past decade.

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  • Little is currently known about CASS4 biology or its role in neurological health and disease.

    “Despite CASS4 being increasingly linked to AD risk in humans (EADB et al., 2026; Lambert et al., 2013; Lin et al., 2017; Ramos de Matos et al., 2018; Schwartzentruber et al., 2021; Wang et al., 2015b), little is currently known about CASS4 biology or its role in neurological health and disease.”

    From Alzheimer’s genetic risk factor CASS4 controls microglial focal adhesion biology and amyloidosis (2026) · cites this paper as Tikhmyanova et al., 2010

    The Introduction, section (1) (page unavailable), says relatively few publications addressed CASS4 function, supporting the claim that its biology was little understood when this 2010 review was written. Section (8) discusses neurological disease in relation to NEDD9, not CASS4. The review does not establish how much was known about CASS4’s neurological roles at the citing paper’s later date. (LLM, conf=0.84)

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  1. [1]Kanner SB Reynolds AB Parsons JT 1991 Tyrosine phosphorylation of a 120-kilodalton pp60src substrate upon epidermal growth factor and platelet-derived growth factor receptor stimulation and in polyomavirus middle-T-antigen-transformed cells Mol Cell Biol 11 713 720 1703631 PMC359722
  2. [2]Reynolds AB Roesel DJ Kanner SB Parsons JT 1989 Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene Mol Cell Biol 9 629 638 2469003 PMC362640
  3. [3]Sakai R Iwamatsu A Hirano N Ogawa S Tanaka T Mano H Yazaki Y Hirai H 1994 A novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent manner EMBO J 13 3748 3756 8070403 PMC395286
  4. [4]Brinkman A van der Flier S Kok EM Dorssers LC 2000 BCAR1, a human homologue of the adapter protein p130Cas, and antiestrogen resistance in breast cancer cells J Natl Cancer Inst 92 112 120 10639512
  5. [5]Ishino M Ohba T Sasaki H Sasaki T 1995 Molecular cloning of a cDNA encoding a phosphoprotein, Efs, which contains a Src homology 3 domain and associates with Fyn Oncogene 11 2331 2338 8570184
  6. [6]Alexandropoulos K Baltimore D 1996 Coordinate activation of c-Src by SH3- and SH2-binding sites on a novel p130Cas-related protein, Sin Genes Dev 10 1341 1355 8647432
  7. [7]Law SF Estojak J Wang B Mysliwiec T Kruh G Golemis EA 1996 Human enhancer of filamentation 1, a novel p130cas-like docking protein, associates with focal adhesion kinase and induces pseudohyphal growth in Saccharomyces cerevisiae Mol Cell Biol 16 3327 3337 8668148 PMC231327
  8. [8]Minegishi M Tachibana K Sato T Iwata S Nojima Y Morimoto C 1996 Structure and function of Cas-L, a 105-kD Crk-associated substrate-related protein that is involved in beta 1 integrin-mediated signaling in lymphocytes J Exp Med 184 1365 1375 8879209 PMC2192828
  9. [9]Kumar S Tomooka Y Noda M 1992 Identification of a set of genes with developmentally down-regulated expression in the mouse brain Biochem Biophys Res Commun 185 1155 1161 1378265
  10. [11]Astier A Manie SN Avraham H Hirai H Law SF Zhang Y Golemis EA Fu Y Druker BJ Haghayeghi N Freedman AS Avraham S 1997 The related adhesion focal tyrosine kinase differentially phosphorylates p130Cas and the Cas-like protein, p105HEF1 J Biol Chem 272 19719 19724 9242628
  11. [12]Manie SN Beck AR Astier A Law SF Canty T Hirai H Druker BJ Avraham H Haghayeghi N Sattler M Salgia R Griffin JD Golemis EA Freedman AS 1997 Involvement of p130(Cas) and p105(HEF1), a novel Cas-like docking protein, in a cytoskeleton-dependent signaling pathway initiated by ligation of integrin or antigen receptor on human B cells J Biol Chem 272 4230 4236 9020138
  12. [13]Iwata S Souta-Kuribara A Yamakawa A Sasaki T Shimizu T Hosono O Kawasaki H Tanaka H Dang NH Watanabe T Arima N Morimoto C 2005 HTLV-I Tax induces and associates with Crk-associated substrate lymphocyte type (Cas-L) Oncogene 24 1262 1271 15592516
  13. [14]Hunter AJ Shimizu Y 1997 Alpha 4 beta 1 integrin-mediated tyrosine phosphorylation in human T cells: characterization of Crk- and Fyn-associated substrates (pp105, pp115, and human enhancer of filamentation-1) and integrin-dependent activation of p59fyn1 J Immunol 159 4806 4814 9366405
  14. [15]Kamiguchi K Tachibana K Iwata S Ohashi Y Morimoto C 1999 Cas-L is required for beta 1 integrin-mediated costimulation in human Tcells J Immunol 163 563 568 10395641
  15. [16]Ohashi Y Iwata S Kamiguchi K Morimoto C 1999 Tyrosine Phosphorylation of Crk-Associated Substrate Lymphocyte-Type Is a Critical Element in TCR- and {beta}1 Integrin-Induced T Lymphocyte Migration J Immunol 163 3727 3734 10490968
  16. [17]van Seventer GA Salmen HJ Law SF O’Neill GM Mullen MM Franz AM Kanner SB Golemis EA van Seventer JM 2001 Focal adhesion kinase regulates beta1 integrin-dependent T cell migration through an HEF1 effector pathway Eur J Immunol 31 1417 1427 11465098
  17. [18]Sattler M Salgia R Shrikhande G Verma S Uemura N Law SF Golemis EA Griffin JD 1997 Differential signaling after beta1 integrin ligation is mediated through binding of CRKL to p120(CBL) and p110(HEF1) J Biol Chem 272 14320 14326 9162067
  18. [19]Kirsch KH Georgescu MM Hanafusa H 1998 Direct binding of p130(Cas) to the guanine nucleotide exchange factor C3G J Biol Chem 273 25673 25679 9748234
  19. [20]Garton AJ Burnham MR Bouton AH Tonks NK 1997 Association of PTP-PEST with the SH3 domain of p130cas; a novel mechanism of protein tyrosine phosphatase substrate recognition Oncogene 15 877 885 9285683
  20. [21]Liu F Sells MA Chernoff J 1998 Protein tyrosine phosphatase 1B negatively regulates integrin signaling Curr Biol 8 173 176 9443918
  21. [22]Nakamoto T Yamagata T Sakai R Ogawa S Honda H Ueno H Hirano N Yazaki Y Hirai H 2000 CIZ, a zinc finger protein that interacts with p130(cas) and activates the expression of matrix metalloproteinases Mol Cell Biol 20 1649 1658 10669742 PMC85348
  22. [23]Harte MT Hildebrand JD Burnham MR Bouton AH Parsons JT 1996 p130Cas, a substrate associated with v-Src and v-Crk, localizes to focal adhesions and binds to focal adhesion kinase J Biol Chem 271 13649 13655 8662921
  23. [24]Wisniewska M Bossenmaier B Georges G Hesse F Dangl M Kunkele KP Ioannidis I Huber R Engh RA 2005 The 1.1 A resolution crystal structure of the p130cas SH3 domain and ramifications for ligand selectivity J Mol Biol 347 1005 1014 15784259
  24. [25]Petruzzelli L Takami M Herrera R 1996 Adhesion through the interaction of lymphocyte function-associated antigen-1 with intracellular adhesion molecule-1 induces tyrosine phosphorylation of p130cas and its association with c-CrkII J Biol Chem 271 7796 7801 8631823
  25. [26]Nojima Y Morino N Mimura T Hamasaki K Furuya H Sakai R Sato T Tachibana K Morimoto C Yazaki Y 1995 Integrin-mediated cell adhesion promotes tyrosine phosphorylation of p130Cas, a Src homology 3-containing molecule having multiple Src homology 2-binding motifs J Biol Chem 270 15398 15402 7541040
  26. [27]Salgia R Pisick E Sattler M Li JL Uemura N Wong WK Burky SA Hirai H Chen LB Griffin JD 1996 p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene J Biol Chem 271 25198 25203 8810278
  27. [28]Ishino M Ohba T Inazawa J Sasaki H Ariyama Y Sasaki T 1997 Identification of an Efs isoform that lacks the SH3 domain and chromosomal mapping of human Efs Oncogene 15 1741 1745 9349509
  28. [29]Kostic A Sheetz MP 2006 Fibronectin rigidity response through Fyn and p130Cas recruitment to the leading edge Mol Biol Cell 17 2684 2695 16597701 PMC1474803
  29. [30]Sawada Y Tamada M Dubin-Thaler BJ Cherniavskaya O Sakai R Tanaka S Sheetz MP 2006 Force sensing by mechanical extension of the Src family kinase substrate p130Cas Cell 127 1015 1026 17129785 PMC2746973
  30. [31]Garron ML Arsenieva D Zhong J Bloom AB Lerner A O’Neill GM Arold ST 2009 Structural insights into the association between BCAR3 and Cas family members, an atypical complex implicated in anti-oestrogen resistance J Mol Biol 386 190 203 19103205
  31. [32]Briknarova K Nasertorabi F Havert ML Eggleston E Hoyt DW Li C Olson AJ Vuori K Ely KR 2005 The serine-rich domain from Crk-associated substrate (p130cas) is a four-helix bundle J Biol Chem 280 21908 21914 15795225
  32. [33]Vuori K Hirai H Aizawa S Ruoslahti E 1996 Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases Mol Cell Biol 16 2606 2613 8649368 PMC231251
  33. [34]O’Neill GM Golemis EA 2001 Proteolysis of the docking protein HEF1 and implications for focal adhesion dynamics Mol Cell Biol 21 5094 5108 11438665 PMC87235
  34. [35]Law SF Zhang YZ Fashena SJ Toby G Estojak J Golemis EA 1999 Dimerization of the docking/adaptor protein HEF1 via a carboxy-terminal helix-loop-helix domain Exp Cell Res 252 224 235 10502414
  35. [36]Nakamoto T Sakai R Ozawa K Yazaki Y Hirai H 1996 Direct binding of C-terminal region of p130Cas to SH2 and SH3 domains of Src kinase J Biol Chem 271 8959 8965 8621540
  36. [37]Nasertorabi F Tars K Becherer K Kodandapani R Liljas L Vuori K Ely KR 2006 Molecular basis for regulation of Src by the docking protein p130Cas J Mol Recognit 19 30 38 16245368
  37. [38]Sakakibara A Ohba Y Kurokawa K Matsuda M Hattori S 2002 Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation J Cell Sci 115 4915 4924 12432078
  38. [39]Cai D Felekkis KN Near RI O’Neill GM van Seventer JM Golemis EA Lerner A 2003 The GDP exchange factor AND-34 is expressed in B cells, associates with HEF1, and activates Cdc42 J Immunol 170 969 978 12517963
  39. [40]Feng L Guedes S Wang T 2004 Atrophin-1-interacting protein 4/human Itch is a ubiquitin E3 ligase for human enhancer of filamentation 1 in transforming growth factor-beta signaling pathways J Biol Chem 279 29681 29690 15051726
  40. [41]Nourry C Maksumova L Pang M Liu X Wang T 2004 Direct interaction between Smad3, APC10, CDH1 and HEF1 in proteasomal degradation of HEF1 BMC Cell Biol 5 20 15144564 PMC420458
  41. [42]Pellicena P Miller WT 2001 Processive phosphorylation of p130Cas by Src depends on SH3-polyproline interactions J Biol Chem 276 28190 28196 11389136
  42. [43]Law SF O’Neill GM Fashena SJ Einarson MB Golemis EA 2000 The Docking Protein HEF1 Is an Apoptotic Mediator at Focal Adhesion Sites Mol Cell Biol 20 5184 5195 10866674 PMC85967
  43. [44]Law SF Zhang YZ Klein-Szanto AJ Golemis EA 1998 Cell cycle-regulated processing of HEF1 to multiple protein forms differentially targeted to multiple subcellular compartments Mol Cell Biol 18 3540 3551 9584194 PMC108935
  44. [45]Kook S Shim SR Choi SJ Ahnn J Kim JI Eom SH Jung YK Paik SG Song WK 2000 Caspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells Mol Biol Cell 11 929 939 10712510 PMC14821
  45. [46]Petch LA Bockholt SM Bouton A Parsons JT Burridge K 1995 Adhesion-induced tyrosine phosphorylation of the p130 src substrate J Cell Sci 108 1371 1379 7542255
  46. [47]Polte TR Hanks SK 1995 Interaction between focal adhesion kinase and Crk-associated tyrosine kinase substrate p130Cas Proc Natl Acad Sci U S A 92 10678 10682 7479864 PMC40675
  47. [48]Ohba T Ishino M Aoto H Sasaki T 1998 Interaction of two proline-rich sequences of cell adhesion kinase beta with SH3 domains of p130Cas-related proteins and a GTPase-activating protein, Graf Biochem J 330 Pt 3 1249 1254 9494093 PMC1219269
  48. [49]Nakamoto T Sakai R Honda H Ogawa S Ueno H Suzuki T Aizawa S Yazaki Y Hirai H 1997 Requirements for localization of p130cas to focal adhesions Mol Cell Biol 17 3884 3897 9199323 PMC232241
  49. [50]Polte TR Hanks SK 1997 Complexes of focal adhesion kinase (FAK) and Crk-associated substrate (p130(Cas)) are elevated in cytoskeleton-associated fractions following adhesion and Src transformation. Requirements for Src kinase activity and FAK proline-rich motifs J Biol Chem 272 5501 5509 9038154
  50. [51]Makkinje A Near RI Infusini G Vanden Borre P Bloom A Cai D Costello CE Lerner A 2009 AND-34/BCAR3 regulates adhesion-dependent p130Cas serine phosphorylation and breast cancer cell growth pattern Cell Signal 21 1423 1435 19454314 PMC2740797
  51. [52]Pugacheva EN Golemis EA 2005 The focal adhesion scaffolding protein HEF1 regulates activation of the Aurora-A and Nek2 kinases at the centrosome Nat Cell Biol 7 937 946 16184168 PMC2652766
  52. [54]Donaldson JC Dempsey PJ Reddy S Bouton AH Coffey RJ Hanks SK 2000 Crk-Associated Substrate p130Cas Interacts with Nephrocystin and Both Proteins Localize to Cell-Cell Contacts of Polarized Epithelial Cells Experimental Cell Research 256 168 178 10739664
  53. [55]Kim W Kook S Kim DJ Teodorof C Song WK 2004 The 31-kDa caspase-generated cleavage product of p130cas functions as a transcriptional repressor of E2A in apoptotic cells J Biol Chem 279 8333 8342 14660614
  54. [56]Defilippi P Di Stefano P Cabodi S 2006 p130Cas: a versatile scaffold in signaling networks Trends Cell Biol 16 257 263 16581250
  55. [57]Honda H Oda H Nakamoto T Honda Z Sakai R Suzuki T Saito T Nakamura K Nakao K Ishikawa T Katsuki M Yazaki Y Hirai H 1998 Cardiovascular anomaly, impaired actin bundling and resistance to Src-induced transformation in mice lacking p130Cas Nat Genet 19 361 365 9697697
  56. [58]Astier A Manie SN Law SF Canty T Haghayghi N Druker BJ Salgia R Golemis EA Freedman AS 1997 Association of the Cas-like molecule HEF1 with CrkL following integrin and antigen receptor signaling in human B-cells: potential relevance to neoplastic lymphohematopoietic cells Leuk Lymphoma 28 65 72 9498705
  57. [59]Kanda H Mimura T Morino N Hamasaki K Nakamoto T Hirai H Morimoto C Yazaki Y Nojima Y 1997 Ligation of the T cell antigen receptor induces tyrosine phosphorylation of p105CasL, a member of the p130Cas-related docking protein family, and its subsequent binding to the Src homology 2 domain of c-Crk Eur J Immunol 27 2113 2117 9295052
  58. [60]Natarajan M Stewart JE Golemis EA Pugacheva EN Alexandropoulos K Cox BD Wang W Grammer JR Gladson CL 2006 HEF1 is a necessary and specific downstream effector of FAK that promotes the migration of glioblastoma cells Oncogene 25 1721 1732 16288224
  59. [61]Thao le B Vu HA Yasuda K Taniguchi S Yagasaki F Taguchi T Watanabe T Sato Y 2009 Cas-L was overexpressed in imatinib-resistant gastrointestinal stromal tumor cells Cancer Biol Ther 8 683 688 19417561
  60. [62]Kim M Gans JD Nogueira C Wang A Paik JH Feng B Brennan C Hahn WC Cordon-Cardo C Wagner SN Flotte TJ Duncan LM Granter SR Chin L 2006 Comparative oncogenomics identifies NEDD9 as a melanoma metastasis gene Cell 125 1269 1281 16814714
  61. [63]Merrill RA See AW Wertheim ML Clagett-Dame M 2004 Crk-associated substrate (Cas) family member, NEDD9, is regulated in human neuroblastoma cells and in the embryonic hindbrain by all-trans retinoic acid Dev Dyn 231 564 575 15376324
  62. [64]Merrill RA Ahrens JM Kaiser ME Federhart KS Poon VY Clagett-Dame M 2004 All-trans retinoic acid-responsive genes identified in the human SH-SY5Y neuroblastoma cell line and their regulated expression in the nervous system of early embryos Biol Chem 385 605 614 15318809
  63. [65]Liu X Elia AE Law SF Golemis EA Farley J Wang T 2000 A novel ability of Smad3 to regulate proteasomal degradation of a Cas family member HEF1 EMBO J 19 6759 6769 11118211 PMC305889
  64. [66]Zheng M McKeown-Longo PJ 2002 Regulation of HEF1 expression and phosphorylation by TGF-beta 1 and cell adhesion J Biol Chem 277 39599 39608 12189134
  65. [67]Richer JK Jacobsen BM Manning NG Abel MG Wolf DM Horwitz KB 2002 Differential gene regulation by the two progesterone receptor isoforms in human breast cancer cells J Biol Chem 277 5209 5218 11717311
  66. [68]Buterin T Koch C Naegeli H 2006 Convergent transcriptional profiles induced by endogenous estrogen and distinct xenoestrogens in breast cancer cells Carcinogenesis 27 1567 1578 16474171
  67. [69]Monroe DG Getz BJ Johnsen SA Riggs BL Khosla S Spelsberg TC 2003 Estrogen receptor isoform-specific regulation of endogenous gene expression in human osteoblastic cell lines expressing either ERalpha or ERbeta J Cell Biochem 90 315 326 14505348
  68. [70]Martin-Rendon E Hale SJ Ryan D Baban D Forde SP Roubelakis M Sweeney D Moukayed M Harris AL Davies K Watt SM 2007 Transcriptional profiling of human cord blood CD133+ and cultured bone marrow mesenchymal stem cells in response to hypoxia Stem Cells 25 1003 1012 17185612
  69. [71]Aquino JB Lallemend F Marmigere F Adameyko II Golemis EA Ernfors P 2009 The retinoic acid inducible Cas-family signaling protein Nedd9 regulates neural crest cell migration by modulating adhesion and actin dynamics Neuroscience 162 1106 1119 19464348 PMC2797478
  70. [72]Vogel T Ahrens S Buttner N Krieglstein K 2009 Transforming Growth Factor {beta} Promotes Neuronal Cell Fate of Mouse Cortical and Hippocampal Progenitors In Vitro and In Vivo: Identification of Nedd9 as an Essential Signaling Component Cereb Cortex PMC2820705 19587023
  71. [73]Boyer LA Lee TI Cole MF Johnstone SE Levine SS Zucker JP Guenther MG Kumar RM Murray HL Jenner RG Gifford DK Melton DA Jaenisch R Young RA 2005 Core Transcriptional Regulatory Circuitry in Human Embryonic Stem Cells Cell 122 947 956 16153702 PMC3006442
  72. [74]Bui LC Tomkiewicz C Chevallier A Pierre S Bats AS Mota S Raingeaud J Pierre J Diry M Transy C Garlatti M Barouki R Coumoul X 2009 Nedd9/Hef1/Cas-L mediates the effects of environmental pollutants on cell migration and plasticity Oncogene 19648964
  73. [75]Tran DH Satou K Ho TB 2008 Finding microRNA regulatory modules in human genome using rule induction BMC Bioinformatics 9 Suppl 12 S5 19091028 PMC2638145
  74. [76]Schlaepfer DD Broome MA Hunter T 1997 Fibronectin-stimulated signaling from a focal adhesion kinase-c-Src complex: involvement of the Grb2, p130cas, and Nck adaptor proteins Mol Cell Biol 17 1702 1713 9032297 PMC231895
  75. [77]Tachibana K Urano T Fujita H Ohashi Y Kamiguchi K Iwata S Hirai H Morimoto C 1997 Tyrosine phosphorylation of Crk-associated substrates by focal adhesion kinase. A putative mechanism for the integrin-mediated tyrosine phosphorylation of Crk-associated substrates J Biol Chem 272 29083 29090 9360983
  76. [78]Sanders MA Basson MD 2005 p130cas but not paxillin is essential for Caco-2 intestinal epithelial cell spreading and migration on collagen IV J Biol Chem 280 23516 23522 15817476
  77. [79]Schlaepfer DD Hauck CR Sieg DJ 1999 Signaling through focal adhesion kinase Prog Biophys Mol Biol 71 435 478 10354709
  78. [80]Cai D Clayton LK Smolyar A Lerner A 1999 AND-34, a novel p130Cas-binding thymic stromal cell protein regulated by adhesion and inflammatory cytokines J Immunol 163 2104 2112 10438950
  79. [81]Cai D Iyer A Felekkis KN Near RI Luo Z Chernoff J Albanese C Pestell RG Lerner A 2003 AND-34/BCAR3, a GDP exchange factor whose overexpression confers antiestrogen resistance, activates Rac, PAK1, and the cyclin D1 promoter Cancer Res 63 6802 6808 14583477
  80. [82]Abassi YA Rehn M Ekman N Alitalo K Vuori K 2003 p130Cas Couples the tyrosine kinase Bmx/Etk with regulation of the actin cytoskeleton and cell migration J Biol Chem 278 35636 35643 12832404
  81. [83]Korah R Choi L Barrios J Wieder R 2004 Expression of FGF-2 alters focal adhesion dynamics in migration-restricted MDA-MB-231 breast cancer cells Breast Cancer Res Treat 88 17 28 15538042
  82. [84]Avraham HK Lee TH Koh Y Kim TA Jiang S Sussman M Samarel AM Avraham S 2003 Vascular endothelial growth factor regulates focal adhesion assembly in human brain microvascular endothelial cells through activation of the focal adhesion kinase and related adhesion focal tyrosine kinase J Biol Chem 278 36661 36668 12844492
  83. [85]Podar K Shringarpure R Tai YT Simoncini M Sattler M Ishitsuka K Richardson PG Hideshima T Chauhan D Anderson KC 2004 Caveolin-1 is required for vascular endothelial growth factor-triggered multiple myeloma cell migration and is targeted by bortezomib Cancer Res 64 7500 7506 15492276
  84. [86]Ceacareanu AC Ceacareanu B Zhuang D Chang Y Ray RM Desai L Chapman KE Waters CM Hassid A 2006 Nitric oxide attenuates IGF-I-induced aortic smooth muscle cell motility by decreasing Rac1 activity: essential role of PTP-PEST and p130cas Am J Physiol Cell Physiol 290 C1263 1270 16354758
  85. [87]Nakamura I Rodan GA Duong le T 2003 Distinct roles of p130Cas and c-Cbl in adhesion-induced or macrophage colony-stimulating factor-mediated signaling pathways in prefusion osteoclasts Endocrinology 144 4739 4741 12959979
  86. [88]Rozengurt E 1998 Signal transduction pathways in the mitogenic response to G protein-coupled neuropeptide receptor agonists J Cell Physiol 177 507 517 10092204
  87. [89]Zhang Z Baron R Horne WC 2000 Integrin engagement, the actin cytoskeleton, and c-Src are required for the calcitonin-induced tyrosine phosphorylation of paxillin and HEF1, but not for calcitonin-induced Erk1/2 phosphorylation J Biol Chem 275 37219 37223 10954702
  88. [90]Zhang Z Hernandez-Lagunas L Horne WC Baron R 1999 Cytoskeleton-dependent tyrosine phosphorylation of the p130(Cas) family member HEF1 downstream of the G protein-coupled calcitonin receptor. Calcitonin induces the association of HEF1, paxillin, and focal adhesion kinase J Biol Chem 274 25093 25098 10455189
  89. [91]Kovacic-Milivojevic B Roediger F Almeida EA Damsky CH Gardner DG Ilic D 2001 Focal adhesion kinase and p130Cas mediate both sarcomeric organization and activation of genes associated with cardiac myocyte hypertrophy Mol Biol Cell 12 2290 2307 11514617 PMC58595
  90. [92]Jope RS Song L Grimes CA Zhang L 1999 Oxidative stress oppositely modulates protein tyrosine phosphorylation stimulated by muscarinic G protein-coupled and epidermal growth factor receptors J Neurosci Res 55 329 340 10348664
  91. [93]Takahashi T Kawahara Y Taniguchi T Yokoyama M 1998 Tyrosine phosphorylation and association of p130Cas and c-Crk II by ANG II in vascular smooth muscle cells Am J Physiol 274 H1059 1065 9575907
  92. [94]Yang CC Ogawa H Dwinell MB McCole DF Eckmann L Kagnoff MF 2005 Chemokine receptor CCR6 transduces signals that activate p130Cas and alter cAMP-stimulated ion transport in human intestinal epithelial cells Am J Physiol Cell Physiol 288 C321 328 15483227
  93. [95]Cowell LN Graham JD Bouton AH Clarke CL O’Neill GM 2006 Tamoxifen treatment promotes phosphorylation of the adhesion molecules, p130Cas/BCAR1, FAK and Src, via an adhesion-dependent pathway Oncogene 25 7597 7607 16799644
  94. [96]Sasaki T Iwata S Okano HJ Urasaki Y Hamada J Tanaka H Dang NH Okano H Morimoto C 2005 Nedd9 protein, a Cas-L homologue, is upregulated after transient global ischemia in rats: possible involvement of Nedd9 in the differentiation of neurons after ischemia Stroke 36 2457 2462 16210561
  95. [97]Lee TN Gold G Workman R Cook CA Konrad RJ 2004 Glucose stimulates the association of Crk with p130Cas in pancreatic beta cells Pancreas 29 e100 105 15502635
  96. [98]Ma A Richardson A Schaefer EM Parsons JT 2001 Serine Phosphorylation of Focal Adhesion Kinase in Interphase and Mitosis: A Possible Role in Modulating Binding to p130Cas Mol Biol Cell 12 1 12 11160818 PMC30563
  97. [99]Yamakita Y Totsukawa G Yamashiro S Fry D Zhang X Hanks SK Matsumura F 1999 Dissociation of FAK/p130CAS/c-Src Complex during Mitosis: Role of Mitosis-specific Serine Phosphorylation of FAK J Cell Biol 144 315 324 9922457 PMC2132894
  98. [100]Hoon Kim D Jeon Choi S Kook S Kim W Keun Song W 2003 Phosphorylation-dependent cleavage of p130cas in apoptotic rat-1 cells Biochem Biophys Res Commun 300 141 148 12480533
  99. [101]Wang X Weng LP Yu Q 2000 Specific inhibition of FGF-induced MAPK activation by the receptor-like protein tyrosine phosphatase LAR Oncogene 19 2346 2353 10822386
  100. [102]Weng LP Wang X Yu Q 1999 Transmembrane tyrosine phosphatase LAR induces apoptosis by dephosphorylating and destabilizing p130Cas Genes Cells 4 185 196 10320483
  101. [103]Garton AJ Flint AJ Tonks NK 1996 Identification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST Mol Cell Biol 16 6408 6418 8887669 PMC231642
  102. [104]Garton AJ Tonks NK 1999 Regulation of fibroblast motility by the protein tyrosine phosphatase PTP-PEST J Biol Chem 274 3811 3818 9920935
  103. [105]Cote JF Charest A Wagner J Tremblay ML 1998 Combination of gene targeting and substrate trapping to identify substrates of protein tyrosine phosphatases using PTP-PEST as a model Biochemistry 37 13128 13137 9748319
  104. [106]Sirois J Cote JF Charest A Uetani N Bourdeau A Duncan SA Daniels E Tremblay ML 2006 Essential function of PTP-PEST during mouse embryonic vascularization, mesenchyme formation, neurogenesis and early liver development Mech Dev 123 869 880 17070019 PMC4671782
  105. [107]Yo K Iwata S Hashizume Y Kondo S Nomura S Hosono O Kawasaki H Tanaka H Dang NH Morimoto C 2009 SHP-2 inhibits tyrosine phosphorylation of Cas-L and regulates cell migration Biochem Biophys Res Commun 382 210 214 19275884
  106. [108]Noguchi T Tsuda M Takeda H Takada T Inagaki K Yamao T Fukunaga K Matozaki T Kasuga M 2001 Inhibition of cell growth and spreading by stomach cancer-associated protein-tyrosine phosphatase-1 (SAP-1) through dephosphorylation of p130cas J Biol Chem 276 15216 15224 11278335
  107. [109]Yokoyama N Miller WT 2001 Protein phosphatase 2A interacts with the Src kinase substrate p130(CAS) Oncogene 20 6057 6065 11593413
  108. [110]Zheng M McKeown-Longo PJ 2006 Cell adhesion regulates Ser/Thr phosphorylation and proteasomal degradation of HEF1 J Cell Sci 119 96 103 16352661
  109. [111]Hivert V Pierre J Raingeaud J 2009 Phosphorylation of human enhancer of filamentation (HEF1) on serine 369 induces its proteasomal degradation Biochem Pharmacol 78 1017 1025 19539609
  110. [112]Achiwa H Lazo JS 2007 PRL-1 tyrosine phosphatase regulates c-Src levels, adherence, and invasion in human lung cancer cells Cancer Res 67 643 650 17234774
  111. [113]Daouti S Li WH Qian H Huang KS Holmgren J Levin W Reik L McGady DL Gillespie P Perrotta A Bian H Reidhaar-Olson JF Bliss SA Olivier AR Sergi JA Fry D Danho W Ritland S Fotouhi N Heimbrook D Niu H 2008 A selective phosphatase of regenerating liver phosphatase inhibitor suppresses tumor cell anchorage-independent growth by a novel mechanism involving p130Cas cleavage Cancer Res 68 1162 1169 18281492
  112. [114]Sorokin A Reed E 1998 Insulin stimulates the tyrosine dephosphorylation of docking protein p130cas (Crk-associated substrate), promoting the switch of the adaptor protein crk from p130cas to newly phosphorylated insulin receptor substrate-1 Biochem J 334 Pt 3 595 600 9729467 PMC1219728
  113. [115]Black DS Bliska JB 1997 Identification of p130Cas as a substrate of Yersinia YopH (Yop51), a bacterial protein tyrosine phosphatase that translocates into mammalian cells and targets focal adhesions EMBO J 16 2730 2744 9184219 PMC1169883
  114. [116]Persson C Carballeira N Wolf-Watz H Fallman M 1997 The PTPase YopH inhibits uptake of Yersinia, tyrosine phosphorylation of p130Cas and FAK, and the associated accumulation of these proteins in peripheral focal adhesions EMBO J 16 2307 2318 9171345 PMC1169832
  115. [117]Bruce-Staskal PJ Weidow CL Gibson JJ Bouton AH 2002 Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake J Cell Sci 115 2689 2700 12077360
  116. [118]Bannerman DD Sathyamoorthy M Goldblum SE 1998 Bacterial lipopolysaccharide disrupts endothelial monolayer integrity and survival signaling events through caspase cleavage of adherens junction proteins J Biol Chem 273 35371 35380 9857080
  117. [119]Fashena SJ Einarson MB O’Neill GM Patriotis C Golemis EA 2002 Dissection of HEF1-dependent functions in motility and transcriptional regulation J Cell Sci 115 99 111 11801728
  118. [120]Klemke RL Leng J Molander R Brooks PC Vuori K Cheresh DA 1998 CAS/Crk coupling serves as a "molecular switch" for induction of cell migration J Cell Biol 140 961 972 9472046 PMC2141747
  119. [121]Vuori K Ruoslahti E 1995 Tyrosine phosphorylation of p130Cas and cortactin accompanies integrin-mediated cell adhesion to extracellular matrix J Biol Chem 270 22259 22262 7545676
  120. [122]Cary LA Han DC Polte TR Hanks SK Guan JL 1998 Identification of p130Cas as a mediator of focal adhesion kinase-promoted cell migration J Cell Biol 140 211 221 9425168 PMC2132604
  121. [123]Nakamura I Jimi E Duong LT Sasaki T Takahashi N Rodan GA Suda T 1998 Tyrosine phosphorylation of p130Cas is involved in actin organization in osteoclasts J Biol Chem 273 11144 11149 9556601
  122. [124]Moro L Dolce L Cabodi S Bergatto E Boeri Erba E Smeriglio M Turco E Retta SF Giuffrida MG Venturino M Godovac-Zimmermann J Conti A Schaefer E Beguinot L Tacchetti C Gaggini P Silengo L Tarone G Defilippi P 2002 Integrin-induced epidermal growth factor (EGF) receptor activation requires c-Src and p130Cas and leads to phosphorylation of specific EGF receptor tyrosines J Biol Chem 277 9405 9414 11756413
  123. [125]Kiyokawa E Hashimoto Y Kobayashi S Sugimura H Kurata T Matsuda M 1998 Activation of Rac1 by a Crk SH3-binding protein, DOCK180 Genes Dev 12 3331 3336 9808620 PMC317231
  124. [126]Feller SM Posern G Voss J Kardinal C Sakkab D Zheng J Knudsen BS 1998 Physiological signals and oncogenesis mediated through Crk family adapter proteins J Cell Physiol 177 535 552 10092207
  125. [127]Kanda H Mimura T Hamasaki K Yamamoto K Yazaki Y Hirai H Nojima Y 1999 Fyn and Lck tyrosine kinases regulate tyrosine phosphorylation of p105CasL, a member of the p130Cas docking protein family, in T-cell receptor-mediated signalling Immunology 97 56 61 10447714 PMC2326814
  126. [128]O’Neill GM Fashena SJ Golemis EA 2000 Integrin signalling: a new Cas(t) of characters enters the stage Trends Cell Biol 10 111 119 10675905
  127. [129]Ridley AJ 2001 Rho GTPases and cell migration J Cell Sci 114 2713 2722 11683406
  128. [130]Simpson KJ Selfors LM Bui J Reynolds A Leake D Khvorova A Brugge JS 2008 Identification of genes that regulate epithelial cell migration using an siRNA screening approach Nat Cell Biol 10 1027 1038 19160483
  129. [131]Smith HW Marra P Marshall CJ 2008 uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180 J Cell Biol 182 777 790 18725541 PMC2518715
  130. [132]Furuya K Nakamoto T Shen ZJ Tsuji K Nifuji A Hirai H Noda M 2000 Overexpression of Cas-interacting zinc finger protein (CIZ) suppresses proliferation and enhances expression of type I collagen gene in osteoblast-like MC3T3E1 cells Exp Cell Res 261 329 335 11112339
  131. [133]Janssen H Marynen P 2006 Interaction partners for human ZNF384/CIZ/NMP4--zyxin as a mediator for p130CAS signaling? Exp Cell Res 312 1194 1204 16510139
  132. [134]Pratt SJ Epple H Ward M Feng Y Braga VM Longmore GD 2005 The LIM protein Ajuba influences p130Cas localization and Rac1 activity during cell migration J Cell Biol 168 813 824 15728191 PMC2171823
  133. [135]Yi J Kloeker S Jensen CC Bockholt S Honda H Hirai H Beckerle MC 2002 Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers J Biol Chem 277 9580 9589 11782456
  134. [136]Dolfi F Garcia-Guzman M Ojaniemi M Nakamura H Matsuda M Vuori K 1998 The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathway Proc Natl Acad Sci U S A 95 15394 15399 9860979 PMC28053
  135. [137]Fagerstrom S Pahlman S Nanberg E 1998 Protein kinase C-dependent tyrosine phosphorylation of p130cas in differentiating neuroblastoma cells J Biol Chem 273 2336 2343 9442079
  136. [138]Gustavsson A Yuan M Fallman M 2004 Temporal dissection of beta1-integrin signaling indicates a role for p130Cas-Crk in filopodia formation J Biol Chem 279 22893 22901 15044442
  137. [139]Alexander NR Branch KM Parekh A Clark ES Iwueke IC Guelcher SA Weaver AM 2008 Extracellular matrix rigidity promotes invadopodia activity Curr Biol 18 1295 1299 18718759 PMC2555969
  138. [140]Cho SY Klemke RL 2002 Purification of pseudopodia from polarized cells reveals redistribution and activation of Rac through assembly of a CAS/Crk scaffold J Cell Biol 156 725 736 11839772 PMC2174083
  139. [141]Zaidel-Bar R Kam Z Geiger B 2005 Polarized downregulation of the paxillin-p130CAS-Rac1 pathway induced by shear flow J Cell Sci 118 3997 4007 16129884
  140. [142]Dadke D Jarnik M Pugacheva EN Singh MK Golemis EA 2006 Deregulation of HEF1 impairs M-phase progression by disrupting the RhoA activation cycle Mol Biol Cell 17 1204 1217 16394104 PMC1382310
  141. [143]Bargon SD Gunning PW O’Neill GM 2005 The Cas family docking protein, HEF1, promotes the formation of neurite-like membrane extensions Biochim Biophys Acta 1746 143 154 16344118
  142. [144]Kyaw M Yoshizumi M Tsuchiya K Kagami S Izawa Y Fujita Y Ali N Kanematsu Y Toida K Ishimura K Tamaki T 2004 Src and Cas are essentially but differentially involved in angiotensin II-stimulated migration of vascular smooth muscle cells via extracellular signal-regulated kinase 1/2 and c-Jun NH2-terminal kinase activation Mol Pharmacol 65 832 841 15044612
  143. [145]Wendt MK Smith JA Schiemann WP 2009 p130Cas is required for mammary tumor growth and transforming growth factor-{beta} (TGF-{beta})-mediated metastasis through regulation of Smad2/3 activity J Biol Chem PMC2797185 19822523
  144. [146]Gingras D Michaud M Di Tomasso G Beliveau E Nyalendo C Beliveau R 2008 Sphingosine-1-phosphate induces the association of membrane-type 1 matrix metalloproteinase with p130Cas in endothelial cells FEBS Lett 582 399 404 18164686
  145. [147]Imhof BA Aurrand-Lions M 2004 Adhesion mechanisms regulating the migration of monocytes Nat Rev Immunol 4 432 444 15173832
  146. [148]Regelmann AG Danzl NM Wanjalla C Alexandropoulos K 2006 The Hematopoietic Isoform of Cas-Hef1-Associated Signal Transducer Regulates Chemokine-Induced Inside-Out Signaling and T Cell Trafficking Immunity 25 907 918 17174122
  147. [149]Gotoh T Cai D Tian X Feig LA Lerner A 2000 p130Cas regulates the activity of AND-34, a novel Ral, Rap1, and R-Ras guanine nucleotide exchange factor J Biol Chem 275 30118 30123 10896938
  148. [150]Hisakawa N Tanaka H Hosono O Nishijima R Ohashi Y Saito S Nishiya K Hashimoto K Morimoto C 2002 Aberrant responsiveness to RANTES in synovial fluid T cells from patients with rheumatoid arthritis J Rheumatol 29 1124 1134 12064824
  149. [151]Yu HG Schrader H Otte JM Schmidt WE Schmitz F 2004 Rapid tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130Cas by gastrin in human colon cancer cells Biochem Pharmacol 67 135 146 14667936
  150. [152]Dutt P Wang JF Groopman JE 1998 Stromal cell-derived factor-1 alpha and stem cell factor/kit ligand share signaling pathways in hemopoietic progenitors: a potential mechanism for cooperative induction of chemotaxis J Immunol 161 3652 3658 9759889
  151. [153]Wang JF Park IW Groopman JE 2000 Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces migration of hematopoietic progenitor cells: roles of phosphoinositide-3 kinase and protein kinase C Blood 95 2505 2513 10753828
  152. [154]Zhang XF Wang JF Matczak E Proper JA Groopman JE 2001 Janus kinase 2 is involved in stromal cell-derived factor-1alpha-induced tyrosine phosphorylation of focal adhesion proteins and migration of hematopoietic progenitor cells Blood 97 3342 3348 11369622
  153. [155]Fernandis AZ Cherla RP Ganju RK 2003 Differential regulation of CXCR4-mediated T-cell chemotaxis and mitogen-activated protein kinase activation by the membrane tyrosine phosphatase, CD45 J Biol Chem 278 9536 9543 12519755
  154. [156]Seo S Asai T Saito T Suzuki T Morishita Y Nakamoto T Ichikawa M Yamamoto G Kawazu M Yamagata T Sakai R Mitani K Ogawa S Kurokawa M Chiba S Hirai H 2005 Crk-associated substrate lymphocyte type is required for lymphocyte trafficking and marginal zone B cell maintenance J Immunol 175 3492 3501 16148091
  155. [157]Donlin LT Danzl NM Wanjalla C Alexandropoulos K 2005 Deficiency in Expression of the Signaling Protein Sin/Efs Leads to T-Lymphocyte Activation and Mucosal Inflammation Mol Cell Biol 25 11035 11046 16314525 PMC1316950
  156. [158]Rosenblatt J Raff MC Cramer LP 2001 An epithelial cell destined for apoptosis signals its neighbors to extrude it by an actin- and myosin-dependent mechanism Curr Biol 11 1847 1857 11728307
  157. [159]Frisch SM Francis H 1994 Disruption of epithelial cell-matrix interactions induces apoptosis J Cell Biol 124 619 626 8106557 PMC2119917
  158. [161]Wei L Yang Y Zhang X Yu Q 2004 Cleavage of p130Cas in anoikis J Cell Biochem 91 325 335 14743392
  159. [162]Bhattacharya S Guo H Ray RM Johnson LR 2007 Basic helix-loop-helix protein E47-mediated p21Waf1/Cip1 gene expression regulates apoptosis of intestinal epithelial cells Biochem J 407 243 254 17617061 PMC2049013
  160. [163]Wei L Yang Y Zhang X Yu Q 2002 Anchorage-independent phosphorylation of p130(Cas) protects lung adenocarcinoma cells from anoikis J Cell Biochem 87 439 449 12397603
  161. [164]Wendt MK Drury LJ Vongsa RA Dwinell MB 2008 Constitutive CXCL12 expression induces anoikis in colorectal carcinoma cells Gastroenterology 135 508 517 18558091 PMC2583344
  162. [165]Cabodi S Tinnirello A Di Stefano P Bisaro B Ambrosino E Castellano I Sapino A Arisio R Cavallo F Forni G Glukhova M Silengo L Altruda F Turco E Tarone G Defilippi P 2006 p130Cas as a new regulator of mammary epithelial cell proliferation, survival, and HER2-neu oncogene-dependent breast tumorigenesis Cancer Res 66 4672 4680 16651418
  163. [166]Brinkman A de Jong D Tuinman S Azaouagh N van Agthoven T Dorssers LC 2009 The substrate domain of BCAR1 is essential for anti-estrogen-resistant proliferation of human breast cancer cells Breast Cancer Res Treat 19412734
  164. [167]van der Flier S Brinkman A Look MP Kok EM Meijer-van Gelder ME Klijn JG Dorssers LC Foekens JA 2000 Bcar1/p130Cas protein and primary breast cancer: prognosis and response to tamoxifen treatment J Natl Cancer Inst 92 120 127 10639513
  165. [168]Casanova I Bosch R Lasa A Parreno M Cespedes MV Brunet S Nomdedeu JF Mangues MA Sierra J Mangues R 2008 A celecoxib derivative inhibits focal adhesion signaling and induces caspase-8-dependent apoptosis in human acute myeloid leukemia cells Int J Cancer 123 217 226 18398841
  166. [169]Ta HQ Thomas KS Schrecengost RS Bouton AH 2008 A novel association between p130Cas and resistance to the chemotherapeutic drug adriamycin in human breast cancer cells Cancer Res 68 8796 8804 18974122 PMC2597570
  167. [170]Hakak Y Martin GS 1999 Cas mediates transcriptional activation of the serum response element by Src Mol Cell Biol 19 6953 6962 10490632 PMC84690
  168. [171]Pylayeva Y Gillen KM Gerald W Beggs HE Reichardt LF Giancotti FG 2009 Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling J Clin Invest 119 252 266 19147981 PMC2631302
  169. [172]Dorssers LC van Agthoven T Brinkman A Veldscholte J Smid M Dechering KJ 2005 Breast cancer oestrogen independence mediated by BCAR1 or BCAR3 genes is transmitted through mechanisms distinct from the oestrogen receptor signalling pathway or the epidermal growth factor receptor signalling pathway Breast Cancer Res 7 R82 92 15642172 PMC1064102
  170. [173]Izumchenko E Singh MK Plotnikova OV Tikhmyanova N Little JL Serebriiskii IG Seo S Kurokawa M Egleston BL Klein-Szanto A Pugacheva EN Hardy RR Wolfson M Connolly DC Golemis EA 2009 NEDD9 promotes oncogenic signaling in mammary tumor development Cancer Res 69 7198 7206 19738060 PMC2758619
  171. [174]Cabodi S Moro L Baj G Smeriglio M Di Stefano P Gippone S Surico N Silengo L Turco E Tarone G Defilippi P 2004 p130Cas interacts with estrogen receptor alpha and modulates non-genomic estrogen signaling in breast cancer cells J Cell Sci 117 1603 1611 15020686
  172. [175]Kim W Seok Kang Y Soo Kim J Shin NY Hanks SK Song WK 2008 The integrin-coupled signaling adaptor p130Cas suppresses Smad3 function in transforming growth factor-beta signaling Mol Biol Cell 19 2135 2146 18321991 PMC2366878
  173. [176]Marumoto T Zhang D Saya H 2005 Aurora-A - a guardian of poles Nat Rev Cancer 5 42 50 15630414
  174. [177]Honda K Mihara H Kato Y Yamaguchi A Tanaka H Yasuda H Furukawa K Urano T 2000 Degradation of human Aurora2 protein kinase by the anaphase-promoting complex-ubiquitin-proteasome pathway Oncogene 19 2812 2819 10851084
  175. [178]Zhou H Kuang J Zhong L Kuo WL Gray JW Sahin A Brinkley BR Sen S 1998 Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation Nat Genet 20 189 193 9771714
  176. [179]Pugacheva EN Golemis EA 2006 HEF1-aurora A interactions: points of dialog between the cell cycle and cell attachment signaling networks Cell Cycle 5 384 391 16479169 PMC2547350
  177. [180]Fritz G Kaina B 2006 Rho GTPases: promising cellular targets for novel anticancer drugs Curr Cancer Drug Targets 6 1 14 16475973
  178. [181]Glotzer M 2003 Cytokinesis: progress on all fronts Curr Opin Cell Biol 15 684 690 14644192
  179. [182]Singla V Reiter JF 2006 The primary cilium as the cell’s antenna: signaling at a sensory organelle Science 313 629 633 16888132
  180. [183]Plotnikova OV Golemis EA Pugacheva EN 2008 Cell cycle-dependent ciliogenesis and cancer Cancer Res 68 2058 2061 18381407 PMC2546565
  181. [184]Roodman GD 1996 Advances in Bone Biology: The Osteoclast Endocr Rev 17 308 332 8854048
  182. [185]Duong LT Lakkakorpi PT Nakamura I Machwate M Nagy RM Rodan GA 1998 PYK2 in osteoclasts is an adhesion kinase, localized in the sealing zone, activated by ligation of alpha(v)beta3 integrin, and phosphorylated by src kinase J Clin Invest 102 881 892 9727056 PMC508953
  183. [186]Lakkakorpi PT Nakamura I Nagy RM Parsons JT Rodan GA Duong LT 1999 Stable association of PYK2 and p130(Cas) in osteoclasts and their co-localization in the sealing zone J Biol Chem 274 4900 4907 9988732
  184. [187]Nakamura I Kadono Y Takayanagi H Jimi E Miyazaki T Oda H Nakamura K Tanaka S Rodan GA Duong le T 2002 IL-1 regulates cytoskeletal organization in osteoclasts via TNF receptor-associated factor 6/c-Src complex J Immunol 168 5103 5109 11994463
  185. [188]Duong LT Nakamura I Lakkakorpi PT Lipfert L Bett AJ Rodan GA 2001 Inhibition of osteoclast function by adenovirus expressing antisense protein-tyrosine kinase 2 J Biol Chem 276 7484 7492 11102447
  186. [189]Chellaiah MA Biswas RS Yuen D Alvarez UM Hruska KA 2001 Phosphatidylinositol 3,4,5-trisphosphate directs association of Src homology 2-containing signaling proteins with gelsolin J Biol Chem 276 47434 47444 11577104
  187. [190]Zhang Z Neff L Bothwell AL Baron R Horne WC 2002 Calcitonin induces dephosphorylation of Pyk2 and phosphorylation of focal adhesion kinase in osteoclasts Bone 31 359 365 12231407
  188. [191]Weidow CL Black DS Bliska JB Bouton AH 2000 CAS/Crk signalling mediates uptake of Yersinia into human epithelial cells Cell Microbiol 2 549 560 11207607
  189. [192]Shi J Casanova JE 2006 Invasion of host cells by Salmonella typhimurium requires focal adhesion kinase and p130Cas Mol Biol Cell 17 4698 4708 16914515 PMC1635395
  190. [193]Halle M Gomez MA Stuible M Shimizu H McMaster WR Olivier M Tremblay ML 2009 The Leishmania surface protease GP63 cleaves multiple intracellular proteins and actively participates in p38 mitogen-activated protein kinase inactivation J Biol Chem 284 6893 6908 19064994 PMC2652307
  191. [194]Gower TL Peeples ME Collins PL Graham BS 2001 RhoA is activated during respiratory syncytial virus infection Virology 283 188 196 11336544
  192. [195]Li E Stupack DG Brown SL Klemke R Schlaepfer DD Nemerow GR 2000 Association of p130CAS with phosphatidylinositol-3-OH kinase mediates adenovirus cell entry J Biol Chem 275 14729 14735 10799562
  193. [196]Ilic D Furuta Y Kanazawa S Takeda N Sobue K Nakatsuji N Nomura S Fujimoto J Okada M Yamamoto T 1995 Reduced cell motility and enhanced focal adhesion contact formation in cells from FAK-deficient mice Nature 377 539 544 7566154
  194. [197]Kovacic-Milivojevic B Damsky CC Gardner DG Ilic D 2002 Requirements for the localization of p130 Cas to Z-lines in cardiac myocytes Cell Mol Biol Lett 7 323 329 12097978
  195. [198]Beaty TH Fallin MD Hetmanski JB McIntosh I Chong SS Ingersoll R Sheng X Chakraborty R Scott AF 2005 Haplotype diversity in 11 candidate genes across four populations Genetics 171 259 267 15965248 PMC1456517
  196. [199]Toriello HV 2009 Are the oral-facial-digital syndromes ciliopathies? Am J Med Genet A 149A 1089 1095 19396822
  197. [200]Huang Z Yazdani U Thompson-Peer KL Kolodkin AL Terman JR 2007 Crk-associated substrate (Cas) signaling protein functions with integrins to specify axon guidance during development Development 134 2337 2347 17537798
  198. [201]Burnham MR Harte MT Richardson A Parsons JT Bouton AH 1996 The identification of p130cas-binding proteins and their role in cellular transformation Oncogene 12 2467 2472 8649789
  199. [202]Iwahara T Akagi T Fujitsuka Y Hanafusa H 2004 CrkII regulates focal adhesion kinase activation by making a complex with Crk-associated substrate, p130Cas Proc Natl Acad Sci U S A 101 17693 17698 15598735 PMC539787
  200. [203]Sakai R Nakamoto T Ozawa K Aizawa S Hirai H 1997 Characterization of the kinase activity essential for tyrosine phosphorylation of p130Cas in fibroblasts Oncogene 14 1419 1426 9136985

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Cited by

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Authors
Tikhmyanova, N., Little, J. L., & Golemis, E. A.
Affiliations
Fox Chase Cancer Center (US)
Corresponding author
Golemis, Erica A.
ORCID
Venue
Cellular and Molecular Life Sciences
Publisher
Springer Science and Business Media LLC
Published
2009-11-25
Volume
67
Issue
7
Pages
1025-1048
ISSN
  • 1420-682X (ISSN-L)
  • 1420-9071
DOI
10.1007/s00018-009-0213-1
PMC
PMC2836406
OpenAlex
W1964246500
Cited by
187
References
3
Citations by year
2026: 2 · 2025: 8 · 2024: 3 · 2023: 5 · 2022: 6 · 2021: 10 · 2020: 6 · 2019: 4 · 2018: 13 · 2017: 12 · 2016: 9 · 2015: 11 · 2014: 19 · 2013: 20 · 2012: 33
FWCI
1.51
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (tdm)
Locations
  • Cellular and Molecular Life Sciences (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
Funders
National Cancer Institute (NIH R01 CA63366, R01CA113342, NIH T32 CA009035, T32CA009035, R01CA063366, P30CA006927, CA06927)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cancer Mechanisms and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mechanisms of cancer metastasis
Keywords
scaffold proteins, cell migration, chemotaxis, apoptosis, cell cycle, cell differentiation, progenitor cells, metastasis, chemoresistance, breast cancer, lung cancer, glioblastoma, melanoma, inflammatory diseases, Alzheimer's disease, Parkinson's disease, developmental defects
MeSH terms
Cell Movement, Humans, Neoplasms, Phosphoproteins, Apoptosis, Adaptor Proteins, Signal Transducing, Crk-Associated Substrate Protein

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